Category: 39895-56-2

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39895-56-2, name is (4-(Aminomethyl)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of (4-(Aminomethyl)phenyl)methanol

To a solution of (2R,5S,8R, 14S,17R,20S,21S,22S,E)-8-benzyl-20-((E)-but-2-en- 2-yl)-14-((R)-sec-butyl)-2-isobutyl-557510, 17,2 l,25-hexamethyl-3,6,9, 12,15, 18,26-heptaoxo- 1 , 19-dioxa-4,7, 10, 13, 16-pentaazacyclohexacos-24-en-22-yl (4-nitrophenyi) carbonate (5.0 mg, 5.044 muetaiotaomicron, 1.0 eq; Intermediate 1 from Example 1) in DCM (0.1 mL, 5.04 muetaiotaomicron) was added (4-(aminomethyl)phenyl)methanol (3.46 mg, 0.025 mrnol , 5.0 eq) and DIPEA (8.81 muEpsilon, 0.050 mrnol, 10.0 eq) and stirred overnight. The reaction was monitored by reverse phase HPLC. The reaction mixture was concentrated on the rotavap and the crude residue obtained was purified by reverse phase flash chromatography (acetonitrile with 0.1% formic acid/ H20 with 0.1 % formic acid) to afford (2R,5S,8R,14S,17R,20S,21S,22S,E)-8-benzyl-20-((E)-but- 2-en-2-yl)-14-((R)-sec-butyl)-2-isobutyl-557 0,17,21,25-hexamethyl-356,9, 12s 15,18526- heptaoxo- 1 , 19-dioxa~4,7, 10, 13,16-pentaazacyclohexacos~24-en~22-yl ( – (hydroxymethy])benzyl)carbamate (2.75 mg, 2.78 muetaiotaomicron, 55.1 %). Observed HRMS (ESI) m/z: 989.565 | M 1 11

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Reference:
Patent; SIRENAS LLC; USUI, Ippei; LEE, Bryan, Junn; COHEN, Steven, Bruce; MACHERLA, Venkat, Rami Reddy; BEVERAGE, Jacob, Neal; PAN, Chung-mao; BARMARE, Farhana; ESQUENAZI, Eduardo; (265 pag.)WO2018/45245; (2018); A1;,
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Electric Literature of 39895-56-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 39895-56-2 as follows.

1-Methyl-4-piperidone (84 muL, 0.73 mmol) was dissolved in methanol (5 mL) and 4-(aminomethyl)benzylalcohol (57MBT52B) (100 mg, 0.73 mmol) was added followed by acetic acid (125 muL). NaBH3CN (92 mg, 1.46 mmol) was added and the mixture was stirred for 3 h. The reaction mixture was evaporated and 2M NaOH (5 mL) was added. Extraction with CH2Cl2 (4*5 mL), drying with Na2SO4 and evaporation gave 152 mg (87%) of N-((4-(hydroxymethyl)phenyl)methyl)-4-amino-1-methylpiperidine (57MBT56D) as a white solid. HPLC-MS (method B) showed MH+=235. UV/MS (%)=100/100.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39895-56-2, its application will become more common.

Reference:
Patent; ACADIA Pharmaceuticals Inc.; ANDERSSON, Carl-Magnus A.; CROSTON, Glenn; HANSEN, Eva Louise; ULDAM, Allan Kjaersgaard; US2015/259291; (2015); A1;,
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Application of 39895-56-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.39895-56-2, name is (4-(Aminomethyl)phenyl)methanol, molecular formula is C8H11NO, molecular weight is 137.179, as common compound, the synthetic route is as follows.

Furthermore, 4-(4,6-dichloro-1,3,5-triazin-2-yl)morpholine (9a, Scheme 2; 0.588 g, 2.5 mmol),(4-(aminomethyl)phenyl)methanol (1 eq., 0.343 g, 2.5 mmol), and K2CO3 (1 eq., 0.343 g, 2.5 mmol)were combined in a flask. The solid material was dissolved in DMF (10 mL), and was stirred for 72 h atroom temperature (heated if necessary on the last day). Brine (100 mL) was added to the flask and theproduct was precipitated. The solid was filtered and dried overnight under high vacuum. The productwas purified using column chromatography (silica) with 50% ethyl acetate in hexanes as the eluent.White product (10b, Scheme 2) was produced (0.428 g, 1.28 mmol, 51%). 1H-NMR (300 MHz, CDCl3) delta 7.29 (m, 4H), 5.92 (s, 1H), 4.69 (s, 2H), 4.57 (d, J = 6.1 Hz, 2H), 3.79 (m, 4H), 3.69 (t, J = 4.6 Hz, 4H),1.88 (br s, 1H). 13C-NMR (101 MHz, DMSO-d6) delta 169.35, 168.74, 166.01, 165.66, 164.46, 164.32, 141.59,137.98, 137.93, 127.65, 127.30, 126.91, 126.87, 66.16, 63.15, 44.00, 43.95. Most 13C-NMR resonances showevidence of two conformers due to hindered rotation around the C-NHR bond.

The chemical industry reduces the impact on the environment during synthesis 39895-56-2, I believe this compound will play a more active role in future production and life.

Reference:
Article; Nelson, Ronald A; Schronce, Taylor; Huang, Yue; Albugami, Alanoud; Kulik, George; Welker, Mark E.; Molecules; vol. 23; 7; (2018);,
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Electric Literature of 39895-56-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 39895-56-2 as follows.

To a mixture of 4-pyrrolidin-1-ylbenzoic acid (2.0 g, 10.5 mmol), (4- aminomethylphenyl) methanol (4.3 g, 31.4 mmol), 1-hydroxybenzotriazole (1.7 g, 12.6 mmol), and DMAP (256 mg, 2.1 mmol) in pyridine (50 mL) was added EDC (3.0 g, 15.7 mmol), and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and an aqueous NaHCO3 solution (50 mL) was added. The mixture was extracted with 5% MeOH in CHC13 (150 mL x 2), and the organic layer was dried (MgS04) and evaporated under reduced pressure. The crude product was purified by MPLC on silica gel (3% MeOH in CHC13) to afford the titled compound (2.56 g, 79%) as a white solid. H NMR (DMSO-d6) 8 1.96 (m, 4H), 3.28 (m, 4H), 4.41-4. 47 (m, 4H), 5.10 (t, 1H, J= 5.7 Hz), 6.53 (m, 2H), 7.25 (apparent s, 4H), 7.75 (m, 2H), 8. 59 (br t, 1H, J=6.0 Hz)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39895-56-2, its application will become more common.

Reference:
Patent; SK CHEMICALS, CO., LTD.; IN2GEN CO., LTD.; WO2003/87066; (2003); A1;,
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