Liu, Yan-Kai et al. published their research in Organic Letters in 2015 |CAS: 42900-89-0

The Article related to lactol nitroalkene stereoselective michael reaction enamine catalysis, functionalized lactone stereoselective preparation, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Quality Control of Isochroman-3-ol

On April 17, 2015, Liu, Yan-Kai; Li, Zhi-Long; Li, Ji-Yao; Feng, Huan-Xi; Tong, Zhi-Ping published an article.Quality Control of Isochroman-3-ol The title of the article was Open-Close: An Alternative Strategy to α-Functionalization of Lactone via Enamine Catalysis in One Pot under Mild Conditions. And the article contained the following:

An open-close strategy in asym. catalysis is newly developed. With this powerful strategy, lactols are directly applied as potential precursors of lactones in enamine-based asym. Michael reactions providing a facile access to α-functionalized lactones containing two adjacent stereogenic centers as a single diastereomer, e.g. I, in good to excellent yields (up to 99%) and with excellent enantioselectivities (most cases >99%). Moreover, the reaction products are shown to give highly functionalized derivatives by stepwise systematic transformations. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Quality Control of Isochroman-3-ol

The Article related to lactol nitroalkene stereoselective michael reaction enamine catalysis, functionalized lactone stereoselective preparation, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Quality Control of Isochroman-3-ol

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Wang, Linqing et al. published their research in Angewandte Chemie, International Edition in 2018 |CAS: 42900-89-0

The Article related to triphenylphosphine oxide byproduct magnesium catalyst enantioselective hemiacetal phosphorus ylide, asymmetric synthesis, chiral ethers, hemiacetals, magnesium, phosphorus ylides and other aspects.Formula: C9H10O2

Wang, Linqing; Yang, Dongxu; Li, Dan; Liu, Xihong; Wang, Pengxin; Wang, Kezhou; Zhu, Haiyong; Bai, Lutao; Wang, Rui published an article in 2018, the title of the article was The Important Role of the Byproduct Triphenylphosphine Oxide in the Magnesium(II)-Catalyzed Enantioselective Reaction of Hemiacetals and Phosphorus Ylides.Formula: C9H10O2 And the article contains the following content:

By employing a simple in situ generated magnesium catalyst, a direct asym. reaction between hemiacetals and phosphorus ylides was achieved through a tandem Wittig-oxa-Michael reaction sequence. Enantioenriched chromans, isochromans, and tetrahydropyrans were obtained in good chem. yields, and (-)-erythrococcamide B was synthesized in enantioenriched form. The byproduct triphenylphosphine oxide was identified as a necessary additive for this process. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Formula: C9H10O2

The Article related to triphenylphosphine oxide byproduct magnesium catalyst enantioselective hemiacetal phosphorus ylide, asymmetric synthesis, chiral ethers, hemiacetals, magnesium, phosphorus ylides and other aspects.Formula: C9H10O2

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Young, Robert N. et al. published their patent in 1989 |CAS: 42900-89-0

The Article related to quinoline preparation leukotriene antagonist, antiasthmatic quinoline preparation, antiallergic quinoline preparation, antiinflammatory quinoline preparation, antiulcer quinoline preparation and other aspects.Formula: C9H10O2

On May 31, 1989, Young, Robert N.; Zamboni, Robert; Gauthier, Jacques Y.; Belley, Michel L. published a patent.Formula: C9H10O2 The title of the patent was Quinoline diacid derivatives useful as leukotriene antagonists, and their pharmaceutical compositions and use in medicaments. And the patent contained the following:

Title compounds I [R1 = H, halo, alkyl, alkenyl, alkynyl, CF3, SR2, S(O)R2, S(O)2R2, NR3R3, OR3, CO2R3, COR3, C(OH)R3R3, cyano,NO2, N3, (un)substituted Ph, PhCH2, PhCH2CH2, pyridyl; R2 = alkyl, alkenyl, alkynyl, CF3, (un)substituted Ph, PhCH2, PhCH2CH2; R3 = H, R2; R4 = H, halo, NO2, N3, cyano, SR2, NR3R3, OR3, alkyl, COR3; R5 = H, alkyl; Y = CR3:CR3, C:C, CO, NR3CO, CONR3, O, S, NR3, etc.; X1, X2 = complex chains, 1 or both containing C6H4, pyridine, or thiophene nucleus; Q1, Q2 = CO2R3, tetrazole, cyano, CHO, CH2OH, COCH2OH, etc.] are prepared for use as leukotriene antagonists (no data), and thereby as antiasthmatic, antiallergic, antiinflammatory, and cytoprotective agents. Thus, Wittig reaction of Me 2-[3-[2-(methoxycarbonyl)ethylthio]-3-(3-formylphenyl)propyl]benzoate (prepared in 6 steps) with [(7-chloroquinolin-2-yl)methyl]triphenylphosphonium bromide using BuLi in THF, and basic hydrolysis and salification of the product, gave [[[(chloroquinolinyl)ethenyl]phenyl](carboxyethylthio)propyl]benzoic acid di-Na salt II. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Formula: C9H10O2

The Article related to quinoline preparation leukotriene antagonist, antiasthmatic quinoline preparation, antiallergic quinoline preparation, antiinflammatory quinoline preparation, antiulcer quinoline preparation and other aspects.Formula: C9H10O2

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Belley, Michel L. et al. published their patent in 1992 |CAS: 42900-89-0

The Article related to quinolylmethoxyphenylthiaheptanoate preparation leukotriene antagonist, antiasthmatic quinolylmethoxyphenylthiaheptanoate preparation, antiinflammatory quinolylmethoxyphenylthiaheptanoate preparation and other aspects.Safety of Isochroman-3-ol

On April 15, 1992, Belley, Michel L.; Leblanc, Yves; Labelle, Marc published a patent.Safety of Isochroman-3-ol The title of the patent was Preparation of 7-phenyl-5-[(quinolylmethoxy)phenyl]-4-thiaheptanoates and analogs as leukotriene antagonists. And the patent contained the following:

R1YZCR7[X2r(CR3R3)mZ1n(CR3R22)pQ1]X3r'(CR3R3)m’Z2n'(CR3R4)p’CR2R3Q2 [Q1 = CO2R3, tetrazolyl, cyano, CONH2, etc.; Q2 = OH, amino; R1 = (substituted)-2-quinolyl; R2 = alkyl, alkenyl, CF3, Ph, CH2Ph, etc.; R3 = H, groups cited for R2; CR3R22 = amino acid residue; R4 = halo, NO2, cyano, groups cited for R3, etc.; R7 = H, alkyl; X2, X3 = O, SO0-2, (substituted) CH2; Y = CR3R3X1, X1CR3R3, NR3CO, etc.; X1 = O, SO0-2, NR3; Z = (substituted) phenylenediyl; Z1, Z2 = (substituted) phenylenediyl, heteroarylenediyl; m, m’, p, p’ = 0-8; n, n’, r, r’ = 0, 1] were prepared as leukotriene antagonists (no data). Thus, 7-chloro-2-(bromomethyl)quinoline was condensed with 3-HOC6H4CHO and the product converted in 3 steps to RCH2PPh3Br (R = quinolylmethoxyphenyl group Q) which was condensed with 1H-3-hydroxy-3,4-dihydro-2-benzopyran to give, after oxidation, 2-(MeO2C)C6H4CH2CH:CHR (R = Q). The latter was condensed with HSCH2CHMeCO2H to give, after MeMgBr treatment, title compound I (R = Q). The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Safety of Isochroman-3-ol

The Article related to quinolylmethoxyphenylthiaheptanoate preparation leukotriene antagonist, antiasthmatic quinolylmethoxyphenylthiaheptanoate preparation, antiinflammatory quinolylmethoxyphenylthiaheptanoate preparation and other aspects.Safety of Isochroman-3-ol

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Young, Robert N. et al. published their patent in 1990 |CAS: 42900-89-0

The Article related to arylstyrylquinoline diacid preparation leukotriene antagonist, cytoprotection arylstyrylquinoline diacid, eye antiinflammatory arylstyrylquinoline diacid, antiasthmatic arylstyrylquinoline diacid, srsa inhibitor arylstyrylquinoline diacid preparation and other aspects.Recommanded Product: Isochroman-3-ol

On November 28, 1990, Young, Robert N.; Gauthier, Jacques Yves; Zamboni, Robert; Belley, Michel L. published a patent.Recommanded Product: Isochroman-3-ol The title of the patent was Preparation of diarylstyrylquinoline diacids as leukotriene antagonists. And the patent contained the following:

Title compounds I [R1 = 7-Cl, 7-MeO, 6-F3C, 7-F3C, 6-MeSO2, H, 6,7-Cl2; Y = CH:CH, CH2CH2, CH2O, CHMeCH2; A = HO2C(CH2)2S, Me2NCO(CH2)2S, 3-(HO2C)C6H4S, Me3CNHCO(CH2)2S, 4-carboxy-2-pyridyl, [(1-adamantylamino)carbonylethyl]thio, 1-tetrazol-5-ylmethylthio, etc.; B = 2-(HO2C)C6H4CH2CH2, 3-(HO2C)C6H4, 5-carboxy-2-thiophenyl, HO2CCH2CHMe(CH2)2, 6-carboxy-2-pyridyl, 2-(Me3CNHCO)C6H4S, 3-[(1-tetrazol-5-yl)methyl]phenyl, etc.] and their salts, useful as inhibitors of leukotriene biosynthesis, antiasthmatic, antiallergic, antiinflammatory, and cytoprotective agents (no data, assays described), are prepared I may also be used to treat erosive gastritis, inflammatory bowel disease, prevention of SRA-release (no data). To a suspension of [(7-chloroquinolin-2-yl)methyl]triphenylphosphonium bromide in THF was added BuLi, the reaction mixture was stirred at -78° and Me 2-[3-[2-(methoxycarbonyl)ethylthio]-3-(3-formylphenyl)propyl]benzoate [preparation from 3-(BrCH2)C6H4CN given] added, the mixture warmed to room temperature to give I [R1 = 7-Cl; Y = CH:CH; A = HO2C(CH2)2S; B = 2-(HO2C)C6H4CH2CH2] (II) as the di-Me ester, which in THF and MeOH was saponified to give II.2Na salt. A capsule, injectable suspension and tablet formulations comprising I are given. Pharmaceutical composition of I may comprise an addnl. active ingredient such as nonsteroidal antiinflammatory drug, peripheral analgesic, cyclooxygenase inhibitor, etc. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Recommanded Product: Isochroman-3-ol

The Article related to arylstyrylquinoline diacid preparation leukotriene antagonist, cytoprotection arylstyrylquinoline diacid, eye antiinflammatory arylstyrylquinoline diacid, antiasthmatic arylstyrylquinoline diacid, srsa inhibitor arylstyrylquinoline diacid preparation and other aspects.Recommanded Product: Isochroman-3-ol

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Kraiss, G. et al. published their research in Acta Chimica Academiae Scientiarum Hungaricae in 1976 |CAS: 42900-89-0

The Article related to ester dicarboxylate reduction, carboxylate di ester reduction, aromatic dicarboxylate ester reduction, cyclohexanedicarboxylate ester reduction, glutarate ester reduction, lactol, isochromanol, isobenzofuranol, cyclization reduction dicarboxylate ester and other aspects.HPLC of Formula: 42900-89-0

Kraiss, G.; Povarny, M.; Nador, K. published an article in 1976, the title of the article was Reduction of dicarboxylic acid esters with diisobutylaluminum hydride.HPLC of Formula: 42900-89-0 And the article contains the following content:

In reduction of di-Et homophthalate (I), phthalate (II), cis-1,2-cyclohexanedicarboxylate, or glutarate with 1-4 equivalent of (Me2CHCH2)2AlH, selective lactol formation occurred only in the case of I and II; with 3 equivalent (Me2CHCH2)2AlH I gave 100% III and II gave 82% IV. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).HPLC of Formula: 42900-89-0

The Article related to ester dicarboxylate reduction, carboxylate di ester reduction, aromatic dicarboxylate ester reduction, cyclohexanedicarboxylate ester reduction, glutarate ester reduction, lactol, isochromanol, isobenzofuranol, cyclization reduction dicarboxylate ester and other aspects.HPLC of Formula: 42900-89-0

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Kuehne, Martin et al. published their patent in 1990 |CAS: 42900-89-0

The Article related to vinblastine cycloalkyl aryl preparation antitumor, cycloalkylvinblastine preparation antitumor, vincristine cycloalkyl aryl preparation antitumor, cycloalkylvincristine preparation antitumor, antitumor vinblastine vincristine cycloalkyl aryl, arylvinblastine preparation antitumor, arylvincristine preparation antitumor and other aspects.Safety of Isochroman-3-ol

On June 19, 1990, Kuehne, Martin published a patent.Safety of Isochroman-3-ol The title of the patent was Preparation of cycloalkyl and aromatic moieties-containing vinblastines and vincristines as antitumors. And the patent contained the following:

The title compounds [I; R1R2 = alkylene, benzo; R10 = HCO, Me; R11 = alkoxy, trialkylammoniumyl; R12 = alkanoyloxy, OH; R13 = alkyl] were prepared Vindoline-HCl was condensed with Me (3aRS,4RS,11bSR)]-3-benzyl-4-[2-(tert-butyldimethylsilyloxymethyl)phenyl]-1,2,3,3a,4,5-hexahydro-7H-pyrrolo[2,3-d]carbazole-6-carboxylate to give, after desilylation, a 1:1 mixture of (5R,7S)-3-benzyl-5-[2-(hydroxymethyl)phenyl]-1,2,3,4,5,6,7,8-octahydroazonino[5,4-b]indole-7-(15-vindolinyl)-7-carboxylate (II) and its 5R,7R-diastereomer. II was then cyclized in CH2Cl2 containing Et3N and p-toluenesulfonic anhydride to give, after hydrogenolysis, (9R,11S)-15-[1,2,4,9,10,11,12,17-octahydro-11-(methoxycarbonyl)indolo[2′,3′:6,7]azonino[1,2,3:bc]isoquinolin-11-yl]vindoline (III). III had an ED50 comparable to that of vinblastine against P388 leukemia cells resistant to adriamycin. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Safety of Isochroman-3-ol

The Article related to vinblastine cycloalkyl aryl preparation antitumor, cycloalkylvinblastine preparation antitumor, vincristine cycloalkyl aryl preparation antitumor, cycloalkylvincristine preparation antitumor, antitumor vinblastine vincristine cycloalkyl aryl, arylvinblastine preparation antitumor, arylvincristine preparation antitumor and other aspects.Safety of Isochroman-3-ol

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Kuehne, Martin E. et al. published their research in Organic & Biomolecular Chemistry in 2003 |CAS: 42900-89-0

The Article related to vinblastine congener preparation antitumor, microtubular disassembly spiralization induction polymerization inhibition vinblastine congener, spiralization induction microtubular vinblastine congener, polymerization inhibition microtubular vinblastine congener, colon adenocarcinoma inhibition vinblastine congener and other aspects.Related Products of 42900-89-0

On June 21, 2003, Kuehne, Martin E.; Bornmann, William G.; Marko, Istvan; Qin, Yong; LeBoulluec, Karen L.; Frasier, Deborah A.; Xu, Feng; Mulamba, Tshilundu; Ensinger, Carol L.; Borman, Linda S.; Huot, Anne E.; Exon, Christopher; Bizzarro, Fred T.; Cheung, Julia B.; Bane, Susan L. published an article.Related Products of 42900-89-0 The title of the article was Syntheses and biological evaluation of vinblastine congeners. And the article contained the following:

Sixty-two congeners of vinblastine (VLB), e.g. I, , primarily with modifications of the piperidine ring in the carbomethoxycleavamine moiety of the binary alkaloid, were synthesized. For example, I was prepared starting from δ-valerolactone (II). Methylation of II at the 3-position followed by ring opening gave MeO2CCH(Me)CH2CH2CHO which was reacted with indoloazepine III. The resulting bridged indoloazepine was N-benzylated to give pyrrolocarbazolecarboxylate IV. IV then went through a series of reactions, including addition to vindoline to give I in 81% yield. These compounds were evaluated for cytotoxicity against murine L1210 leukemia and RCC-2 rat colon cancer cells, and for their ability to inhibit polymerization of microtubular protein at <10-6 M, and for induction of spiralization of microtubular protein, and for microtubular disassembly at 10-4 M concentrations An ID50 range of >107 M concentrations was found for L1210 inhibition by these compounds, with the most active 1000× as potent as vinblastine. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Related Products of 42900-89-0

The Article related to vinblastine congener preparation antitumor, microtubular disassembly spiralization induction polymerization inhibition vinblastine congener, spiralization induction microtubular vinblastine congener, polymerization inhibition microtubular vinblastine congener, colon adenocarcinoma inhibition vinblastine congener and other aspects.Related Products of 42900-89-0

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