Category: 403-41-8

Maji, Milan; Kundu, Sabuj published the artcile< Cooperative ruthenium complex catalyzed multicomponent synthesis of pyrimidines>, Computed Properties of 403-41-8, the main research area is ruthenium complex catalyst multicomponent preparation pyrimidine.

A new set of 2-(2-benzimidazolyl) pyridine ligand based air and moisture stable ruthenium complexes were synthesized and characterized. The catalytic behaviors of these complexes were evaluated towards the multicomponent synthesis of highly substituted pyrimidines directly from various amidines, primary alcs., and secondary alcs. Among all the metal complexes, 2-hydroxypyridine and benzimidazole fragments containing complex I showed the best reactivity in this reaction. In addition, the N-H proton of benzimidazole and the hydroxyl group of pyridine played a critical role in enhancing catalytic activity. Several control experiments and mechanistic studies were carried out to understand this multicomponent synthesis of pyrimidines using complex I.

Dalton Transactions published new progress about Amidines Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Computed Properties of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jin, Bei; Wang, Jinguo; Xu, Fengxia; Li, Dianfeng; Men, Yong published the artcile< Hierarchical hollow WO3 microspheres with tailored surface oxygen vacancies for boosting photocatalytic selective conversion of biomass-derived alcohols>, Category: alcohols-buliding-blocks, the main research area is ierarchical hollow WO3 microspheres tailored surface oxygen vacancies; photocatalytic selective conversion biomass derived alc.

Selective conversion of biomass-derived alcs. into carbonyl compounds via visible-light photocatalysis is realized over hierarchical hollow WO3 microspheres with tailored surface oxygen vacancies, which presents the remarkably boosted photoactivity in terms of selectivity and activity, intrinsically attributing to the strong synergetic effect of hierarchical spherical cavity and surface oxygen vacancies simultaneously. The hierarchical spherical cavity, substantially constructed by the self-interconnected nanosheets, enhances the light-harvesting ability via multiple light reflections not only in spherical cavity but also among the self-interconnected nanosheets. Surface oxygen vacancies favor the energy band gap narrowing via forming a miniband just below the conduction band and then extend the photoresponse region, further boosting the light-harvesting ability. Importantly, surface oxygen vacancies function as the electron sinks to capture photoelectrons and thus restrict their recombination probability with holes, finally improving the photoelectron-hole separation efficiency. Meanwhile, this photocatalyst presents excellent reusability, showing its promising potential in practical applications. This work sheds light on a new application of hierarchical WO3 microspheres with tailored surface oxygen vacancies and its strong synergetic effect of hierarchical structures and surface oxygen vacancies on photocatalytic performance, delivering new insights for rationally designing highly active photocatalysts applied in future green and sustainable organic transformation reactions.

Applied Surface Science published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent) (biomass-derived). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Jiahao; Li, Weikang; Li, Yinwu; Liu, Yan; Ke, Zhuofeng published the artcile< Selective C-alkylation between Alcohols Catalyzed by N-Heterocyclic Carbene Molybdenum>, Reference of 403-41-8, the main research area is primary secondary alc molybdenum complex alkylation chemoselectivity green chem; secondary alc preparation; Alcohols; Alkylation; Borrowing hydrogen; Molybdenum catalysis; N-heterocyclic carbene.

The implementation of a molybdenum complex with an easily accessible bis-N-heterocyclic carbene ligand to catalyze β-alkylation of secondary alcs. via borrowing-hydrogen (BH) strategy using alcs. as alkylating agents was reported. Remarkably high activity, excellent selectivity and broad substrate scope compatibility with advantages of catalyst usage low to 0.5 mol%, a catalytic amount of NaOH as the base and H2O as the byproduct were demonstrated in this green and step-economical protocol. Mechanistic studies indicated a plausible outer-sphere mechanism in which the alc. dehydrogenation is the rate-determining step.

Chemistry – An Asian Journal published new progress about Alkylation catalysts (chemoselective). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Reference of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nandi, Pran Gobinda; Kumar, Pradhuman; Kumar, Akshai published the artcile< Ligand-free Guerbet-type reactions in air catalyzed by in situ formed complexes of base metal salt cobaltous chloride>, Related Products of 403-41-8, the main research area is phenyl ethanol benzyl alc Guerbet type reaction green chem; cobaltous chloride complex catalyst.

Inexpensive, earth-abundant and environmentally benign cobaltous chloride efficiently accomplishes the catalytic β-alkylation of alcs. in air at 140°. At higher loadings of cobaltous chloride (1 mol%) in the presence of 2.5 mol% NaOtBu, there is a rapid formation of heterogeneous Co nanoparticles (NPs) which are apparently sensitive to air and result in poor yields (ca. 25%) of β-alkylated products. In contrast, performing the reaction in an argon atm. under otherwise identical conditions leads to higher yields (ca. 44%). The heterogenization and eventual loss of activity in air could be delayed by operating at a lower (0.01 mol%) CoCl2 loading in the presence of 2.5 mol% NaOtBu at 140°. Under these conditions, the catalytic β-alkylation of alcs. proceeded with high yields (up to 89%) and unprecedented turnovers (ca. 8900). Mechanistic studies are indicative of the involvement of catalysts based on in situ generated mol. Co complexes of alcs. Labeling studies provide key evidence for the involvement of C-H activation in the cobaltous chloride catalyzed β-alkylation with a KIE of 1.61. Kinetic studies indicate linear dependence of the rate on the concentration of cobaltous chloride and sodium t-butoxide along with a non-linear dependence on the concentration of 1-Ph ethanol and benzyl alc.

Catalysis Science & Technology published new progress about Alkylation. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Related Products of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Luo, Huihui; Wang, Lianyue; Shang, Sensen; Li, Guosong; Lv, Ying; Gao, Shuang; Dai, Wen published the artcile< Cobalt Nanoparticles-Catalyzed Widely Applicable Successive C-C Bond Cleavage in Alcohols to Access Esters>, COA of Formula: C8H9FO, the main research area is ester preparation cobalt nanoparticle catalyst carbon bond cleavage alc; C−C bond; aerobic oxidative cleavage; alcohols; esters; heterogeneous cobalt catalyst.

Selective cleavage and functionalization of C-C bonds have important applications in organic synthesis and biomass use. However, functionalization of C-C bonds by controlled cleavage remains difficult and challenging because they are inert. Herein, the authors describe an unprecedented efficient protocol for the breaking of successive C-C bonds in alcs. to form esters with one or multiple carbon atoms less using heterogeneous cobalt nanoparticles as catalyst with dioxygen as the oxidant. A wide range of alcs. including inactive long-chain alkyl aryl alcs. undergo smoothly successive cleavage of adjacent -(C-C)n- bonds to afford the corresponding esters. The catalyst was used for seven times without any decrease in activity. Characterization and control experiments disclose that cobalt nanoparticles are responsible for the successive cleavage of C-C bonds to achieve excellent catalytic activity, while the presence of Co-Nx has just the opposite effect. Preliminary mechanistic studies reveal that a tandem sequence reaction is involved in this process.

Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, COA of Formula: C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hashimoto, Toru; Ishimaru, Toshiya; Shiota, Keisuke; Yamaguchi, Yoshitaka published the artcile< Bottleable NiCl2(dppe) as a catalyst for the Markovnikov-selective hydroboration of styrenes with bis(pinacolato)diboron>, Reference of 403-41-8, the main research area is nickel dppe complex catalyst Markovnikov hydroboration styrene bispinacolatodiboron.

Although transition-metal-catalyzed hydroboration reactions of alkenes have been extensively studied, only three examples using Ni complexes have been reported so far. In this study, we have examined hydroboration reactions of alkenes using Ni/phosphine complexes. The com. available and bottleable complex NiCl2(dppe) (dppe = 1,2-bis(diphenylphosphino)ethane) serves as a catalyst for the highly Markovnikov-selective hydroboration of styrene derivatives that affords the desired Markovnikov products in high yield.

Chemical Communications (Cambridge, United Kingdom) published new progress about Hydroboration catalysts. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Reference of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chardon, Aurelien; Rouden, Jacques; Blanchet, Jerome published the artcile< Borinic Acid Mediated Hydrosilylations: Reductions of Carbonyl Derivatives>, Synthetic Route of 403-41-8, the main research area is borinic acid mediated hydrosilylation reduction ketone aldehyde imine.

4-Fluoro-2-chlorophenylborinic acid acts as a precatalyst in the presence of phenylsilane for the facile reduction of ketones, aldehydes and imines. Notably, synergistic mediation of a tertiary amine was found essential to trigger silicon to boron hydride transfer to generate a key amine-diarylhydroborane Lewis complex.

European Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Synthetic Route of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qi, Xinghao; Zheng, Tingting; Zhou, Junhao; Dong, Yanhong; Zuo, Xia; Li, Xiaoyan; Sun, Hongjian; Fuhr, Olaf; Fenske, Dieter published the artcile< Synthesis and Catalytic Activity of Iron Hydride Ligated with Bidentate N-Heterocyclic Silylenes for Hydroboration of Carbonyl Compounds>, HPLC of Formula: 403-41-8, the main research area is iron silylene amidine supported hydride complex preparation hydroboration catalyst; aldehyde ketone hydroboration pinacolboronate preparation alc iron silylene catalyst; crystal structure iron silylene amidine supported hydride complex; mol structure iron silylene amidine supported hydride complex.

We report the synthesis of a novel bidentate N-heterocyclic silylene (NHSi) ligand, N-(LSi:)-N-methyl-2-pyridinamine (1) (L = PhC(NtBu)2), and the first bischelate disilylene iron hydride I, [(Si,N)(Si,C)Fe(H)(PMe3)] (2, R = tBu), and monosilylene iron hydride, [(Si,C)Fe(H)(PMe3)3] (2′), through Csp2-H activation of the NHSi ligand. Compounds 1 and 2 were fully characterized by spectroscopic methods and single-crystal X-ray diffraction anal. D. functional theory calculations indicated the multiple-bond character of the Fe-Si bonds and the π back-donation from Fe(II) to the Si(II) center. Moreover, the strong donor character of ligand 1 enables 2 to act as an efficient catalyst for the hydroboration reaction of carbonyl compounds at room temperature Chemoselective hydroboration is attained under these conditions. This might be the first example of hydroboration of ketones and aldehydes catalyzed by a silylene hydrido iron complex. A catalytic mechanism was suggested and partially exptl. verified.

Organometallics published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, HPLC of Formula: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 403-41-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol. A new synthetic method of this compound is introduced below.

0039] H Equipped with a magnetic stirrer in round bottom flask methyl benzyl alcohol (12. 22g, 100. Ommol, namely formula The R1 is 4-methyl, R2 is hydrogen, X is carbon, eta is 1, m is 0), ferric chloride (0. 81g, 5mmol), L- isoleucineAcid (1.31g, 10mmol), TEMP0 (1.56g, 10mmol), toluene 300. OmL was added , then the reaction with oxygen in the air bottleReplacement, stirred and reflux for 6h. After completion of reaction, the reaction mixture was cooled to room temperature, filtered, the filtrate evaporated to give the crude product,The resultant crude product was purified by column chromatography, with n-hexane: Elution: (10 1 volume ratio) mixed liquid of ethyl acetate containing the desired collectionLabeled compound of the eluent, evaporation of the solvent and dried to give the product p-tolualdehyde 10. 93g, 91% yield. 1- (4-fluorophenyl) ethanol (1 · 40g, 10. Ommol, i.e., of formula (I), R1 is 4-fluoro,R2 is methyl, X is carbon, [eta] is l, m is 0) is used, experimental methods and procedures were the same as in Example 1, except that: trifluoromethanesulfonate Iron(0 · 50g, 1. Ommol), L- isoleucine (0 · 26g, 2 · Ommol), TEMPO (0 · 16g, 1 · Ommol), xylene 30. OmL,After stirring at reflux with oxygen reaction bottle of air displacement 48h. To give the final product 1.23g, 88% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,403-41-8, 1-(4-Fluorophenyl)ethyl Alcohol, and friends who are interested can also refer to it.

Reference:
Patent; Zhejiang University; Zhang, Guofu; Li, Shasha; Ding, Chengrong; Zhang, Guihua; Xie, Xiaoqiang; Lei, Jie; (12 pag.)CN105294413; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol, molecular formula is C8H9FO, molecular weight is 140.16, as common compound, the synthetic route is as follows.Computed Properties of C8H9FO

General procedure: To a mixture of 1,3-dicarbonyl compound (2 mmol),alcohol or styrene derivatives (1 mmol), and 0.6 gSBNPSA, was added 2 cm3 nitromethane as solvent. Themixture was stirred under reflux conditions and the reactionwas followed by TLC. After completion, the mixture wasfiltered, and the remaining was washed with warm ethanolto separate catalyst and nitromethane was removed underreduced pressure. Then, the crude products were recrystallizedfrom mixture of dichloromethane and n-hexane.All the synthesized products were known and characterized by comparison of their spectral and physical data withthose reported in literature.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,403-41-8, 1-(4-Fluorophenyl)ethyl Alcohol, and friends who are interested can also refer to it.

Reference:
Article; Karimzadeh, Morteza; Saberi Asl, Hamed; Hashemi, Hajar; Saberi, Dariush; Niknam, Khodabakhsh; Monatshefte fur Chemie; vol. 149; 12; (2018); p. 2237 – 2244;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts