Category: 431-38-9

Related Products of 431-38-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol, molecular formula is C3H6F3NO, molecular weight is 129.0811, as common compound, the synthetic route is as follows.

3-Oxo-2-(pyridin-3-yl)-6-[4-(trifluoromethyl)phenyl]-2 ,3-di hydropyridazi ne-4-carboxylic acid (100 mg, 0.277 mmcl) was dissolved in anhydrous DMF (2.1 mL). (2RS)-3-Amino-1,1,1- trifluoropropan-2-ol (71.5 mg, 0.55 mmol), N-ethyl-N-isopropylpropan-2-amine (314 pL, 1.80mmol), and propane phosphonic acid anhydride (T3P, 243 pL, 50% in DMF, 415 pmol) were successively added. It was stirred at rt overnight. The reaction mixture was diluted with dichloromethane and concentrated under vacuum. The residue was purified by RP-HPLC (column: X-Bridge 018 5pm lOOx3Omm, mobile phase: (water + 0.2 vol% aqueous ammonia (32%)) acetonitrile, gradient) yielding 57.3 mg (44%) of the title compound.1H-NMR (400MHz, DMSO-d6): 6 [ppm] = 3.49 (ddd, 1H), 3.76 (ddd, 1H), 4.18-4.29 (m, 1H),6.68 (br s, 1H), 7.65 (ddd, 1H), 7.89 (d, 2H), 8.18 (ddd, 1H), 8.22 (d, 2H), 8.71 (dd, 1H), 8.75(s, 1H), 8.93 (d, 1H), 9.59 (t, 1H).

Statistics shows that 431-38-9 is playing an increasingly important role. we look forward to future research findings about 3-Amino-1,1,1-trifluoropropan-2-ol.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM; GUTCHER, Ilona; ROeHN, Ulrike; SCHMEES, Norbert; ZORN, Ludwig; ROeSE, Lars; BADER, Benjamin; KOBER, Christina; CARRETERO, Rafael; STOeCKIGT, Detlef; IRLBACHER, Horst; PLATTEN, Michael; (397 pag.)WO2018/146010; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

Preparation 10: 4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3,3-trifluoro-2-hydroxypropyl)-1-naphthamide To a solution of 4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1-naphthoic acid (Preparation 7, 1 g, 2.1 mmol) in DMF (25 mL) was added HATU (970 mg, 2.5 mmol) and triethylamine (1.0 mL, 7.0 mmol).The reaction was stirred at room temperature for 15 minutes then treated with 3-amino-1,1,1-trifluoro-2-propanol (275 mg, 2.1 mmol). The reaction was stirred at room temperature for 18 hours. Next, the reaction was diluted with 0.1NNaOH and extracted with EtOAc (2¡Á150 mL). The combined organic phase was dried (Na2SO4) and concentrated under vacuum. The crude material was chromatographed (80 g Redi-Sep column) eluting from 100% heptane to 40:60 EtOAc:heptane to afford the intermediate (1.06 g, 85%) as a solid. 1HNMR (CDCl3) delta ppm: 8.81 (1H), 8.28 (1H), 7.71-7.57 (5H), 7.49 (1H), 6.55 (1H) 4.32-4.25 (3H), 4.08-3.91 (1H), 3.85 (1H), 3.79-3.74 (1H); m/z (Cl) 583 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER INC.; US2012/77765; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol, the common compound, a new synthetic route is introduced below. Formula: C3H6F3NO

A solution of 150 mg intermediate 17, 1 12 mg 3-amino-1 ,1 ,1 -trifluoropropan-2-ol, 248 mg HATU and 0.23 mL ethyldiisopropylamine in 7.5 mL of DMF was stirred at room temperature for 14 hours. Then the reaction was quenched by water, and the mixture was extracted with dichloromethane two times. The combined organic phases were dried over sodium sulfate and evaporated to dryness. The residue was subjected to RP-HPLC ((column: X-Bridge C18 5muetaiota 100x30mm, mobile phase: acetonitrile / water (0.1 Vol% formic acid)-gradient)) to yield 130 mg 6-(4-chlorophenyl)-2-(3-fluorophenyl)-3-oxo-/V-(3,3,3-trifluoro-2-hydroxypropyl)-2,3- dihydropyridazine-4-carboxamide. 1H-NMR (400 MHz, DMSO-de): delta = 3.47 (ddd, 1 H); 3.75 (ddd, 1 H); 4.17-4.27 (m, 1 H); 6.66 (d, 1 H); 7.39 (ddt, 1 H); 7.53-7.66 (m, 5H); 8.00 (d, 2H); 8.67 (s, 1 H); 9.64 (t, 1 H).

The synthetic route of 431-38-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ); SCHMEES, Norbert; GUTCHER, Ilona; IRLBACHER, Horst; BADER, Benjamin; ZHAO, Na; PLATTEN, Michael; (437 pag.)WO2017/202816; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 431-38-9 ,Some common heterocyclic compound, 431-38-9, molecular formula is C3H6F3NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 150 mg intermediate 6-[4-(trifluoromethoxy)phenyl]-2-(3-fluorophenyl)-3-oxo-2,3- dihydropyridazine-4-carboxylic acid, 90.2 mg 3-amino-1 ,1 ,1 -trifluoro-2-propanol, 260.4 mg HATU, 0.18 mL ethyldiisopropylamine and 2 mg 4-dimethylaminopyridine in 2.5 mL of DMF was stirred at room temperature for 3 hours. Then the reaction mixture was filtered and subjected to RP-HPLC (Instrument: Labomatic HD-3000 HPLC gradient pump, Labomatic Labocol Vario-2000 fraction collector; column: Chromatorex C-18 125 mm x 30 mm, eluent A: 0.1 % formic acid in water, eluent B: acetonitrile; gradient: A 60% / B 40%? A 20% / B 80%; flow: 150 mL/min; UV-detection: 254 nm) to yield 101 mg 2-(3-fluorophenyl)-3-oxo-N-(3,3,3- trifluoro-2-hydroxypropyl)-6-[4-(trifluoromethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide. 1H NMR (400 MHz, DMSO-d6) delta ppm = 3.47 (ddd, 1 H), 3.70 – 3.81 (m, 1 H), 4.18 – 4.28 (m, 1 H), 6.66 (d, 1 H), 7.36 – 7.44 (m, 1 H), 7.51 (d, 2 H), 7.54 – 7.59 (m, 1 H), 7.59 – 7.67 (m, 2 H), 8.10 (d, 2 H), 8.69 (s, 1 H), 9.64 (t, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,431-38-9, its application will become more common.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ); SCHMEES, Norbert; GUTCHER, Ilona; IRLBACHER, Horst; BADER, Benjamin; ZHAO, Na; PLATTEN, Michael; (437 pag.)WO2017/202816; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 431-38-9 ,Some common heterocyclic compound, 431-38-9, molecular formula is C3H6F3NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 50 mg intermediate 3-oxo-2-(pyridin-3-yl)-6-[4-(trifluoromethoxy)phenyl]-2 ,3-dihydropyridazine-4-carboxylic acid, 34 mg 3-amino-i ,i ,i-trifluoro-2-propanol, 101 mg HATU,0.1 mL ethyldiisopropylamine and 1 mg 4-dimethylaminopyridine in 1 mL of DMF was stirred atrt for 14 hours. Then the reaction mixture was filtered and subjected to RP-HPLC (instrument:Labomatic HD-3000 HPLC gradient pump, Labomatic Labocol Vario-2000 fraction collector;column: Chromatorex 0-18 125 mm x 30 mm, eluent A: water + 0.2 vol% aqueous ammonia(32%), eluent B: acetonitrile; gradient: A 70% I B 30% – A 30% I B 70%; flow: 150 mLlmin;UV-detection: 254 n m) to yield 8 mg rac-3-oxo-2-(pyrid in-3-yl)-N-[3,3,3-trifluoro-2-hydroxypropyl]-6-[4-(trifluoromethoxy)phenyl]-2,3-d ihyd ropyridazine-4-carboxamide.1H NMR (400 MHz, DMSO-d6) 6 [ppm] = 3.48 (ddd, 1 H), 3.70 – 3.79 (m, 1 H), 4.16 -4.29 (m, 1H), 6.66 (d, 1 H), 7.52 (d, 2 H), 7.64 (dd, 1 H), 8.09 – 8.14 (m, 2 H), 8.15 – 8.20 (m, 1 H), 8.67 -8.72 (m, 2 H), 8.93 (d, 1 H), 9.61 (t, 1 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM; GUTCHER, Ilona; ROeHN, Ulrike; SCHMEES, Norbert; ZORN, Ludwig; ROeSE, Lars; BADER, Benjamin; KOBER, Christina; CARRETERO, Rafael; STOeCKIGT, Detlef; IRLBACHER, Horst; PLATTEN, Michael; (397 pag.)WO2018/146010; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 3-Amino-1,1,1-trifluoropropan-2-ol, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 3-Amino-1,1,1-trifluoropropan-2-ol

General procedure: To a stirred solution of amino alcohol 5 (8.80 mmol, 1.10 equiv.) in DMF (16.0 mL, 0.5M) atroom temperature was added isothiocyanate 4 (8.00 mmol, 1.00 equiv.). After stirring for 2minutes at room temperature, Vilsmeier salt 3 (12.00 mmol, 1.50 equiv.) and iPr2NEt (12.00mmol, 1.50 equiv.) were added sequentially. The reaction mixture was allowed to stir at 75Cuntil adjudged complete by TLC, generally 4 hours. The reaction was diluted with EtOAc(50mL) and sequentially washed with sat. aq. NaHCO3 (25mL) and brine (25mL). The organiclayer was dried over MgSO4, polish filtered, and concentrated under reduced pressure. The cruderesidue was purified by silica gel column chromatography (100% heptane to 80% EtOAc inheptane gradient) to give 6.

The synthetic route of 431-38-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Corbett, Michael T.; Caille, Seb; Synlett; vol. 28; 20; (2017); p. 2845 – 2850;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 431-38-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol, molecular formula is C3H6F3NO, molecular weight is 129.0811, as common compound, the synthetic route is as follows.

A mixture of propyl-(2,6, 8-trichloro-pyrimido [5 ,4-dj pyrimidin-4-yl)-amine(2) (250 mg, 0.85 mmol) and 3-amino-1,1,1-trifluoro-propan-2-ol (221 mg, 1.71 mmol) inTHF (7 mL) was stirred at room temperature for 1 8h. A saturated NaHCO3 solution (30 mL) was added, the resulting suspension was extracted with dichloromethane (3 x 10 mL). The combined organic extracts were washed with brine (30 mL) and dried over solid anhydrous Na2SO4. After filtering, the solvent was removed and the residue was purified by flashcolumn chromatography using gradient elution from PE/EtOAc (3:1) to PE/EtOAc (1:9) to give 3-(2,6-dichloro-8-propylamino-pyrimido[5,4-djpyrimidin-4-ylamino)-1 ,1,1 -trifluoropropan-2-ol (21) (277 mg, 84% yield). ESI-MS (m/z): 385, 387, 389 [M+Hf?.

Statistics shows that 431-38-9 is playing an increasingly important role. we look forward to future research findings about 3-Amino-1,1,1-trifluoropropan-2-ol.

Reference:
Patent; GALLEON PHARMACEUTICALS, INC.; DAX, Scott L.; MENCEL, James Joseph; OZOLA, Vita; SUNA, Edgars; SHUBIN, Kirill; (294 pag.)WO2017/3822; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 431-38-9, blongs to alcohols-buliding-blocks compound. 431-38-9

A solution of 100 mg intermediate 6, 83.2 mg 3-amino-1,1,1-trifluoropropan-2-ol, 184 mgHATU and 0.17 mL ethyldiisopropylamine in 5 mL of DMF was stirred at room temperature for14 hours. Then the reaction was quenched by water, and the mixture was extracted with dichloromethane two times. The combined organic phases were dried over sodium sulfate and evaporated to dryness. The residue was subjected to flash chromatography (dichloromethane / methanol gradient with up to 2% methanol) to yield 65mg 6-(4-methylphenyl)-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-N-(3 ,3,3-trifluoro-2-hydroxypropyl)-2 ,3-dihydropyridazi ne-4-carboxamide.1H-NMR (400 MHz, CDCI3): 6 [ppm] = 2.44 (s, 3H); 3.78 (ddd, 1H); 3.90 (ddd, 1H); 3.99 (s,3H); 4.18-4.27 (m, 1H); 4.56 (d, 1H); 7.33 (d, 2H); 7.82 (d, 2H); 8.16 (s, 1H); 8.33 (s, 1H); 8.71(s, 1H); 10.24 (bt, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,431-38-9, its application will become more common.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM; GUTCHER, Ilona; ROeHN, Ulrike; SCHMEES, Norbert; ZORN, Ludwig; ROeSE, Lars; BADER, Benjamin; KOBER, Christina; CARRETERO, Rafael; STOeCKIGT, Detlef; IRLBACHER, Horst; PLATTEN, Michael; (397 pag.)WO2018/146010; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

431-38-9 , The common heterocyclic compound, 431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol, molecular formula is C3H6F3NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 130mg intermediate ii, 101 mg 3-amino-1,1,1-trifluoropropan-2-ol, 224mg HATU and 0.21 mL ethyldiisopropylamine in 10 mL of DMF was stirred at room temperature for 14 hours. Then the reaction was quenched by water, and the mixture was extracted with dichloromethane two times. The combined organic phases were dried over sodium sulfate and evaporated to dryness. The residue was subjected to flash chromatography (dichloromethanemethanol gradient with up to 2% methanol) to yield 160 mg 6-(4-chlorophenyl)-2-(1 -methyl-i,3,3-trifluoro-2-hydroxypropyl)-2 ,3-di hydropyridazi ne-4-carboxamide.1H-NMR (400 MHz, CDCI3): 6 [ppm] = 3.70-3.79 (m, 1H); 3.93 (ddd, 1H); 3.98 (s, 3H); 4.21-4.28 (m, 1 H); 4.64 (br s, 1 H); 7.49 (d, 2H); 7.85 (d, 2H); 8.11 (s, 1 H); 8.31 (s, 1 H); 8.66 (s, 1i0.15(bt,1H).

According to the analysis of related databases, 431-38-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM; GUTCHER, Ilona; ROeHN, Ulrike; SCHMEES, Norbert; ZORN, Ludwig; ROeSE, Lars; BADER, Benjamin; KOBER, Christina; CARRETERO, Rafael; STOeCKIGT, Detlef; IRLBACHER, Horst; PLATTEN, Michael; (397 pag.)WO2018/146010; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 431-38-9, blongs to alcohols-buliding-blocks compound. 431-38-9

A solution of 100 mg intermediate 32, 75 mg 3-amino-1 ,1 ,1 -trifluoropropan-2-ol, 167 mg HATU and 0.15 mL ethyldiisopropylamine in 5 mL of DMF was stirred at room temperature for 14 hours. Then the reaction was quenched by water, and the mixture was extracted with dichloromethane two times. The combined organic phases were dried over sodium sulfate and evaporated to dryness. The residue was subjected to RP-HPLC (column: X-Bridge C18 5muetaiota 100x30mm, mobile phase: acetonitrile / water (0.1 Vol% formic acid)-gradient)) to yield 90 mg 2-(3,5-difluorophenyl)-6-(4-methylphenyl)-3-oxo-/V-(3,3,3-trifluoro-2-hydroxypropyl)-2,3- dihydropyridazine-4-carboxamide. 1H-NMR (400 MHz, DMSO-d6): delta = 2.37 (s, 3H); 3.47 (ddd, 1 H); 3.74 (ddd, 1 H); 4.17-4.28 (m, 1 H); 6.66 (d, 1 H); 7.34 (d, 2H); 7.47 (tt, 1 H); 7.53-7.58 (m, 2H); 7.87 (d, 2H); 8.64 (s, 1 H); 9.60 (t, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,431-38-9, its application will become more common.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ); SCHMEES, Norbert; GUTCHER, Ilona; IRLBACHER, Horst; BADER, Benjamin; ZHAO, Na; PLATTEN, Michael; (437 pag.)WO2017/202816; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts