Category: 42822-86-6

Hisama, Masayoshi published the artcileSuppression of mutagens-induced SOS response by phytoncide solution using Salmonella typhimurium TA1535/pSK1002 umu test, Computed Properties of 42822-86-6, the main research area is antimutagen phytoncide solution SOS response Salmonella umu gene.

Four types of phytoncide solution (A-Type, AB-Type, D-Type and G-Type) were evaluated as anti-mutagenic agents with suppressive effects on the SOS-inducing activity of the mutagen 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide (furylfuramide) using Salmonella typhimurium TA1535/pSK1002 umu test. The A-Type, AB-Type, D-Type and G-Type of phytoncide solution suppressed the SOS-inducing activity on furylfuramide at a concentration of 100 μg/mL by 86.1%, 74.7%, 69.5% and 55.4%, resp., and the ID50 (50% ID) values were 9.0 μg/mL, 22.5 μg/mL, 36.0 μg/mL and 72.8 μg/mL. They also showed the suppression of SOS-inducing activity against other chem. mutagens, such as 4-nitroquinoline 1-oxide (4NQO) and N-methyl-N’-nitro-N-nitrosoguanidine (MNNG), which do not require liver metabolizing enzymes, and against 2-aminoanthracene (2AA) and 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), which require these enzymes, and against UV irradiation, which is a well known phys. mutagen. In the search for the component-activity relationship, the A-Type of phytoncide solution suppressed the SOS-inducing activity greater than the other types of phytoncide solution for furylfuramide, 4NQO and MNNG. However, in case of 2AA and Trp-P-1, the D-Type of phytoncide solution was most effective in suppressing the SOS-inducing activity in the umu test. From these results, the four types of phytoncide solutions showed the suppressive effect of SOS-inducing activity against chem. and phys. mutagens.

Journal of Oleo Science published new progress about Antitumor agents. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Computed Properties of 42822-86-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

El-Garawani, Islam published the artcileFoeniculum Vulgare and Pelargonium Graveolens Essential Oil Mixture Triggers the Cell Cycle Arrest and Apoptosis in MCF-7 Cells, Safety of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, the main research area is Foeniculum Pelargonium essential oil breast cancer cell cycle apoptosis; Fennel; GC-MS; MCF-7; anticancer; apoptosis; geranium..

This study aimed to evaluate the anticancer mechanism of fennel and geranium oils combined treatment on MCF-7 cells. The GC-MS method for essential oil characterization as well as the in vitro cytotoxicity, morphol. changes, real-time PCR and immunocytochem. investigation for apoptosis-related markers, in addition, to flow cytometric cell cycle distribution anal. were done. The major constituents of both essential oils were anethole (55.33%) and estragole (11.57%) for fennel essential oil. However, cintronellol (34.40%) and geraniol (8.67%) were identified in geranium oil. The results revealed an IC50 of 220±5.7 and 60±2.1μg/mL for fennel and geranium oils, resp. The mechanistic anticancer properties were investigated throughout the 70, 50, and 25μg/mL of oils mixture The marked apoptotic morphol. and the flow cytometric cell cycle distribution anal. in addition to the levels of apoptosisrelated makers such as p53, caspase-3, mir-21, mir-92a, Bcl-2, and ki-67 confirmed that fennel and geranium oils combination induced cell cycle arrest and apoptosis in MCF-7 cells. Moreover, the oils mixture did not exert any significant (P<0.01) toxicity on normal human peripheral blood lymphocytes in vitro. The findings showed that the mixture of oils exerted selective cytotoxicity towards MCF-7 cells through induction of cell cycle arrest and apoptosis which may be triggered by the synergistic effect between the active ingredients of fennel and geranium oils. Anti-Cancer Agents in Medicinal Chemistry published new progress about Antitumor agents. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Safety of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Barnard, Donald R. published the artcileLaboratory evaluation of mosquito repellents against Aedes albopictus, Culex nigripalpus, and Ochlerotatus triseriatus (Diptera: Culicidae), COA of Formula: C10H20O2, the main research area is mosquito repellent Aedes Culex Ochlerotatus; Autan Off Skinsations BiteBlocker mosquito repellent; GonE Natrapel NeemAura Sunswat mosquito repellent; MosquitoSafe Repel mosquito repellent.

Four synthetic mosquito repellents (Autan [10% KBR3023], IR3535 [7.5%], Off! [15% deet], Skinsations [7% deet]) and 8 natural (primarily plant extracts and/or essential oils) product-based repellents (Bite Blocker [2% soybean oil], ByGone, GonE!, Natrapel [10% citronella], Neem Aura, Sunswat, MosquitoSafe [25% geraniol], and Repel [26% p-menthane-3,8-diol]) were tested in the laboratory against Aedes albopictus Skuse, Culex nigripalpus Theobald, and Ochlerotatus triseriatus (Say). When estimated mean protection time (eMPT) responses for each repellent were averaged for all three mosquito species, Autan, Bite Blocker, Off!, and Repel prevented biting for ≥7.2 h; IR3535, MosquitoSafe, and Skinsations for 3.2-4.8 h; and ByGone, Natrapel, GonE, NeemAura, and SunSwat for 0.9-2.3 h. Against Ae. albopictus, the eMPT for Off! and Repel exceeded 7.0 h and ranged from 5.0 to 5.7 h for Autan, Bite Blocker, and Skinsations. Bygone, GonE, NeemAura, and SunSwat provided 0.2 h protection against Ae. albopictus and Oc. triseriatus, whereas Autan, Bite Blocker, Off!, and Repel prevented bites by Oc. triseriatus for ≥7.3 h. All 12 repellents provided an eMPT ≥2.8 h against Cx. nigripalpus (maximum: 8.5 h for Bite Blocker). When the average eMPT for each repellent (for all species) was divided by the eMPT for 7% deet (Skinsations), the order of repellent effectiveness and the corresponding repellency index (Ri) was Repel (1.7) > Bite Blocker (1.5) = Autan (1.5) = Off! (1.5) > Skinsations (1.0) > IR3535 (0.8) > MosquitoSafe (0.6) > Natrapel (0.5) > Neem Aura (0.3) = SunSwat (0.3) = Bygone (0.3) > GonE (0.2).

Journal of Medical Entomology published new progress about Aedes albopictus. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, COA of Formula: C10H20O2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Uzzan, Bernard published the artcileEfficacy of four insect repellents against mosquito bites: a double-blind randomized placebo-controlled field study in Senegal, Synthetic Route of 42822-86-6, the main research area is icaridine DEET paramenthanediol insecticide repellent topical skin mosquito bite.

Insect-borne diseases represent a worldwide threat. In addition to fight against vectors (insecticides) and disease prevention (vaccination against yellow fever, chemoprophylaxis against malaria), insect repellents applied on the skin could help reduce the heavy burden related to these diseases. In a field study performed in Senegal, we compared the efficacy of one skin application between 3 and 4 p.m. of four spray repellents [icaridine 20%, para-menthane-diol (PMD) 20% and 50% and DEET 50%] against placebo, among 100 healthy male and female volunteers experienced with mosquito capture. Double-blind randomized cross-over placebo-controlled study (Latin-square design) during five consecutive nights (7 p.m. to midnight) in two villages was conducted. To avoid residual effect, right or left leg was alternately exposed during consecutive nights and the exposed leg was washed before next night. The statistical model was random and mixed effects ANOVA. All four active repellents provided a significant and similar protection compared with placebo, lasting 8 h. However, there was a non-significant trend for a higher protection by DEET 50% than by PMD 20% (P = 0.07). Duration of protection was similar for all repellents. Their effects were similar among men and women, and against Anopheles or other species. No serious adverse drug reaction was noticed. Using a rigorous methodol. and a large number of volunteers, our well-controlled study demonstrated an important and similar protective effect of all four repellents compared with placebo. Such field studies should be required before approval of any newly developed repellent.

Fundamental & Clinical Pharmacology published new progress about Culicidae (bites). 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Synthetic Route of 42822-86-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Barasa, Stephen S. published the artcileRepellent activities of stereoisomers of p-menthane-3,8-diols against Anopheles gambiae (Diptera: Culicidae), Application In Synthesis of 42822-86-6, the main research area is menthanediol stereoisomer insect repellent Anopheles.

Four stereoisomers of p-menthane-3,8-diol, which make up the natural product obtained from Eucalyptus citriodora, were synthesized through stereoselective procedures. Repellency assays showed that all the four were equally active against Anopheles gambiae s.s. Racemic blends and the diastereoisomeric mixture of all the four isomers were also equally repellent. 1-α-Terpineol, with a single hydroxyl function at C-8 and unsaturation at C-8, and menthol, with a single hydroxyl function at C-3, were not repellent. The practical implication of these results is discussed.

Journal of Medical Entomology published new progress about Anopheles gambiae. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Application In Synthesis of 42822-86-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ciera, Lucy published the artcileElectrospinning repellents in polyvinyl alcohol-nanofibers for obtaining mosquito-repelling fabrics, Name: 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, the main research area is polyvinyl alc nanofiber repellent electrospinning mosquito repelling fabric; mech property; electrospinning; emulsion; micro-capsules; mosquito; repellent.

Recently, the use of repellents for preventing the transmission of mosquito-borne diseases is getting increasingly more attention. However, most of the current repellents are volatile in nature and must be frequently re-applied as their efficacy is only limited to a short period of time. Therefore, a slow release and abrasion-resistant mechanism is needed for prolonging the protection time of the repellents. The focus of this study is on the direct micro-encapsulation of repellents from an emulsion and integration of already encapsulated repellents into nanofibres via electrospinning. Different repellents were electrospun in polyvinyl alc. (PVA) nanofibrous structures, namely p-menthane-3,8-diol micro-capsules, permethrin, chilli and catnip oil. The repellents were successfully incorporated in the nanofibres and the tensile properties of the resulting samples did not have a significant change. This means that the newly created textiles were identical to current PVA nanofibrous textiles with the added benefit of being mosquito repellent. Principally, all incorporated repellents in the nanofibrous structures showed a significantly reduced number of mosquito landings compared to the control. Consequently, the currently described method resulted in a new and very effective repelling textile material that can be used in the prevention against mosquito-associated diseases.

Royal Society Open Science published new progress about Anopheles gambiae. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Name: 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kirton, L. G. published the artcileLaboratory and field tests of the effectiveness of the lemon-eucalyptus extract, citriodiol, as a repellent against land leeches of the genus Haemadipsa (Haemadipsidae), Application of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, the main research area is citriodiol Corymbia citriodora extract land leech repellent.

Citridiol is an extract of the leaves of Corymbia citriodora (Myrtaceae), the lemon eucalyptus, and mostly consists of p-menthane-3,8-diol isomers. The effectiveness of this extract as a repellent against land leeches of the genus Haemadipsa (Haemadipsidae), primarily H. sylvestris, was tested in the laboratory and field, in Peninsular Malaysia. The formulation tested, Mosi-guard Natural spray, contained 40% (weight/weight) citriodiol in a base of EtOH, water, and isopropanol. In the laboratory test, specimens of H. sylvestris that were placed within moist, untreated arenas enclosed by treated paper rings made numerous attempts to cross the rings but were prevented or delayed from crossing over, in a dose-dependent manner. Mortality was high among the leeches that attempted to cross over the paper rings that had been sprayed to saturation point but low among the leeches that attempted to cross over paper rings that had only been partially treated, with a droplet-spray. The field study was carried out using indexes that were formulated to reflect the severity of leech attack and the degree of repellency. Heavy or moderate spraying of footwear and trouser legs (tucked into socks) not only gave complete protection against bites by H. sylvestris and H. picta but also provided high enough repellency to keep the treated footwear virtually free of leeches. Even a light spray greatly reduced the numbers of leeches on footwear and delayed their progression toward biting the test subjects, although it failed to prevent bites completely. There was no decline in the repellency of the citriodiol when hourly assessments were made over a 6-h test period in the field. The results of the study show that citriodiol is highly repellent as well as toxic to leeches, and can be effectively used to prevent leech bites in the field.

Annals of Tropical Medicine & Parasitology published new progress about Corymbia citriodora. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Application of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bhattacharjee, Apurba K. published the artcileIn Silico Stereo-Electronic Analysis of PMD (p-Menthane-3-8-Diol) and its Derivatives for Pharmacophore Development May Aid Discovery of Novel Insect Repellents, Formula: C10H20O2, the main research area is menthanediol derivative electrostatic potential model insect repellent.

PMD (p-menthane-3-8-diol) is an insect repellent that can be synthesized chem. or derived from a steam distillate residue of the leaves of lemon eucalyptus, Corymbia citriodora. It is one of the few natural product endorsed by the Center for Disease Control (USA) for topical application to protect against mosquitoes though it is not as effective as the common repellent DEET (N,N-diethyl-1,3-toluamide). However, DEET has several undesirable side effects and toxicity too. Thus, although PMDs are comparatively safer than DEET, no quant. structure activity relationship (QSAR) and pharmacophore modeling studies have been reported in literature to improve efficacy and aid further development of more effective PMD analogs. In this study, we report results of quantum chem. anal. of stereoelectronic properties and pharmacophore modeling of PMD and eight of its synthetic derivatives to aid discovery and design of more effective PMD analogs. Stereo-electronic anal. indicates that lower aqueous stabilization (favorable lipophilicity) and larger separation of electrostatic potential energy together with a large localized neg. electrostatic potential region by the oxygen atom play important roles for repellent activity. Consistent to these properties, the generated pharmacophore model of the PMDs showed two aliphatic hydrophobic and a hydrogen-bond donor features for potent activity. These results aided us to design more effective PMD repellents which are currently under further investigations.

Current Computer-Aided Drug Design published new progress about Corymbia citriodora. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Formula: C10H20O2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rehman, S. U. published the artcileDetermination of volatiles using GC-MS from peel essential oils of various citrus varieties of Pakistani origin, Formula: C10H20O2, the main research area is peel essential oil citrus fruit volatile.

Peel essential oil of citrus varieties, Malta (Citrus sinensis), grapefruit (C. paradisi), Kinnow (C. reticulata), Fewtrell’s early (C. reticulata), Mosambi (C. sinensis), and Eureka lemon (C. limon) were evaluated by GC-MS technique, after extracting through cold expressing. The results delineated that limonene followed by myrcene and α-pinene were the main components. β-Panasinsene, α-bisabolol, and citronellal were also common volatiles identified as sesquiterpene, monoterpene alc. and aldehyde. Among monoterpenes, β-pinene and γ-terpinene were identified in Eureka lemon, γ-muurolene in Fewtrell’s early and pantaene in grapefruit. Sesquiterpenes including α-caryophyllene, γ-elemene and 1,2,1-docosadiene were identified in Fewtrell’s early, bisabolene and di-Me, 1,3,6-octatriene in Eureka lemon, cyclopentene in Kinnow and bergapten in grapefruit peel oils. Regarding monoterpene and sesquiterpene alcs., 1-nonanol in Fewtrell’s early and nerol, elemol and α-bisabolol in grapefruit and nerolidol, cis-nerolidol and 2,6-octadien-1-ol in Eureka lemon and 3-cyclohexene-1 methanol in Kinnow peel oil have been identified. Among aldehydes, capraldehyde and 3-cyclohexene-1 carboxaldehyde in Kinnow, α-sinensal in Malta, cis-9-hexadecenal and tetradecanal in Fewtrell’s early peel oils were also found. The ketones identified were 5, 9-undecadien-2-on and dihyrocarvone in grapefruit and 3-isopropylidene-5-methyl-hex-4-en-2-2- one, β-elemenone and 9-oxa-bicyclo (3.3.1) nona-3, 6-dien-2-one in Kinnow peel oil. Similarly, terpinyl propionate in Kinnow, neryl acetate in grapefruit, 3,7-dimethyl-Me ester in Eureka lemon, citronellyl acetate in grapefruit, 3, 7 dimethyl-acetate in Eureka lemon were present as esters. A number of individual volatiles as oxides have also been identified, which included geranyl bromide and α-bisabolene epoxide in Eureka lemon, (2S, 4R)-p-mentha-6,8-diene 2-hydroperoxide and (1R, 4R)-p-mentha-2, 8-diene 1-hydroperoxide in Kinnow peel oils. Moreover, some acidic volatiles as dodecanoic acid and tetradecanoic acid in Kinnow and phthalic acid in grapefruit peel oil were also identified.

Journal of Food Science and Technology published new progress about Alcohols Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Formula: C10H20O2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Inokuchi, Tsutomu published the artcileElectroreductive ring-opening of α,β-epoxy carbonyl compounds and their homologs through recyclable use of diphenyl diselenide or diphenyl ditelluride as a mediator, Product Details of C10H20O2, the main research area is electrochem ring cleavage epoxy carbonyl compound; aldol; hydroxy ketone; nitrile hydroxy; ester hydroxy; regiochem reduction cleavage epoxy carbonyl.

A novel access to β-hydroxy carbonyl compounds from the corresponding α,β-epoxy carbonyl compounds is attained by the recyclable use of Ph2Se2 or Ph2Te2 as an electroreduction mediator in a MeOH-NaClO4-Pt system. α,β-Epoxy ketones are converted to the corresponding aldols in the presence of malonic esters. Similarly, α,β-epoxy esters and nitriles are reduced to the corresponding β-hydroxy compounds in the presence of AcOH.

Journal of Organic Chemistry published new progress about Carboxylic acids, epoxy, esters Role: RCT (Reactant), RACT (Reactant or Reagent). 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Product Details of C10H20O2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts