Category: 4139-61-1

Electric Literature of 4139-61-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4139-61-1, name is 6-Bromo-4-hydroxycoumarin. A new synthetic method of this compound is introduced below.

Step one: the 6 – bromo -4 – hydroxy coumarin (1 mmol) with triethylamine (1.5 mmol) dissolved in 10 ml dichloromethane after, cold water bath cooling, trifluoromethyl sulfonic acid anhydride (1.5 mmol) is added slowly dropping in the reaction system, the reaction 3 hours later, and steaming and to remove the solvent, after concentrating column separation (petroleum ether and ethyl acetate to the volume proportion 4:1) to obtain 6 – bromo -4 – trifluoromethanesulfonic acid ester – coumarin.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4139-61-1, its application will become more common.

Reference:
Patent; Henan University of Technology; Wang Hongyan; Wei Xuning; Liu Yu; Guo Tao; Lin Xiangbin; Kong Linghui; (33 pag.)CN107629050; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 4139-61-1, 6-Bromo-4-hydroxycoumarin, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C9H5BrO3, blongs to alcohols-buliding-blocks compound. COA of Formula: C9H5BrO3

EXAMPLE 27 6-Bromo-4-hydroxy-3-[4-(2-methoxyphenyl)butyl]-2H-1-benzopyran-2-one The title compound was prepared from 4-hydroxy-6-bromo-2H-1-benzopyran-2-one, and 4-(2-methoxyphenyl)butanoic acid using the procedure described in Example 13. A 55% yield of the title compound was obtained, m.p. 147.5-148.5 C.

The synthetic route of 4139-61-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Warner-Lambert Company; US5510375; (1996); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 4139-61-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4139-61-1, name is 6-Bromo-4-hydroxycoumarin, molecular formula is C9H5BrO3, molecular weight is 241.04, as common compound, the synthetic route is as follows.

EXAMPLE 50 6-Bromo-4-[3-(tetrahydro-pyran-2-yloxy)-propoxy]-1-benzopyran-2-one 6-Bromo-4-hydroxycoumarin (1.19 mmol, 0.287 g), K2CO3 (3.57 mmol, 0.493 g) and 2-3-(bromopropoxy)tetrahydro-2H-pyran (1.19 mmol, 0.264 g) is suspended in 10 mL of acetone, and is heated to 55 C. for 24 hrs at which time the reaction is not complete. Cs2CO3 (1.54 mmol, 0.5 g) and 5 mL of DMF are added and the reaction is heated for an additional 2 hrs. Twenty-five percent of the crude THP protected material is purified by HPLC to afford the title compound (70.8 mg, 62%); 1H NMR (CDCl3, 300 MHz) delta 7.91 (1H, d, J=2.25 Hz), 7.82 (1H, dd, J=2.5, 9 Hz), 7.39 (1H, d, J=9 Hz), 5.98 (1H, s), 4.59 (1H, m), 4.31 (2H, t, J=6 Hz), 3.83 (1H, m), 3.72 (1H, m), 3.55 (2H, m), 2.09 (2H, m), 1.65 (2H, m), 1.45 (4H, m); MS (ESI, Pos.) calcd for C17H19BrO5 m/z [M+H]=383.0, found 383.1.

The chemical industry reduces the impact on the environment during synthesis 4139-61-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Aventis Pharmaceuticals Inc.; US2005/54681; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts