Category: 403-41-8

Emayavaramban, Balakumar; Chakraborty, Priyanka; Manoury, Eric; Poli, Rinaldo; Sundararaju, Basker published the artcile< Cp*Co(III)-catalyzed N-alkylation of amines with secondary alcohols>, Reference of 403-41-8, the main research area is amine alkylation sec alc cobalt catalyst; tetrahydroquinoline preparation; aminoalc intramol amination cobalt catalyst.

Herein Cp*Co(III)-catalyzed direct N-alkylation of amines starting from secondary alcs. was reported for the first time. The reaction tolerates a wide variety of functional groups, including various aryl amines and amides. Various 1,5-aminoalcs. efficiently underwent intramol. amination with excellent isolated yields of the expected 2-aryltetrahydroquinolines. The preliminary mechanistic investigations and DFT calculations suggest that [Cp*CoI2] is an active species, that PCy3 stabilizes the high-valent hydride intermediate, and that the reaction indeed proceeds through hydrogen auto-transfer processes.

Organic Chemistry Frontiers published new progress about Alkylation. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Reference of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Passera, Alessandro; Mezzetti, Antonio published the artcile< The Manganese(I)-Catalyzed Asymmetric Transfer Hydrogenation of Ketones: Disclosing the Macrocylic Privilege>, Related Products of 403-41-8, the main research area is chiral aryl alkyl alc synthesis asym transfer hydrogenation acetophenone; ligand designed manganese catalyzed asym transfer hydrogenation acetophenone; alcohols; asymmetric catalysis; hydrogenation; ligand design; manganese.

The bis(carbonyl) manganese(I) complex [Mn(CO)2(ligand)]Br with a chiral (NH)2P2 macrocyclic ligand catalyzes the asym. transfer hydrogenation of polar double bonds with 2-propanol as the hydrogen source. Ketones (43 substrates) are reduced to alcs. in high yields (up to >99%) and with excellent enantioselectivities (90-99% ee). A stereochem. model based on attractive CH-π interactions is proposed.

Angewandte Chemie, International Edition published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Related Products of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xiao, Miao; Yue, Xin; Xu, Ruirui; Tang, Weijun; Xue, Dong; Li, Chaoqun; Lei, Ming; Xiao, Jianliang; Wang, Chao published the artcile< Transition-Metal-Free Hydrogen Autotransfer: Diastereoselective N-Alkylation of Amines with Racemic Alcohols>, Reference of 403-41-8, the main research area is diastereoselective alkylation amines alc chiral amine synthesis; alcohols; alkylation; amines; deuterium; reaction mechanisms.

A practical method for the synthesis of α-chiral amines by alkylation of amines with alcs. in the absence of any transition-metal catalysts has been developed. Under the co-catalysis of a ketone and NaOH, racemic secondary alcs. reacted with Ellman’s chiral tert-butanesulfinamide by a hydrogen autotransfer process to afford chiral amines with high diastereoselectivities (up to >99:1) [e.g., 1-phenylethanol + (R)-(+)-tert-butanesulfinamide → I (70%, > 95:5 d.r.) in presence of acetophenone and NaOH in toluene]. Broad substrate scope and up to a 10 g scale production of chiral amines were demonstrated. The method was applied to the synthesis of chiral deuterium-labeled amines with high deuterium incorporation and optical purity, including examples of chiral deuterated drugs. The configuration of amine products is found to be determined solely by the configuration of the chiral tert-butanesulfinamide regardless of that of alcs., and this is corroborated by DFT calculations Further mechanistic studies showed that the reaction is initiated by the ketone catalyst and involves a transition state similar to that proposed for the Meerwein-Ponndorf-Verley (MPV) reduction, and importantly, it is the interaction of the sodium cation of the base with both the nitrogen and oxygen atoms of the sulfinamide moiety that makes feasible, and determines the diastereoselectivity of, the reaction.

Angewandte Chemie, International Edition published new progress about Alkylation catalysts, stereoselective. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Reference of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Azizi, Kobra; Akrami, Sedigheh; Madsen, Robert published the artcile< Manganese(III) Porphyrin-Catalyzed Dehydrogenation of Alcohols to form Imines, Tertiary Amines and Quinolines>, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is manganese porphyrin chloride catalyst dehydrogenative coupling alcs amine; imine synthesis; tertiary amine synthesis; quinoline synthesis; alcohols; dehydrogenation; homogeneous catalysis; manganese; synthetic methods.

Manganese(III) porphyrin chloride complexes have been developed for the first time as catalysts for the acceptorless dehydrogenative coupling of alcs. and amines. The reaction has been applied to the direct synthesis of imines, tertiary amines and quinolines where only hydrogen gas and/or water are formed as the byproduct(s). The mechanism is believed to involve the formation of a manganese(III) alkoxide complex which degrades into the aldehyde and a manganese(III) hydride species. The latter reacts with the alc. to form hydrogen gas and thereby regenerates the alkoxide complex.

Chemistry – A European Journal published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chakraborty, Gargi; Sikari, Rina; Mondal, Rakesh; Mandal, Sutanuva; Paul, Nanda D. published the artcile< Nickel-Catalyzed Synthesis of Pyrimidines via Dehydrogenative Functionalization of Alcohols>, Application of C8H9FO, the main research area is pyrimidine preparation; alc amidine multicomponent dehydrogenative coupling nickel catalyst.

Herein, a comparative study of nickel-catalyzed syntheses of pyrimidines via dehydrogenative multi-component coupling of alcs. and amidines using two different classes of nickel catalysts differing with respect to their mode of action during catalysis is reported. The catalysts are either two tetracoordinate Ni(II)-complexes containing two apparently redox-inactive tetraaza macrocyclic ligands or square planar Ni(II)-complexes featuring redox-active diiminosemiquinonato type scaffolds. Tetracoordinate Ni(II) catalysts dehydrogenate alcs. via a two-electron hydride transfer pathway involving energetically demanding nickel-centered redox events while in the presence of square planar Ni(II)-complexes dehydrogenation of alcs. proceeds via a one-electron hydrogen atom transfer (HAT) pathway via synergistic participation of metal and ligand centered redox processes avoiding high energy nickel centered redox events. Detailed substrate screening and control experiments were performed to unveil the reaction sequence and understand the advantages/disadvantages of these two pathways.

Asian Journal of Organic Chemistry published new progress about Amidines Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Application of C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kilic, Ahmet; Ozbahceci, Orcun; Durgun, Mustafa; Aydemir, Murat published the artcile< Different Hemi-Salen/Salan Ligand Containing Binuclear Boron-Fluoride Complexes: Synthesis, Spectroscopy, Fluorescence Properties, and Catalysis>, Name: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is boron fluoride hemi salen salan binuclear preparation fluorescence; acetophenone transfer hydrogenation catalyzed boron hemisalen hemisalan complex.

A family of hemi-salen and hemi-salan ligands-based N,O-chelated binuclear B-fluoride or complexes were prepared and characterized by a variety of spectroscopic techniques (1H, 13C and 19F NMR, FTIR, UV-visible, LC-MS, and fluorescence spectra) and elemental anal. All of the binuclear B-fluoride complexes exhibit strong absorption bands due to S0→S1 transitions and strong fluorescence properties were observed at room temperature in the solution The binuclear B complexes containing two naphthyl groups are significantly red shifted in comparison with the other binuclear B-fluoride complexes. After the structures were characterized, these hemi-salen and salan ligand-based N, O-chelated binuclear B-fluoride complexes were used to the transfer hydrogenation of the different acetophenone derivatives conversion to 1-phenylethanol derivatives as catalysts.

Polycyclic Aromatic Compounds published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Name: 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lu, Li-Yu; Zhang, Pu; Qin, Yu-Jun; Guo, Zhi-Xin published the artcile< A mechanochemical domino reaction: From α-methylbenzyl alcohols to diacylfuroxans>, HPLC of Formula: 403-41-8, the main research area is diacylfuroxan preparation solvent free; alpha methylbenzyl alc mechanochem domino reaction.

A domino reaction was discovered in which diacylfuroxans were prepared directly from α-methylbenzyl alcs. in a solvent-free reaction, via in situ generation of the corresponding acetophenones, by combining with the reagents of Fe(NO3)3·9H2O and P2O5 under high-speed ball milling reaction conditions.

Results in Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, HPLC of Formula: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pandey, Bedraj; Xu, Shi; Ding, Keying published the artcile< Switchable β-alkylation of Secondary Alcohols with Primary Alcohols by a Well-Defined Cobalt Catalyst>, Electric Literature of 403-41-8, the main research area is alkylation primary secondary alc preparation cobalt triphosphine pyridine catalyst; switchable ketone secondary alc preparation alkylation benzenemethanol cobalt catalyst.

β-Alkylation of secondary alcs. R1CH(OH)Me with primary alcs. R2CH2OH catalyzed by cobalt(I) triphosphine-pyridine complex in the presence of KOtBu selectively generate either alcs. R1CH(OH)CH2CH2R2 or ketones R1COCH2CH2R2 in dependence of catalyst and base loadings and hydrogen presence or removal. Remarkably, a low catalyst loading of 0.7 mol% can be employed for the reaction. More significantly, this study represents the first Co-catalyzed switchable alc./ketone synthesis by simply manipulating the reaction parameters. In addition, the transformation is environmentally friendly, with water as the only byproduct.

Organometallics published new progress about Alkylation. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Electric Literature of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Poly, Sharmin Sultana; Hashiguchi, Yuta; Sultana, Asima; Nakamura, Isao; Shimizu, Ken-ichi; Yasumura, Shunsaku; Fujitani, Tadahiro published the artcile< Flow reactor approach for the facile and continuous synthesis of efficient Pd@Pt core-shell nanoparticles for acceptorless dehydrogenative synthesis of pyrimidines from alcohols and amidines>, Related Products of 403-41-8, the main research area is palladium platinum core shell nanoparticle dehydrogenative pyrimidine alc amidine.

Carbon supported Pd@Pt core-shell nanoparticles catalyst was prepared in a flow reactor toachieve enhanced catalytic activities with low Pt loading for the acceptorless dehydrogenative synthesis of pyrimidines. Spectroscopic (XAS anal.) and microscopic (HAADF-STEM) techniques reveled that the core-shell structure was formed by the applied preparation method. The Pd@Pt/PVP (polyvinylpyrrolidone)/C catalyst showed the activity for the three component one pot synthesis of pyrimidines through a series of consecutive reactions including oxidation of alcs., C-C, and C-N coupling, followed by heterocyclization and dehydrogenation employing various primary alcs., secondary alcs., and amidines. The reaction mechanism on Pd@Pt/PVP/C catalyst was explored by comparison with the control experiments

Applied Catalysis, A: General published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Related Products of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hamdi, Naceur.; Slimani, Ichraf; Mansour, Lamjed; Alresheedi, Faisal; Ozdemir, Ismail; Gurbuz, Nevin published the artcile< Rhodium(I) complexes with N-heterocyclic carbene ligands: synthesis, biological properties and catalytic activity in the hydrosilylation of aromatic ketones>, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is rhodium NHC benzimidazolylidene cyclooctadiene complex preparation antibacterial antitumor agent; ketone hydrosilylation catalyst rhodium NHC benzimidazolylidene cyclooctadiene complex; crystal mol structure buried volume rhodium NHC benzimidazolylidene complex.

New rhodium(I) N-heterocyclic carbene (NHC) complexes were synthesized in good yields by the reactions of rhodium dimer [Rh(OMe)(cycloocta-1,5-diene:COD)]2 with benzimidazolium salts in THF. All the complexes were characterized by IR, 1H-NMR, and 13C-NMR spectroscopy, DART-TOF mass spectrometry and elemental anal. All complexes were used as catalysts in the hydrosilylation of acetophenone derivatives with triethylsilane at 80°C for 1 h. These Rh(I) NHC showed good catalytic performance for the hydrosilylation of acetophenone derivatives by using 1 mol % of the rhodium complexes. In addition the new rhodium(I) NHC complexes were tested against MCF7 and MDA-MB-231 cancer cells, Micrococcus luteus LB 14110, Listeria monocytogenes ATCC 19117, Salmonella Typhimurium ATCC 14028, Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa and Candida albicans microorganisms. The synthesized rhodium(I) NHC complex was found the most active against MCF7 cancer cells (half-growth inhibition concentration (IC50) = 0.3μg mL-1), as well as the most potent antimicrobial against L. monocytogenes ATCC 19117 (inhibition zone (IZ) = 29 mm). Moreover, the antioxidant activity determination of these complexes was studied with the DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) and compared with gallic acid and butylated hydroxytoluene.

Journal of Coordination Chemistry published new progress about Antibacterial agents. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts