Category: 41790-30-1

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 41790-30-1, name is (5,6,7,8-Tetrahydronaphthalen-1-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. name: (5,6,7,8-Tetrahydronaphthalen-1-yl)methanol

To a solution of S5 (5.24 g, 32.3 mmol) in DCM (200 mL) at 0 C was added thionyl chloride (8.45 g, 71.1 mmol). The reaction mixture was stirred at r.t. for 24 h, then solvent was removed under reduced pressure. The residue was diluted with DCM (100 mL) and quenched with ice-water (100 mL). The organic phase was washed with sat. aq. NaHCO3, dried with Na2SO4 and concentrated to give 5-(chloromethyl)-1,2,3,4-tetrahydronaphthalene (S6) as a brown oil (3.25 g, 56%). 1H NMR (CDCl3) delta 7.16-7.05 (m, 3H), 4.59 (s, 2H), 2.86 (t, J = 6.3 Hz, 2H), 2.79 (t, J = 6.4 Hz, 2H), 1.88-1.77 (m, 4H). Found: [M+H]=181.6.

With the rapid development of chemical substances, we look forward to future research findings about 41790-30-1.

Reference:
Article; Sutherland, Hamish S.; Tong, Amy S.T.; Choi, Peter J.; Blaser, Adrian; Conole, Daniel; Franzblau, Scott G.; Lotlikar, Manisha U.; Cooper, Christopher B.; Upton, Anna M.; Denny, William A.; Palmer, Brian D.; Bioorganic and Medicinal Chemistry; vol. 27; 7; (2019); p. 1292 – 1307;,
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Electric Literature of 41790-30-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41790-30-1, name is (5,6,7,8-Tetrahydronaphthalen-1-yl)methanol, molecular formula is C11H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 2 – Tetralin-5-carbaldehyde (0543) [00350] To a solution of tetralin-5-ylmethanol (7.20 g, 44.3 mmol) in dichloromethane (100 mL) was added manganese dioxide (19.2 g, 221 mmol) under a nitrogen atmosphere. The mixture was stirred at 20 C for 6 hrs. On completion, the mixture was filtered; the filtrate was concentrated in vacuo to afford a residue. The residue was purified with silica gel chromatography (petroleum ether:ethyl acetate = 20:1) to afford the title compound. 1H NMR (400MHz, DMSO-d6) delta = 10.23 (s, 1H), 7.65 (dd, J = 1.1, 7.4 Hz, 1H), 7.41 – 7.35 (m, 1H), 7.35 – 7.29 (m, 1H), 3.15 (t, J = 6.1 Hz, 2H), 2.79 (t, J = 6.0 Hz, 2H), 1.79 – 1.69 (m, 4H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 41790-30-1, (5,6,7,8-Tetrahydronaphthalen-1-yl)methanol.

Reference:
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; MOYER, Mikel P.; SAIAH, Eddine; (264 pag.)WO2017/156181; (2017); A1;,
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