Category: 431-23-2

Electric Literature of 431-23-2, Adding some certain compound to certain chemical reactions, such as: 431-23-2, name is 3,3,3-Trifluoro-2-methylpropan-1-ol,molecular formula is C4H7F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 431-23-2.

To methyl 5-hydroxy-4-methoxypyridine-2-carboxylate (100 mg, 0.55 mmol) in THF is added 3,3,3-trifluoro-2-methylpropan-1 -ol (105 mg, 0.82 mmol) and triphenylphosphine (286 mg, 1 .10 mmol) and followed by diisopropylazodicarboxylate (221 mg, 1.10 mmol). The reaction mixture is stirred at RT for 3h, The reaction mixture is evaporated under reduced pressure and the residue is purified by HPLC. The product containing fractions are combined and lyophilized. (0796) Yield: 160 mg (quantitative)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 431-23-2, 3,3,3-Trifluoro-2-methylpropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HYDRA BIOSCIENCES, INC.; BOUYSSOU, Thierry; GOTTSCHLING, Dirk; HEINE, Niklas; SMITH KEENAN, Lana Louise; LOWE, Michael D.; RAZAVI, Hossein; SARKO, Christopher Ronald; SURPRENANT, Simon; TAKAHASHI, Hidenori; TURNER, Michael Robert; WU, Xinyuan; (182 pag.)WO2019/81637; (2019); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 431-23-2, name is 3,3,3-Trifluoro-2-methylpropan-1-ol. A new synthetic method of this compound is introduced below., COA of Formula: C4H7F3O

To a solution of 3,3,3-trifluoro-2-methylpropan-1-ol (800 mg, 6.25 mmol) in DCM (20 mL) was added triethylamine (950 mg, 9.39 mmol).The reaction mixture was cooled to -20 C,Then trifluoromethanesulfonic anhydride (2.20 g, 7.70 mmol) was added to the above system.The reaction was stirred at 0 & lt; 0 & gt; C overnight.The reaction mixture was diluted with DCM (50 mL)And then washed with 1 M aqueous hydrochloric acid (50 mL x 2)The separated organic phases were dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the title compound as a yellow oil(1.1 g, 68% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 431-23-2, 3,3,3-Trifluoro-2-methylpropan-1-ol.

Reference:
Patent; Sunshine Lake Pharma Co., Ltd.; Xi, Ning; Dai, Weilong; Li, Minxiong; Chen, Wuhong; Zhang, Tao; Hu, Haiyang; Li, Xiaobo; Liu, Jun; Wang, Tingjin; (146 pag.)CN106478651; (2017); A;,
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Synthetic Route of 431-23-2 ,Some common heterocyclic compound, 431-23-2, molecular formula is C4H7F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 3,3,3-trifluoro-2-methylpropan-1-ol (800 mg, 6.25 mmol) in DCM (20mL) was added triethylamine (950 mg, 9.39 mmol). The mixture was cooled to -20 oc andtrifluoromethanesulfonic anhydride (2.20 g, 7.70 mmol) was added. The mixture was stirred at0 oc overnight. The mixture was diluted with DCM (50 mL), washed with 1 M HCl aqueoussolution (50 mLx 2). The separated organic layer was dried over anhydrous Na2S04, and thenconcentrated in vacuo to give the title compound as yellow oil (1.1 g, yield 68% ).1HNMR (400 MHz, CDCh) 8 (ppm): 4.64-4.46 (m, 2H), 2.79-2.67 (m, 1H), 1.29 (d, J= 7.1 Hz,3H).19F NMR (376 MHz, CDCh) 8 (ppm): -71.6, -74.5.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 431-23-2, 3,3,3-Trifluoro-2-methylpropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; DAI, Weilong; XI, Ning; LI, Minxiong; ZHANG, Tao; LI, Xiaobo; HU, Haiyang; CHEN, Wuhong; WANG, Tingjin; LIU, Jun; (188 pag.)WO2017/48675; (2017); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 431-23-2, name is 3,3,3-Trifluoro-2-methylpropan-1-ol, the common compound, a new synthetic route is introduced below. Recommanded Product: 431-23-2

Iodine (44.58 g, 175.6 mmol) was added in five portions to a stirring solution of (S*)-3,3,3-trifluoro-2-methylpropan-1-ol (15.0 g, 117 mmol, Intermediate 89), PPh3 (46.07 g, 175.6 mmol) and imidazole (11.96 g, 175.7 mmol) in NMP (75 mL) at a rate that maintained the internal temperature between 40 and 50 C. The mixture was then warmed to 55-60 C. and stirred until the reaction went to completion. The reaction mixture was then distilled directly to afford the title compound as a solution in NMP (50.5% w/w, bp 50-65 C. at 1-2 mm Hg).

The synthetic route of 431-23-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Janssen Pharmaceutica NV; Goldberg, Steven; Martin, Connor L.; Fennema, Elizabeth G.; Kummer, David A.; Nishimura, Rachel T.; Woods, Craig R.; Wolin, Ronald L.; Jones, William M.; Fourie, Anne M.; Xue, Xiaohua; (180 pag.)US2019/382349; (2019); A1;,
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