Category: 42514-50-1

Related Products of 42514-50-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 42514-50-1, name is 3-Amino-3-methylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Step 4: (3-Hydroxy-1,1-dimethyl-propyl)-carbamic acid tert-butyl ester. 3-Amino-3-methyl-butan-1-ol(5.0 g, 0.04 mol) was dissolved in 150 mL CH2Cl2 and treated with di-tert-butyl dicarbonate(11.12 g, 0.05 mol). The resulting mixture was stirred for 18 h at 25 C. The mixture was concentrated to the desired material as an amber oil(9.8 g, 100%); 1H NMR (DMSO-d6) delta 3.55 (s,1H), delta 4.43 (t, J=5 Hz, 1H), delta 3.46 (m, 2H), delta 1.71 (t, J=7 Hz, 2H), delta 1.37(s, 9H), delta 1.12(s, 6H).

According to the analysis of related databases, 42514-50-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kim, Kyoung S.; Lu, Songfeng; Sheng, X. Christopher; Crews JR., Alvin Donald; US2004/242596; (2004); A1;,
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Electric Literature of 42514-50-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 42514-50-1, name is 3-Amino-3-methylbutan-1-ol. A new synthetic method of this compound is introduced below.

Component XI [preparation of the compound of formula (IIIb)]N-tert-butoxycarbonyl-4,4-dimethyl-[1,2,3]oxathiazinane-2,2-dioxide a. tert-butyl (3-hydroxy-1,1-dimethylpropyl)-carbamidate 3-amino-3-methylbutan-1-ol (200.0 g, 1.94 mol) is dissolved in ethyl acetate (0.75 l) and within one hour combined with a solution of di-tert-butyl-dicarbonate (435.0 g, 1.99 mol) in ethyl acetate (0.75 l). After the addition has ended the reaction mixture is stirred for another 30 min. After elimination of the solvent the title compound is obtained, which is used in the next step without further purification. Yield: 412.5 g 1H-NMR (DMSO, 400 MHz): 1.19 (s, 9H); 1.36 (s, 6H); 1.68-1.74 (m, 2H); 3.42-3.50 (m, 2H); 4.39 (t, J=4.8, 1H); 6.36 (br s, 1H). Alternatively tert-butyl (3-hydroxy-1,1-dimethylpropyl)-carbamidate may also be prepared using the methods described for example in J. of Labell. Compounds & Radioph. 2001, 44(4), 265-275 or der WO 03/037327, p. 82/83.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,42514-50-1, its application will become more common.

Reference:
Patent; Walter, Rainer; Hamilton, Bradford S.; Trieselmann, Thomas; Netherton, Matthew R.; Santagostino, Marco; Konetzki, Ingo; US2007/105906; (2007); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 42514-50-1, name is 3-Amino-3-methylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C5H13NO

3-Amino-3-methyl-butan-1-ol (5.0 g, 0.04 mol) was dissolved in 150 mL CH2Cl2 and treated with di-tert-butyl dicarbonate (11.12 g, 0.05 mol). The resulting mixture was stirred for 18 h at 25 C. The mixture was concentrated to the desired material as an amber oil (9.8 g, 100%): 1H NMR (DMSO-d6) delta 3.55 (s, 1H), 4.43 (t, 1H, J = 5 Hz), 3.46 (m, 2H), 1.71 (t, 2H, J = 7 Hz), 1.37 (s, 9H), 1.12 (s, 6H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42514-50-1, 3-Amino-3-methylbutan-1-ol.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/99286; (2003); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 42514-50-1, name is 3-Amino-3-methylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. name: 3-Amino-3-methylbutan-1-ol

To the primary amine 36 (3 g, 29 mmol) was added formic acid (2.86 mL, 73 mmol) and formalin (5.43 mL, 73 mmol) slowly. The resulting reaction mixture was heated up to reflux for 5h, then cooled to room temperature and basified by excess KOH. The mixture was extracted with ether (100 mL x 2). The ether layer was dried over Na2SO4 and concentrated to give a colorless oil. The oil (Ig, 7.63 mmol) was dissolved in chloroform(15 mL) and thionyl chloride (2.78 mL, 38.2 mmol) was added. The reaction mixture was heated to reflux for 2 hours, evaporated to dryness, and then triturated by ether. The resulting off-white solid (1.35 g, 95% yield) was dried in vacuum over night. 1H NMR (CDCl3) delta 1.41 (s, 6H), 2.20 (t, 2H, J= 8.0), 2.65 (s, 3H), 2.68 (s, 3H), 3.62 (t, 2H, J= 8.0); 13C NMR (CDCl3) delta 21.9, 37.6, 38.8, 39.6, 63.7

With the rapid development of chemical substances, we look forward to future research findings about 42514-50-1.

Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY; LAVOIE, Edmond, J.; FENG, Wei; LIU, Leroy, F.; WO2010/102219; (2010); A1;,
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Adding a certain compound to certain chemical reactions, such as: 42514-50-1, 3-Amino-3-methylbutan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 42514-50-1, blongs to alcohols-buliding-blocks compound. Recommanded Product: 3-Amino-3-methylbutan-1-ol

Step 2: Synthesis of benzyl 3-[(4-hydroxy-2-methylbutan-2-yl)amino]-4- nitrobenzoate A stirred solution of benzyl 3-fluoro-4-nitrobenzoate (2.67 g, 9.69 mmol) and 3-amino-3- methylbutan-l-ol (1.00 g, 9.69 mmol) in acetonitrile (20 mL) containing potassium carbonate (1.34 g, 9.69 mmol) is heated to 80 C for 16 h. The solvent is evaporated, water (100 mL) is added, and the mixture is extracted with EtOAc (3 x 100 mL). The combined organic layers are dried (MgS04), concentrated and purified by flash chromatography in heptanes/EtOAc to afford the title compound (395 mg, 1.10 mmol).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,42514-50-1, its application will become more common.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOYER, Stephen, James; BURKE, Jennifer; GUO, Xin; KIRRANE JR., Thomas, Martin; SNOW, Roger, John; ZHANG, Yunlong; WO2011/71725; (2011); A1;,
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Adding a certain compound to certain chemical reactions, such as: 42514-50-1, 3-Amino-3-methylbutan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 42514-50-1, blongs to alcohols-buliding-blocks compound. name: 3-Amino-3-methylbutan-1-ol

Step 2: Synthesis of benzyl 3-[(4-hydroxy-2-methylbutan-2-yl)amino]-4- nitrobenzoate A stirred solution of benzyl 3-fluoro-4-nitrobenzoate (2.67 g, 9.69 mmol) and 3-amino-3- methylbutan-l-ol (1.00 g, 9.69 mmol) in acetonitrile (20 mL) containing potassium carbonate (1.34 g, 9.69 mmol) is heated to 80 C for 16 h. The solvent is evaporated, water (100 mL) is added, and the mixture is extracted with EtOAc (3 x 100 mL). The combined organic layers are dried (MgS04), concentrated and purified by flash chromatography in heptanes/EtOAc to afford the title compound (395 mg, 1.10 mmol).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,42514-50-1, its application will become more common.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOYER, Stephen, James; BURKE, Jennifer; GUO, Xin; KIRRANE JR., Thomas, Martin; SNOW, Roger, John; ZHANG, Yunlong; WO2011/71725; (2011); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 42514-50-1, name is 3-Amino-3-methylbutan-1-ol, the common compound, a new synthetic route is introduced below. Application In Synthesis of 3-Amino-3-methylbutan-1-ol

3-CHLORO-N-(5-{[7-(3-CHLOROPROPOXY)-6-METHOXYQUINAZOLIN-4-YL] AMINO} PYRIDIN-2- yl) benzamide hydrochloride (1.07 g, 2.00 MMOL), 3-AMINO-3-METHYLBUTANOL (1.03 g, 10.0 mmol) and potassium iodide (32 MG, 0.2 mmol) in dimethylacetamide (2.5 ml) was heated at 80 C for 4 days. The mixture was cooled, diluted with dichloromethane (25 ml) and the solution absorbed onto silica gel. Purification by flash chromatography, eluting with dichloromethane: methanol: aqueous ammonia (100: 5: 0.5 to 100: 25 : 2), yielded 3-chloro-N- {5- [ (7- {3- [ (3-hydroxy-1, 1-dimethylpropyl) AMINO] PROPOXY}-6-METHOXYQUINAZOLIN-4- yl) AMINO] PYRIDIN-2-YL} BENZAMIDE as a pale yellow solid (804 mg, 71 % yield): IH-NMR (DMSO-d6): 10.92 (br s, 1H), 9.68 (s, 1H), 8. 80 (s, 1H), 8.48 (s, 1H), 8.29 (d, 1H), 8.19 (d, 1H), 8.08 (s, 1H), 8.00 (d, 1H), 7.88 (s, 1H), 7.66 (d, 1H), 7. 55 (dd, 1H), 7.20 (s, 1H), 4.20 (t, 2H), 3.97 (s, 3H), 3.50 (M, 2H), 2.74 (t, 2H), 1.94 (M, 2H), 1.57 (m, 2H), 1.07 (s, 6H) MS (-ve ESI): 563 (M-H)-, MS (+ve ESI): 565 (M+H)+.

The synthetic route of 42514-50-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/58782; (2004); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 42514-50-1, name is 3-Amino-3-methylbutan-1-ol. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks

vTn a glass RBF equipped with a Teflon-coated magnetic stirrer was combined 4-fluoro-1,2-dinitrobenzene (1 eq.), 3- amino-3-methylbutan-1-ol (1 eq.) and ethyl diisopropyl amine (1.5 eq.) in DMSO (0.5 M). The resulting mixture was then heated at 100C for 24 h. The reaction mixture was then diluted with water and extracted with EtOAc. The combined organic extracts were washed further with water and brine, dried over MgSO4, filtered and the filtrate concentrated in vacuo. Further purification of the crude product thus obtained by way of column chromatography (Si02, gradient elution, 9:1 (v/v) Hex: EtOAc – EtOAc) furnished the desired product (22% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42514-50-1, 3-Amino-3-methylbutan-1-ol.

Reference:
Patent; MERCK PATENT GMBH; JORAND-LEBRUN, Catherine; LAN, Ruoxi; CHEN, Austin; CLARK, Ryan C.; (268 pag.)WO2017/49068; (2017); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 42514-50-1, name is 3-Amino-3-methylbutan-1-ol. A new synthetic method of this compound is introduced below., HPLC of Formula: C5H13NO

To a stirred suspension of sodium hydride (0.3Og, 80% dispersion in mineral oil) in dry N,N-dimethylformamide (2ml) under an atmosphere of nitrogen at ambient temperature was added dropwise a solution of 1-hydroxy-3-methylbut-3-ylamine (0.52g) in N1N- dimethylformamide (5ml). The mixture was stirred for 3 hours, methyl iodide (0.74g) in N,N-dimethylformamide (5ml) added over 5 minutes then stirred for another 2.25 hours and stored for 18 hours at ambient temperature. The solution was diluted with water, extracted into ethyl acetate (three times) and the extracts combined then extracted with dilute hydrochloric acid. The aqueous acidic extract was evaporated under reduced pressure and co-distilled with toluene to remove residual water to give 1-methoxy-3- methylbut-3-ylamine hydrochloride as a yellow gum.1H NMR (CDCI3) delta ppm: 1.54(6H,s); 1.96-2.00(2H,t); 3.48(3H,s); 3.62-3.66(2H,t).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42514-50-1, 3-Amino-3-methylbutan-1-ol.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WO2008/110355; (2008); A1;,
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