Category: 4152-92-5

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4152-92-5, name is (2-(Aminomethyl)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C8H11NO

[00177] Compound 24: An ice-cold pyridine solution (10 mL) of compound 23 (1 mmol) is treated successively, in a dropwise fashion with acetyl choride (1 mmol), then after 5 min with MsCl (1.1 mmol). The solution is warmed to room temperature then the solvent is removed. The residue is dissolved in EtOAc, washed with water, dried (MgS04), filtered and reduced in vacuo. Purification by column chromatography affords pure compound 24.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4152-92-5, (2-(Aminomethyl)phenyl)methanol.

Reference:
Patent; ONTORII, INC.; VERDINE, Gregory, L.; MEENA, Meena; IWANOTO, Naoki; BUTLER, David, Charles Donnell; WO2013/12758; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4152-92-5, name is (2-(Aminomethyl)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C8H11NO

[00177] Compound 24: An ice-cold pyridine solution (10 mL) of compound 23 (1 mmol) is treated successively, in a dropwise fashion with acetyl choride (1 mmol), then after 5 min with MsCl (1.1 mmol). The solution is warmed to room temperature then the solvent is removed. The residue is dissolved in EtOAc, washed with water, dried (MgS04), filtered and reduced in vacuo. Purification by column chromatography affords pure compound 24.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4152-92-5, (2-(Aminomethyl)phenyl)methanol.

Reference:
Patent; ONTORII, INC.; VERDINE, Gregory, L.; MEENA, Meena; IWANOTO, Naoki; BUTLER, David, Charles Donnell; WO2013/12758; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 4152-92-5 ,Some common heterocyclic compound, 4152-92-5, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Step i: Ketone 1 (1 mmol), primary amine 2 (1 mmol), and a mixture of Ti(Oi-Pr)4 (3.1 mg, 1.1 mol%) in 1-(trimethylsilyl)-2-pyrrolidinone (393 mg, 2.5 mmol) were heated at 70C with shaking in a sealed vial for 6 h. Step ii: After cooling down to r.t., EtOH (2 mL) was added to the solution and it was shaken until homogenization followed by the addition of NaBH4 (68 mg, 1.8 mmol). The resulting heterogeneous mixture was left staying overnight at r.t. Then, H2O (2 mL) was added and the mixture was sonicated for 2 h at r.t. to decompose the excess of NaBH4. The product was extracted with CHCl3 (3 mL), and the organic phase was washed with H2O (3 × 7 mL), dried (Na2SO4), and evaporated to give the respective secondary amine 3. Samples with purity below 95% as determined by LC-MS or 1H NMR spectroscopy were further purified by column chromatography (SiO2,eluent A: CHCl3, eluent B: i-PrOH, a linear gradient from 0% eluent B to 100% eluent B was used).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4152-92-5, its application will become more common.

Reference:
Article; Bogolubsky, Andrey V.; Moroz, Yurii S.; Pipko, Sergey E.; Panov, Dmitriy M.; Konovets, Anzhelika I.; Doroschuk, Roman; Tolmachev, Andrey; Synthesis; vol. 46; 13; (2014); p. 1765 – 1772;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 4152-92-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4152-92-5, name is (2-(Aminomethyl)phenyl)methanol, molecular formula is C8H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 1(3R,6f?)-3-(2,3-Dihydro-1 H-inden-2-yl)-6-(1 -ethylpropyl)-1 -[2(hydroxymethyl)- benzyI]piperazine-2,5-dione [2-(Aminomethyl)phenyl]methanol (4.12g, 30 mmol) was dissolved in methanol (30ml) and 2-ethylbutanal (3.7ml, 30 mmol) added followed by (2R)-2,3-dihydro-1H-inden-2- yl({[(1 ,1-dimethylethyl)oxy]carbonyl}amino)ethanoic acid (8.74g, 30 mmol). The mixture was stirred for 15 minutes before 4-chlorophenylisonitrile (4.13g, 30 mmol) was added. The mixture was stirred for 2.25 hours and then left to stand at room temperature overnight (16.3 hours) before it was cooled in an ice / water bath. Then acetyl chloride (12.75ml, 179.5 mmol) was added dropwise, keeping the reaction temperature below 200C. Then the mixture was stirred in the cooling bath for a further 10 minutes before it was stirred at room temperature. After 5 hours the mixture was evaporated under reduced pressure to leave a dark brown gum. The gum was stirred in chloroform (75ml) and saturated aqueous sodium bicarbonate solution (75ml) for 20 minutes before it was diluted with chloroform (75ml) and the phases separated. The aqueous phase was extracted with chloroform (3 * 75ml). The combined organic phase was dried (MgSO4) and concentrated under reduced pressure to ca. 75ml. The chloroform solution was treated with glacial acetic acid (3ml) and left to stand, at room temperature over the weekend. Then the reaction mixture was washed with 2M hydrochloric acid (75ml), followed by saturated aqueous sodium bicarbonate solution (75ml). The organic phase was dried (MgSO4) and evaporated under reduced pressure and dried to leave a brown foam. The foam was loaded in dichloromethane onto a 33Og flash silica chromatography column (pre-eluted with 20% ethyl acetate in cyclohexane). The column was eluted with 20% to 100% ethyl acetate in cyclohexane to afford (3f?,6R)-3-(2,3-dihydro-1H-inden-2- yl)-6-(1-ethylpropyl)-1-[2-(hydroxymethyl)benzyl]piperazine-2,5-dione (4.12g) as a pale brown solid. HPLC (A) Rt = 3.26 minutes; m/z [M+H]+ = 421. EPO 1H NMR (CDCI3) delta 7.37 (m, 1 H), 7.30 (m, 2H), 7.21 (m, 5H), 6.84 (br d,1 H), 5.45 (d, 1 H), 4.74 and 4.63 (d, 2H), 4.16 (d, 1 H), 4.08 (dd, 1 H), 4.04 (d, 1 H), 3.15 (m, 3H), 2.92 (m, 1H), 2.78 (m, 2H), 1.76 (m, 1 H), 1.62 (m, 3H), 1.31 (m, 1 H), 0.92 (m, 6H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4152-92-5, (2-(Aminomethyl)phenyl)methanol.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/67462; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 4152-92-5, Adding some certain compound to certain chemical reactions, such as: 4152-92-5, name is (2-(Aminomethyl)phenyl)methanol,molecular formula is C8H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4152-92-5.

A solution of 1.7 g of 2-(aminomethyl)benzyl alcohol (12. 4 mmol) and 1.76 mL of triethylamine (12. 4 mmol) was dissolved in 20 mL anhydrous methanol, 1.96 mL of ethyl trifluoroacetate (16.4 mmol) was added dropwise under argon and the reaction was stirred at 25 C for 2 hours. After the reaction, ethyl acetate (30 mL) and water (30 mL) were added to the extract. The ethyl acetate layer was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate overnight, and the solvent was removed in vacuo to give 2-[(trifluoroacetamido)methyl]benzyl alcohol. The crude product was purified by silica gel column chromatography eluting with ethyl acetate / cyclohexane (1: 2, v / v) to give 2-[(trifluoroacetamido)methyl]benzyl alcohol (2.0 g, 8.6 mmol), 69% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4152-92-5, (2-(Aminomethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Beijing University of Technology; Zhao, Lijiao; Sun, Guohui; Zhong, RuGang; (20 pag.)CN104031048; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 4152-92-5 , The common heterocyclic compound, 4152-92-5, name is (2-(Aminomethyl)phenyl)methanol, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

An ice-cold pyridine solution (10 mL) of compound 23 (1 mmol) is treated successively, in a dropwise fashion with acetyl chloride (1 mmol), then after 5 min with MsCl (1.1 mmol). The solution is warmed to room temperature then the solvent is removed. The residue is dissolved in EtOAc, washed with water, dried (MgS04), filtered and concentrated in vacuo. Purification by column chromatography affords pure compound 24.

The synthetic route of 4152-92-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ONTORII, INC.; BUTLER, David; IWAMOTO, Naoki; MEENA, Meena; SVRZIKAPA, Nenad; VERDINE, Gregory L.; ZLATEV, Ivan; WO2014/12081; (2014); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts