Category: 403-41-8

Meng, Shan-Shui; Lin, Li-Rong; Luo, Xiang; Lv, Hao-Jun; Zhao, Jun-Ling; Chan, Albert S. C. published the artcile< Aerobic oxidation of alcohols with air catalyzed by decacarbonyldimanganese>, Reference of 403-41-8, the main research area is manganese catalyzed aerobic oxidation functionalized alc.

The oxidation of alcs. to carbonyl compounds using air as the terminal oxidant is highly desirable. As described in previous reports, the abstraction of α-H of the alc. is the most important step, and it typically requires not only a metal catalyst but also complex ligands, co-catalysts and bases. Herein, we report a practical and efficient method for the oxidation of primary alcs., secondary alcs., 1,2-diols, 1,2-amino alcs., and other α-functionalized alcs. using a com. available catalyst, Mn2(CO)10, and no additives. Preliminary mechanistic studies indicated that an alkoxyl radical intermediate existed in our system, and a plausible mechanism consistent with the exptl. results and literature was proposed.

Green Chemistry published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Reference of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nisanci, Bilal; Dagalan, Ziya published the artcile< A facile and highly efficient transfer hydrogenation of ketones and aldehydes catalyzed by palladium nanoparticles supported on mesoporous graphitic carbon nitride>, Formula: C8H9FO, the main research area is carbonyl compound ammonia borane palladium catalyst hydrogenation; alc preparation.

A novel transfer hydrogenation methodol. for the reduction of ketones (14 examples) and benzaldehyde derivatives (12 examples) to the corresponding alcs. using Pd nanoparticles supported on mesoporous graphitic carbon nitride (mpg-C3N4/Pd) as a reusable catalyst and ammonia borane as a safe hydrogen source in an aqueous solution MeOH/H2O (volume/volume = 1/1) was described. The catalytic hydrogenation reactions were conducted in a com. available high-pressure glass tube at room temperature and the corresponding alcs. were obtained in high yields in 2-5 min. Moreover, the presented transfer hydrogenation protocol showed partial halogen selectivity with bromo-, fluoro- and chloro-substituted carbonyl analogs. In addition, the present catalyst can be reused up to five times without losing its efficiency and scaling-up the reaction enabled α-methylbenzyl alc. to be produced in 90% isolated yield.

Journal of Chemical Research published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Formula: C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Miyazaki, Kanako; Nakata, Kenya published the artcile< Two-Step Kinetic Resolution of Racemic Secondary Benzylic Alcohols Using the Combination of Enantioselective Silylation and Acylation: One-Pot Procedure Catalyzed by Chiral Guanidine>, Synthetic Route of 403-41-8, the main research area is alc benzylic enantioselective preparation kinetic resolution; ester preparation enantioselective kinetic resolution benzylic alc; benzylic alc chiral guanidine catalyst silylation acylation kinetic resolution.

A novel two-step kinetic resolution of racemic secondary benzylic alcs. with practical enantiomeric ratios was achieved. The reactions were carried out via a one-pot operation by combining enantioselective silylation and acylation mediated by the same chiral guanidine catalyst.

Journal of Organic Chemistry published new progress about Acylation catalysts (stereoselective). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Synthetic Route of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Chong; Hu, Bowen; Chen, Dafa; Xia, Haiping published the artcile< Manganese(I)-Catalyzed Transfer Hydrogenation and Acceptorless Dehydrogenative Condensation: Promotional Influence of the Uncoordinated N-Heterocycle>, Name: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is manganese pyridylquinoline pyridylnaphthyridine preparation catalyst transfer hydrogenation dehydrogenative condensation; transfer hydrogenation ketone aldehyde catalyzed manganese carbonyl pyridylquinoline pyridylnaphthyridine; dehydrogenative condensation alc ketone catalyzed manganese carbonyl pyridylnaphthyridine; crystal structure manganese carbonyl bipyridinol complex.

The four bidentate Mn(I) complexes [(C5H4N-C5H3N-OH)Mn(CO)3Br] (1), [(C9H6N-C5H3N-OH)Mn(CO)3Br] (2), [(C8H5N2-C5H3N-OH)Mn(CO)3Br] (3), and [(C8H5N2-C5H3N-OCH3)Mn(CO)3Br] (4) were synthesized. These complexes were tested as catalysts for the transfer hydrogenation of ketones, and 3 showed the highest activity. The reactions proceeded well with 0.5 mol % of catalyst loading and 20 mol % of t-BuOK at 85° for 24 h. Also, 3 was also used as a catalyst for the synthesis of primary alcs. via transfer hydrogenation of aldehydes and the synthesis of 1,2-disubstituted benzimidazoles and quinolines via acceptorless dehydrogenative condensations.

Organometallics published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Name: 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Arora, Vinay; Narjinari, Himani; Kumar, Akshai published the artcile< Pincer-Nickel Catalyzed Selective Guerbet-Type Reactions>, Application of C8H9FO, the main research area is pincer nickel bis imino pyridine preparation crystal mol structure; Guerbet type reaction pincer iminopyridine nickel catalyzed; alkylation phenyl ethanol benzyl alc nickel iminopyridine catalyzed.

Authors report here the synthesis and characterization of a series of NNN pincer-nickel complexes of the type (R2NNN)NiCl2(CH3CN) (R = iPr, tBu, Cy, Ph, and p-F-C6H4) based on bis(imino)pyridine ligands. In solution, these complexes are equilibrium mixtures containing one and two pincer ligands, resp. While the crystal structure of the former was reported by us recently for R = iPr, they report the crystal structure of the latter in this study for R = p-F-C6H4. The considered NNN pincer-Ni complexes have been successfully employed to accomplish the catalytic β-alkylation of several secondary alcs. with a variety of benzyl alcs. at 140° with high yields and unprecedented turnovers. A maximum of 92% yield of the β-alkylated product at 18 400 TON was obtained in the reaction of benzyl alc. with 1-(4-(trifluoromethyl)phenyl)ethane-1-ol in the presence of 0.005 mol % of (Ph2NNN)NiCl2(CH3CN) and 5 mol % of NaOtBu at 140° after 24 h. The reaction exhibits zero-order dependence of rate on catalyst concentration and first-order dependence on the concentration of base, benzyl alc., and 1-Ph ethanol which points to the base-mediated aldol condensation as the rate-determining step. Most of the intermediates involved in catalysis have been identified by HRMS. To the best of their knowledge, this is the first report on a pincer-Ni catalyzed β-alkylation of alcs. and, hitherto, such unprecedented turnovers have not been reported with a homogeneous mol. nickel-based catalyst.

Organometallics published new progress about Aldol condensation. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Application of C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chakraborty, Priyanka; Gangwar, Manoj Kumar; Emayavaramban, Balakumar; Manoury, Eric; Poli, Rinaldo; Sundararaju, Basker published the artcile< α-Alkylation of Ketones with Secondary Alcohols Catalyzed by Well-Defined Cp*CoIII-Complexes>, Safety of 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is alkyl aryl ketone preparation; ketone secondary alc alkylation cobalt catalyst; alkylation; cobalt; ketones; secondary alcohols; α-alkylation.

Herein a well-defined, high-valence cobalt(III)-catalyst was applied for successful α-alkylation of ketones RC(O)CH3 (R = pentamethylphenyl, Ph, naphthalen-2-yl, etc.) and 1,2,3,4-tetrahydronaphthalen-1-one with secondary alcs. R1OH (R1 = 1-phenylethyl, cyclopentyl, octan-2-yl, etc.). A wide-variety of secondary alcs., which include cyclic, acyclic, sym., and unsym. compounds, was employed as alkylating agents to produce β-alkyl aryl ketones RC(O)CH2R1 and 2-(1-phenylethyl)-3,4-dihydronaphthalen-1(2H)-one.

ChemSusChem published new progress about Alkyl aryl ketones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Safety of 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cao, Zhengqiang; Qiao, Hong; Zeng, Fanlong published the artcile< Design, Synthesis, and Application of NNN Pincer Ligands Possessing a Remote Hydroxyl Group for Ruthenium-Catalyzed Transfer Hydrogenation of Ketones>, COA of Formula: C8H9FO, the main research area is ketone transfer hydrogenation alc preparation ruthenium pincer catalyst; crystal structure ruthenium NNN pincer triphenylphosphine dichloro complex preparation.

A new family of pyridyl-based NNN pincer ligands bearing a remote pendent OH group were developed. Considerable acceleration effects on the activity of Ru-catalyzed transfer hydrogenation of ketones were imparted by the pendent OH group, and importantly, introducing a CH2OH group to the 4′-position of the pyrazolyl moiety is an appropriate choice. The results present a general strategy for exploring bifunctional ligands to construct effective catalysts.

Organometallics published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, COA of Formula: C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

De Almeida, Laiza A.; Marcondes, Thayna H.; Milagre, Cintia D. F.; Milagre, Humberto M. S. published the artcile< Lipase-oxovanadium heterogeneous catalysis system: a robust protocol for the dynamic kinetic resolution of sec-alcohols>, Computed Properties of 403-41-8, the main research area is lipase oxovanadium dynamic kinetic resolution secondary alc.

Herein, we present a robust and eco-friendly dynamic kinetic resolution (DKR) protocol for secondary alcs. using a combined heterogeneous catalytic CAL-B/VOSO4 system at 50°C in the relatively green solvent heptane. This catalytic system is active and chemo- and enantioselective for up to 5 cycles. A set of 13 aromatic and heteroaromatic secondary alcs. were evaluated to determine the substrate scope. The performance of the combined CAL-B/VOSO4 system was improved by employing a low-cost, homemade Teflon tube to compartmentalize the catalysts in one-pot conditions, making this system for up to 8 reaction cycles.

ChemCatChem published new progress about Enantioselective biochemical synthesis. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Computed Properties of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kucinski, Krzysztof; Hreczycho, Grzegorz published the artcile< Lithium triethylborohydride as catalyst for solvent-free hydroboration of aldehydes and ketones>, Product Details of C8H9FO, the main research area is alc preparation green chem solvent free; aldehyde ketone hydroboration hydrolysis lithium triethylborohydride catalyst.

Com. available and inexpensive lithium triethylborohydride (LiHBEt3) acts as an efficient catalyst for the solvent-free hydroboration of a wide range of aldehydes and ketones, which were subsequently transformed to corresponding 1° and 2° alcs. in one-pot procedure at room temperature (rt).

Green Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Product Details of C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Das, Kanu; Yasmin, Eileen; Das, Babulal; Srivastava, Hemant Kumar; Kumar, Akshai published the artcile< Phosphine-free pincer-ruthenium catalyzed biofuel production: high rates, yields and turnovers of solventless alcohol alkylation>, COA of Formula: C8H9FO, the main research area is phosphine pincer ruthenium biofuel solventless alc alkylation.

Phosphine-free pincer-ruthenium carbonyl complexes based on bis(imino)pyridine and 2,6-bis(benzimidazole-2-yl) pyridine ligands have been synthesized. For the β-alkylation of 1-Ph ethanol with benzyl alc. at 140 °C under solvent-free conditions, (Cy2NNN)RuCl2(CO) (0.00025 mol%) in combination with NaOH (2.5 mol%) was highly efficient (ca. 93% yield, 372 000 TON at 12 000 TO h-1). These are the highest reported values hitherto for a ruthenium based catalyst. The β-alkylation of various alc. combinations was accomplished with ease which culminated to give 380 000 TON at 19 000 TO h-1 for the β-alkylation of 1-Ph ethanol with 3-methoxy benzyl alc. DFT studies were complementary to mechanistic studies and indicate the β-hydride elimination step involving the extrusion of acetophenone to be the overall RDS. While the hydrogenation step is favored for the formation of α-alkylated ketone, the alcoholysis step is preferred for the formation of β-alkylated alc. The studies were extended for the upgradation of ethanol to biofuels. Kinetic studies indicate first order dependence on concentration of both the catalyst and ethanol. Phosphine-free catalytic systems operating with unprecedented activity at a very low base loading to couple lower alcs. to higher alcs. of fuel and pharmaceutical importance are the salient features of this report.

Catalysis Science & Technology published new progress about Alkylation. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, COA of Formula: C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts