Category: 35564-86-4

Ugawa, Tohru; Kurihara, Kenzo published the artcile< Enhancement of canine taste responses to umami substances by salts>, Category: alcohols-buliding-blocks, the main research area is taste umami substance dog salt type; MSG taste dog salt type; GMP taste dog salt type.

The effects of salts on canine taste responses to umami substances were examined by recording the activity of the chorda tympani nerve. The responses to monosodium glutamate (MSG), disodium 5′-guanylate (GMP), and that induced by the synergism between MSG and GMP were enhanced by the presence of various salts. The effective salts were those carrying inorganic cations such as Na, K, and Mg, while CaCl2 had no enhancing effect. Salts carrying organic cations such as tris(hydroxymethyl)aminomethane (Tris), choline, N-methyl-D-glucamine, and 1,3-bis[tris(hydroxymethyl)methylamino]propane also produced pos. results. The dependence of the umami responses on NaCl and MgCl2 concentrations showed a bell-shaped response curve with the maximal enhancing effect being seen at 100 mM NaCl and 3-10 mM MgCl2. The degree of the enhancement depended not only on the species of the cation, but also on that of anion. For example, 100 mM NaCl showed a much larger enhancing effect than Na phosphate, Na2SO4, and Na4Fe(CN)6 at equimolar Na. The enhancing effects of salts on the responses to the umami substances could not be simply explained in terms of the permeability of cation and anion of salts. It was speculated that the binding of both cations and anions to the receptor membranes leads to changes in the interaction of the umami substances with the receptor proteins.

American Journal of Physiology published new progress about Canis familiaris. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Schulz, Patrick; Dueck, Benjamin; Mourot, Alexandre; Hatahet, Lina; Fendler, Klaus published the artcile< Measuring ion channels on solid supported membranes>, Reference of 35564-86-4, the main research area is measurement ion channel solid supported membrane.

Application of solid supported membranes (SSMs) for the functional investigation of ion channels is presented. SSM-based electrophysiol., which has been introduced previously for the investigation of active transport systems, is expanded for the anal. of ion channels. Membranes or liposomes containing ion channels are adsorbed to an SSM and a concentration gradient of a permeant ion is applied. Transient currents representing ion channel transport activity are recorded via capacitive coupling. The authors demonstrate the application of the technique to liposomes reconstituted with the peptide cation channel gramicidin, vesicles from native tissue containing the nicotinic acetylcholine receptor, and membranes from a recombinant cell line expressing the ionotropic P2X2 receptor. It is shown that stable ion gradients, both inside as well as outside directed, can be applied and currents are recorded with an excellent signal/noise ratio. For the nicotinic acetylcholine receptor and the P2X2 receptor excellent assay quality factors of Z’ = 0.55 and Z’ = 0.67, resp., are obtained. This technique opens up new possibilities in cases where conventional electrophysiol. fails like the functional characterization of ion channels from intracellular compartments. It also allows for robust fully automatic assays for drug screening.

Biophysical Journal published new progress about Adsorption. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Reference of 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lasser, Elliott C.; Walters, Alton; Reuter, Stewart R.; Lang, Joseph published the artcile< Histamine release by contrast media>, HPLC of Formula: 35564-86-4, the main research area is histamine release contrast media; methylglucamines contrast media allergy.

Close arterial injections of x-ray contrast media into dogs increased plasma histamine (I) [51-45-6] levels in blood draining the liver or lungs. I levels were increased by injections of methylglucamine acetrizoate [22154-43-4], methylglucamine diatrizoate [131-49-7], or methylglucamine iodipamide [3521-84-4]. The Na salts of the contrast media showed much less histamine-releasing activity than the methylglucamine salts. Methylglucamine chloride [6284-40-8] also elevated plasma I. It is suggested that some allergic reactions to contrast media are mediated by I release.

Radiology (Oak Brook, IL, United States) published new progress about Allergy. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, HPLC of Formula: 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lasser, Elliott C.; Walters, Alton J.; Lang, Joseph H. published the artcile< Experimenatal basis for histamine release in contrast material reactions>, Application of C7H18ClNO5, the main research area is contrast media histamine release; methylglucamine histamine release.

Perfusion of the canine liver or lung with methylglucamine contrast media or with methylglucamine chloride [35564-86-4] increased plasma histamine [51-45-6] levels. The sodium salts of the contrast media were less effective than the methylglucamine salts, indicating an important role for the methylglucamine ion in histamine release. A threshold effect for contrast media-induced release of histamine was indicated, as well as a potentiating effect for sequential injections. Prolonged injection of a given quantity of contrast media resulted in greater histamine release than did rapid injections.

Radiology (Oak Brook, IL, United States) published new progress about Liver. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Application of C7H18ClNO5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lasser, Elliott C.; Walters, Alton; Reuter, Stewart R.; Lang, Joseph published the artcile< Histamine release by contrast media>, HPLC of Formula: 35564-86-4, the main research area is histamine release contrast media; methylglucamines contrast media allergy.

Close arterial injections of x-ray contrast media into dogs increased plasma histamine (I) [51-45-6] levels in blood draining the liver or lungs. I levels were increased by injections of methylglucamine acetrizoate [22154-43-4], methylglucamine diatrizoate [131-49-7], or methylglucamine iodipamide [3521-84-4]. The Na salts of the contrast media showed much less histamine-releasing activity than the methylglucamine salts. Methylglucamine chloride [6284-40-8] also elevated plasma I. It is suggested that some allergic reactions to contrast media are mediated by I release.

Radiology (Oak Brook, IL, United States) published new progress about Allergy. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, HPLC of Formula: 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lasser, Elliott C.; Walters, Alton J.; Lang, Joseph H. published the artcile< Experimenatal basis for histamine release in contrast material reactions>, Application of C7H18ClNO5, the main research area is contrast media histamine release; methylglucamine histamine release.

Perfusion of the canine liver or lung with methylglucamine contrast media or with methylglucamine chloride [35564-86-4] increased plasma histamine [51-45-6] levels. The sodium salts of the contrast media were less effective than the methylglucamine salts, indicating an important role for the methylglucamine ion in histamine release. A threshold effect for contrast media-induced release of histamine was indicated, as well as a potentiating effect for sequential injections. Prolonged injection of a given quantity of contrast media resulted in greater histamine release than did rapid injections.

Radiology (Oak Brook, IL, United States) published new progress about Liver. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Application of C7H18ClNO5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rodighiero, S.; De Simoni, A.; Formenti, A. published the artcile< The voltage-dependent nonselective cation current in human red blood cells studied by means of whole-cell and nystatin-perforated patch-clamp techniques>, Synthetic Route of 35564-86-4, the main research area is cation current erythrocyte cell nystatin perforated patch clamp.

Human red blood cells (RBC) can be studied by means of whole-cell and nystatin-perforated patch-clamp techniques. In 85% of the whole-cell experiments (n=86) and 69% of the perforated-patch recordings (n=13), steps to pos. potentials, from a holding potential of 0 mV, induced a slow-activating non-inactivating persistent outward current which reverted at about 0 mV. The current activation phase fitted well with a two-component exponential curve. Half-maximal conductance was reached at about 42 mV. Na+ and K+ carried this current, which was not affected by 20 nM charybdotoxin or 20 mM TEA, but was reduced following a partial substitution of extracellular Cl- by tartrate. This current has characteristics similar to the single-channel currents already described in RBC and may be involved in the rapid adaptations of these cells in the circulation.

Biochimica et Biophysica Acta, Biomembranes published new progress about Bioelectric conductivity. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Synthetic Route of 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Zheng; Yu, Haijie; Huang, Junhao; Faouzi, Malika; Schmitz, Carsten; Penner, Reinhold; Fleig, Andrea published the artcile< The TRPM6 Kinase Domain Determines the Mg·ATP Sensitivity of TRPM7/M6 Heteromeric Ion Channels>, Recommanded Product: N-Methyl-D-glucamine Hydrochloride, the main research area is TRPM6 kinase magnesium ATP TRPM7 heteromer ion channel human; Magnesium; Metabolic Regulation; Protein Complexes; Protein Kinases; TRP channels.

The transient receptor potential melastatin member 7 (TRPM7) and member 6 (TRPM6) are divalent cation channel kinases essential for magnesium (Mg2+) homeostasis in vertebrates. It remains unclear how TRPM6 affects divalent cation transport and whether this involves functional homomeric TRPM6 plasma membrane channels or heteromeric channel assemblies with TRPM7. We show that homomeric TRPM6 is highly sensitive to intracellular free Mg2+ and therefore unlikely to be active at physiol. levels of [Mg2+]i. Co-expression of TRPM7 and TRPM6 produces heteromeric TRPM7/M6 channels with altered pharmacol. and sensitivity to intracellular Mg·ATP compared with homomeric TRPM7. Strikingly, the activity of heteromeric TRPM7/M6 channels is independent of intracellular Mg·ATP concentrations, essentially uncoupling channel activity from cellular energy status. Disruption of TRPM6 kinase phosphorylation activity re-introduces Mg·ATP sensitivity to the heteromeric channel similar to that of TRPM7. Thus, TRPM6 modulates the functionality of TRPM7, and the TRPM6 kinase plays a critical role in tuning the phenotype of the TRPM7·M6 channel complex.

Journal of Biological Chemistry published new progress about Biological cation transport. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Recommanded Product: N-Methyl-D-glucamine Hydrochloride.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jowett, Laura A.; Howe, Ethan N. W.; Soto-Cerrato, Vanessa; Van Rossom, Wim; Perez-Tomas, Ricardo; Gale, Philip A. published the artcile< Indole-based perenosins as highly potent HCl transporters and potential anti-cancer agents>, Quality Control of 35564-86-4, the main research area is breast cancer perenosin hydrogen chloride transporter anticancer cytotoxicity.

Prodigiosin is one of the most potent anion transporters in lipid bilayer membranes reported to date. Inspired by the structure of this natural product, we have recently designed and synthesized a new class of H+/Cl- cotransporters named ‘perenosins’. Here we report a new library of indole-based perenosins and their anion transport properties. The new transporters demonstrated superior transmembrane transport efficiency when compared to other indole-based transporters, due to favorable encapsulating effects from the substituents on the perenosin backbone. Anion transport assays were used to determine the mechanism of chloride transport revealing that the compounds function as ‘strict’ HCl cotransporters. Cell viability studies showed that some compounds specifically trigger late-onset cell death after 72 h with a unique correlation to the position of alkyl chains on the perenosins. Further investigations of cell death mechanism showed a mixture of cell cycle arrest and apoptosis was responsible for the observed decrease in cell viability.

Scientific Reports published new progress about Antitumor agents. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Quality Control of 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Labarthe, Benoit; Idee, Jean-Marc; Burnett, Roger; Corot, Claire published the artcile< In Vivo Comparative Antithrombotic Effects of Ioxaglate and Iohexol and Interaction With the Platelet Antiaggregant Clopidogrel>, Synthetic Route of 35564-86-4, the main research area is ionic nonionic contrast media antithrombotic interaction clopidogrel.

RATIONALE AND OBJECTIVES. Experiments were designed to (1) compare the effects of iodinated contrast media (CM) on a rat model of arterial thrombosis, (2) evaluate which element of the ioxaglate solution supports its antithrombotic activity, and (3) investigate the interaction of ionic and non-ionic CM with the antiplatelet agent clopidogrel. MATERIALS AND METHODS. Carotid thrombosis was induced in rats by extravascular application of a filter paper soaked in FeCl (35% vol/wt), proximal to an ultrasonic flow probe. (1) The antithrombotic potential of low-osmolar ionic (ioxaglate Na/meglumine) or nonionic contrast media (iohexol and iodixanol) (all 1600 mg iodine/kg, IV) was assessed by measuring the time to occlusion (TTO) of the carotid artery and the thrombus weight (TW). (2) Isotonic saline and iso-osmolar (280 mOsm/kg) and hyperosmolar (560 mOsm/kg) solutions of meglumine hydrochloride, meglumine ioxaglate (560 mOsm/kg), sodium ioxaglate (600 mOsm/kg) and sodium and meglumine ioxaglate (com. solution) were tested under similar conditions. (3) Interaction with clopidogrel was tested by injecting lower dose of CM (960 mg iodine/kg) 2 h after clopidogrel (2 mg/kg per os). RESULTS: (1) Ioxaglate prolonged TTO when compared with saline (30.0 ± 1.1 min vs. 19.6 ± 2.4 min, <0.001), whereas iohexol had no effect (21.3 ± 1.3 min). Ioxaglate's effect was associated with a reduction in TW with ioxaglate vs. saline (2.6 ± 0.4 mg and 4.7 ± 0.7 mg, resp., <0.05) whereas TW remained unchanged in the iohexol group (4.2 ± 0.4 mg). The nonionic dimer iodixanol induced a direct vasoconstrictor effect on the carotid artery and was consequently excluded from the study. (2) Neither iso-osmolar nor hyperosmolar solutions of meglumine had any effect on TTO whereas both sodium and meglumine salts of ioxaglic acid prolonged TTO, suggesting that the antithrombotic effect of ioxaglate is mediated by the ioxaglic acid moiety alone as neither meglumine, osmolality or sodium played a significant role. (3) A synergistic effect on TTO was found when ioxaglate was associated with clopidogrel whereas no such effect was observed with iohexol. CONCLUSIONS: These data show a greater in vivo antithrombotic potential for the ionic contrast medium ioxaglate than for the non-ionic contrast medium iohexol and, for the first time, a synergistic effect between a contrast medium and a platelet antiaggregant drug in vivo. Investigative Radiology published new progress about Anticoagulants. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Synthetic Route of 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts