Category: 403-41-8

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol, molecular formula is C8H9FO, molecular weight is 140.16, as common compound, the synthetic route is as follows.Computed Properties of C8H9FO

General procedure: To a mixture of 1,3-dicarbonyl compound (2 mmol),alcohol or styrene derivatives (1 mmol), and 0.6 gSBNPSA, was added 2 cm3 nitromethane as solvent. Themixture was stirred under reflux conditions and the reactionwas followed by TLC. After completion, the mixture wasfiltered, and the remaining was washed with warm ethanolto separate catalyst and nitromethane was removed underreduced pressure. Then, the crude products were recrystallizedfrom mixture of dichloromethane and n-hexane.All the synthesized products were known and characterized by comparison of their spectral and physical data withthose reported in literature.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,403-41-8, 1-(4-Fluorophenyl)ethyl Alcohol, and friends who are interested can also refer to it.

Reference:
Article; Karimzadeh, Morteza; Saberi Asl, Hamed; Hashemi, Hajar; Saberi, Dariush; Niknam, Khodabakhsh; Monatshefte fur Chemie; vol. 149; 12; (2018); p. 2237 – 2244;,
Alcohol – Wikipedia,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol, molecular formula is C8H9FO, molecular weight is 140.16, as common compound, the synthetic route is as follows.SDS of cas: 403-41-8

Dissolve 1-(4-fluorophenyl)ethanol (1.24 g, 8.85 mmol) in n-hexane (29.5 mL),CAL-B (195 mg), vinyl acetate (1.60 mL, 17.7 mmol) and triethylamine (0.0710 mL, 0.885 mmol) were added.The reaction mixture was stirred at room temperature for 12 hours. The mixture was filtered to remove impurities and reduced pressure to remove solvent. The mixture was purified by silica gel column chromatography (n-hexane / EtOAc = 8: 1, Rf = 0.25 (n-hexane / EtOAc = 4: 1)) and purified.(S)-1-(4-fluorophenyl)ethan-1-ol (574 mg, 46%) was obtained as a colorless oil (Formula 9)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,403-41-8, 1-(4-Fluorophenyl)ethyl Alcohol, and friends who are interested can also refer to it.

Reference:
Patent; ERICA Industry-University Cooperation Foundation of Hanyang University; Min Seon-jun; Kim Ju-hyeon; Chu Hyeon-a; Cho Yong-seo; Lee Jae-gyun; Bae Ae-nim; (23 pag.)KR2019/115976; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 403-41-8, Adding some certain compound to certain chemical reactions, such as: 403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol,molecular formula is C8H9FO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 403-41-8.

General procedure: beta-Dicarbonyl compound (3.0 mmol) and alcohol (1.0 mmol) were combined in 2 mL of nitromethane, and H2SO4 (2.7 muL, 0.05 mmol) was added, and the resulting mixture was stirred under 101 oC with the microwave irradiation (650 W, 70%) for 5 min. Then Na2CO3 (10 mg) was added to the reaction mixture to quench the reaction and the solvent of the reaction mixture was removed under reduced pressure and the residue was passed through the flash column chromatography on silica gel to afford the product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 403-41-8, 1-(4-Fluorophenyl)ethyl Alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Xia, Fei; Zhao, Zheng Le; Liu, Pei Nian; Tetrahedron Letters; vol. 53; 23; (2012); p. 2828 – 2832;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 1-(4-Fluorophenyl)ethyl Alcohol

To a stirred solution l-(4-fluorophenyl)ethan-l-ol (2, 0.5 g, 3.57 mmol) in DCM (5 mL), was added SOCl2(0.7 mL, 7.10 mmol) drop wise at 0 C and the reaction mixture was stirred at rt for 1 h (Reaction condition b). The reaction mixture was evaporated under vacuum and dried to afford the product as brown oil (3) (0.5 g, 89%, Yield).XHNMR (400 MHz, DMSO-d6) delta (ppm): 7.53-7.51 (m, 2H), 7.21-7.16 (m, 2H), 5.36-5.33 (m, 1H), 1.76 (d, = 6.8 Hz, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 403-41-8.

Reference:
Patent; JUBILANT BIOSYS LIMITED; HALLUR, Gurulingappa; DURAISWAMY, Athisayamani Jeyaraj; PURRA, Buchi Reddy; RAO, N.V.S.K.; RAJAGOPAL, Sridharan; KRISTAM, Rajendra; (200 pag.)WO2019/77631; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

To a solution of 1-(4-fluorophenyl)ethanol (200 mg, 0.0014 mol, commercial source: Aochem) in dichloromethane (4 mL), triethylamine (0.4 mL, 0.0029 mol, commercial source: Finar) and mesyl chloride (0.16 mL, 0.0021 mol, commercial source: Avra) were added at 0 C. The reaction mixture was stirred at 26 C for 16 h. Upon completion, dichloromethane (60 mL) and water (10 mL) were added. The organic layer was dried over anhydrous Na2S04, filtered and the filtrate was concentrated under reduced pressure to afford crude 1-(4-fluorophenyl)ethyl methanesulfonate (300 mg) as a pale tellow liquid that was used in the next step without further purification.

With the rapid development of chemical substances, we look forward to future research findings about 403-41-8.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ALEMPARTE-GALLARDO, Carlos; ENCINAS, Lourdes; ESQUIVIAS PROVENCIO, Jorge; (206 pag.)WO2019/34729; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 403-41-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A solution of corresponding alcohol 1a,b,d-al (8 mmol), nitroxide 4a (0.085 g, 0.4 mmol) and compound 6d (0.097 g, 0.8 mmol) in CH2Cl2 (10 mL) was added to a vigorously stirred solution of NaHCO3 (2.016 g, 24 mmol) in water (10 mL) at 20 C. Then I2 (4.06 g, 16 mmol) powder was added in one portion to the formed reaction mixture at vigorous stirring and temperature 20-22 C. The reaction mixture was stirred at 20-22 C for appropriate time (see Table 1 in the article). Then, a saturated solution of sodium thiosulfate was added to the stirred reaction mixture for discoloration. Organic and aqueous phases were separated and the aqueous phase was then extracted with CH2Cl2 (3×5 mL). Organic phase and the extracts were combined and washed subsequently with saturated aqueous solution of NaCl (5 mL), aqueous solutionof HCl (1%) saturated with NaCl (3 mL), and then with water (5 mL). The washed extract was dried with anhydrous Na2SO4 and evaporated to dryness to give crude product, which was then purified by vacuum distillation under argon atmosphere or by recrystallization.

According to the analysis of related databases, 403-41-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kashparova, Vera P.; Klushin, Victor A.; Zhukova, Irina Yu.; Kashparov, Igor S.; Chernysheva, Daria V.; Il’chibaeva, Irina B.; Smirnova, Nina V.; Kagan, Efim Sh.; Chernyshev, Victor M.; Tetrahedron Letters; vol. 58; 36; (2017); p. 3517 – 3521;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 403-41-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol. A new synthetic method of this compound is introduced below.

General procedure: Bi(OTf)3 (1.0 mol%) was added to a solution of the appropriate secbenzylalcohol (1.0 equiv) and TMSN3 (1.2 equiv) in CH2Cl2 (4.0mL/mmol) at r.t. When the reaction was complete (TLC), the solventwas removed and the crude material was purified by column chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,403-41-8, its application will become more common.

Reference:
Article; Tummatorn, Jumreang; Thongsornkleeb, Charnsak; Ruchirawat, Somsak; Thongaram, Phanida; Kaewmee, Benyapa; Synthesis; vol. 47; 3; (2015); p. 323 – 329;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 403-41-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol. A new synthetic method of this compound is introduced below.

General procedure: A round-bottom flask was charged with alcohol (2 mmol), CuOTf (0.1 mmol, 0.05 equiv) (S)-5-(pyrrolidin-2-yl)-1H-tetrazole (0.1 mmol, 0.05 equiv), TEMPO (0.1 mmol, 0.05 equiv), t-BuOK (2 mmol, 1 equiv) and DMF (5 ml). The reaction mixture was stirred at 25 C open to air until the completion of the reaction, as monitored by TLC. The mixture was then diluted with CH2Cl2 (20 ml), washed with water, dried over Na2SO4, and evaporated under vacuum to give the crude product, which was purified by column chromatography to give the pure product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,403-41-8, 1-(4-Fluorophenyl)ethyl Alcohol, and friends who are interested can also refer to it.

Reference:
Article; Liu, Yangyang; Xie, Aming; Li, Junjian; Xu, Xiao; Dong, Wei; Wang, Boliang; Tetrahedron; vol. 70; 52; (2014); p. 9791 – 9796;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

403-41-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol. A new synthetic method of this compound is introduced below.

General procedure: The catalyst solutionwas prepared by dissolving complex 3(36.1 mg,0.05mmol) in methanol (5.0 mL).Under a nitrogen atmosphere, the mixture of an alcohol substrate (2.0 mmol) and1.0 mL of the catalyst solution (0.01mmol) in 20mL acetone was stirred at 56 Cfor 10 minutes. tBuOK(22.4mg, 0.2 mmol)was then added to initiate the reaction.At the stated time, 0.1 mL of the reaction mixture was sampled and immediately diluted with 0.5 mL acetone pre-cooled-to-0 C for GC or NMR analysis. After the reaction was complete, the reaction mixture was condensed under reduced pressure and subject to purification by flash silica gel column chromatography to afford the corresponding ketone product, which was identified by comparison with the authentic sample through NMR and GC analysis.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 403-41-8, 1-(4-Fluorophenyl)ethyl Alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wang, Qingfu; Du, Wangming; Liu, Tingting; Chai, Huining; Yu, Zhengkun; Tetrahedron Letters; vol. 55; 9; (2014); p. 1585 – 1588;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A common compound: 403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol,molecular formula is C8H9FO, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 403-41-8

Step 1 1 -(4-Fluorophenyl)ethyl methanesulfonate A mixture of l-(4-fluorophenyl)ethanol (300 mg, 2.14 mmol, 1.0 eq), MsCI (293 mg, 2.57 mmol, 1.2 eq) and TEA (941 mg, 3.2 mmol, 1.5 eq) in DCM (5 mL) was stirred at room temperature overnight. TLC (PE/EA = 3/1) showed the starting material was consumed completely. The reaction was quenched with aqueous citric acid solution and then extracted with DCM (5 mL x 3). The organic phase was dried over Na2S04, filtered and concentrated to give l-(4-fluorophenyl)ethyl methanesulfonate (400 mg, yield 86%), which was used in next step without further purification.

With the rapid development of chemical substances, we look forward to future research findings about 403-41-8.

Reference:
Patent; BIOGEN MA INC.; KUMARAVEL, Gnanasambandam; PENG, Hairuo; XIN, Zhili; WO2015/188051; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts