Category: 431-38-9

Reference of 431-38-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol. A new synthetic method of this compound is introduced below.

Into a microwave vial under an inert atmosphere of N2, were placed intermediate from Step B (220 mg, 0.40 mmol), in N-methyl-2-pyrrolidinone (3 mL) and THF (3 mL), and 3-amino-1,1,1-trifluoropropan-2-ol (207 mg, 1.60 mmol). The mixture wasirradiated with microwave radiation at 180 C for 3 h, then cooled to RT, quenched with water (100 mL), and extracted with EtOAc (3 x 100 mL). The combined organic layer was washed with water (2 x 100 mL), dried over anhydr. Na2SO4, filtered and concentrated in vacuo to dryness. The residue was purified by column chromatography with MeOH/DCM (0- 5%) to afford the racemic title compound, which was resolved by chiral-prep-HPLC ColumnPhenomenex Lux 5u Cellulose-4, to afford isomers A (faster eluting) and B (slower eluting) of the title compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WHITEHEAD, Alan; ORNOSKI, Olga; RAGHAVAN, Subharekha; BERGER, Raphaelle; GARFUNKLE, Joie; YANG, Zhiqiang; JI, Gang; JIANG, Falong; FU, Jianmin; (132 pag.)WO2017/197555; (2017); A1;,
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Reference of 431-38-9, Adding some certain compound to certain chemical reactions, such as: 431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol,molecular formula is C3H6F3NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 431-38-9.

To a solution of intermediate Int-13 (1.0 equiv.) and racemic-3-amino-l,l,l-trifluoropropan-2-ol (3.0 equiv.) in 3: 1 dioxane/water (1.3 mL) was added triethylamine (5.0 equiv.). The reaction mixture was stirred at 90C for 18 h. After cooling to room temperature, the reaction mixture was reduced to half its volume, diluted with 1N aqueous HC1 solution and ethyl acetate. The layers were separated and the organic layer was washed successively with water then saturated aqueous sodium chloride solution, dried (sodium sulfate), and concentrated in vacuo to afford a crude solid. The crude material was purified by reverse phase HPLC using a gradient of 30 to 60% acetonitrile in water (modified by 0.1% formic acid) to provide racemic Compound 1-8 (34.5 mg, 55 % yield) as a pale yellow solid. 1H NMR (500 MHz, CD3OD) d (ppm): 9.35 (s, 1 H), 8.32 (s, 1 H), 8.12 (s, 1 H), 7.80 (s, 1 H), 7.25 – 7.30 (m, 1 H), 7.17 – 7.24 (m, 1 H), 6.99 – 7.02 (m, 1 H), 7.02 – 7.07 (m, 1 H), 4.66 (s, 2 H), 4.33 – 4.41 (m, 1 H), 4.03 (dd, 1 H), 3.76 (dd, 1 H). MS ES+ m/z = 467.2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CYCLERION THERAPEUTICS, INC.; RENNIE, Glen, Robert; RENHOWE, Paul, Allan; NAKAI, Takashi; MERMERIAN, Ara; CUMBERBATCH, Helen; (99 pag.)WO2019/126354; (2019); A1;,
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Synthetic Route of 431-38-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol, molecular formula is C3H6F3NO, molecular weight is 129.0811, as common compound, the synthetic route is as follows.

A solution of 150 mg intermediate 33, 107 mg 3-amino-1 ,1 ,1 -trifluoropropan-2-ol, 317 mg HATU, 2.5 mg 4-dimethylaminopyridine and 0.22 mL ethyldiisopropylamine in 3.1 mL of DMF was stirred at room temperature for 14 hours. Then the reaction was filtered and the solution was subjected to RP-HPLC ((column: X-Bridge C18 5muetaiota 100x30mm, mobile phase: acetonitrile / water (0.2 Vol% ammonia 32%)-gradient)) to yield 1 14 mg 6-[4- (difluoromethyl)phenyl]-2-(3-fluorophenyl)-3-oxo-/V-(3,3,3-trifluoro-2-hydroxypdihydropyridazine-4-carboxamide. 1H-NMR (400 MHz, DMSO-d6): delta = 3.43-3.52 (m, 1 H); 3.72-3.80 (m, 1 H); 4.19-4.27 (m, 1 H); 6.67 (s, 1 H); 7.13 (t, 1 H); 7.40 (ddt, 1 H); 7.54-7.67 (m, 3H); 7.72 (d, 2H); 8.12 (d, 2H); 8.71 (s, 1 H); 9.64 (t, 1 Eta).

Statistics shows that 431-38-9 is playing an increasingly important role. we look forward to future research findings about 3-Amino-1,1,1-trifluoropropan-2-ol.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ); SCHMEES, Norbert; GUTCHER, Ilona; IRLBACHER, Horst; BADER, Benjamin; ZHAO, Na; PLATTEN, Michael; (437 pag.)WO2017/202816; (2017); A1;,
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Electric Literature of 431-38-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 431-38-9 as follows.

2-(3-Fluorophenyl)-3-oxo-6-[4-(trifluoromethyl)phenyl]-2,3-dihydropyridazine-4-carboxylic acid (100 mg, 0.26 mmol) was dissolved in anhydrous DMF (2 mL). (2RS)-3-Amino-1 ,1 ,1 – trifluoropropan-2-ol (68 mg, 0.53 mmol), N-ethyl-N-isopropylpropan-2-amine (0.207 mL, 1.19 mmol), and propane phosphonic acid anhydride (T3P, 231 muIota_, 50% in DMF, 397 muetaetaomicronIota) were successively added. It was stirred at rt overnight. The crude reaction mixture was purified by RP-HPLC (column: X-Bridge C18 5muetaiota 100x30mm, mobile phase: (water + 0.1 vol% formic acid (99%)) / acetonitril gradient) to yield 73.9 mg (57%) of the title compound. 1H-NMR (400MHz, DMSO-de): delta [ppm] = 3.48 (ddd, 1 H), 3.71 – 3.80 (m, 1 H), 4.17 – 4.29 (m, 1 H), 6.67 (d, 1 H), 7.37 – 7.44 (m, 1 H), 7.55 – 7.59 (m, 1 H), 7.60 – 7.67 (m, 2H), 7.89 (d, 2H), 8.20 (d, 2H), 8.74 (s, 1 H), 9.62 (t, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,431-38-9, its application will become more common.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ); SCHMEES, Norbert; GUTCHER, Ilona; IRLBACHER, Horst; BADER, Benjamin; ZHAO, Na; PLATTEN, Michael; (437 pag.)WO2017/202816; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

[1369] A solution of 3-amino-1,1,1-trifluoropropan-2-ol (0.016 g, 0.122 mmol), HATU (0.046 mg, 0.122 mmol), and 3-amino-6-(5-(3-amino-1,1,1-trifluoro-2-hydroxy-3-oxopropan-2-yl)-2-methylphenyl)pyrazine-2-carboxylic acid (0.030 g, 0.081 mmol) (single enantiomer, synthesized according to procedure in Example 38) in DMF (0.810 mL) was stirred at rt for 5 min, treated with triethylamine (0.034 mL, 0.243 mmol), and stirred at rt for 30 min. The reaction mixture was concentrated and purified by flash column chromatography using methanol in dichloromethane (0% to 20%) to give the desired product that still contained some impurities. This material was repurified by flash column chromatography using ethyl acetate in hexanes (0% to 100%) to give the desired product as a mixture of diastereomers. The mixture of diastereomers was separated via preparative chiral HPLC (Chiral Technologies ChiralPak IA [20250 mm, 5 micron], eluting with 15% ethanol in hexanes, at flow rate of 20 mL/min, loading about 8 mg in 1.8 mL ethanol) to give the first eluting diastereomer (3.20 mg, 8.21%) as 43A and the second eluting diastereomer (3.00 mg, 7.69%) as 43B. The first diastereomer that eluted had a retention time of 12.2 min. The second diastereomer that eluted had a retention time of 16.6 min. 43A: LCMS for C18H18F6N5O4(M+H)+: m/z=482.1; Found: 482.1. 43B: LCMS for C18H18F6N5O4 (M+H)+: m/z=482.1; Found: 482.1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; Incyte Corporation; Douty, Brent; Ai, Yanran; Burns, David M.; Combs, Andrew P.; Falahatpisheh, Nikoo; Levy, Daniel; Polam, Padmaja; Shao, Lixin; Shepard, Stacey; Shvartsbart, Artem; Yue, Eddy W.; (132 pag.)US2020/2295; (2020); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol, molecular formula is C3H6F3NO, molecular weight is 129.0811, as common compound, the synthetic route is as follows.Recommanded Product: 3-Amino-1,1,1-trifluoropropan-2-ol

General procedure: Sodium triacetoxyhydroborate (900 mg, 4.2 mmol) was added to a solution of 1-naphthaldehyde (2.8 mmol) and the amine (2.8 mmol) in 1,2-dichloroethane (80 mL) at r.t. under nitrogen atmosphere. The reaction mixture was stirred for 6 h at r.t. and was quenched with sat. aq. NaHCO3 (20 mL) and extracted with DCM (3 x 50 mL). The combined organic layer was washed with brine (50 mL), dried and evaporated. The compound was purified by preparative HPLC on a XBridge C18 column (10 m 250×19 ID mm) using a gradient of 30-80% Acetonitrile in H2O/ACN/NH3 95/5/0.2 buffer over 20 minutes with a flow of 19 mL/min. The compounds were detected by UV at 220 nm to provide the product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, and friends who are interested can also refer to it.

Reference:
Article; Giordanetto, Fabrizio; Wallberg, Andreas; Ghosal, Saswati; Iliefski, Tommy; Cassel, Johan; Yuan, Zhong-Qing; Von Wachenfeldt, Henrik; Andersen, Soren M.; Inghardt, Tord; Tunek, Anders; Nylander, Sven; Bioorganic and medicinal chemistry letters; vol. 22; 21; (2012); p. 6671 – 6676,6;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol, molecular formula is C3H6F3NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C3H6F3NO

EXAMPLE 20 17-(5-fluoropyridin-3-yl)-N-[(RS)-3,3,3-trifluoro-2-hydroxypropyl]oestra-1,3,5(10),16-tetraene-3-carboxamide Analogously to Example 8, 250 mg of 17-(5-fluoropyridin-3-yl)oestra-1,3,5(10),16-tetraene-3-carboxylic acid were reacted with 171 mg of 2-amino-1-(trifluoromethyl)ethan-1-ol to give 161 mg of the title compound. C27H28F4N2O2 UPLC analysis (Method 1) Rt=1.45 min, mass found ESI(+) 488.21. 1H NMR (300 MHz, DMSO-d6): delta [ppm]=0.99 (s, 3H), 1.35-1.80 (m, 5H), 1.85-1.97 (m, 1H), 2.05-2.21 (m, 2H), 2.25-2.43 (m, 3H), 2.81-2.95 (m, 2H), 3.18-3.26 (m, 1H), 3.49-3.62 (m, 1H), 4.07-4.22 (m, 1H), 6.40-6.30 (m, 1H), 6.45 (d, 1H), 7.33 (d, 1H), 7.52-7.62 (m, 2H), 7.64-7.73 (m, 1H), 8.43 (d, 1H), 8.47-8.51 (m, 1H), 8.55 (t, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 431-38-9.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BOTHE, Ulrich; BUSEMANN, Matthias; BARAK, Naomi; ROTGERI, Andrea; FISCHER, Oliver Martin; MARQUARDT, Tobias; (41 pag.)US2016/24142; (2016); A1;,
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Application of 431-38-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol, molecular formula is C3H6F3NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

6-(4-Ch lorophenyl)-3-oxo-2-(pyridin-3-yl)-2 ,3-d ihyd ropyridazine-4-carboxylic acid (100 mg,0.31 mmol) was dissolved in anhydrous DMF (2.3 mL). (2RS)-3-Amino-1,1,1-trifluoropropan-2-ol (78.8 mg, 0.61 mmol), N-ethyl-N-isopropylpropan-2-amine (0.239 mL, 1.37 mmol), and propane phosphonic acid anhydride (T3P, 267 pL, 50% in DMF, 458 pmol) were successively added. It was stirred at rt overnight. The crude reaction mixture was purified by RP-HPLC (column: X-Bridge 018 5pm lOOx3Omm, mobile phase: (water + 0.2 vol% aqueous ammonia (32%)) acetonitrile, gradient) to yield 23 mg (23%) of the title compound.1H-NMR (400MHz, DMSO-d6): 6 [ppm] = 3.43 -3.52 (m, 1H), 3.71 -3.79 (m, 1H), 4.17-4.28(m, 1H), 6.66 (d, 1H), 7.57 -7.61 (m, 2H), 7.64 (dd, 1H), 7.99 -8.04 (m, 2H), 8.17 (ddd, 1H),8.66 – 8.73 (m, 2H), 8.92 (br s, 1 H), 9.61 (t, 1 H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM; GUTCHER, Ilona; ROeHN, Ulrike; SCHMEES, Norbert; ZORN, Ludwig; ROeSE, Lars; BADER, Benjamin; KOBER, Christina; CARRETERO, Rafael; STOeCKIGT, Detlef; IRLBACHER, Horst; PLATTEN, Michael; (397 pag.)WO2018/146010; (2018); A1;,
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Reference of 431-38-9 ,Some common heterocyclic compound, 431-38-9, molecular formula is C3H6F3NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 150 mg intermediate 6-[4-(difluoromethoxy)phenyl]-2-(3-fluorophenyl)-3-oxo-2,3- dihydropyridazine-4-carboxylic acid, 92.6 mg amino-1 ,1 ,1 -trifluoro-2-propanol, 273 mg HATU, 0.19 mL ethyldiisopropylamine and 2.2 mg 4-dimethylaminopyridine in 3 mL of DMF was stirred at room temperature for 48 hours. Then the reaction mixture was filtered and subjected to RP-HPLC (Instrument: Waters Autopurification MS SingleQuad; Colum: Waters XBrigde C18 5mu 100x30mm; eluent A: water + 0.2 vol % aqueous ammonia (32%), eluent B: acetonitrile; gradient: 0-5.5 min 5-100% B; flow 70 mL/min; temperature: 25 C; DAD scan: 210-400 nm) to yield 62 mg 6-[4-(difluoromethoxy)phenyl]-2-(3-fluorophenyl)-3-oxo-N-(3,3,3- trifluoro-2-hydroxypropyl)-2,3-dihydropyridazine-4-carboxamide. 1H NMR (400 MHz, DMSO-d6) delta ppm = 3.48 (br dd, 1 H), 3.69 – 3.81 (m, 1 H), 4.22 (br s, 1 H), 6.66 (br d, 1 H), 7.27 – 7.43 (m, 4 H), 7.55 (br d, 1 H), 7.58 – 7.66 (m, 2 H), 7.99 – 8.08 (m, 2 H), 8.67 (s, 1 H), 8.62 – 8.74 (m, 1 H), 9.66 (br s, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,431-38-9, its application will become more common.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ); SCHMEES, Norbert; GUTCHER, Ilona; IRLBACHER, Horst; BADER, Benjamin; ZHAO, Na; PLATTEN, Michael; (437 pag.)WO2017/202816; (2017); A1;,
Alcohol – Wikipedia,
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Synthetic Route of 431-38-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

A suspension of intermediate Int-21 (1.0 equiv.) and (0487) racemic-3- Amino- l,l,l-trifluoro-propan-2-ol (3.0 equiv.), and triethylamine (5.0 equiv) in 3: 1 dioxane/water (1.3 mL) was heated at 90 C for 12 hours, after which LC-MS analysis indicated that the conversion was complete. The reaction mixture was diluted with water and adjusted to pH 6-7 with 1.0 N aqueous hydrochloric acid solution, leading to the formation of an orange precipitate. The solid was filtered and dried. Purification of the crude solid was achieved by reverse phase HPLC utilizing a gradient of 10 to 40 % acetonitrile in water (modified by 0.1% trifluoroacetic acid) over 20min to afford racemic Compound 1-11 (57.4 mg, 48 % yield) as an off-white solid. 1H NMR: (500 MHz, CD3OD), d (ppm): 9.63 (s, 1 H), 8.61 (s, 1 H), 7.74 (s, 1 H), 7.30 – 7.33 (m, 1 H), 7.15 – 7.20 (m, 1 H), 6.97 – 7.01 (m, 2 H, overlapping shifts), 4.67 (s, 2 H), 4.28 – 4.32 (m, 1 H), 3.98 – 4.02 (m, 4 H, overlapping shifts), 3.86 – 3.91 (m, 1 H). MS ES+ m/z 464.2 [M+H]+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol.

Reference:
Patent; CYCLERION THERAPEUTICS, INC.; RENNIE, Glen, Robert; RENHOWE, Paul, Allan; NAKAI, Takashi; MERMERIAN, Ara; CUMBERBATCH, Helen; (99 pag.)WO2019/126354; (2019); A1;,
Alcohol – Wikipedia,
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