Category: 403-41-8

Gawali, Suhas Shahaji; Pandia, Biplab Keshari; Pal, Souvik; Gunanathan, Chidambaram published the artcile< Manganese(I)-Catalyzed Cross-Coupling of Ketones and Secondary Alcohols with Primary Alcohols>, Product Details of C8H9FO, the main research area is cross coupling manganese catalyzed ketone primary alc.

Catalytic cross-coupling of ketones and secondary alcs. with primary alcs. is reported. An abundant manganese based pincer catalyst catalyzes the reactions. Low loading of catalyst (2 mol %) and catalytic use of a mild base (5-10 mol %) are sufficient for efficient cross-coupling. Various aryl and heteroaryl ketones are catalytically cross-coupled with primary alcs. to provide the selective α-alkylated products. Challenging α-ethylation of ketones is also attained using ethanol as an alkylating reagent. Further, direct use of secondary alcs. in the reaction results in in situ oxidation to provide the ketone intermediates, which undergo selective α-alkylation. The reaction proceeds via the borrowing hydrogen pathway. The catalyst oxidizes the primary alcs. to aldehydes, which undergo subsequent aldol condensation with ketones, promoted by catalytic amount of Cs2CO3, to provide the α,β-unsaturated ketone intermediates. The hydrogen liberated from oxidation of alcs. is used for hydrogenation of α,β-unsaturated ketone intermediates. Notably either water or water and dihydrogen are the only byproducts in these environmentally benign catalytic processes. Mechanistic studies allowed inferring all the intermediates involved. Dearomatization-aromatization metal-ligand cooperation in the catalyst facilitates the facile O-H bond activation of both primary and secondary alcs. and the resultant manganese alkoxide complexes produce corresponding carbonyl compounds, perhaps via β-hydride elimination. The manganese(I) hydride intermediate plays dual role as it hydrogenates α,β-unsaturated ketones and liberates mol. hydrogen to regenerate the catalytically active dearomatized intermediate. Metal-ligand cooperation allows all the manganese intermediate to exist in same oxidation state (+1) and plays an important role in these catalytic cross-coupling reactions.

ACS Omega published new progress about Cross-coupling reaction. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Product Details of C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bettoni, Leo; Gaillard, Sylvain; Renaud, Jean-Luc published the artcile< Iron-Catalyzed α-Alkylation of Ketones with Secondary Alcohols: Access to β-Disubstituted Carbonyl Compounds>, Electric Literature of 403-41-8, the main research area is iron catalyzed alkylation ketone secondary alc borrowing hydrogen.

An iron-catalyzed borrowing hydrogen strategy has been applied in the synthesis of β-branched carbonyl compounds Various secondary benzylic and aliphatic alcs. have been used as alkylating reagents under mild reaction conditions. The ketones have been isolated in good to excellent yield. Deuterium labeling experiments provide evidence that the alc. is the hydride source in this reaction and that no reversible step or hydrogen/deuterium scrambling takes place during the process.

Organic Letters published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Electric Literature of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bettoni, Leo; Gaillard, Sylvain; Renaud, Jean-Luc published the artcile< Iron-Catalyzed α-Alkylation of Ketones with Secondary Alcohols: Access to β-Disubstituted Carbonyl Compounds>, Electric Literature of 403-41-8, the main research area is iron catalyzed alkylation ketone secondary alc borrowing hydrogen.

An iron-catalyzed borrowing hydrogen strategy has been applied in the synthesis of β-branched carbonyl compounds Various secondary benzylic and aliphatic alcs. have been used as alkylating reagents under mild reaction conditions. The ketones have been isolated in good to excellent yield. Deuterium labeling experiments provide evidence that the alc. is the hydride source in this reaction and that no reversible step or hydrogen/deuterium scrambling takes place during the process.

Organic Letters published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Electric Literature of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kooti, M.; Nasiri, E. published the artcile< Synthesis of a novel magnetic nanocatalyst based on rhodium complex for transfer hydrogenation of ketones>, Electric Literature of 403-41-8, the main research area is aralkyl alc preparation green chem; ketone transfer hydrogenation rhodium nanocatalyst.

A magnetic heterogeneous nanocatalyst based on novel rhodium complex is designed. The transfer hydrogenation of ketones R1C(O)R2 [R1 = Ph, PhCH2, 4-BrC6H4, etc., R2 = Me; R1 = Ph, R2 = BrCH2; R1 = 4-MeOC6H4, R2 = NCSCH2; R1R2 = (CH2)5] with 2-propanol as hydrogen donor and the rhodium complex as nanocatalyst was achieved. High yields of alcs. R1CH(OH)R2 under mild conditions were obtained from easily available precursors.

Applied Organometallic Chemistry published new progress about Green chemistry. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Electric Literature of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ma, Shuai; Cui, Jing-Wang; Rao, Cai-Hui; Jia, Meng-Ze; Chen, Yun-Rui; Zhang, Jie published the artcile< Boosting activity of molecular oxygen by pyridinium-based photocatalysts for metal-free alcohol oxidation>, HPLC of Formula: 403-41-8, the main research area is boosting oxygen pyridinium photocatalyst metal alc oxidation.

An eco-friendly and economical approach for the photocatalytic oxidation of organic inter-mediates by air under mild conditions is highly desirable in green and sustainable chem., where the photogeneration of active oxygen species plays a key role in improving conversion efficiency and selectivity. By using pyridinium derivatives as mol. mediators for electron transfer and energy transfer, the simultaneous activation of O2 from air into superoxide radicals and singlet oxygen species can be achieved, and a photoinduced electron transfer catalytic system for the oxidation of alcs. has been developed. Thus, we have successfully simplified the complicated catalytic system into a single mol. catalyst without any addnl. noble metals and co-catalysts/additives. The current photocatalytic system shows high catalytic efficiency not only for aromatic alcs. but also for aliphatic alcs. that are generally difficult to undergo aerobic oxidation at room temperature under air atm., representing an ideal photocatalytic platform for green and economical organic syntheses.

Green Chemistry published new progress about Crystal structure. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, HPLC of Formula: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Guoqi; Zeng, Haisu; Li, Sihan; Johnson, Jahvon; Mo, Zixuan; Neary, Michelle C.; Zheng, Shengping published the artcile< 1-D manganese(II)-terpyridine coordination polymers as precatalysts for hydrofunctionalization of carbonyl compounds>, HPLC of Formula: 403-41-8, the main research area is aldehyde ketone hydrofunctionalization manganese terpyridine coordination polymer catalyst.

Reductive catalysis with earth-abundant metals is currently of increasing importance and shows potential in replacing precious metal catalysis. In this work, catalytic hydroboration and hydrosilylation of ketones and aldehydes achieved by a structurally defined manganese(II) coordination polymer (CP) as a precatalyst under mild conditions is reported. The manganese-catalyzed methodol. can be applied to a range of functionalized aldehydes and ketones with turnover numbers (TON) of up to 990. Preliminary results on the regioselective catalytic hydrofunctionalization of styrenes by the Mn-CP catalyst are also presented.

Dalton Transactions published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, HPLC of Formula: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yangyang; Du, Zhengyin; Zheng, Tingting; Sun, Hongjian; Li, Xiaoyan published the artcile< Efficient transfer hydrogenation of carbonyl compounds catalyzed by selenophenolato hydrido iron(II) complexes>, COA of Formula: C8H9FO, the main research area is carbonyl compound isopropanol selenophenolato hydrido iron catalyst transfer hydrogenation; alc preparation.

1,3-Cis-Selenophenolato hydrido iron(II) complexes I [R = H, 2-Me, 4-MeO] catalyzed transfer hydrogenation of aldehydes and ketones. Among the three complexes, catalyst I [R = H] exhibited the highest catalytic activity. The catalytic reactions took place under very mild conditions, using isopropanol as solvent and hydrogen source, tBuONa as base under 60-80°. This catalytic system had good tolerance for many functional groups, such as halides, C=C double bonds, nitro groups and cyano groups at the Ph ring of the substrates.

Catalysis Communications published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, COA of Formula: C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Meng-Juan; Li, Hong-Xi; Young, David J.; Li, Hai-Yan; Lang, Jian-Ping published the artcile< Reaction condition controlled nickel(II)-catalyzed C-C cross-coupling of alcohols>, Category: alcohols-buliding-blocks, the main research area is nickel cluster catalyst preparation crystal structure; primary secondary alc acceptorless dehydrogenation coupling; aryl alkyl ketone preparation; unsaturated ketone preparation; quinoline preparation.

A controlled approach to a diverse range of β-alkylated secondary alcs., α-alkylated ketones and α,β-unsaturated ketones using the acceptorless dehydrogenation coupling methodol. employing a Ni(II) 4,6-dimethylpyrimidine-2-thiolate cluster catalyst under different reaction conditions was reported. This catalyst could tolerate a wide range of substrates and exhibited a high activity for the annulation reaction of secondary alcs. with 2-aminobenzyl alcs. to yield quinolines. This work is an example of precise chemoselectivity control by careful choice of reaction conditions.

Organic & Biomolecular Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Xiangchao; Li, Shun; Luo, Shiyuan; Yang, Jiazhi; Li, Feng published the artcile< Direct couplings of secondary alcohols with primary alkenyl alcohols to α-alkylated ketones via a tandem transfer hydrogenation/hydrogen autotransfer process catalyzed by a metal-ligand bifunctional iridium catalyst>, Application In Synthesis of 403-41-8, the main research area is alpha alkylated ketone preparation; secondary alc primary alkenyl tandem transfer hydrogenation hydrogen; autotransfer coupling catalyst iridium.

A new strategy for the synthesis of α-alkylated ketones R1C(O)R2 [R1 = i-Pr, t-Bu, 4-MeC6H4, etc.; R2 = pentyl, isohexyl, heptyl, etc.] from secondary alcs. and primary alkenyl alcs. via a tandem transfer hydrogenation/hydrogen autotransfer process was proposed and successfully accomplished. Mechanistic experiments supported that functional groups in bpy ligand were crucial for the transfer hydrogenation and hydrogen autotransfer process. Furthermore, the utilization of the present catalytic system for the gram-scale synthesis of a biol. active compound was presented.

Journal of Catalysis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Application In Synthesis of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zeng, Haisu; Wu, Jing; Li, Sihan; Hui, Christina; Ta, Anita; Cheng, Shu-Yuan; Zheng, Shengping; Zhang, Guoqi published the artcile< Copper(II)-Catalyzed Selective Hydroboration of Ketones and Aldehydes>, Name: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is divalent copper catalyzed chemoselective hydroboration ketone aldehyde; nonanuclear copper complex one pot self assembly preparation.

A novel nonanuclear copper(II) complex obtained by a facile one-pot self-assembly was found to catalyze the hydroboration of ketones and aldehydes with the absence of an activator under mild, solvent-free conditions. The catalyst is air- and moisture-stable, displaying high efficiency (1980 h-1 turnover frequency, TOF) and chemoselectivity on aldehydes over ketones and ketones over imines. This represents a rare example of divalent copper catalyst for the hydroboration of carbonyls.

Organic Letters published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Name: 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts