Category: 3973-18-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3973-18-0, name is Propynol ethoxylate. A new synthetic method of this compound is introduced below., Quality Control of Propynol ethoxylate

Production of 2-((4-methylcyclohexa-l,4-dienyl)methoxy)ethyl 4-methylbenzenesulfonate and 2-((5 -methylcyclohexa- 1 ,4-dienyl)methoxy)ethyl 4-methylbenzenesulfonate[Chem. 24] 100.00 g (0.59 mol) of the diene alcohol obtained in Example 36, 90.29 g (0.89 mol) of Iriethylamine, and 73.20 g (0.89 mol) of 1-methylimidazole were dissolved in 400 ml of toluene. In an ice bath, a toluene solution (400 ml) of 130.33 g (0.68 mol) of p-toluenesulfonyl chloride was slowly added dropwise to the solution, and then the resulting mixture was stirred for one hour at room temperature. Water was added thereto, and the organic layer was separated. The obtained organic layer was washed sequentially with 15% sulfuric acid, water, and a saturated aqueous sodium hydrogen carbonate. The solvent was distilled off under reduced pressure, and thus 188.01 g of the desired tosylate was obtained as a colorless oil. Yield 98.1% (l,4-type/l,5-type = 91/9).1.67 (s, 3H), 2.44 (s, 3H), 2.58 (brs, 4H), 3.58 – 3.55 (m, 2H), 3.84 (s, 2H), 4.18 – 4.14 (m, 2H), 5.41 – 5.40 (m, 1H), 5.64 – 5.63 (m, 1H), 7.33 (d, J = 8.3 Hz, lH), 7.80 (d, J = 8.3 Hz, 1H);HRMS (ESI):Calculated value: [M+H]+ 323.1312Found value: 323.1325

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3973-18-0, Propynol ethoxylate.

Reference:
Patent; TAKASAGO INTERNATIONAL CORPORATION; TOUGE, Taichiro; NARA, Hideki; HAKAMADA, Tomohiko; WO2012/26201; (2012); A1;,
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Application of 3973-18-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3973-18-0, name is Propynol ethoxylate. A new synthetic method of this compound is introduced below.

General procedure: Bis-boc-adenine1,2 (302 mg, 0.90 mmol) and triphenylphosphine (467 mg, 1.78 mmol) were dissolved in THF (10 mL), and the mixture was stirred at C. 2-(Prop-2-yn-1-yloxy)ethanol3 (134 mg, 1.34 mmol) and a 40% solutionof DEAD in toluene (0.82 mL, 1.79 mmol) were added. The reaction mixture was stirred for 3hours at C and then concentrated under reduced pressure. The residue was purified by flash column chromatography (0-4% CH3OH in CH2Cl2) to give the crude intermediate S1. This was dissolved in CH3OH (3.5 mL) and 3 M HCl (3.5 mL) was added. The reaction mixture was stirred at 45 C for 16 h and then neutralised by the addition of a 0.2 M aqueous solution of Na2CO3. The mixture was concentrated under reduced pressure and then dissolved in DMF followed by filtration and concentration under reduced pressure. The residue was purified by flash column chromatography (0-20% CH3OH in CH2Cl2) to give the product S2 as a white powder (51 mg, 26% over two steps).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3973-18-0, Propynol ethoxylate, and friends who are interested can also refer to it.

Reference:
Article; Dreier, Ida; Hansen, Lykke H.; Nielsen, Poul; Vester, Birte; Bioorganic and Medicinal Chemistry Letters; vol. 24; 4; (2014); p. 1043 – 1046;,
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Application of 3973-18-0 ,Some common heterocyclic compound, 3973-18-0, molecular formula is C5H8O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of 2-(prop-2-yn-1-yloxy)ethanol (7.90 g, 78.9 mmol) in DCM (80.0 mL) was added TEA (15.9 g, 158 mmol) followed by the addition of a solution of methanesulfonyl chloride (13.6 g, 119 mmol) at 0 C under nitrogen atmosphere. The resulting solution was stirred for additional 2 h at room temperature. Upon completion, the reaction was quenched with water (100 mL) at 0 C. The mixture was extracted with EtOAc (2 x 100 mL). The combined organic phase was washed with brine (100 mL), dried with anhydrous Na2SO4 and filtered. The filtrate was concentrated under reduced pressure to afford 2-(prop-2-yn-1-yloxy)ethyl methanesulfonate (14.0 g, 99 %) as a colorless oil. 1H NMR (400 MHz, DMSO-d6) d 4.37-4.28 (m, 2H), 4.21 (d, J = 2.4 Hz, 2H), 3.76-3.63 (m, 2H), 3.53-3.42 (m, 1H), 3.19 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3973-18-0, its application will become more common.

Reference:
Patent; KYMERA THERAPEUTICS, INC.; JI, Nan; MAINOLFI, Nello; WEISS, Matthew; (977 pag.)WO2020/10210; (2020); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3973-18-0, name is Propynol ethoxylate, molecular formula is C5H8O2, molecular weight is 100.1158, as common compound, the synthetic route is as follows.3973-18-0

General procedure: To a 0.30mL of a solution of azide 14 (23mM in tBuOH-H2O (2: 1)) in an eppendorf, 0.10mL of a solution of the corresponding alkyne (a-s) (83mM in tBuOH) was added followed by 25muL of an aqueous solution of sodium ascorbate (30mM) and 25muL of an aqueous solution of CuSO4 (9.4mM). The final concentration of the azide 14 in each eppendorf was 15mM. The resulting mixtures were shaken at room temperature for 24h and monitored for completion by TLC and ESI-MS (see Supplementary data for mass spectra analysis). Then, the reactions were diluted with water to the desired concentration and placed in a 96-well microtiter plate in order to perform the enzymatic assays. In the preliminary screening of the resulting crude (pyrrolidin-2-yl)triazoles 14a-s, % of inhibition towards beta-glucosidase from almonds was determined at 10muM of the pyrrolidine-triazole on each well (assuming quantitative conversion in the click reaction).

Statistics shows that 3973-18-0 is playing an increasingly important role. we look forward to future research findings about Propynol ethoxylate.

Reference:
Article; Martinez-Bailen, Macarena; Carmona, Ana T.; Moreno-Clavijo, Elena; Robina, Inmaculada; Ide, Daisuke; Kato, Atsushi; Moreno-Vargas, Antonio J.; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 532 – 542;,
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3973-18-0 ,Some common heterocyclic compound, 3973-18-0, molecular formula is C5H8O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In 175 mL of dichloromethane, 1,2-bis(diphenylphosphino)ethane (1.73 g, 4.40 mmol), cobalt bromide (0.865 g, 4.00 mmol), and zinc iodide (4.2 g, 13.15 mmol) were dissolved, followed by stirring at 30 C. for 30 minutes. Then, 2-(propynyloxy)ethanol (8.94 g, 91.0 mmol) and butadiene (20% by weight toluene solution) (36.8 ml, 136.5 mmol) were added thereto, and then Bu4NBH4 (1.1 g, 4.3 mmol) was added. After stirring at 45 C. for 1 hour, the solvent was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate=5/1). Thus, 11.7 g of the title compound, an alcohol, was obtained as a colorless oily substance. Yield: 85.0%. [0149] 1H NMR (CDCl3, 300 MHz): delta 5.80-5.60 (m, 3H), 3.92 (s, 1H), 3.72 (t, 2H), 3.48 (t, 2H), 2.75-2.60 (m, 4H), 2.22 (brs, 1H)

According to the analysis of related databases, 3973-18-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TAKASAGO INTERNATIONAL CORPORATION; Touge, Taichiro; Hakamata, Tomohiko; Nara, Hideki; US2014/39220; (2014); A1;,
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3973-18-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3973-18-0, name is Propynol ethoxylate. This compound has unique chemical properties. The synthetic route is as follows.

4-((2-azidoethyl)amino)-N-(4-fluorophenyl)-N’-hydroxy-1,2,5-oxadiazole-3-carboxamidine (III-4, 0.75g, 2.45mmol) into a 50mL eggplant-shaped bottle,Add 3mL of water and 18mL of acetonitrile solution respectively. Under ice bath, add ethoxylated propynol (290 muL, 2.94 mmol) and cuprous iodide (93 mg, 0.49 mmol),Keep warm and stir for 0.5h, then transfer to room temperature and continue stirring for about 8h.TLC monitored the reaction until the reaction was complete (developing agent: dichloromethane: methanol = 15:1 v/v); the solvent was distilled off under reduced pressure, methanol (20 mL) was added and stirred for 30 min, filtered with suction, and the solvent was distilled off under reduced pressure to obtain a light brown solid , Column chromatography purification (eluent: petroleum ether: ethyl acetate = 2:1 ~ 1:4v/v), to obtain 165mg white solid I-8, the yield was 17.3%,

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3973-18-0, Propynol ethoxylate.

Reference:
Patent; China Pharmaceutical University; Zhu Qihua; Zhang Shan; He Guangchao; Shen Hui; Wang Yiwei; Gu Shuhui; Sun Zeren; Xu Yungen; (24 pag.)CN111138425; (2020); A;,
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Adding some certain compound to certain chemical reactions, such as: 3973-18-0, name is Propynol ethoxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3973-18-0. 3973-18-0

A solution of 1.7 g of lib and 3 ml of triethyl amine in 20 ml of diethyl ether was treated at O0C with 1.5 ml of methanesulfonyl chloride. The mixture was stirred for an additional 30 min and then diluted with 35 ml of water and extracted with ethyl acetate. The combined organic layers were washed with IM aq. K2CO3 solution and water, dried and concentrated, to provide 2.45 of lie as a colorless oil; Rf 0.45 (heptane/ethyl acetate 1/1).NMR (CDCl3) delta 2.48 (t, 1, acetylene-H), 3.08 (s, 3, CH3SO2), 3,82 (m, 2, CH2), 4.03( d, 2, CH2), 4.41 (m, 2, CH2).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3973-18-0.

Reference:
Patent; N.V. ORGANON; LOOZEN, Hubert, Jan, Jozef; TIMMERS, Cornelis, Marius; STOCK, Herman, Thijs; WO2011/12600; (2011); A1;,
Alcohol – Wikipedia,
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3973-18-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3973-18-0, name is Propynol ethoxylate, molecular formula is C5H8O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[Synthesis 10]Production of N-((lR,2R)-2-(2-((4-methylcyclohexa-l,4-dienyl)methoxy)ethylamino)-l,2-diphen ylethyl)-2-(trifluoromethyl)benzenesulfonamide hydrochlorideIn 31.6 ml of toluene, 8.07 g (26.1 mmol) of the above-described tosylates obtained in Synthesis 7 were dissolved. To this solution, 3.38 g (26.2 mmol) of DIPEA, 10.00 g (23.8 mmol) of (R,R)-0-TFTsDPEN and 4.34 g (26.2 mmol) of potassium iodide were added, followed by stirring at 135C for 6 hours. The reaction solution was concentrated and purified with a silica gel column chromatography to obtain 10.1 g of diamine (Yield: 74.5 %). Then, 110 ml of dichloromethane and 65.3 ml of HCl in methanol solution (IN) were added to 10.1 g (17.7 mmol) of the diamine, followed by stirring for 0.5 hours, and the solvent was removed to obtain 11.1 g of the target diamine hydrochloride. Yield: 93.9%?- MRCDMSO, 300MHz) 8:1.62(m, 3H), 2.60(s, 3H), 2.78-3.12(m, 2H), 3.52-3.70(m, 2H), 3.86(s, 2H) ,4.75(m,1H), 4.92(m, 1H), 5.40(m, 1H), 5.68(m, 1H), 6.75-7.35(m, 10H), 7.40(t, 1H), 7.50(t, 1H), 7.60(d, 1H), 7.75(d, 1H), 8.90(m, 1H), 8.98(brd, 1H), 9.92(brd, 1H);-57.16;HRMS (ESI):[M-C1]+ calcd for – HCl: 571.2237; found: 571.2244

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3973-18-0, Propynol ethoxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAKASAGO INTERNATIONAL CORPORATION; TANAKA, Shigeru; TOUGE, Taichiro; NARA, Hideki; ISHIDA, Kenya; WO2013/65867; (2013); A1;,
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Alcohols – Chemistry LibreTexts