Category: 4254-29-9

Application of 4254-29-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4254-29-9, name is 2,3-Dihydro-1H-inden-2-ol, molecular formula is C9H10O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a 25 mL, one-necked, round-bottomed flask was placed Fe(acac)3 (36 mg, 0.10 mmol, 5 mol %), benzyl alcohol (216 mg, 208 muL, 2 mmol), and Na2CO3 (10.6 mg, 0.10 mmol, 5 mol %) in 10 mL heptane at room temperature under nitrogen atmosphere. A solution of methyl benzoate (272 mg, 256 muL, 2 mmol) in heptane (10 mL) was added via syringe. The resulting mixture was heated to reflux with the removal of the methanol by Dean-Stark apparatus and the reaction progress was monitored by TLC, 1H NMR spectroscopy, and GC analysis until completion of the reaction (6 h). The reaction mixture was then gradually cooled to room temperature and quenched with saturated aqueous NH4Cl solution (5 mL), then extracted with 20 mL ethyl acetate. The combined organic layer was dried (anhydrous MgSO4), filtered, and evaporated to give a crude product that was purified by column chromatography on silica gel (hexane/AcOEt=50/1) to provide the pure benzyl benzoate product 412 mg, 97% yield.

According to the analysis of related databases, 4254-29-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Weng, Shiue-Shien; Ke, Chih-Shueh; Chen, Fong-Kuang; Lyu, You-Fu; Lin, Guan-Ying; Tetrahedron; vol. 67; 9; (2011); p. 1640 – 1648;,
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Reference of 4254-29-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4254-29-9, name is 2,3-Dihydro-1H-inden-2-ol, molecular formula is C9H10O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 94 yV7,/V7-Dimethyl-7,8-dihydro-6W-indeno[5,6-e][1,2,4]triazine-3,7-diamine 1 -Oxide (111). /V,/V-Dimethyl-2-indanamine (107). Methanesulfonyl chloride (11.5 mL, 149 mmol) was added dropwise to a stirred solution of 2-indanol (106) (20 g, 149 mmol) and JPr2NEt (28.6 mL, 164 mmol) in DCM (300 mL) at 0 0C, and the solution stirred at 20 0C for 16 h. The solution was washed with 1 M HCI (80 mL), aqueous saturated NaHCO3 solution (80 mL) and brine (100 mL), dried and the solvent evaporated. The residue was recrystallised from EtOH to give 2,3-dihydro-1/V-inden-2-yl methanesulfonate (31.14 g, 98%) as a white solid. Aqueous HNMe2 (40%, 180 mL, 1.42 mol) was added slowly to a stirred solution of mesylate (30.25 g, 143 mmol) in DMF (200 mL) and the solution stirred at 20 0C for 16 h. The solution was partitioned between EtOAc (400 mL) and water (800 mL) and the organic fraction washed with water (3 x 80 mL), brine (100 mL), dried and the solvent evaporated. The residue was suspended in 1 M HCI (400 mL) and washed with DCM (3 x 80 mL). The pH of the aqueous fraction was adjusted to 14 with NaOH, the mixture chilled at 5 0C for 8 h and the precipitate filtered. The precipitate was washed with water (50 mL) and dried to give amine 107 (21.54 g, 93%) as a light gray solid: 1H NMR delta 7.10-7.17 (m, 4 H, Harom), 3.01-3.08 (m, 3 H, H-2, CH2), 2.82-2.91 (m, 2 H1 CH2), 2.31 [s, 6 H, N(CHa)2].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4254-29-9, 2,3-Dihydro-1H-inden-2-ol.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2006/104406; (2006); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4254-29-9, name is 2,3-Dihydro-1H-inden-2-ol, the common compound, a new synthetic route is introduced below. Formula: C9H10O

To a solution of 2,3-dihydro-1H-inden-2-ol 215A (1.6 g, 12 mmol) in CHCl3(40 mL) was added pyridine (0.24 mL) and PBr3(1.28 mL) at 0 C. The mixture was heated at reflux for 1 hour and stirred at room temperature overnight. The reaction mixture was poured into ice-water (50 mL) and extracted with dichloromethane (30 mL x 3). The combined organic layers was washed with brine (40 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified with column chromatography on silica gel (petroleum ether, 100% v/v) to furnish Compound 215B. LC-MS (ESI) m/z: non-ionizable compound under routine conditions used;1H-NMR (CDCl3, 400 MHz): delta (ppm) 3.32-3.37 (m, 2H), 3.49-3.55 (m, 2H), 4.74-4.79 (m, 1H), 7.20- 7.28 (m, 4H).

The synthetic route of 4254-29-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; (552 pag.)WO2017/214505; (2017); A1;,
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Adding a certain compound to certain chemical reactions, such as: 4254-29-9, 2,3-Dihydro-1H-inden-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2,3-Dihydro-1H-inden-2-ol, blongs to alcohols-buliding-blocks compound. name: 2,3-Dihydro-1H-inden-2-ol

General procedure: To a dry 25 mL, bottomed flask equipped with a Dean-Stark trap containing a plug of 4A molecular sieves (pellets) and topped with a reflux condenser was added of Fe(acac)3 ( 36 mg, 0.10 mmol, 5 mol%) and a solution of methyl bezoate (272 mg, 256 .L, 2.0 mmol), benzyl alcohol (216 mg, 208 .L, 2.0 mmol) and triphenyl methane (488 mg, 2 mmol, as internal standard) in heptane (20 mL). The mixture was heated to reflux (105 C) for an indicated time periods. After completion of the reaction as monitored by TLC, 1H NMR and GC, the reaction mixture was cooled to room temperature and the solvent was evaporated. The crude product was purified by column chromatography on silica gel to afforded benzyl benzoate 403 mg, 95% yield. The product obtained was characterized by 1H, 13C NMR, ESI-MS or GC-MS spectroscopic methods. The conversions of the products determined by GC are based on triphenyl methane as an internal standard and are response-corrected based on authentic samples.

The synthetic route of 4254-29-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Weng, Shiue-Shien; Ke, Chih-Shueh; Chen, Fong-Kuang; Lyu, You-Fu; Lin, Guan-Ying; Tetrahedron; vol. 67; 9; (2011); p. 1640 – 1648;,
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Related Products of 4254-29-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4254-29-9, name is 2,3-Dihydro-1H-inden-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of indan-2-ol (15, 99.7 mg, 0.74 mmol, 1 eq.), pyridinium chlorochromate (241.9 mg, 1.12 mmol, 1.5 eq.) and CH2Cl2 (3 mL) was vigorously stirred for 4 h at rt. A small amount of silica was added. Et2O (5 mL) was added and the reaction mixture was filtered under pressure. The residue was washed with Et2O. The filtrate was concentrated in vacuo. The crude product was purified by fc (d = 2 cm, l = 11 cm, v = 10 mL, cyclohexane:EtOAc 8:2, Rf = 0.11), yellow oil, yield 67.1 mg (68 %). C9H8O (132.2 g/mol). FT-IR (neat): nu (cm-1) = 2924 (C-H), 1743 (C=O), 740 and 648 (1,2-disubst. arom.). 1H NMR (400 MHz, CDCl3): delta (ppm) = 3.57 (s, 4H, 1-CH2, 3-CH2), 7.26 – 7.34 (m, 4H, Ar-H). 13C NMR (101 MHz, CD3OD): delta (ppm) = 44.2 (2C, C-1, C-3), 125.1 (2C, Cind), 127.5 (2C, Cind), 137.9 (2C, Cqind), 215.3 (1C, C=O). Exact Mass (APCI): m/z = 133.0654 (calcd. 133.0648 for C9H9O [M+H+]). Purity (HPLC, method 2) = 98.8 % (tR = 14.29 min).

According to the analysis of related databases, 4254-29-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Bechthold, Elena; Gawaskar, Sandeep; Robaa, Dina; Schepmann, Dirk; Schreiber, Julian A.; Seebohm, Guiscard; Sippl, Wolfgang; Temme, Louisa; Wuensch, Bernhard; European Journal of Medicinal Chemistry; vol. 190; (2020);,
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Reference of 4254-29-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4254-29-9, name is 2,3-Dihydro-1H-inden-2-ol, molecular formula is C9H10O, molecular weight is 134.18, as common compound, the synthetic route is as follows.

General procedure: The alkylation was performed following a published procedure [29] with minor modifications. 1 (1.0 eq.) was dissolved in dry THF under nitrogen in oven-dried round-bottomed flask and alcohol (1.1-2.5 eq.) and PPh3 (1.1-2.5 eq.) was added. The nitrogen flow was temporarily removed when solid alcohols were added. When all of the PPh3 was dissolved, DIAD (1.0-2.5eq.), were added drop wise. The reaction was stirred at room temperature under nitrogen, until TLC indicated full consumption of the starting material, unless otherwise noted. The solvent was removed under reduced pressure and the crude product was purified by flash column chromatography or automated flash column chromatography.

The chemical industry reduces the impact on the environment during synthesis 4254-29-9, I believe this compound will play a more active role in future production and life.

Reference:
Article; Pettersson, Mariell; Bliman, David; Jacobsson, Jimmy; Nilsson, Jesper R.; Min, Jaeki; Iconaru, Luigi; Guy, R. Kiplin; Kriwacki, Richard W.; Andreasson, Joakim; Gr°tli, Morten; PLoS ONE; vol. 10; 5; (2015);,
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Synthetic Route of 4254-29-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4254-29-9, name is 2,3-Dihydro-1H-inden-2-ol. A new synthetic method of this compound is introduced below.

General procedure: General Procedure C A flame-dried flask with Teflon stir bar was charged with triphenylphosphine (1.2 equiv.) and I2(1.2 equiv.) in CH2Cl2, the mixture was stirred for 10 min at room temperature. Imidazole (1.2equiv.) was added to the resulting mixture. After 10 min of stirring, the corresponding alcohol(1.0 equiv.) was added and the reaction was stirred for additional 5 h at room temperature andwas checked by TLC until completion. The reaction mixture was quenched with Sat. Na2SO3.The mixture was transferred to a separatory funnel using CH2Cl2 and brine to aid the transferand separation. The aqueous and organic layers were separated and the aqueous layer wasextracted by CH2Cl2 (3x). The combined organic layers were washed with brine and dried overNa2SO4, filtered, and concentrated in vacuum. The crude reaction mixture was purified by flashchromatograph on silica gel and evaporated to give the alkyl iodide compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4254-29-9, its application will become more common.

Reference:
Article; Bai, Songlin; Gao, Yadong; Jiang, Chao; Liu, Xiaolei; Qi, Xiangbing; Wang, Jing; Wu, Qingcui; Yang, Chao; Chem; vol. 6; 3; (2020); p. 675 – 688;,
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Adding a certain compound to certain chemical reactions, such as: 4254-29-9, 2,3-Dihydro-1H-inden-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 4254-29-9, blongs to alcohols-buliding-blocks compound. Recommanded Product: 4254-29-9

2-hydroxy indan (100 g) was dissolved in 1,2-dichloroethane (400 ml) and added to thionyl chloride (125 g) slowly over a period of an hour. Temperature was maintained at less than 10 C. Thereafter, the reaction mass was slowly heated and refluxed till the completion of the reaction. The reaction was monitored by TLC. The reaction mass was cooled to room temperature and poured in to ice water, stirred for 1 hour and organic layer was separated. The aqueous layer was extracted with dichloroethane. Organic layers were combined and washed with water, sodium bicarbonate solution and dried over anhydrous sodium sulphate. Solvent was distilled out completely and the crude product was distilled under vacuum to obtain 2-chloroindan as a colorless liquid (118 g).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4254-29-9, 2,3-Dihydro-1H-inden-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; REDDY, G. Pratap; SUNKU, Venkataiah; BABU, Sunkaraneni Suresh; (14 pag.)US2018/215714; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 4254-29-9, 2,3-Dihydro-1H-inden-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4254-29-9, blongs to alcohols-buliding-blocks compound. 4254-29-9

(41D) Methyl (3S)-3-[4-(2,3-dihydro-1H-inden-2-yloxy)phenyl]-3-ethoxypropionate Methyl (3S)-3-ethoxy-3-(4-hydroxyphenyl)propionate (100 mg, 0.446 mmol) produced in (41C) and indan-2-ol (90 mg, 0.669 mmol) were dissolved in tetrahydrofuran (10 mL), and triphenylphosphine (178 mg, 0.680 mmol) and a 40% diethyl azodicarboxylate toluene solution (309 muL, 0.680 mmol) were added thereto at room temperature, and then, the resulting mixture was stirred under a nitrogen atmosphere at 50 C. for 4 hours. After the reaction solution was cooled to room temperature, the solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=100:0 to 95:5 (v/v)), whereby the objective title compound was obtained as a yellow oily substance (103 mg, yield: 68%). 1H NMR (CDCl3, 400 MHz): delta1.14 (3H, t, J=7.0 Hz), 2.58 (1H, dd, J=4.7, 15.3 Hz), 2.82 (1H, dd, J=8.9, 15.2 Hz), 3.20 (2H, dd, J=2.7, 16.4 Hz), 3.31-3.41 (4H, m), 3.68 (3H, s), 4.70 (1H, dd, J=5.1, 9.0 Hz), 5.14-5.19 (1H, m), 6.88 (2H, d, J=8.6 Hz), 7.19 (1H, d, J=5.9 Hz), 7.20 (1H, t, J=5.5 Hz), 7.24-7.26 (4H, m)

With the rapid development of chemical substances, we look forward to future research findings about 4254-29-9.

Reference:
Patent; DAIICHI SANKYO COMPANY, LIMITED; US2011/53974; (2011); A1;,
Alcohol – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4254-29-9, name is 2,3-Dihydro-1H-inden-2-ol. This compound has unique chemical properties. The synthetic route is as follows. 4254-29-9

General procedure: To a solution of 18 (100 mg,0.420 mmol) and [4-(trifluoromethyl)phenyl]methanol (111 mg,0.630 mmol) in THF (10.0 mL), PPh3 (178 mg, 0.68 mmol), a 40%diethyl azodicarbonate toluene solution (309 lL, 0.680 mmol)were added at room temperature, and stirred under N2 atmosphereat 60 C for 4 h. After cooling to room temperature, the solvent wasdistilled off under reduced pressure. The residue was purified bysilica gel column chromatography (hexane/AcOEt = 100:0 to 95:5(v/v)) to obtain 19k as colorless oil (125 mg, 75%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4254-29-9, 2,3-Dihydro-1H-inden-2-ol.

Reference:
Article; Takano, Rieko; Yoshida, Masao; Inoue, Masahiro; Honda, Takeshi; Nakashima, Ryutaro; Matsumoto, Koji; Yano, Tatsuya; Ogata, Tsuneaki; Watanabe, Nobuaki; Hirouchi, Masakazu; Kimura, Takako; Toda, Narihiro; Bioorganic and Medicinal Chemistry; vol. 23; 17; (2015); p. 5546 – 5565;,
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