Category: 3818-50-6

Chowdhury, Amiya K. Roy published the artcileR.S.(P), a new isolate from the root of Rauwolfia serpentina, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Indian Medical Journal (1964), 58(12), 241-52, database is CAplus.

The pharmacol. actions of a nonalkaloidal fraction isolated from the root of R. serpentina are given. This fraction, R.S.(P), was less potent than reserpine but equipotent to Rauwolfia total extract (1%) in lowering the blood pressure in anesthetized cats. In suitable doses it increased the pentobarbital sleeping time, reduced the spontaneous motility, postponed Metrazol convulsion and lethality, and affected the conditioned behavior in rats (maze test). Coordinated muscular movements were least affected, except when very high doses were used. Electroencephalogram studies in unanesthetized rabbits revealed considerable slowing of the brain wave pattern with the calming and quieting effect on the animals. Sometimes behavioral nonreactivity was seen. The drug appeared to have a central site of action. Its action differed from that of reserpine in many respects. It may possibly be used as an antihypertensive and anticonvulsant or sedative agent.

Indian Medical Journal published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rajasekariah, G. R. published the artcileResponse of preadult Necator americanus to some known anthelminthics in hamsters, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Chemotherapy (Basel, Switzerland) (1986), 32(1), 75-82, database is CAplus and MEDLINE.

Hamsters infected with laboratory-adapted preadult N. americanus were dosed with 6 reference anthelmintics; their efficacy was measured in terms of percentage cure of infected animals as well as percentage worm reduction following treatment. Mebendazole and pyrantel were equally effective in this system. Other anthelmintics, including the anti-hookworm compound, bephenium hydroxynaphthoate, were less effective. The comparative results revealed that the N. americanus model is sensitive and reliable for identifying and characterizing new anti-parasite preparations

Chemotherapy (Basel, Switzerland) published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Goulart, Enio G. published the artcileAnthemintic drugs. Their ovicidal and larvicidal actions, Category: alcohols-buliding-blocks, the publication is Revista Brasileira de Medicina (1974), 31(11), 791-4, database is CAplus.

Of 9 chemotherapeutic anthelmintics tested in vitro against eggs and larvae of Ascaris lumbricoides, Trichuris trichiura, and Ancylostoma caninum, pyrantel pamoate [22204-24-6] and tetrachloroethylene [127-18-4] (10 and 100 mg each) inhibited development of A. caninum; similar results were obtained with 1 mg tetramisole-HCl (I-HCl) [5086-74-8] and thiabendazole (II) [148-79-8]. Stilbazium iodide [3784-99-4], pyrvinium pamoate [3546-41-6], and bephenium hydroxynaphthoate [3818-50-6] showed anthelmintic activity which was directly related to the concentrations None of the compounds tested showed embryogenic blocking activity against A. lumbricoides or T. trichiura. Prophylactic treatments of contaminated soil or organic fertilizer are apparently ineffective.

Revista Brasileira de Medicina published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chong, Curtis R. published the artcileA clinical drug library screen identifies astemizole as an antimalarial agent, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Nature Chemical Biology (2006), 2(8), 415-416, database is CAplus and MEDLINE.

The high cost and protracted time line of new drug discovery are major roadblocks to creating therapies for neglected diseases. To accelerate drug discovery the authors created a library of 2687 existing drugs and screened for inhibitors of the human malaria parasite Plasmodium falciparum. The antihistamine astemizole and its principal human metabolite are promising new inhibitors of chloroquine-sensitive and multidrug-resistant parasites, and they show efficacy in two mouse models of malaria.

Nature Chemical Biology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Botero, David published the artcileComparative study of pyrantel pamoate, bephenium hydroxynaphthoate, and tetrachloroethylene in the treatment of Necator americanus infections, HPLC of Formula: 3818-50-6, the publication is American Journal of Tropical Medicine and Hygiene (1972), 22(1), 45-52, database is CAplus and MEDLINE.

A study of 105 patients with the hookworm N. americanus infections was undertaken to compare the new anthelmintic pyrantel pamoate (I-pamoate) [22204-24-6] and 2 commonly used drugs bephenium hydroxynaphthoate [3818-50-6] and tetrachloroethylene [127-18-4]. I, in a dose of 10 mg/day, orally, for 3 days, had action comparable or superior to the other drugs against the hookworm. In addition, I caused an almost 100% cure rate in patients infected with Ascaris lumbricoides, and caused a slight decrease in egg count in patients infected with Trichuris trichiura. I was tolerated well and no toxic effects were observed by hematol. and biochem. examination

American Journal of Tropical Medicine and Hygiene published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, HPLC of Formula: 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sapleva, V. T. published the artcileDetermination of naphthamon using rhodamine 6G, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Farmatsiya (Moscow, Russian Federation) (1974), 23(1), 39-42, database is CAplus and MEDLINE.

The reaction of naphthamon (2-phenoxyethyldimethylbenzylammonium β-hydroxynaphthoate) (I) with rhodamine 6G was used for the quant. determination of I. The resulting complex compound was extracted with benzene and the optical d. of the extract was determined at 512 nm. The relative error of the determination is ±2.2%.

Farmatsiya (Moscow, Russian Federation) published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ray, D. K. published the artcileEfficacy of seven anthelmintics against Ancylostoma ceylanicum in the golden hamster, Mesocricetus auratus, Related Products of alcohols-buliding-blocks, the publication is Annals of Tropical Medicine & Parasitology (1978), 72(1), 55-8, database is CAplus and MEDLINE.

The infection of A. ceylanicum in hamsters was treated with 7 anthelmintics: bephenium hydroxynaphthoate [3818-50-6], tetramisole [5036-02-2], tetrachlorethylene [127-18-4], phenylene 1,4-diisothiocyanate [4044-65-9],thiabendazole [148-79-8],parbendazole [14255-87-9], and mebendazole [31431-39-7]. Mebendazole was most effective, whereas tetrachlorethylene and tetramisole were least effective.

Annals of Tropical Medicine & Parasitology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Melukhova, A. G. published the artcileKinetics of choline esterase activity in Ascaris suum, Safety of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Meditsinskaya Parazitologiya i Parazitarnye Bolezni (1971), 40(6), 672-4, database is CAplus.

Bephenium (I) [7181-73-9], naphthamon [3818-50-6], and preparation 397 were 8, 6, and 22 times more inhibitive toward the cholinesterase [9001-08-5] of the ascarid A. suum than toward the cholinesterase of rat brain. This may account for the selective activity of these antihelminthic preparations against the worm in mammalian bodies.

Meditsinskaya Parazitologiya i Parazitarnye Bolezni published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Safety of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Braude, M. B. published the artcileChemical structure and anthelmintic activity. V. Analogs of the anthelmintics neftamon and difezil, SDS of cas: 3818-50-6, the publication is Khimiko-Farmatsevticheskii Zhurnal (1975), 9(10), 12-14, database is CAplus.

I (R = H, 4-Cl, 2-MeCO2, 4-Me; X = CO2, OCH2CO2, CO; R1 = Ph, 2,3,5-HO(Ac)(Cl)C6H2, CH2COPh; A = Cl, p-ClC6H4SO3, iodo, hydroxynaphthoate) were prepared in 56.5-100% yield by standard methods. RCO2CH2CH2NMe2 (R = Ph, p-ClC6H4, p-ClC6H4OCH2) were prepared in 88-95% yield. I (R = H, X = CO2, R1 = Ph, 2,3,5-HO(Ac)(Cl)C6H2) at 0.4-0.6 g/kg in mice infected with Trichocephalus muris were less effective and more toxic than neftamon and difezil. The introduction of an acetoxy group in position 2 and a halo group in position 4 lowered the toxicity and effectiveness.

Khimiko-Farmatsevticheskii Zhurnal published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, SDS of cas: 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Singh, Bharpoor published the artcileMouth dissolving tablets: an innovative deviation in drug delivery system, Quality Control of 3818-50-6, the publication is Journal of Pharmaceutical Sciences and Research (2019), 11(4), 1186-1194, database is CAplus.

The main aim of novel drug delivery system is to develop a dosage form which is easy to administer, free from side effects, exhibit immediate release and offer enhanced bioavailability for better patient compliance. To achieve such results oral drug delivery system, preferably, tablets are the most widely accepted dosage forms which offer numerous advantages. Beside those advantages, Dysphagia is the most common disadvantage of conventional tablets which is associated with number of conditions like sudden exposure of allergies, mental disability, motion sickness, unconsciousness, unavailability of water etc. To get rid from these problems several innovative drug delivery systems have been developed like Mouth Dissolving Tablets (MDT′s) which dissolve in saliva within a few seconds, when put on tongue. These tablets can be administered anywhere and anytime, without the need of water and are thus quite suitable for children, elderly and mentally disabled patients.

Journal of Pharmaceutical Sciences and Research published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C19H14Cl2, Quality Control of 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts