Category: 403-41-8

Goclik, Lisa; Offner-Marko, Lisa; Bordet, Alexis; Leitner, Walter published the artcile< Selective hydrodeoxygenation of hydroxyacetophenones to ethyl-substituted phenol derivatives using a FeRu@SILP catalyst>, Synthetic Route of 403-41-8, the main research area is ionic liquid supported iron ruthenium nanoparticle catalyst preparation; ethyl substituted phenol preparation; hydroxyacetophenone seelective deoxygenation.

The selective hydrodeoxygenation of hydroxyacetophenone derivatives is achieved opening a versatile pathway for the production of valuable substituted ethylphenols from readily available substrates. Bimetallic iron ruthenium nanoparticles immobilized on an imidazolium-based supported ionic liquid phase (Fe25Ru75@SILP) show high activity and stability for a broad range of substrates without acidic co-catalysts.

Chemical Communications (Cambridge, United Kingdom) published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Synthetic Route of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mondal, Rakesh; Sinha, Suman; Das, Siuli; Chakraborty, Gargi; Paul, Nanda D. published the artcile< Iron Catalyzed Synthesis of Pyrimidines Under Air>, Safety of 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is pyrimidine preparation; alc amidine multicomponent dehydrogenative coupling iron catalyst.

A well-defined Fe(II)-complex featuring redox non-innocent 2-phenylazo-(1,10-phenanthroline) ligand, as a catalyst, a wide array of 2,4,6-trisubstituted pyrimidines I (R = NH2, Me, Ph, 4-chlorophenyl, cyclopropy; R1 = Ph, thiophen-2-yl, pyridin-3-yl, etc.; R2 = Ph, cyclopropyl, 4-(trifluoromethyl)phenyl, etc.) was prepared via multicomponent dehydrogenative coupling of primary R2CH2OH and secondary alcs. R1CH(CH3)OH with amidines NH2N(R)=NH under air at 100°C. A few control experiments were carried out to understand and unveil the plausible reaction mechanism.

Advanced Synthesis & Catalysis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Safety of 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Rongzhou; Qi, Jipeng; Yue, Yuancheng; Lian, Zhe; Xiao, Haibin; Zhuo, Shuping; Xing, Lingbao published the artcile< Ambient-pressure hydrogenation of ketones and aldehydes by a metal-ligand bifunctional catalyst [Cp*Ir(2,2'-bpyO)(H2O)] without using base>, Quality Control of 403-41-8, the main research area is secondary alc preparation green chem; ketone hydrogenation bifunctional iridium complex catalyst; primary alc preparation green chem; aldehyde hydrogenation bifunctional iridium complex catalyst.

An efficient catalytic system for hydrogenation of ketones R1C(O)R2 [R1 = Me, 3,4-dichlorophenyl, 2-naphthyl, pyridin-2-yl, etc.; R2 = Me, Pr, hexyl; R1R2 = -(CH2)5-] and aldehydes R3CHO (R3 = nonyl, cyclohexyl, 4-cyanophenyl, pyridin-2-yl, etc.) using a Cp*Ir complex [Cp*Ir(2,2′-bpyO)(H2O)] bearing a bipyridine-based functional ligand as catalyst has been developed. A wide variety of secondary and primary alcs. (R1)(R2)CHOH and R3CH2OH resp. was synthesized by the catalyzed hydrogenation of ketones and aldehydes under facile atm.-pressure without a base. The catalyst also displays an excellent chemoselectivity towards other carbonyl functionalities and unsaturated motifs. This catalytic system exhibits high activity for hydrogenation of ketones and aldehydes with H2 gas.

Tetrahedron published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Quality Control of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Magre, Marc; Paffenholz, Eva; Maity, Bholanath; Cavallo, Luigi; Rueping, Magnus published the artcile< Regiodivergent Hydroborative Ring Opening of Epoxides via Selective C-O Bond Activation>, Quality Control of 403-41-8, the main research area is secondary tertiary alc regiodivergent synthesis hydroborative ring opening epoxide.

A magnesium-catalyzed regiodivergent C-O bond cleavage protocol is presented. Readily available magnesium catalysts achieve the selective hydroboration of a wide range of epoxides and oxetanes yielding secondary and tertiary alcs. in excellent yields and regioselectivities. Exptl. mechanistic investigations and DFT calculations provide insight into the unexpected regiodivergence and explain the different mechanisms of the C-O bond activation and product formation.

Journal of the American Chemical Society published new progress about C-O bond activation. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Quality Control of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wei, Duo; Dorcet, Vincent; Darcel, Christophe; Sortais, Jean-Baptiste published the artcile< Synthesis of Quinolines Through Acceptorless Dehydrogenative Coupling Catalyzed by Rhenium PN(H)P Complexes>, Application In Synthesis of 403-41-8, the main research area is quinoline preparation green chem; aryl alc hydroxymethyl aniline dehydrogenative coupling rhenium catalyst; ketone hydroxymethyl aniline dehydrogenative coupling rhenium catalyst; nitrile hydroxymethyl aniline dehydrogenative coupling rhenium catalyst; annulation; dehydrogenative coupling; hydrogen borrowing; quinoline; rhenium.

The practical and sustainable synthesis of substituted quinolines I (R1 = C6H5, cyclopropyl, NH2, etc.; R2 = H, C6H5, CH3, etc.; R1R2 = (CH2)4, (CH2)6) and 5,6-dihydro-benzo[c]acridine was achieved through the annulation of 2-aminobenzyl alc. with various secondary alcs. R1CH(OH)CH2R2, ketones R1C(O)CH2R2, phenylacetaldehyde, or nitriles R2CH2CN, under hydrogen-borrowing conditions. Under the catalysis of well-defined rhenium complexes bearing tridentate diphosphinoamino ligands, the reaction proceeded efficiently (31 examples were isolated with yields up to 96%) for affording a variety of quinoline derivatives I and 5,6-dihydro-benzo[c]acridine.

ChemSusChem published new progress about Aromatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Application In Synthesis of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Jian; Zhu, Shaolin published the artcile< Nickel-Catalyzed Multicomponent Coupling: Synthesis of α-Chiral Ketones by Reductive Hydrocarbonylation of Alkenes>, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is alpha ketone preparation regio chemo enantioselective; alkene benzyl chloride ethyl chloroformate reductive hydroformylation carbonylation nickel; NHP ester amino acid alkene propylchloroformate reductive hydroformylation carbonylation.

A nickel-catalyzed, multicomponent regio- and enantioselective coupling via sequential hydroformylation and carbonylation from readily available starting materials has been developed. This modular multicomponent hydrofunctionalization strategy enables the straightforward reductive hydrocarbonylation of a broad range of unactivated alkenes to produce a wide variety of unsym. dialkyl ketones bearing a functionalized α-stereocenter, including enantioenriched chiral α-aryl ketones and α-amino ketones. It uses chiral bisoxazoline as a ligand, silane as a reductant, chloroformate as a safe CO source, and a racemic secondary benzyl chloride or an N-hydroxyphthalimide (NHP) ester of a protected α-amino acid as the alkylation reagent. The benign nature of this process renders this method suitable for late-stage functionalization of complex mols.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mastalir, Matthias; Glatz, Mathias; Pittenauer, Ernst; Allmaier, Guenter; Kirchner, Karl published the artcile< Rhenium-Catalyzed Dehydrogenative Coupling of Alcohols and Amines to Afford Nitrogen-Containing Aromatics and More>, Reference of 403-41-8, the main research area is quinoline pyrimidine quinoxaline pyrrole preparation rhenium catalyzed dehydrogenative coupling; aminomethylated arene preparation rhenium catalyzed acceptorless dehydrogenative coupling.

An efficient synthesis of quinolines, pyrimidines, quinoxalines, pyrroles, and aminomethylated aromatic compounds catalyzed by a well-defined Re(I) PNP pincer complex is described. All reactions proceed with liberation of dihydrogen and elimination of water. Under optimized reaction conditions a wide range of organic functional groups are tolerated. This study demonstrates that rhenium catalysts are performing extremely well in dehydrogenative processes with considerably lower catalyst loadings and shorter reaction times when compared to analogous Mn(I) complexes.

Organic Letters published new progress about Aminomethylation. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Reference of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Budweg, Svenja; Wei, Zhihong; Jiao, Haijun; Junge, Kathrin; Beller, Matthias published the artcile< Iron-PNP-Pincer-Catalyzed Transfer Dehydrogenation of Secondary Alcohols>, Category: alcohols-buliding-blocks, the main research area is iron PNP pincer catalyst transfer dehydrogenation secondary alc; ketone preparation mol modeling; homogeneous catalysis; iron; oxidation; pincer ligands; transfer dehydrogenation.

The well-defined iron PNP pincer complex catalyst [Fe(H)(BH4)(CO)(HN{CH2CH2P(iPr)2}2)] was used for the catalytic dehydrogenation of secondary alcs. to give the corresponding ketones. Using acetone as inexpensive hydrogen acceptor enables the oxidation with good to excellent yields. DFT computations indicate an outer-sphere mechanism and support the importance of an acceptor to achieve this transformation under milder conditions.

ChemSusChem published new progress about Dehydrogenation catalysts. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pan, Yingying; Gong, Yuxin; Song, Yanhong; Tong, Weiqi; Gong, Hegui published the artcile< Deoxygenative cross-electrophile coupling of benzyl chloroformates with aryl iodides>, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is diaryl methane preparation; benzyl chloroformate aryl iodide deoxygenative cross electrophile coupling reaction.

This work describes Ni-catalyzed cross-electrophile coupling of benzyl chloroformate derivatives R1CH(R2)OC(O)Cl (R1 = C6H5, 4-FC6H4, 3-CH3C6H4, etc.; R2 = H, Me, butyl) with aryl iodides ArI (Ar = biphenyl-4-yl, naphthalen-1-yl, 3-oxo-2,3-dihydro-1H-inden-5-yl, 1-benzothiophen-5-yl, etc.) that generates a wide range of diaryl methane products R1CH(R2)Ar. The mild reaction conditions merit the C-O bond radical fragmentation of benzyl chloroformates via halide abstraction or a single electron reduction by a Ni catalyst. This work offers a new substrate type for cross-electrophile couplings.

Organic & Biomolecular Chemistry published new progress about Aromatic hydrocarbons Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhong, Rui; Wei, Zeyuan; Zhang, Wei; Liu, Shun; Liu, Qiang published the artcile< A Practical and Stereoselective In Situ NHC-Cobalt Catalytic System for Hydrogenation of Ketones and Aldehydes>, Synthetic Route of 403-41-8, the main research area is cobalt complex catalyst preparation; secondary alc primary preparation diastereoselective; ketone hydrogenation cobalt catalyst; aldehyde hydrogenation cobalt catalyst.

Herein, a practical in situ catalytic system generated by easily available pincer NHC precursors, CoCl2 and a base enabled efficient and high-yielding hydrogenation of a broad range of ketones and aldehydes (over 50 examples and a maximum turnover number [TON] of 2,610) to afford alcs. was reported. This was the first example of NHC-Co-catalyzed hydrogenation of C=O bonds using flexible pincer NHC ligands consisting of a N-H substructure. Diastereodivergent hydrogenation of substituted cyclohexanone derivatives was also realized by fine-tuning of the steric bulk of pincer NHC ligands. Addnl., a bis(NHCs)-Co complex was successfully isolated and fully characterized and it exhibited excellent catalytic activity that equals that of the in-situ-formed catalytic system.

Chem published new progress about Alcohols Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Synthetic Route of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts