Category: 37729-18-3

Application of 37729-18-3, Adding some certain compound to certain chemical reactions, such as: 37729-18-3, name is 2-([1,1′-Biphenyl]-4-yl)ethanol,molecular formula is C14H14O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37729-18-3.

(1-3) Preparation of 4- (2-iodoethyl) biphenyl A solution of methanesulfonyl chloride (9.54 g) in tetrahydrofuran (150 ml) was added dropwise to a solution 2- (biphenyl-4-yl) ethanol (5.53 g) and triethylamine (10.18 g) in tetrahydrofuran (150 ml) at 5C under nitrogen atmosphere. After stirring at room temperature for 6 hours, the precipitated crystals were collected by filtration. The filtrate was concentrated under reduced pressure and the resultant residue was purified with silica-gel column chromatography using a 1 : 1 mixture of hexane/ethyl acetate to give methanesulfonate of 2- (BIPHENYL-4-YL) ethanol as a colorless liquid. Sodium iodide (6.23 g) was added to a solution of the methanesulfonate in 2-butanone (150 ml) and stirred at 70C for 3 hours. The precipitate was filtered off and 5% aqueous sodium thiosulfate (30 ml) was added to the filtrate and extracted with ethyl acetate. The ethyl acetate layer was washed with an aqueous saturated saline solution and then dried over anhydrous sodium sulfate. The solvent was distilled off, and the resultant residue was purified with silica-gel column chromatography using a 5: 1 mixture of hexane and ethyl acetate to give the title compound (7.31 g) as a colorless liquid.

According to the analysis of related databases, 37729-18-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Mitsubishi Pharma Corporation; WO2005/14525; (2005); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 37729-18-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 37729-18-3, name is 2-([1,1′-Biphenyl]-4-yl)ethanol. A new synthetic method of this compound is introduced below.

Compound 30:Acrylic acid (13.5 mg, 0.05 mmol) was added sequentially to a 25 mL two-necked flask,2-biphenylethyl alcohol (49.5 mg, 0.25 mmol),N, O-bis (diethylsilyl) trifluoroacetamide (213.6 mg, 0.75 mmol)Potassium peroxy monosulfonate (307.0 mg, 0.50 mmol)The gas was replaced with dry N2 for 3 times,Finally, dry tetrahydrothiopyran (0.5 mL) was added under N2.Stirred at room temperature and heated to 50 C to carry out the reaction,Until the thin layer chromatography monitoring of raw materials is completed.At the end of the reaction, 15.0 mL of NaCl solution was added at room temperature,Extracted with ether 15.0 mL three times,The combined organic phase was distilled under reduced pressure and the product was purified by column chromatography in 65% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,37729-18-3, 2-([1,1′-Biphenyl]-4-yl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Nanjing Normal University; Han Wei; Zhao Hongyuan; (19 pag.)CN107056732; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 37729-18-3, name is 2-([1,1′-Biphenyl]-4-yl)ethanol. A new synthetic method of this compound is introduced below., SDS of cas: 37729-18-3

Under nitrogen atmosphere, to a stirred solution of 2-(4-phenylphenyl)-ethanol (0.30 g,1.41 mmol) in dry CH2C12 (15 mL), DMAP (0.014 g, 0.11 mmol) and 2-DPC (0.37 g, 1.70mmol) were added. The reaction mixture was stirred at r.t. for 16h, then diluted with CH2C12 (15mL) and sequentially washed with sat. NH4C1 solution (15 mL) and sat. NaHCO3 solution (315 mL). The organic layer was dried over Na2SO4, filtered and concentrated to dryness giving an oily residue (0.46 g), as a mixture (1:1.7 ratio) of 2-(4-phenylphenyl)-ethyl-2-pyridyl carbonate and 2-(4-phenylphenyl)-ethyl-2-oxopyridine- 1 -carboxylate. The mixture of isomers was not separated and used in the next step without any further purification. R = 2.63 mm. MS (ESI)m/z: 244 [M-H], 266 [M-Na]. MS (ESI) m/z: 242 EM-Hr.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 37729-18-3, 2-([1,1′-Biphenyl]-4-yl)ethanol.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA; PIOMELLI, Daniele; BANDIERA, Tiziano; BERTOZZI, Fabio; NUZZI, Andrea; FIASELLA, Annalisa; PONZANO, Stefano; PAGLIUCA, Chiara; REGGIANI, Angelo Mario; WO2014/144836; (2014); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 37729-18-3, Adding some certain compound to certain chemical reactions, such as: 37729-18-3, name is 2-([1,1′-Biphenyl]-4-yl)ethanol,molecular formula is C14H14O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37729-18-3.

2-biphenyl ethanol (1 g, 5 mmol), 4-nitrophenol (834 mg, 6 mmol), andtriphenylphosphine (1.59 g, 6 mmol) was dissolved in 20 mL dichloromethane. Thesolution was chilled in an ice-water bath prior to the addition of diethylazodicarboxylate(949 i, 6 mmol). The reaction was then stirred overnight, and the ice-water bath slowlywarmed to room temperature. Crude product was purified by flash chromatography toyield 640 mg crystalline solid. ]H NMR (400 MHz, DMSO-d6) 5 8.1 (d), 7.6 (m), 7.47-7.41 (m), 7.34 (m), 7.17 (m), 4.39 (t, 2H), 3.13 (t, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 37729-18-3, 2-([1,1′-Biphenyl]-4-yl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PRAECIS PHARMACEUTICALS, INC.; WO2006/20951; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 37729-18-3, name is 2-([1,1′-Biphenyl]-4-yl)ethanol. A new synthetic method of this compound is introduced below., Quality Control of 2-([1,1′-Biphenyl]-4-yl)ethanol

4-Biphenylethanol (see Kawasaki et al., Tetrahedron: Asymmetry 2001, 12, 585-596) (1.47 g, 7.41 mmol) and CBr4 (1.12 equiv) were dissolved in CH2Cl2 (25 mL), the mixture was cooled to 0 C and triphenylphosphine (1.1 equiv) was added in small portions. The reaction mixture was warmed at room temperature and stirred for 1 h before the solvent was removed in vacuo. Flash chromatography (0-5% EtOAc-hexanes) yielded 4-(2-bromoethyl)biphenyl (1.59 g, 82%). The title compound was prepared from S7 (55 mg, 0.27 mmol) and 4-(2-bromoethyl)biphenyl (280 mg, 1.07 mmol) by using general procedure D. Flash chromatography (SiO2, 1.5 x 18 cm, 50-100% EtOAc-hexanes) afforded the title compound (38 mg, 40%) as a white solid: 1H NMR (CDCl3, 500 MHz) delta 8.84 (dd, IH, J = 0.7, 4.7 Hz), 8.29 (d, IH, J = 7.9 Hz), 7.92 (dt, IH, J = 1.7, 7.8 Hz), 7.57 (m, 2H), 7.53 (m, 3H), 7.42 (t, 2H, J = 7.7 Hz), 7.33 (m, 3H), 3.60 (t, 2H, J = 7.5 Hz), 3.19 (t, 2H, J = 7.5 Hz); 13C NMR (CDCl3, 150 MHz) delta 186.2, 165.3, 161.3, 150.9, 142.7, 141.0, 139.6, 139.0, 137.5, 129.0, 128.9, 127.5, 127.3, 127.2, 126.9, 124.2, 41.7, 29.1 ; HRMS-ESI-TOF m/z 356.1392 ([M+H]+, C22H17N3O2 requires 356.1393).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 37729-18-3, 2-([1,1′-Biphenyl]-4-yl)ethanol.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; BOGER, Dale, L.; WO2010/5572; (2010); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts