Category: 401797-00-0

The author of 《Iridium-bipyridine periodic mesoporous organosilica catalyzed direct C-H borylation using a pinacolborane》 were Maegawa, Yoshifumi; Inagaki, Shinji. And the article was published in Dalton Transactions in 2015. Electric Literature of C14H21BO2 The author mentioned the following in the article:

Heterogeneous catalysis for direct C-H borylation of arenes and heteroarenes in the combination of iridium (Ir) complex fixed on periodic mesoporous organosilica containing bipyridine ligands within the framework (Ir-BPy-PMO) and pinacolborane (HBpin) is reported. Ir-BPy-PMO showed higher catalytic activity toward the borylation of benzene with inexpensive HBpin compared to expensive bis(pinacolato)diboron (B2pin2). The precatalyst could be handled without the use of a glove box. The catalyst was easily recovered from reaction mixtures by simple filtration under air. The recovered catalyst still showed good catalytic activity for at least three more times for the borylation of benzene. A variety of arenes and heteroarenes were successfully borylated with high boron efficiency by Ir-BPy-PMO using HBpin, whereas almost no activity was observed for borylation of some heteroarenes with B2pin2. The system using Ir-BPy-PMO and HBpin was also utilized in syntheses of multi-boronated thiophene-based building blocks containing ladder-, acenefused-, and fused-thiophene skeletons. The combination of a stable and reusable solid catalyst and inexpensive HBpin is expected to be superior to conventional approaches for the development of industrial applications. In the experiment, the researchers used many compounds, for example, 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Electric Literature of C14H21BO2)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.Electric Literature of C14H21BO2 Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.

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Safety of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneOn March 16, 2015, Gonzalez, Miguel I.; Bloch, Eric D.; Mason, Jarad A.; Teat, Simon J.; Long, Jeffrey R. published an article in Inorganic Chemistry. The article was 《Single-Crystal-to-Single-Crystal Metalation of a Metal-Organic Framework: A Route toward Structurally Well-Defined Catalysts》. The article mentions the following:

Metal-organic frameworks featuring ligands with open chelating groups are versatile platforms for the preparation of a diverse set of heterogeneous catalysts through postsynthetic metalation. The crystalline nature of these materials allows them to be characterized via x-ray diffraction, which provides valuable insight into the structure of the metal sites that facilitate catalysis. A highly porous and thermally robust zirconium-based metal-organic framework, Zr6O4(OH)4(bpydc)6 (bpydc2- = 2,2′-bipyridne-5,5′-dicarboxylate), bears open bipyridine sites that readily react with a variety of solution- and gas-phase metal sources to form the corresponding metalated frameworks. Remarkably, Zr6O4(OH)4(bpydc)6 undergoes a single-crystal-to-single-crystal transformation upon metalation that involves a change in space group from Fm3-m to Pa3-. This structural transformation leads to an ordering of the metalated linkers within the framework, allowing structural characterization of the resulting metal complexes. Also, Zr6O4(OH)4(bpydc)6 yields an active heterogeneous catalyst for arene C-H borylation when metalated with [Ir(COD)2]BF4 (COD = 1,5-cyclooctadiene). These results highlight the unique potential of metal-organic frameworks as a class of heterogeneous catalysts that allow unparalleled structural characterization and control over their active sites. The results came from multiple reactions, including the reaction of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Safety of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Safety of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

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Murata, Miki; Ueda, Yosuke; Hyogo, Mayu; Kohari, Yoshihito; Namikoshi, Takeshi; Watanabe, Shinji published an article in Journal of Chemical Research. The title of the article was 《Ruthenium-catalysed dehydrogenative C-H borylation of arenes with pinacolborane》.Formula: C14H21BO2 The author mentioned the following in the article:

A ruthenium complex prepared in situ from [RuCl2(p-cymene)]2 and TpMe2K [TpMe2 = hydrotris(3,5-dimethylpyrazolyl)borate] is efficient for aromatic C-H borylation with pinacolborane (4,4,5,5-tetramethyl-1,3,2-dioxaborolane). Arenes were borylated at more electron-rich positions. DFT calculations and kinetic isotope effect experiments suggest that the catalytic cycle should involve an electrophilic aromatic substitution with a borenium cation. In the part of experimental materials, we found many familiar compounds, such as 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Formula: C14H21BO2)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Formula: C14H21BO2 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

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《Highly active, separable and recyclable bipyridine iridium catalysts for C-H borylation reactions》 was published in Catalysis Science & Technology in 2018. These research results belong to Mamlouk, Hind; Suriboot, Jakkrit; Manyam, Praveen Kumar; AlYazidi, Ahmed; Bergbreiter, David E.; Madrahimov, Sherzod T.. Reference of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane The article mentions the following:

Iridium complexes generated from Ir(I) precursors and PIB oligomer functionalized bpy ligands efficiently catalyzed the reactions of arenes with bis(pinacolato)diboron under mild conditions to produce a variety of arylboronate compounds The activity of this PIB bound homogeneous catalyst is similar to that of an original non-recyclable catalyst which allows it to be used under milder conditions than other reported recyclable catalysts. This oligomer-supported Ir catalyst was successfully recovered through biphasic extraction and reused for eight cycles without a loss of activity. Biphasic separation after the initial use of the catalyst led to an insignificant amount of iridium leaching from the catalyst to the product, and no iridium leaching from the catalyst was observed in the subsequent recycling runs. Arylboronate products obtained after extraction are sufficiently pure as observed by 1H and 13C-NMR spectroscopy that they do not require further purification In addition to this study using 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, there are many other studies that have used 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Reference of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane) was used in this study.

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Reference of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

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The author of 《Paper-Based Colorimetric Sensor System for High-Throughput Screening of C-H Borylation》 were Kim, Han-Sung; Eom, Min Sik; Han, Min Su; Lee, Sunwoo. And the article was published in Chemistry – A European Journal in 2017. SDS of cas: 401797-00-0 The author mentioned the following in the article:

A paper-based colorimetric sensor system (PBCSS) was developed to detect the amount of bis(pinacolato)diboron (B2Pin2) and applied as a high-throughput screening protocol in Ir-catalyzed C-H borylation. First, 96 ligands were screened for the borylation of benzene, and then 12 of them were selected and tested for five substrates. These reaction mixtures were spotted in the PBCSS, showing a blue-violet color. The value of the gray scale of each reaction was obtained from these colored spots and converted to the extent of conversion of B2Pin2. The extents of conversion of B2Pin2 obtained from the PBCSS showed good correlation with those obtained from gas chromatog. anal. The modified conversion using blank data showed good correlation with the yield of products. In the part of experimental materials, we found many familiar compounds, such as 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0SDS of cas: 401797-00-0)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.SDS of cas: 401797-00-0

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Electric Literature of C14H21BO2On September 30, 2020 ,《Undirected ortho-selectivity in C-H borylation of arenes catalyzed by NHC platinum(0) complexes》 was published in Mendeleev Communications. The article was written by Rzhevskiy, Sergey A.; Topchiy, Maxim A.; Golenko, Yulia D.; Gribanov, Pavel S.; Sterligov, Grigorii K.; Kirilenko, Nikita Yu.; Ageshina, Alexandra A.; Bermeshev, Maxim V.; Nechaev, Mikhail S.; Asachenko, Andrey F.. The article contains the following contents:

Borylation of arenes with bis(pinacolato)diboron catalyzed by sterically encumbered NHC platinum complexes proceeds predominantly at ortho-position even in the absence of a directing group (o : m : p ratio up to 10: 3: 1). The similar borylation with pinacolborane would proceed less selectively. In the part of experimental materials, we found many familiar compounds, such as 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Electric Literature of C14H21BO2)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Electric Literature of C14H21BO2

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HPLC of Formula: 401797-00-0On June 12, 2014, Fader, Lee D.; Carson, Rebekah; Morin, Sebastien; Bilodeau, Francois; Chabot, Catherine; Halmos, Ted; Bailey, Murray D.; Kawai, Stephen H.; Coulombe, Rene; Laplante, Steven; Mekhssian, Kevork; Jakalian, Araz; Garneau, Michel; Duan, Jianmin; Mason, Stephen W.; Simoneau, Bruno; Fenwick, Craig; Tsantrizos, Youla; Yoakim, Christiane published an article in ACS Medicinal Chemistry Letters. The article was 《Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV》. The article mentions the following:

A scaffold replacement approach was used to identifying the pyridine series of noncatalytic site integrase inhibitors (NCINIs). These mols. bind with higher affinity to a tetrameric form compared to a dimeric form of integrase. Optimization of the C6 and C4 positions revealed that viruses harboring T124 or A124 amino acid substitutions are highly susceptible to these inhibitors, but viruses having the N124 amino acid substitution are about 100-fold less susceptible. Compound 20 (I) had EC50 values <10 nM against viruses having T124 or A124 substitutions in IN and >800 nM in viruses having N124 substitutions. Compound 20 had an excellent in vitro ADME profile and demonstrated reduced contribution of biliary excretion to in vivo clearance compared to BI 224436, the lead compound from the quinoline series of NCINIs. The experimental part of the paper was very detailed, including the reaction process of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0HPLC of Formula: 401797-00-0)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.HPLC of Formula: 401797-00-0

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In 2011,Chemistry – A European Journal included an article by Chow, Wing-Kin; So, Chau-Ming; Lau, Chak-Po; Kwong, Fuk-Yee. Reference of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. The article was titled 《Palladium-Catalyzed Borylation of Aryl Mesylates and Tosylates and Their Applications in One-Pot Sequential Suzuki-Miyaura Biaryl Synthesis》. The information in the text is summarized as follows:

Palladium-catalyzed borylation with the N-methyl-2-(2′-dicyclohexylphosphino-5′-methoxyphenyl)indole (MeO-CM-Phos) ligand of ten aryl tosylates and twelve aryl mesylates gave the corresponding pinacol aryl boronates in 63% to 97% yield. The reaction conditions are mild and provide excellent functional-group compatibility (e.g., CN, CHO, COOMe, ketone, NH2, benzodioxole, quinolyl, benzothiazole or NH-indole). E.g., reaction of 3-cyanophenyl mesylate with bis(pinacolato)diboron afforded pinacol (3-benzonitrile) boronate in 97% yield. The Pd/MeO-CM-phos catalyst system allows one-pot sequential reactions in the preparation of unsym. biaryls. Four biaryls were prepared by one-pot two-step and one-pot three-step transformations of aryl tosylates and 3-cyanophenol, resp. In the experiment, the researchers used 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Reference of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Reference of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

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Frey, Guido D.; Rentzsch, Christoph F.; von Preysing, Denise; Scherg, Tobias; Muehlhofer, Michael; Herdtweck, Eberhardt; Herrmann, Wolfgang A. published their research in Journal of Organometallic Chemistry on December 15 ,2006. The article was titled 《N-Heterocyclic carbenes. Part 48. Rhodium and iridium complexes of N-heterocyclic carbenes: Structural investigations and their catalytic properties in the borylation reaction》.Formula: C14H21BO2 The article contains the following contents:

Bridged and unbridged N-heterocyclic carbene (NHC) ligands are metalated with [Ir/Rh(COD)2Cl]2 to give Rh(I/III) and Ir(I) mono- and biscarbene substituted complexes. All complexes were characterized by spectroscopy, and in addition [Ir(COD)(NHC)2][Cl,I] [COD = 1,5-cyclooctadiene, NHC = 1,3-dimethyl- or 1,3-dicyclohexylimidazolin-2-ylidene] (1, 4, resp.), and the bis(carbene) chelate complexes [(η4-1,5-cyclooctadiene)(1,1′-di-n-butyl-3,3′-ethylene-diimidazolin-2,2′-diylidene)iridium(I) bromide] (12) and [(η4-1,5-cyclooctadiene)(1,1′-dimethyl-3,3′-o-xylylene-diimidazolin-2,2′-diylidene)iridium(I) bromide] (14) were characterized by single crystal x-ray anal. The relative σ-donor/π-acceptor qualities of various NHC ligands were examined and classified in monosubstituted NHC-Rh and NHC-Ir dicarbonyl complexes by IR spectroscopy. For the 1st time, bis(carbene)-substituted Ir complexes were used as catalysts in the synthesis of arylboronic acids starting from pinacolborane and arene derivatives2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Formula: C14H21BO2) was used in this study.

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Formula: C14H21BO2

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Recommanded Product: 401797-00-0On March 9, 2016, Zhang, Teng; Manna, Kuntal; Lin, Wenbin published an article in Journal of the American Chemical Society. The article was 《Metal-Organic Frameworks Stabilize Solution-Inaccessible Cobalt Catalysts for Highly Efficient Broad-Scope Organic Transformations》. The article mentions the following:

New and active earth-abundant metal catalysts are critically needed to replace precious metal-based catalysts for sustainable production of commodity and fine chems. We report here the design of highly robust, active, and reusable cobalt-bipyridine- and cobalt-phenanthroline-based metal-organic framework (MOF) catalysts for alkene hydrogenation and hydroboration, aldehyde/ketone hydroboration, and arene C-H borylation. In alkene hydrogenation, the MOF catalysts tolerated a variety of functional groups and displayed unprecedentedly high turnover numbers of ∼2.5 × 106 and turnover frequencies of ∼1.1 × 105 h-1. Structural, computational, and spectroscopic studies show that site isolation of the highly reactive (bpy)Co(THF)2 species in the MOFs prevents intermol. deactivation and stabilizes solution-inaccessible catalysts for broad-scope organic transformations. Computational, spectroscopic, and kinetic evidence further support a hitherto unknown (bpy•-)CoI(THF)2 ground state that coordinates to alkene and dihydrogen and then undergoing σ-complex-assisted metathesis to form (bpy)Co(alkyl)(H). Reductive elimination of alkane followed by alkene binding completes the catalytic cycle. MOFs thus provide a novel platform for discovering new base-metal mol. catalysts and exhibit enormous potential in sustainable chem. catalysis. The results came from multiple reactions, including the reaction of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Recommanded Product: 401797-00-0)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Recommanded Product: 401797-00-0

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