Category: 42900-89-0

Li, Yuehui; Topf, Christoph; Cui, Xinjiang; Junge, Kathrin; Beller, Matthias published an article in 2015, the title of the article was Lewis Acid Promoted Ruthenium(II)-Catalyzed Etherifications by Selective Hydrogenation of Carboxylic Acids/Esters.Recommanded Product: Isochroman-3-ol And the article contains the following content:

Ethers are of fundamental importance in organic chem. and they are an integral part of valuable flavors, fragrances, and numerous bioactive compounds In general, the reduction of esters constitutes the most straightforward preparation of ethers. Unfortunately, this transformation requires large amounts of metal hydrides. Presented herein is a bifunctional catalyst system, consisting of Ru/phosphine complex and aluminum triflate, which allows selective synthesis of ethers by hydrogenation of esters or carboxylic acids. Different lactones were reduced in good yields to the desired products. Even challenging aromatic and aliphatic esters were reduced to the desired products. Notably, the in situ formed catalyst can be reused several times without any significant loss of activity. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Recommanded Product: Isochroman-3-ol

The Article related to lewis acid ruthenium catalyst etherification hydrogenation carboxylate ester, lewis acids, ethers, homogeneous catalysis, hydrogenation, ruthenium, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: Isochroman-3-ol

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Hashimoto, K.; Yanagida, M.; Horikawa, M.; Shirahama, H. published an article in 1989, the title of the article was Syntheses and neuroexcitatory activity of kainoids.Category: alcohols-buliding-blocks And the article contains the following content:

Kainoids, such as kainic acid, domoic acid, acromelic acids A and B, cause marked depolarization against L-glutamate receptor in vertebrates and invertebrates. To find the more potent kainoids and to reveal the structure-activity relationship, efforts were made toward the syntheses of kainoids and related compounds The most rational synthesis of kainoid, i.e., introduction of various substituents to a common intermediate, was achieved by the use of diaryl copper lithium reagent for the substitution reaction of trans-4-tosyloxyproline with retention of configuration. Neuroexcitatory activity of the synthetic compounds was also examined Among the 6 acyclic analogs of kainoid, only the (2S,3R)-isomers, which have π-electrons on the β-substituent, showed neuroexcitatory activity. In the newly synthesized kainoids, the Ph derivative (I) showed comparable activity to kainic acid, the phenol derivative (II) exhibited more potent activity than acromelic acid B or domoic acid, and the methoxyphenyl derivative (III) was 3- to 5-fold more potent than acromelic acid A, and the most potent excitatory reagent known so far. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Category: alcohols-buliding-blocks

The Article related to kainoid preparation neuroexcitatory, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Category: alcohols-buliding-blocks

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On November 19, 1990, Hashimoto, Kimiko; Horikawa, Manabu; Shirahama, Haruhisa published an article.Recommanded Product: Isochroman-3-ol The title of the article was Simple analogs of acromelic acid, which are highly active agonists of kainate type neuroexcitant. And the article contained the following:

The highly stereoselective synthesis of acromelic acid analogs I (R = H, Me) was achieved. The new kainoid I (R = Me) was the strongest neuroexcitant among the kainoids known so far. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Recommanded Product: Isochroman-3-ol

The Article related to neurotransmitter agonist acromelic acid analog, kainate neuroexitant carboxymethylhydroxyphenylproline, proline hydroxyphenyl carboxymethyl kainate neuroexitant, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Recommanded Product: Isochroman-3-ol

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On April 30, 1978, Perchonock, Carl D.; Loev, Bernard published an article.Synthetic Route of 42900-89-0 The title of the article was Synthesis of some aromatic prostaglandin analogs. And the article contained the following:

Some aromatic prostaglandin analogs, with a benzene (I) (R = H, Me) or a dimethoxybenzene ring (II) in place of the cyclopentane moiety, were synthesized. The key intermediates in the syntheses were lactols III and IV, which were elaborated to the final products via two olefination reactions. I (R = H) was twice as potent as phenylbutazone and nine times as potent as aspirin in inhibiting prostaglandin synthetase activity. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Synthetic Route of 42900-89-0

The Article related to aromatic prostaglandin analog, benzene prostaglandin analog, Alicyclic Compounds: Cyclopentanes, Including Fulvenes and Fulvalenes and other aspects.Synthetic Route of 42900-89-0

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On April 26, 1991, Shirahama, Haruhisa; Shinozaki, Atsuhiko published a patent.HPLC of Formula: 42900-89-0 The title of the patent was Preparation of pyrrolidineacetic acid derivatives as nervous system stimulants. And the patent contained the following:

The title compounds (I; R1-R3 = H, alkyl) and their stereoisomers are prepared Selective oxidation of 63 mg methanol derivative II (R = CH2OH) (preparation given) with pyridinium dichromate in DMF followed by esterification with CH2N2 gave 26 mg ester II (R = CO2Me), which (186 mg) was ring-opened by m-ClC6H4CO2OH and esterified by CH2N2 to give 48 mg diester III (R2 = R3 = Me) (IV). Saponification of 48 mg IV gave 26 mg diacid III (R2 = R3 = H), which (20 mg) was deprotected by hydrogenolysis over 5% Pd-C to give 9 mg (2β,3α,4α)-I (R1 = R2 = R3 = H). I caused significant depolarization in newborn rat spinal cord in vitro as measured by elec. potential, against such reference compounds as kainic acid and acromelic acid. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).HPLC of Formula: 42900-89-0

The Article related to pyrrolidineacetic acid preparation nervous stimulant, Heterocyclic Compounds (One Hetero Atom): Pyrroles and Pyrrolizines and other aspects.HPLC of Formula: 42900-89-0

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On April 30, 1978, Perchonock, Carl D.; Loev, Bernard published an article.Synthetic Route of 42900-89-0 The title of the article was Synthesis of some aromatic prostaglandin analogs. And the article contained the following:

Some aromatic prostaglandin analogs, with a benzene (I) (R = H, Me) or a dimethoxybenzene ring (II) in place of the cyclopentane moiety, were synthesized. The key intermediates in the syntheses were lactols III and IV, which were elaborated to the final products via two olefination reactions. I (R = H) was twice as potent as phenylbutazone and nine times as potent as aspirin in inhibiting prostaglandin synthetase activity. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Synthetic Route of 42900-89-0

The Article related to aromatic prostaglandin analog, benzene prostaglandin analog, Alicyclic Compounds: Cyclopentanes, Including Fulvenes and Fulvalenes and other aspects.Synthetic Route of 42900-89-0

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On February 18, 2022, Schmidt, Michael A. published an article.Reference of Isochroman-3-ol The title of the article was Effect of Terminal Alkylation of Aryl and Heteroaryl Hydrazines in the Fischer Indole Synthesis. And the article contained the following:

The effect of alkylation on the terminal position of aryl and heteroaryl hydrazines in the Fischer indole synthesis was examined Compared to their unalkylated counterparts, reactions using alkylated s provided indole products with higher yields and faster rates. The reactions can be conducted at lower temperatures and are compatible with acid-sensitive functionality. The terminally alkylated hydrazines were readily prepared by a new two-step sequence and held as stable hydrazinium salts. The mild formation of the salts along with the favorable Fischer indole reaction conditions highlights the potential of this approach in later-stage synthetic use. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Reference of Isochroman-3-ol

The Article related to fischer indole synthesis, hydrazine ketone alkylation amidation cross coupling, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of Isochroman-3-ol

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On June 28, 1977, Groves, William G.; Loev, Bernard; Perchonock, Carl D. published a patent.Related Products of 42900-89-0 The title of the patent was Aromatic prostaglandin derivatives. And the patent contained the following:

The prostaglandin-like compounds I (R = H, MeO), prepared by several steps from II and III, resp., inhibit natural prostaglandin synthesis and PGE2-induced diarrhea. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Related Products of 42900-89-0

The Article related to benzeneheptanoic acid prostaglandin inhibitor, Noncondensed Aromatic Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Related Products of 42900-89-0

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On October 15, 1999, Roda, Gabriella; Riva, Sergio; Danieli, Bruno published an article.Name: Isochroman-3-ol The title of the article was Almond oxynitrilase-catalyzed transformation of aldehydes is strongly influenced by naphthyl and alkoxy substituents. And the article contained the following:

Different α- and β-substituted aldehydes have been submitted to the catalytic action of almond oxynitrilase (PaHNL), in order to explore the influence of a stereocenter already present in the substrate on the selectivity of this enzyme. The results indicate that naphthyl and alkoxy substituents in the α- and also in the β-position to the aldehyde group significantly influence the stereochem. outcome of the PaHNL-catalyzed transformation. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Name: Isochroman-3-ol

The Article related to almond oxynitrilase catalyst transformation aldehyde cyanohydrin, cyanohydrin preparation almond oxynitrilase catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Aldehydes and Derivatives, Including Sulfur Analogs and other aspects.Name: Isochroman-3-ol

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On May 31, 1987, Cottet, F.; Cottier, L.; Descotes, G. published an article.Computed Properties of 42900-89-0 The title of the article was New syntheses of isochromene. And the article contained the following:

Isochromene (I) was synthesized in 3 steps from homophthalic acid (II) as well as from 2-indanone (III). Esterification of II, followed by selective reduction with diisobutylaluminum hydride gave 52% 3-hydroxyisochroman (IV). IV was also obtained by Baeyer-Villiger oxidation of III with m-chloroperbenzoic acid to 3-isochromanone and subsequent reduction with diisobutylaluminum hydride. IV was dehydrated to I by distillation in the presence of KHSO4 in a total yield of 48% from II and 69% from III. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Computed Properties of 42900-89-0

The Article related to isochromene preparation, homophthalate reduction, dehydration isochromanol, isochromanone hydrogenation, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Computed Properties of 42900-89-0

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