Category: 355-80-6

Application of 355-80-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of 64.7 mmol of organyl dichlorophosphite 3 in 150 mL of an organic solvent [diethyl ether (3a), dichloromethane(60 mL) (3b), hexane (3c, 3d)] was added dropwise with stirring a solution of 155 mmol of polyfluoroalkanol 4 or 5 and 155 mmol ( 15.7 g) of triethylamine in 30 mL of the corresponding solvent for 1-2 h at low temperature [-10-8C (3a, 3b), -30-25C (3c, 3d), dry ice-acetone]. The formation of a white precipitate of triethylamine hydrochloride was observed. The reaction mixture was stirred for 1-2 h at room temperature, argon was passed to remove HCl, and the mixture was kept overnight in the case of obtaining compounds 6a and 6b. The precipitate (triethylamine hydrochloride) was filtered off, washed (3 × 30 mL) with diethyl ether (3a) or hexane (3b-3d). Washings and the filtrate were combined, the solvents were distilled off under reduced pressure, and the residue was distilled in vacuum. To prevent symmetrization of the aryl bis(polyfluoroalkyl) phosphites 6c and 6d, the distillation flask was placed into a heated glycerin bath (100-120) and distillation was carried out rapidly.

According to the analysis of related databases, 355-80-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Arbuzova, S. N.; Belogorlova, N. A.; Bishimbayeva, G. K.; Chernysheva, N. A.; Gusarova, N. K.; Malysheva, S. F.; Nalibayeva, A. M.; Oparina, L. A.; Trofimov, B. A.; Verkhoturova, S. I.; Yas?ko, S. V.; Russian Journal of General Chemistry; vol. 90; 5; (2020); p. 839 – 844; Zh. Obshch. Khim.; vol. 90; 5; (2020); p. 744 – 750;,
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Reference of 355-80-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 355-80-6 as follows.

In a typical experiment, 5,10,15-tris(3-acetoxyphenyl)-20-(pentafluorophenyl)-porphyrin (60.0 mg, 68.2 mupiiotaomicronGamma) was dissolved in a dry DMSO/THF (4: 1) mixture under argon atmosphere, KOH (103.4 mg, 1.84 mmol) and lH, lH,5H-octafluoropentanol (342 ml, 2.46 mmol) were added and the reaction mixture stirred under room temperature for 30 minutes. After aqueous workup, extraction with ethyl acetate and drying with Na2SO/t, the crude product was purified by column cromatography (DCM/MeOH = 95:5) and recrystallized (DCM/hexane) to obtain a purple solid (58.4 mg, 60.5 mupiiotaomicron, 88%). 5,10,15-Tris(3-hydroxy-phenyl)-20-[2,3,5,6-tetra-fluoro-4-(lH,lH,5H-octafluoro- pentyloxy)-phenyl]-porphyrin ^-NMR (500 MHz, acetone-d6): delta = -2.78 (s, 2H, NH), 5.32 (t, J = 13.8 Hz, 2H, OCH2), 6.93 (tt, J = 50.9, 5.5 Hz, 3H, CF2H), 7.30-7.34 (m, 3H, Ar-H-6), 7.62 (mc, 1H, Ar H-5), 7.62 (mc, 2H, Ar2-H-5), 7.68-7.78 (m, 6H, Ar-H-2 + Ar-H-4), 8.80-9.28 (m, 8H, ^-HPylTol) ppm. 13C-NMR (126 MHz, acetone-d6): delta = 70.3 (OCH2), 100.9 (ArF-Cmeso), 108.4 (CF2H), 115.2 (Ar-C-6), 116.4 (ArF-C,pso), 120.8 (Ar-Cmeso), 121.9 (Ar-Cmeso), 122.0 (Ar C-2), 122.0 (Ar2-C-2), 126.3 (Ar C- 4), 126.3 (Ar2-C-4), 127.8 (Ar C-5), 127.8 (Ar2-C-5), 137.4 141.4 (d, lJc.F = 246.2 Hz, ArF-CM), 142.8 (Ar2-C,pso), 143.0 (Ar C,pso), 146.9 (d, lJc.F = 241.0 Hz, ArF-Cort0), 156.0 (Ar C-3), 156.0 (Ar2-C-3) ppm. F-NMR (376 MHz, acetone-d6): delta = -121.25 – -121.42 (m, 2F, CF2), -125.24 – -125.36 (m, 2F, CF2), -130.48 – -130.62 (m, 2F, CF2), -138.95 (d, 2JH.F = 50.8 Hz, 2F, CF2H), -140.83 – -141.01 (m, 2F, Ar-Fort0), -158.30 – -158.48 (m, 2F, Ai-Fmeta) ppm. HRMS (ESI-TOF): m/z calc. for C49H29Fi2N404 [M + H]+: 965.1992; found: 965.2041 UV-VIS (acetone), Amax [log epsilon (L · mol 1 · cm”1)]: 414 (5.37), 511 (4.41), 545 (4.04), 587 (4.08), 643 (3.84) nm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,355-80-6, its application will become more common.

Reference:
Patent; BIOLITEC UNTERNEHMENSBETEILIGUNGS II AG; FREIE UNIVERSITAeT BERLIN; GOLF, Hartwig Richard Arthur; WIEHE, Arno; GRAeFE, Susanna; ALBRECHT, Volker; REISSIG, Hans-ulrich; (110 pag.)WO2016/51361; (2016); A1;,
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Application of 355-80-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol. This compound has unique chemical properties. The synthetic route is as follows.

Synthesis of 4-methyl-2-[(2,2,3,3,4,4,5,5-octafluoropentyl)oxy]-1,3,2-dioxaphosphinane 29.90g (0.129mol) of 2,2,3,3,4,4,5,5-octafluoro-1-pentanol and 15.65g (0.155mol) of triethylamine were dissolved in 180ml of hexane to prepare a solution, and another solution was prepared by dissolving 20.00g (0.129mol) of 2-chloro-4-methyl-1,3,2-dioxaphosphinane in 20ml of hexane. The latter solution was dropped to the former solution while the former solution was fervently agitated at -10C for 3.5 hours. During the process, a formation of a white triethylammonium hydrochloride precipitate was to be found. The reaction mixture was further agitated for 3 hours at room temperature and allowed to stand for one night. The triethylammonium hydrochloride was separated from the resulting mixture and washed with hexane. Then, hexane was removed under the atmospheric pressure, and the residues were distilled under vacuum, obtaining 32.53g of a compound which is 4-methyl-2-[(2,2,3,3,4,4,5,5-octafluoropentyl)oxy]-1,3,2-dioxaphosphinane, represented by the following Chemical Formula 1A, The yield was 72%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol.

Reference:
Patent; Samsung SDI Co., Ltd.; Chernyshov, Denis; Shin, Woo-Cheol; Shatunov, Pavel Alexandrovich; Tereshchenko, Alexey; Egorov, Vladimir; Khasanov, Makhmut; Jeong, Myung-Hwan; EP2746288; (2014); A1;,
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Related Products of 355-80-6 ,Some common heterocyclic compound, 355-80-6, molecular formula is C5H4F8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Glucose (9 g, 0.05 mol), 1-octafluoropentanol (116 g, 0.5 mol) and a catalyst (3.6 g) were placed in a glass reactor. The mixture was stirred for 5 h at 100 C under 200 Torr pressure. The unreacted glucose and the catalyst were separated by filtration, and the reaction products were obtained as a solution in fluoroalcohol. The alcohol was distilled off under reduced pressure on a rotary evaporator.Then 100 mL of water was added to the concentrated products and the remaining fluoroalcohol was removed as an azeotrope. In this way, the water solution of glucoside (containing 20% of non-volatile residue) was prepared. Next, the products were dried to give a pale-green viscous oil and analyzed by the GC/MS method. Analysis was performed using a HP 6890 series GC system (Hewlett-Packard, Palo Alto, CA, USA) equipped with a MSD detector (HP 5973 Network). A 30 m capillary column with 0.2 mm diameter, modified with HP-5M methylphenylsilicone, was used for separation of the reaction products.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Nowicki, Janusz; Mokrzycki, ?ukasz; Sulikowski, Bogdan; Molecules; vol. 20; 4; (2015); p. 6140 – 6152;,
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Reference of 355-80-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, molecular formula is C5H4F8O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A solution of 2-chloro-1,3,2-dioxaphospholane 1 or 2 or 2-chloro-1,3,2-dioxaphosphinane 6 or 7 in 10 mL of hexane was added dropwise with stirring over a period of 2 h to a solution of 0.05 mol of polyfluoroalkanol 3 or 4 and 6.1 g (0.06 mol) of triethylamine in 80 mL of hexane, maintaining the temperature at -10 to -5C. Triethylamine hydrochloride separated from the solution as a white solid. The cooling bath was removed, and the mixture was stirred for 3 h at room temperature and left overnight. The precipitate was filtered off and washed with hexane (3*20 mL). The filtrate was combined with the washings, the solvent was distilled off under reduced pressure, and the residue was distilled in a vacuum.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol.

Reference:
Article; Gusarova; Verkhoturova; Arbuzova; Kazantseva; Albanov; Nalibaeva; Bishimbaeva; Apartsin; Kireeva; Trofimov; Russian Journal of General Chemistry; vol. 88; 4; (2018); p. 705 – 712; Zh. Obshch. Khim.; vol. 88; 4; (2018); p. 623 – 630,8;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol. A new synthetic method of this compound is introduced below., Safety of 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol

Example 32 Preparation of 2,2,3,3,4,4,5,5-octafluoropentyl bis(pentafluoroethyl-) phosphinate, (C2F5)2P(O)OCH2CF2CF2CF2CF2H Potassium fluoride (0.185 g; 3.2 mmol) is suspended in cooled (0 C.) tris-(pentafluoroethyl)phosphine oxide, (C2F5)3P=O, (9.957 g; 24.6 mmol) in a 100 ml glass flask, and 2,2,3,3,4,4,5,5-octafluoropentan-1-ol (5.491 g; 23.7 mmol) is added dropwise. The reaction suspension is warmed and stirred at room temperature for 46.5 h. After condensation in vacuo (10-3 mbar) at room temperature to 60 C. and double fractional distillation in vacuo (6.10-3 mbar) (b.p.: 31 to 32 C.), 2,2,3,3,4,4,5,5-octafluoropentyl bis-(pentafluoroethyl)phosphinate, (C2F5)2P(O)OCH2CF2CF2CF2CF2H, can be isolated as clear and colourless liquid (1.603 g; 3.1 mmol) in a yield of 13% and a purity of 98%. The isolated product is characterised by means of 1H, 19F and 31P NMR spectra in CD3CN. 1H NMR: delta in ppm: 6.44 t, t (1H), 2JH,F=51.1 Hz, 3JH,F=5.3 Hz; 5.11 t, d (2H), 3JH,F=12.9 Hz, 3JH,P=8.0 Hz. 19F NMR: delta in ppm: -81.3 m (6F); -121.7 m (2F); -123.8 m (4F); -125.5 m (2F); -130.7 m (2F); -139.4 d,m (2F), 2JH,F=51.1 Hz. 31P NMR: delta in ppm: 10.6 quin, m, 2JF,P=92.2 Hz.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol.

Reference:
Patent; MERCK PATENT GmbH; Ignatyev, Nikolai Mykola; Schulte, Michael; Jablonka, Christoph Alexander; Koppe, Karsten; Frank, Walter; US2015/45572; (2015); A1;,
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Related Products of 355-80-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, molecular formula is C5H4F8O, molecular weight is 232.0719, as common compound, the synthetic route is as follows.

To a dispersion prepared of 11.22 g (0.2 mol) of KOH and 100 mL of acetonitrile, a portion of 46.4 g (0.2 mol) of 1,1,2,2,3,3,4,4-octafluoropentan-5-ol was added and the mixture was stirred at r.t. for 1.5 h, then 0.22 mol of allyl chloride was added. Then mixture was refluxed for 5 h and kept at r.t. for 24 h. The precipitate was separated by filtration and was washed with cold acetonitrile. The solvent was removed by rotary evaporation and obtained product was purified by trap to trap distillation to give colorless liquid yield 89%. H NMR (CDCl3, delta, ppm): 6.96 (m, 1H, CHF2), 5.79 (m, 1H, CH=CH2), 5.19 (t, 2H, CH2=CH-), 4.04 (d, 2H, CH2O), 3.81 (t, 2H, OCH2CF2),13C NMR (CDCl3, delta, ppm): 133.09 (CH=CH2), 118.98 (CH2=CH), 115.66 (CF2), 111.13 (CF2H), 107.77 (CF2), 104.40 (CF2), 73.55 (CH2O), 66.42 (OCH2). MS (EI, m/z): 273.3 (10.1), 272.2 (91.0) [M+], 95.0 (14.6), 84.0 (9.3), 71.1 (100), 69.1 (26.1), 57.1 (23.3), 56.1 (9.4), 51.0 (31.7).

Statistics shows that 355-80-6 is playing an increasingly important role. we look forward to future research findings about 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol.

Reference:
Article; Januszewski, Rafa?; Kownacki, Ireneusz; Maciejewski, Hieronim; Marciniec, Bogdan; Journal of Organometallic Chemistry; vol. 846; (2017); p. 263 – 268;,
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Synthetic Route of 355-80-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 355-80-6 as follows.

Add trichlorochlorazine (3.68g, 0.02mol) and 40mL of anhydrous dichloromethane to 250mLIn a three-necked flask, stir well under N2 protection at 0-5 C.Add sodium hydroxide (3.2 g, 0.08 mol) to the reaction flask and continue stirring.(2) octafluoropentanol(7mL, 0.05mol) with dichloromethane (20mL)After dilution, it was slowly added dropwise to a three-necked flask and reacted at 0-5 C for 2 hours.The temperature was then slowly raised to reflux, and the reaction was stopped for 4 h.(3) repeatedly washing the reaction solution with deionized water, 5% HCl solution, and deionized water in sequence,Until neutral. Rotary evaporation to remove CH2Cl2 and excess octafluoropentanol,This gave a fluorine-containing coupling agent 2-chloro-4,6-bis (octafluoropentyloxy) -1,3,5-triazine.Fluorinated coupling agentNMR and carbon spectra of 2-chloro-4,6-bis (octafluoropentyloxy) -1,3,5-triazine are shown in Figures 1 and 2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,355-80-6, its application will become more common.

Reference:
Patent; Sichuan Qing Chemical University; Li Yanli; Wang Qinqin; Chen Liyi; Zou Wei; Song Yilan; Yang Hu; Yan Jie; (10 pag.)CN110437066; (2019); A;,
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355-80-6, Adding a certain compound to certain chemical reactions, such as: 355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 355-80-6, blongs to alcohols-buliding-blocks compound.

General procedure: A solution of 2-chloro-1,3,2-dioxaphospholane 1 or 2 or 2-chloro-1,3,2-dioxaphosphinane 6 or 7 in 10 mL of hexane was added dropwise with stirring over a period of 2 h to a solution of 0.05 mol of polyfluoroalkanol 3 or 4 and 6.1 g (0.06 mol) of triethylamine in 80 mL of hexane, maintaining the temperature at -10 to -5C. Triethylamine hydrochloride separated from the solution as a white solid. The cooling bath was removed, and the mixture was stirred for 3 h at room temperature and left overnight. The precipitate was filtered off and washed with hexane (3*20 mL). The filtrate was combined with the washings, the solvent was distilled off under reduced pressure, and the residue was distilled in a vacuum.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,355-80-6, its application will become more common.

Reference:
Article; Gusarova; Verkhoturova; Arbuzova; Kazantseva; Albanov; Nalibaeva; Bishimbaeva; Apartsin; Kireeva; Trofimov; Russian Journal of General Chemistry; vol. 88; 4; (2018); p. 705 – 712; Zh. Obshch. Khim.; vol. 88; 4; (2018); p. 623 – 630,8;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

355-80-6, Adding a certain compound to certain chemical reactions, such as: 355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 355-80-6, blongs to alcohols-buliding-blocks compound.

Example 8Preparation of 5-(2,2,2-trifluoroethoxy)-1,1,2,2,3,3,4,4-octafluoropentane; H(CF2CF2)2CH2OCH2CF3 2,2,3,3,4,4,5,5-Octafluoropentan-1-ol (50 g, 0.215 mol), 2,2,2-trifluoroethyl trifluoromethanesulfonate (50 g, 0.215 mol, obtained from Synquest Labs, Inc., Alachua, Fla.), potassium carbonate (29.7 g, 0.215 mol) and 175 g of acetone (solvent) were combined in a 600-mL Parr pressure reactor. After degassing, the reactor was sealed and the mixture was heated to 75 C. with vigorous stirring for 16 hours. After cooling, the reactor was opened and the contents filtered to remove the insoluble salts. The acetone was removed by rotary evaporation. To this residue was then added an excess of water and the product azeotropically distilled using a Dean Stark trap to give after phase separation and water washing 60.4 g crude product. The yield at this stage by GC analysis was 50 percent. The product was distilled at atmospheric pressure and the distillation cuts greater than 138 C. were combined with the pot and subsequently treated with LiCl (15 g) in N,N-dimethylformamide (250 mL) at 50 C. as described in Example 4 to remove the residual 2,2,2-trifluoroethyl trifluoromethanesulfonate. The product was then distilled through the concentric tube column to give the product ether, boiling point=138-143 C. in 95.9 percent purity. The structure was consistent with GC/MS and 1H NMR analysis.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,355-80-6, its application will become more common.

Reference:
Patent; Flynn, Richard M.; Bulinski, Michael J.; Costello, Michael G.; US2010/108934; (2010); A1;,
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