Category: 355-80-6

355-80-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol. A new synthetic method of this compound is introduced below.

General rocedure: 5.5 ml of aq. solutions of KBr (0.55 mol/dm3), 20 ml MeCN, TEMPO (0.12 g, 0.00077 mol), and 2,2,3-trifluoro-3-(1,1,2,2,3,3-hexafluoro-3-trifluoromethoxy-propoxy)-propan-1-ol (2a) (10 g, 0.0275 mol) were placed in the flask. 14% aq. NaOCl (48 ml) buffered by NaHCO3 (5.2 g) were added via the dropping funnel in 3 portions during two days of stirring in a room temperature (slight exothermic effect). The progress of reaction was monitored by 19F NMR spectroscopy. Then concentrated sulfuric acid followed by water was added. After extraction with diethyl ether, the organic phases were dried over magnesium sulfate. The solvent was evaporated to give a colorless liquid, which was distilled.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, and friends who are interested can also refer to it.

Reference:
Article; Ignatowska, Jolanta; Shyshkov, Oleg; Zipplies, Tilman; Hintzer, Klaus; Roeschenthaler, Gerd-Volker; Journal of Fluorine Chemistry; vol. 141; (2012); p. 35 – 40;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, molecular formula is C5H4F8O, molecular weight is 232.0719, as common compound, the synthetic route is as follows.355-80-6

To a solution of freshly distilled pyridine (0.35 mL, 4.35 mmol) in 2,2,3,3,4,4,5,5-octafluoropentanol (8 mL, 0.06 mol) was added 9H-fluorene-2,4,7-trisulfonyl trichloride 1 (0.50 g, 1.08 mmol). The reaction mass was heated for 1 h in an oil bath maintained at 90-100 C. After cooling, the resulting solution was diluted with 2-propanol (20 mL) and treated with concentrated hydrochloric acid (1 mL). A gel-like precipitate formed throughout the reaction volume. It was allowed to settle down, then filtered off, washed twice with 2-propanol (2 x 5 mL), and finally with water to give the crude product (0.86-0.87 g). It was dissolved in boiling 2-propanol (15 mL) and crystallized on standing. Yield 0.80-0.82 g (71-72%). Mp. 177.0-177.5 C. IR (KBr),?/cm-1: 3096, 1382, 1182, 1036, 803, 592. The filtrate was distilled with steam. The organic phase was then separated, washed with water, and fractionally distilled to regenerate the excess of octafluoropentanol. 1H NMR (Acetone-d6, 300 MHz), deltaH/ppm: 4.54 (2H, s, -CH2-), 4.94 (2H, t, J = 13.5 Hz, -OCH2-), 5.02 (2H, t, J = 13.8 Hz, -OCH2-), 5.05 (2H, t, J = 13.5 Hz, -OCH2-), 6.70 (1H, tt, J1 = 51.0 Hz, J2 = 5.4 Hz, -CHF2), 6.76 (2H, tt, J1 = 51.0 Hz, J2 = 5.4 Hz, -CHF2), 8.24 (1H, d, J = 8.4 Hz, Ar-H), 8.47 (1H, s, Ar-H), 8.69 (1H, s, Ar-H), 8.81 (1H, s, Ar-H), 8.92 (1H, d, J = 8.4 Hz, Ar-H). Found: C, 31.91; H,1.48; S, 9.02%; molecular formula C28H16F24O9S3 requires C, 32.07; H, 1.54; S, 9.17%.

Statistics shows that 355-80-6 is playing an increasingly important role. we look forward to future research findings about 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol.

Reference:
Article; Kurdyukova, Irina V.; Ishchenko, Alexander A.; Mysyk, Dmitriy D.; Dyes and Pigments; vol. 142; (2017); p. 201 – 211;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, molecular formula is C5H4F8O, molecular weight is 232.0719, as common compound, the synthetic route is as follows.355-80-6

EXAMPLE 4 2,2,3,3,4,4,5,5-Octafluoro-n-pentanol (11.6 g, 0.05 mol) and sodium metal (1.4 g, 0.05 mol) were added to 100 ml of dry ether and stirred at room temperature overnight. The solution obtained was added into a solution of 1,2-dichlorohexafluorocyclopentene (12.3 g, 0.05 mol) in 100 ml of dry ether. The reaction mixture was poured into 150 ml of ice water and an organic layer was separated. The aqueous layer was then extracted with 3 portions of 100 ml ether. Next, the extracts were combined with the separated organic layer and dried over sodium sulfate overnight. The desired 2-chlorohexafluorocyclopentyl 2,2,3,3,4,4,5,5-octafluoro-n-pentyl ether (38-42 C./0.3 mmHg) was obtained in 50% yield based on 1,2-dichlorohexafluorocyclopentene used by vacuum distillation.

Statistics shows that 355-80-6 is playing an increasingly important role. we look forward to future research findings about 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol.

Reference:
Patent; The Green Cross Corporation; US4686024; (1987); A;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, molecular formula is C5H4F8O, molecular weight is 232.0719, as common compound, the synthetic route is as follows.355-80-6

General procedure: To 100 mg compound 2 (0.54 mmol) suspended in 5 mL CH2Cl2 was added 0.5 mL oxalyl chloride (0.27 mmol) slowly. The mixturewas reacted under room temperature for 1 h. Solvent was distilled under reduced pressure, residue dissolved in 2 mL CH2Cl2 and dropwised to a mixture containing 0.6 mmol relevant ROH, 1.8 mmol triethylamine and 5 mL CH2Cl2. The mixture was reacted underroom temperature and monitored by TLC to the end of reaction, solvent distilled, residue recrystallization from ethyl acetate and hexane affords target compounds.

Statistics shows that 355-80-6 is playing an increasingly important role. we look forward to future research findings about 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol.

Reference:
Article; Du, Qing-Shan; Shi, Yan-Xia; Li, Peng-Fei; Zhao, Zhen-Jiang; Zhu, Wei-Ping; Qian, Xu-Hong; Li, Bao-Ju; Xu, Yu-Fang; Chinese Chemical Letters; vol. 24; 11; (2013); p. 967 – 969;,
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355-80-6, Adding a certain compound to certain chemical reactions, such as: 355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 355-80-6, blongs to alcohols-buliding-blocks compound.

General procedure: To a solution of the alcohol 2, 5 (1.48 mmol, 1 equiv) in Et2O/MeCN (3.7:1.23 mL, 3:1 v/v) in 0 C successively imidazole (4.43 g, 3 equiv) and triphenylphosphine (2.22 g, 1.5 equiv) were added. Iodine (2.22 g, 1.5 equiv) was added portionwise over 10-15 min. The solution was kept for a further 20 min at 0 C and then was allowed to warm up to rt overnight. The reaction mixture was diluted with Et2O (12 mLl) and washed with saturated aq Na2S2O3 (10 mL) and brine (2 x 10 mL). The organic layer was dried over Na2SO4 and solvent was removed under vacuum. Column chromatography hexane/EtOAc (1:1 v/v) gave pure product 14, 15. 1-iodo-2,2,3,3,4,4,5,5-octafluoropentane (14). Colorless liquid, yield 0.150 g (36%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,355-80-6, its application will become more common.

Reference:
Article; Tomaszewska, Joanna; Koroniak-Szejn, Katarzyna; Koroniak, Henryk; Arkivoc; vol. 2017; 2; (2016); p. 421 – 432;,
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