Category: 403-41-8

Zhang, Shanshan; Wang, Zheng; Cao, Qianrong; Yue, Erlin; Liu, Qingbin; Ma, Yanping; Liang, Tongling; Sun, Wen-Hua published the artcile< Aza-crown compounds synthesised by the self-condensation of 2-amino-benzyl alcohol over a pincer ruthenium catalyst and applied in the transfer hydrogenation of ketones>, HPLC of Formula: 403-41-8, the main research area is aminobenzyl alc pincer ruthenium catalyst self condensation; aza crown compound preparation; alkyl aryl ketone transfer hydrogenation iron catalyst; aralkyl alc preparation.

A well-defined PNN-Ru catalyst was revisited to self-condense 2-aminobenzyl alc. formed a series of novel aza-crown compounds All aza-crown compounds were separated and determined by NMR, IR, and ESI-MS spectroscopy as well as X-ray crystallog., indicated the saddle structure of aza-12-crown-3 and the twisted 1,3-alternate conformation structure of aza-20-crown-5. These aza-crown compounds was explored to study ferric initiation of transfer hydrogenation (TH) of ketones into their corresponding secondary alcs. in the presence of 2-propanol with a basic t-BuOK solution, achieving a high conversion (up to 95%) by a ferric complex with aza-16-crown-4 in a low loading (0.05 mol%).

Dalton Transactions published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, HPLC of Formula: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kishore, Jugal; Thiyagarajan, Subramanian; Gunanathan, Chidambaram published the artcile< Ruthenium(II)-catalyzed direct synthesis of ketazines using secondary alcohols>, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is ketazine preparation diastereoselective; secondary alc hydrazine hydrate oxygen hydrogen bond activation; ruthenium pincer complex catalyst.

Direct one-pot synthesis of ketazines (E,E)-R1R2C:NN:CR1R2 (R1 = Me, Et, Pr, etc.; R2 = C6H5, 4-MeC6H4, 2-MeOC6H4, etc.) from secondary alcs. R1R2CH(OH) and hydrazine hydrate catalyzed by a ruthenium pincer complex is reported, which proceeds through O-H bond activation of secondary alcs. via amine-amide metal-ligand cooperation in the catalyst. Remarkably, liberated mol. hydrogen and water are the only byproducts.

Chemical Communications (Cambridge, United Kingdom) published new progress about Azines Role: SPN (Synthetic Preparation), PREP (Preparation) (ketazines). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Buhaibeh, Ruqaya; Filippov, Oleg A.; Bruneau-Voisine, Antoine; Willot, Jeremy; Duhayon, Carine; Valyaev, Dmitry A.; Lugan, Noel; Canac, Yves; Sortais, Jean-Baptiste published the artcile< Phosphine-NHC Manganese Hydrogenation Catalyst Exhibiting a Non-Classical Metal-Ligand Cooperative H2 Activation Mode>, Application In Synthesis of 403-41-8, the main research area is manganese NHC phosphine complex hydrogenation catalyst cooperative hydrogen activation; DFT calculations; N-heterocyclic carbenes; manganese; metal-ligand cooperation; phosphonium ylides.

Deprotonation of the MnI NHC-phosphine complex fac-[MnBr(CO)3(κ2P,C-Ph2PCH2NHC)] (2, II) under a H2 atmosphere readily gives the hydride fac-[MnH(CO)3(κ2P,C-Ph2PCH2NHC)] (3, III) via the intermediacy of the highly reactive 18-e NHC-phosphinomethanide complex fac-[Mn(CO)3(κ3P,C,C-Ph2PCHNHC)] (6a, VI). DFT calculations revealed that the preferred reaction mechanism involves the unsaturated 16-e mangana-substituted phosphonium ylide complex fac-[Mn(CO)3(κ2P,C-Ph2P=CHNHC)] (6 b) as key intermediate able to activate H2 via a non-classical mode of metal-ligand cooperation implying a formal λ5-P-λ3-P phosphorus valence change. Complex 2 is shown to be one of the most efficient pre-catalysts for ketone hydrogenation in the MnI series reported to date (TON up to 6200).

Angewandte Chemie, International Edition published new progress about Carbene complexes, N-heterocyclic, transition metal complexes Role: CAT (Catalyst Use), PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), USES (Uses), PROC (Process), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Application In Synthesis of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ganguli, Kasturi; Shee, Sujan; Panja, Dibyajyoti; Kundu, Sabuj published the artcile< Cooperative Mn(I)-complex catalyzed transfer hydrogenation of ketones and imines>, Formula: C8H9FO, the main research area is alc preparation chemoselective; ketone transfer hydrogenation manganese catalyst; aryl aldehyde transfer hydrogenation manganese catalyst; imine transfer hydrogenation manganese catalyst.

The synthesis and reactivity of Mn(I) complexes bearing bifunctional ligands comprising both the amine N-H and benzimidazole fragments I and II (R = H, Me; R1 = H, Me, phenyl; R2 = H, Me) are reported. Among the various ligands, the N-((1H-benzimidazol-2-yl)methyl)aniline ligand containing Mn(I) complex II (R = R2 = H; R1 = Ph) presented higher reactivity in the transfer hydrogenation (TH) of ketones R3C(O)R4 (R3 = Ph, thiophen-2-yl, cyclopropyl, etc.; R4 = Me, propan-2-yl, tert-Bu, etc.; R3R4 = 9H-fluoren-9-yl, 1,2,3,4-tetrahydronaphthalen-1-yl, cyclohexyl) in 2-propanol. Exptl., it was established that both the benzimidazole and amine N-H proton played a vital role in the enhancement of the catalytic activity. Utilizing this system, a wide range of ketones R3C(O)R4 and aldehydes R5CHO (R5 = 4-CH3C6H4, thiophen-2-yl, pentyl, etc.) was reduced efficiently. Notably, the TH of several imines R6R7C=NR8 (R6 = 4-OCH3C6H4, thiophen-2-yl, naphthalen-2-yl, etc.; R7 = H, Me, Et; R8 = C6H5, 4-OCH3C6H4, CH3(CH2)3, etc.), as well as chemoselective reduction of unsaturated ketones, was achieved in the presence of this catalyst. DFT calculations were carried out to understand the plausible reaction mechanism which disclosed that the transfer hydrogenation reaction followed a concerted outer-sphere mechanism.

Dalton Transactions published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Formula: C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Zheng; Liu, Yahuan; Han, Mingyang; Ma, Ning; Lyu, Quanming; Liu, Qingbin; Sun, Wen-Hua published the artcile< Efficient transfer hydrogenation of ketones using molybdenum complexes by comprehensively verifying the auxiliary ligands>, SDS of cas: 403-41-8, the main research area is ketone hydrogenation molybdenum complex catalyst.

Molybdenum complexes ligated with N1,N1-dialkyl-N2-(5,6,7,8-tetrahydroquinolin-8-yl)ethane-1,2-diamines and auxiliary ligands, providing various structural features, were developed: [NNH/NNHN]Mo(CO)4/3, [NNHN]Mo(CO)2Br, [NNH]Mo(CO)(η3-C3H5)Br and [NNHN/S]Mo(CO)(PPh3)2. All the complexes were highly active in the transfer hydrogenation (TH) of a model substrate (acetophenone), providing excellent yields of 1-phenylethanol. The structural variation in the ligand framework had a modest effect on the catalyst performance as compared to the changes in the auxiliary ligands Br, PPh3 and CO. This structural evolution provided the complex [Mo(NNH)(η3-C3H5)(CO)2Br] as the most effective catalyst not only for the transfer hydrogenation of acetophenone but also for a wide range of diverse ketones (up to 43 examples). Moreover, easy purification of the products by only removing the acetone byproduct is another noteworthy feature of this environmentally friendly route.

Dalton Transactions published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, SDS of cas: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fu, Xuegang; Wang, Yue; Liu, Liu; Li, Caifeng; Huang, Lin; Huang, Jianhui published the artcile< KOtBu/O2 Mediated Dehydrogenation of N-Heterocycles, Alcohols>, SDS of cas: 403-41-8, the main research area is heterocyclic compound preparation green chem; tetrahydroheterocyclic compound dehydrogenation; ketone preparation; alc dehydrogenation.

A convenient dehydrogenation of a number of N,O-containing heterocycles e.g., 1,2,3,4-tetrahydroquinoline and carbocycles RCH(OH)R1 (R = Ph, 3,4-dimethoxyphenyl, naphthalen-2-yl, pyridin-2-yl, etc.; R1 = Me, OH, t-Bu, Ph, Cy) and 1,2,3,4-tetrahydronaphthalen-1-ol with readily available inorganic base (KOtBu) and oxygen is reported. The oxidation process is proved to be an SRN1 pathway followed by a radical elimination. This radical process has opened up the possibilities for the development of new superoxide mediated synthetic methodologies using KOtBu as the single electron reductant.

ChemistrySelect published new progress about Aromatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, SDS of cas: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ng, Teng Wei; Liao, Gang; Lau, Kai Kiat; Pan, Hui-Jie; Zhao, Yu published the artcile< Room-Temperature Guerbet Reaction with Unprecedented Catalytic Efficiency and Enantioselectivity>, Electric Literature of 403-41-8, the main research area is secondary alc preparation Guerbet catalyst enantioselectivity; Guerbet reaction; alkylation; borrowing hydrogen; enantioselectivity; higher-order alcohols.

The authors report herein an unprecedented highly efficient Guerbet-type reaction at room temperature (catalytic TON up to >6000). This β-alkylation of secondary Me carbinols with primary alcs. has significant advantage of delivering higher-order secondary alcs. in an economical, redox-neutral fashion. In addition, the first enantioselective Guerbet reaction also was achieved using a com. available chiral ruthenium complex to deliver secondary alcs. with moderate yield and up to 92% ee. In both reactions, the use of a traceless ketone promoter proved to be beneficial for the catalytic efficiency.

Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent) (Me carbinols). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Electric Literature of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

P., Sreejyothi; Sarkar, Pallavi; Dutta, Supriti; Das, Arpan; Pati, Swapan K.; Mandal, Swadhin K. published the artcile< Regioselective ring-opening of epoxides towards Markovnikov alcohols: a metal-free catalytic approach using abnormal N-heterocyclic carbene>, Application In Synthesis of 403-41-8, the main research area is alkyl epoxide borabicyclononane heterocyclic carbene regioselective Markovnikov ring opening; alkanol preparation.

The first metal-free regioselective Markovnikov ring-opening of epoxides (selectivity up to 99%) using an abnormal N-heterocyclic carbene (aNHC) to yield secondary alcs was reported. DFT calculations and X-ray crystallog. suggested that the Markovnikov selectivity originated from the high nucleophilicity and steric factors associated with the aNHC.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aliphatic alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Application In Synthesis of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lu, Hongyuan; Yu, Shiqin; Qin, Fengyu; Ning, Wenbo; Ma, Xiaoqiang; Tian, Kaiyuan; Li, Zhi; Zhou, Kang published the artcile< A secretion-based dual fluorescence assay for high-throughput screening of alcohol dehydrogenases>, Related Products of 403-41-8, the main research area is alc dehydrogenase secretion dual fluorescence assay high throughput screening; alcohol dehydrogenase; cascade reaction; directed protein evolution; fluorescence assay; protein secretion.

Alc. dehydrogenases (ADHs) play key roles in the production of various chem. precursors that are essential in pharmaceutical and fine chem. industries. To achieve a practical application of ADHs in industrial processes, tailoring enzyme properties through rational design or directed evolution is often required. Here, we developed a secretion-based dual fluorescence assay (SDFA) for high-throughput screening of ADHs. In SDFA, an ADH of interest is fused to a mutated superfolder green fluorescent protein (MsfGFP), which could result in the secretion of the fusion protein to culture broth. After a simple centrifugation step to remove the cells, the supernatant can be directly used to measure the activity of ADH based on a red fluorescence signal, whose increase is coupled to the formation of NADH (a redox cofactor of ADHs) in the reaction. SDFA allows easy quantification of ADH concentration based on the green fluorescence signal of MsfGFP. This feature is useful in determining specific activity and may improve screening accuracy. Out of five ADHs we have tested with SDFA, four ADHs can be secreted and characterized. We successfully screened a combinatorial library of an ADH from Pichia finlandica and identified a variant with a 197-fold higher kcat/km value toward (S)-2-octanol compared to its wild type.

Biotechnology and Bioengineering published new progress about Catalysis. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Related Products of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Weifan; Luo, Man; Yao, Weiwei; Ma, Mengtao; Pullarkat, Sumod A.; Xu, Li; Leung, Pak-Hing published the artcile< Catalyst-free and solvent-free hydroboration of ketones>, Electric Literature of 403-41-8, the main research area is catalyst solvent free green hydroboration ketone; boronic ester preparation green chem.

The hydroboration of a wide range of ketones with pinacolborane can be achieved under catalyst-free and solvent-free conditions to provide the corresponding boronic esters in quant. yields. A large gram-scale hydroboration of acetophenone with HBpin under the same conditions was also performed to afford the alc. product in a high yield thus demonstrating the scalability of the newly developed simple protocol.

New Journal of Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Electric Literature of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts