Category: 3685-27-6

Ling, Xiujun; Wilcox, Craig S. published the artcile< A Molecular Torsion Balance Study: A Nearby Anionic Group Exerts Little Influence on Hydrophobic Interactions between Nonpolar Surfaces>, Reference of 3685-27-6, the main research area is mol torsion balance folding free energy; hydrophobic interaction; lipophilicity; non-covalent interactions; polarity; protein folding.

Polar groups have a solvent ordering effect on water and therefore may affect hydrophobic binding energies for nearby lipophilic surfaces. This would mean that determinations of excess surface free energy association energies require consideration of nearby polar functional groups. This paper reports results of a study to measure this possible effect. It was concluded from the models used here that an anionic polar group nearby a hydrophobic surface has little or no effect on the magnitude of hydrophobic association

Chemistry – A European Journal published new progress about Biaryls Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3685-27-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H14O2, Reference of 3685-27-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ling, Xiujun; Wilcox, Craig S. published the artcile< A Molecular Torsion Balance Study: A Nearby Anionic Group Exerts Little Influence on Hydrophobic Interactions between Nonpolar Surfaces>, Reference of 3685-27-6, the main research area is mol torsion balance folding free energy; hydrophobic interaction; lipophilicity; non-covalent interactions; polarity; protein folding.

Polar groups have a solvent ordering effect on water and therefore may affect hydrophobic binding energies for nearby lipophilic surfaces. This would mean that determinations of excess surface free energy association energies require consideration of nearby polar functional groups. This paper reports results of a study to measure this possible effect. It was concluded from the models used here that an anionic polar group nearby a hydrophobic surface has little or no effect on the magnitude of hydrophobic association

Chemistry – A European Journal published new progress about Biaryls Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3685-27-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H14O2, Reference of 3685-27-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 3685-27-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3685-27-6, name is trans-4-(Hydroxymethyl)cyclohexanol. This compound has unique chemical properties. The synthetic route is as follows.

176b) (1 r,4r)-4-((3-Bromophenoxy)methyl)cyclohexanol A solution of 3-bromophenol (2 g, 1 1 .56 mmol), triphenylphosphine (3.03 g, 1 1 .56 mmol) and (1 r,4r)-4-(hydroxymethyl)cyclohexanol (2.5 g, 19.20 mmol) in tetrahydrofuran (THF) (150 mL) was added DIAD (2.70 mL, 1 3.87 mmol) in tetrahydrofuran (THF) (150 mL) slowly under nitrogen at 25 C. The reaction mixture was stirred at 25 C for 16 h. The reaction mixture was concentrated. The crude product was purified on silica gel chromatography (hexane:ethyl acetate = 4:1 ) to provide the title compound (1 r,4r)-4-((3- bromophenoxy)methyl)cyclohexanol (1 .2 g, 2.1 04 mmol, 18.20 % yield) as an oil. 1 H NMR (500 MHz, DMSO) delta 7.22 (t, J = 8.1 Hz, 1 H), 7.14 – 7.06 (m, 2H), 6.98 – 6.88 (m, 1 H), 4.52 (d, J = 4.4 Hz, 1 H), 3.90 – 3.73 (m, 2H), 1 .91 – 1 .75 (m, 4H), 1 .06 (dd, J = 1 8.7, 8.5 Hz, 2H), 0.84 (ddd , J = 1 3.0, 7.7, 4.6 Hz, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3685-27-6, trans-4-(Hydroxymethyl)cyclohexanol.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ASTEX THERAPEUTICS LIMITED; CALLAHAN, James Francis; KERNS, Jeffrey K.; LI, Peng; LI, Tindy; MCCLELAND, Brent W.; NIE, Hong; PERO, Joseph E.; DAVIES, Thomas Glanmor; GRAZIA CARR, Maria; GRIFFITHS-JONES, Charlotte Mary; HEIGHTMAN, Thomas Daniel; NORTON, David; VERDONK, Marinus Leendert; WOOLFORD, Alison Jo-Anne; WILLEMS, Hendrika Maria Gerarda; (664 pag.)WO2017/60854; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts