Category: 3637-61-4

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3637-61-4, name is Cyclopentanemethanol, molecular formula is C6H12O, molecular weight is 100.16, as common compound, the synthetic route is as follows.category: alcohols-buliding-blocks

General procedure: The PBr3 (1.5 equiv) was added to a solution of alkyl alcohol (1.0equiv) in anhydrous tetrahydrofuran (5.0 mL) at 0 C and then theice bath was removed and the reaction mixture was further stirredat room temperature for 5 h. Water (30.0 mL) was added and thenextracted with EtOAc, the combined organic extracts were driedwith Na2SO4, and the solvent was evaporated in vacuo to get titlecompound, suitable for the next step without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3637-61-4, Cyclopentanemethanol, and friends who are interested can also refer to it.

Reference:
Article; Chen, Ying; Wu, Bolin; Hao, Yameng; Liu, Yunqi; Zhang, Zhili; Tian, Chao; Ning, Xianling; Guo, Ying; Liu, Junyi; Wang, Xiaowei; European Journal of Medicinal Chemistry; vol. 171; (2019); p. 420 – 433;,
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Related Products of 3637-61-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3637-61-4, name is Cyclopentanemethanol. A new synthetic method of this compound is introduced below.

A solution of triphenylphosphine (28.80 g, 109.8 mmol) and imidazole (14.9 g, 219.6 mmol) in methylene chloride (160 mL) was cooled to 0 C. and then slowly treated with iodine (27.87 g, 109.8 mmol). The reaction mixture was then treated dropwise with a solution of cyclopentylmethanol (10.00 g, 99.8 mmol) in methylene chloride (10 mL). The resulting reaction mixture was allowed to warm to 25 C. where it was stirred for for 4 h. The reaction mixture was then diluted with water (50 mL), and the reaction mixture was further extracted with methylene chloride (3*20 mL). The combined organic layers were dried over sodium sulfate, filtered, and concentrated in vacuo at 25 C. The resulting solid was washed with pentane (4*50 mL) and filtered through a silica gel plug. The filtrate was concentrated in vacuo at 25 C. to afford iodomethylcyclopentane (18.48 g, 88%) as a clear colorless liquid: EI-HRMS m/e calcd for C6H11I (M+) 209.9906, found 209.9911.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3637-61-4, Cyclopentanemethanol, and friends who are interested can also refer to it.

Reference:
Patent; Hoffman-La Roche Inc.; US6610846; (2003); B1;,
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Reference of 3637-61-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3637-61-4, name is Cyclopentanemethanol. This compound has unique chemical properties. The synthetic route is as follows.

Cyclopentanemethanol (263 muL, 2.5 mmol, 5 eq) was added to a suspension of NaH (98 mg, 2.5 mmol, 5 eq) in THF (5 mL) at 0C. The reaction was stirred at 0C for 30 min and 6-(6-bromopyridin-2-yl)-3-[(2-chloro-4-fluorophenyl)sulfanyl]-6-(thiophen- 3-yl)piperidine-2,4-dione (250 mg, 0.49 mmol, 1 eq) was added. The reaction was then stirred overnight under reflux and quenched by the addition of water (10 mL) and HC1 1 M (5 mL). The aqueous phase was extracted with ethyl acetate (3 x 15 mL) and the combined organic phases were dried with Na2S04, filtered and concentrated under reduced pressure. The crude product was purified by flash chromatography on silica gel (eluent: heptane/ ethyl acetate: 75/25) to give 3-[(2-chloro-4- fluorophenyl)sulfanyl]-6-[6-(cyclopentylmethoxy)pyridin-2-yl]-6-(thiophen-3- yl)piperidine-2,4-dione (192 mg, 0.36 mmol) in 74 % yield. 1H NMR (MeOD-d4, 400 MHz): delta = 7.71 (dd, J= 8.0, 7.6 Hz, 1H), 7.44 (dd, J= 8.8, 7.2 Hz, 1H), 7.27 (dd,J=2.8, 1.2 Hz, 1H), 7.15-7.11 (m, 2H), 7.09 (dd,J=4.8, 2.8 Hz, 1 H), 6.75 (d, J= 8.4 Hz, 1 H), 6.54 (td, J= 8.4, 2.8 Hz, 1H), 5.99 (dd, J= 8.8, 6.0 Hz, 1H), 4.27-4.18 (m, 2H), 3.87 (d,J= 16.4 Hz, 1H), 3.45 (d,J = 16.4 Hz, 1H), 2.36-2.28 (m, 1H), 1.83-1.74(m, 2H), 1.66-1.53 (m, 4H), 1.39-1.29 (m, 2H). I C NMR (MeOD-d4, 100 MHz): delta = 166.9, 161.6, 158.6 (d,J= 245 Hz), 157.2, 143.5, 138.2, 130.7 (d, J = 4 Hz), 124.8 (d,J= 8.5 Hz), 124.7, 124.5, 120.1, 114.7 (d, J=25 Hz), 112.3 (d,J=21 Hz), 111.8, 108.0, 100.0,68.3,59.3,39.1,37.3,27.5, 23.4.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3637-61-4, Cyclopentanemethanol.

Reference:
Patent; ARCTIC PHARMA AS; GOLDING, Louise; KLAVENESS, Jo; SIENG, Bora; LUNDVALL, Steffi; BØEN, Claudia Alejandra; HNIDA, Kathrin; (128 pag.)WO2018/211277; (2018); A1;,
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Reference of 3637-61-4 ,Some common heterocyclic compound, 3637-61-4, molecular formula is C6H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

lodomethylcyclopentane; Methanesulfonyl chloride (13.8 ml_, 178 mmol) was added drop wise and at 0 C to a solution of cyclopentanemethanol (16.2 g, 162 mmol) in anhydrous pyridine (35 ml_). The mixture was stirred at 0C for 5 h, poured into water (200 ml_), and extracted with methylene chloride (3 x 50 ml_). The combined organic layers were washed with 1 M HCI (3 x 20 ml_) and brine (2 x 20 ml_), dried with anhydrous magnesium sulphate, and evaporated in vacuo. The residue was dissolved in anhydrous acetone (20 ml_), and a solution of sodium iodide (24 g, 162 mmol) in acetone (50 ml_) was added. The mixture was refluxed for EPO 5 h. The formed precipitate was filtered off, and the filtrate was evaporated in vacuo. The residue was distilled and the fraction boiling at 71 -75 C (1 10 Torr) was collected to give iodomethylcyclopentane. Yield: 13.8 g (41 %). 1H-NMR (CDCI3, delta ppm): 3.21 (d, J=6.9 Hz, 2 H); 2.18 (hept, J=7.5 Hz, 1 H); 1.95-1.45 (m, 6 H); 1.35- 1.11 (m, 2 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3637-61-4, its application will become more common.

Reference:
Patent; NOVO NORDISK A/S; WO2006/58923; (2006); A1;,
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Application of 3637-61-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3637-61-4, name is Cyclopentanemethanol, molecular formula is C6H12O, molecular weight is 100.16, as common compound, the synthetic route is as follows.

REFERENCE EXAMPLE 13 STR43 Methanesulfonyl chloride (1.52 g) was added dropwise to a solution of 1.11 g of cyclopentanemethanol and 1.50 g of triethylamine in 30 ml of dichloromethane with cooling on an ice bath over 5 minutes. The reaction mixture was stirred at room temperature for 30 minutes and then washed in sequence with three portions of water and one portion of saturated aqueous solution of sodium chloride. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 2.06 g of cyclopentanemethyl methanesulfonate. NMR (CDCl3) delta: 1.1~1.9 (8H), 2.1~2.5 (1H, m), 2.02 (3H, s), 4.13 (2H, d, J=7 Hz), MS: m/z 178 (M+) STR44

The chemical industry reduces the impact on the environment during synthesis 3637-61-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Yamanouchi Pharmaceutical Co., Ltd.; US4987132; (1991); A;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3637-61-4, name is Cyclopentanemethanol, molecular formula is C6H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: alcohols-buliding-blocks

1 ,3-Dibromo-5-cyclopentylmethoxy-benzene. [00479] 3,5-Dibromophenol (5.0 g; 19.8 mmol), cyclopentane-methanol (2.0 g; 19.9 mmol) and tributylphosphine (8.8 mL; 35.7 mmol) were dissolved in dry THF (250 mL) in a dried reaction flask under an atmosphere of nitrogen. l,l’-(Azodicarbonyl)dipiperidine (9.01 g; 35.7 mmol) dissolved in dry THF (150 mL) was added to the reaction mixture, which was EPO stirred at room temperature for 16 hours. The reaction mixture was filtered, evaporated to dryness and purified by flash chromatography (heptane – > ethyl acetate: heptane 2:3). Yield: 5.68 g; 86 %.

With the rapid development of chemical substances, we look forward to future research findings about 3637-61-4.

Reference:
Patent; NOVO NORDISK A/S; WO2007/3581; (2007); A1;,
Alcohol – Wikipedia,
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Related Products of 3637-61-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3637-61-4, name is Cyclopentanemethanol, molecular formula is C6H12O, molecular weight is 100.16, as common compound, the synthetic route is as follows.

cyclopentane methanol (119a) (500 mg) was dissolved in pyridine (5 mL), under ice cooling, added TsCl (1.43 g), and the reaction was stirred at room temperature for 36 hours. After concentrating the solvent under reduced pressure, the residue ethyl acetate(50 mL) was added to the organic layer saturated aqueous sodium hydrogen carbonate solution (50 mL), washed with saturated brine (50 mL), and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reducedpressure, the residue was purified by silica gel flash column chromatography (developing solvent nhexane:ethyl acetate =50: 1) to obtain a colorless cyclopentylmethyl tosylate (120a) (864 mg, 68% yield) to give an oil.

Statistics shows that 3637-61-4 is playing an increasingly important role. we look forward to future research findings about Cyclopentanemethanol.

Reference:
Patent; Nagoya City University; Miyata, Naoki; Suzuki, Takayoshi; Ota, Yosuke; Ueda, Ryuzo; Ida, Shinsuke; Rie, Masaki; (47 pag.)JP5725475; (2015); B2;,
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Related Products of 3637-61-4, Adding some certain compound to certain chemical reactions, such as: 3637-61-4, name is Cyclopentanemethanol,molecular formula is C6H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3637-61-4.

Synthesis of methyl 3-(4-cyclopentylmethyloxyphenyl)Propionate (Intermediate 2) (Step e-1) A solution of cyclopentane-methanol (4.05 ml, Ald) in anhydrous tetrahydrofuran (henceforth abbreviated as “THF”, 40 ml) was added with triethylamine (6.49 ml, WAKO), added dropwise with methanesulfonyl chloride (3.48 ml, WAKO) under ice cooling and stirred for 30 minutes.The reaction mixture was added with water (50 ml) and extracted with diethyl ether (80 ml*2).The organic layer was washed with saturated brine and dried, and then the solvent was evaporated under reduced pressure.A solution obtained beforehand by adding 60% sodium hydride (1.15 g, KANTO) to a solution of Intermediate 1 (4.50 g) in N,N-dimethylformamide (henceforth abbreviated as “DMF”, 35 ml) and stirring the mixture for 15 minutes under ice cooling was added with a solution of the aforementioned residue in DMF (10 ml) under ice cooling.The reaction mixture was stirred for 15 minutes, warmed to room temperature, then stirred for 45 minutes and further stirred at 60 C. for 15 hours.The reaction mixture was added with water (100 ml) and diethyl ether (200 ml) for extraction.The organic layer was washed successively with saturated aqueous sodium hydrogencarbonate, saturated aqueous ammonium chloride and saturated brine and dried, and the solvent was evaporated under reduced pressure.The residue was purified by flash column chromatography (hexane:isopropyl ether=9:1) to obtain the title compound (Intermediate 2, 5.58 g).

According to the analysis of related databases, 3637-61-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shoda, Motoshi; Kuriyama, Hiroshi; US2004/44258; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3637-61-4, name is Cyclopentanemethanol, molecular formula is C6H12O, molecular weight is 100.16, as common compound, the synthetic route is as follows.Safety of Cyclopentanemethanol

To a suspension of NaH (61 mg, 1,5 mmol) in THE (3 mL) at 0C cyclopentanemethanol (0.16 mL, 1 .5 mmol) was added. After 30 mm at 0C, 6-(6- hromopyridin-2-yl)-3 -((2-chlorophenyl)thio)-6-(thiophen-3-yl)piperidine-2,4-dione (150 mg, 0.30 mmol) was added and the reaction mixture was stirred for 1 8 hr at reflux. The reaction was stopped by the addition of water (10 mL) and HC1 1M (3 mL). The aqueous phase was extracted with ethyl acetate (3 x 10 mL) and the combined organic phases were dried over Na2SO4, filtered and concentrated under reduced pressure. The crude material was purified by flash column chromatography (Si02, heptane/ethyl acetate: 8/2 to 7/3 to 1/1) to give 3-((2-chlorophenyl)thio)-6-(6- (cyclopentylmethoxy)pyridin-2-yl)-6-(thiophen-3 -yl)piperidine-2,4-dione in 62 % yield.?H NMR (400 MHz, MeOH-d4): 6 7.70 (t, J= 7.8 T-Iz, 1H), 7.43 (dd, J 5.0, 3.0 Hz, IH), 7.28 (br s, 1H), 7.22 (d, J= 7.9 HZ, 1H), 7.15-7.12 (m, 2H), 6.94 (t, J 7.8 Hz, IH), 6.77-6.73 (m, 2H), 5.98 (d, J= 8.0 Hz, 1H), 4.22 (m, 2H9, 3.91 (d, J 16.4 Hz, IH), 3.45 (d, .1= 16.4 Hz, IH), 3.45 (s, IH), 2.35-2.28 (m, lI-I), 1.82-1.73 (m, 2H), 1.64-1.51 (m, 4H), 1.38-1.30 (m, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3637-61-4, Cyclopentanemethanol, and friends who are interested can also refer to it.

Reference:
Patent; SPERMATECH AS; GOLDING, Louise; SIENG, Bora; LUNDVALL, Steffi; BØEN, Claudia Alejandra; HNIDA, Kathrin; (68 pag.)WO2018/211276; (2018); A1;,
Alcohol – Wikipedia,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3637-61-4, name is Cyclopentanemethanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of Cyclopentanemethanol

Synthesis of methyl 3- (4-CYCLOPENTYLMETHYLOXYPHENYL) propionate (Intermediate 2); A solution of cyclopentane methanol (4.05 ml, Ald) in anhydrous tetrahydrofuran (abbreviated as”THF”hereinafter, 40 ml) was added with triethylamine (6.49 ml, WAKO), added dropwise with methanesulfonyl chloride (3.48 ml, WAKO) under ice cooling, and stirred for 30 minutes. The reaction mixture was added with water (50 ml), and extracted with diethyl ether (80 ml X 2). The organic layer was washed with saturated brine and dried, and then the solvent was evaporated under reduced pressure. A solution obtained beforehand by adding 60% sodium hydride (1.15 g, KANTO) to a solution of Intermediate 1 (4.50 g) in N, N-dimethylformamide (abbreviated as”DMF”hereinafter, 35 ml) under ice cooling and stirring the solution for 15 minutes was added with a solution of the aforementioned residue in DMF (10 ml) under ice cooling. The reaction mixture was stirred for 15 minutes, then warmed to room temperature, stirred for 45 minutes, and further stirred at 60C for 15 hours. The reaction mixture was added with water (100 ML) and diethyl ether (200 ml) for extraction. The organic layer was successively washed with saturated aqueous sodium hydrogencarbonate, saturated aqueous ammonium chloride, and saturated brine and dried, and then the solvent was evaporated under reduced pressure. The residue was purified by flash column chromatography (hexane : isopropyl ether = 9: 1) to obtain the title compound (Intermediate 2,5. 58 G).

With the rapid development of chemical substances, we look forward to future research findings about 3637-61-4.

Reference:
Patent; ASAHI KASEI PHARMA CORPORATION; WO2005/16862; (2005); A1;,
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