Adding a certain compound to certain chemical reactions, such as: 42042-68-2, 4-(Methylamino)butan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 4-(Methylamino)butan-1-ol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 4-(Methylamino)butan-1-ol
To a solution of 3.00 g of 2-chloro-5,6-di-p-tolylpyrazine and 1.57 g of 4-(methylamino)-1-butanol in 15 ml of N,N-dimethylformamide, 2.26 g of potassium carbonate was added.. After heating with stirring at 100C for 26 hours, the reaction solution was extracted with diethyl ether after adding ice water.. The extract was washed in turn with water and saturated brine and dried over anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure.. The residue was purified by silica gel column chromatography and the resulting crystal was washed with diisopropyl ether to obtain 2.76 g of the desired compound as a colorless crystal having a melting point of 94 to 96C.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,42042-68-2, 4-(Methylamino)butan-1-ol, and friends who are interested can also refer to it.
Reference:
Patent; Nippon Shinyaku Co., Ltd.; EP1400518; (2004); A1;,
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Alcohols – Chemistry LibreTexts