Category: 35364-79-5

Adding a certain compound to certain chemical reactions, such as: 35364-79-5, 2-(3,4-Dichlorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C8H8Cl2O, blongs to alcohols-buliding-blocks compound. Computed Properties of C8H8Cl2O

(iv) To NaH (6.00 g, 0.2 mol, 80% dispersion in oil) in anhydrous ethylene glycol dimethyl ether (200 mL) was added a solution of 3,4-dichlorophenethyl alcohol (38.87 g, 0.2 mol) in anhydrous ethylene glycol dimethyl ether (100 mL). The resulting mixture was stirred for 3 hours at ambient temperature under argon atmosphere.(v) The mesylate (ii) in anhydrous ethylene glycol dimethyl ether (100 mL) was added quickly to the alkoxide (iv) and the resulting reaction mixture was readily refluxed for 16 hours. To the cooled reaction mixture was added water (200 mL) and the organic solvent was evaporated in vacuo. The resulting aqueous solution was further diluted with water (200 mL) and the pH was adjusted to pH 1.5 with 10% HCl aqueous solution. The acidic aqueous layer was extracted with diethyl ether (500 mL) to eliminate the unreacted 3,4-dichlorophenethyl alcohol. Further basification of the aqueous layer with 5M NaOH aqueous solution to pH 5.7 followed by extraction with diethyl ether provided the crude title compound contaminated with some remaining mesylate (ii). The solvent of the organic extract at pH 5.7 was evaporated in vacuo, the residue was then refluxed in a mixture of ethanol-water (1:1, v/v, 200 mL) in the presence of sodium hydride (4.12 g, 0.1 mol) for 2 hours in order to hydrolyzed the remaining mesylate. The cooled reaction mixture was diluted with water (300 mL) and the organic solvent was evaporated in vacuo. The pH of the residual aqueous solution was adjusted to pH 5.7 with 6M HCl aqueous solution followed by extraction with diethyl ether (700 mL). The organic extract was concentrated in vacuo to yield the pure aminoether. The residual product was then partitioned between 1M HCl aqueous solution (300 mL) and dichloromethane (300 mL). The acidic aqueous solution was extracted twice more with dichloromethane (2 x 300 mL). The combined organic layers were dried over sodium sulfate, the solvent was evaporated in vacuo and the residue was recrystallized from a mixture of ethanol-hexanes (3:7, v/v, 700 mL) to yield 49.3 g of the title compound, having the elemental analysis indicated in Table 1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,35364-79-5, 2-(3,4-Dichlorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Nortran Pharmaceuticals Inc.; EP1087934; (2004); B1;,
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Application of 35364-79-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.35364-79-5, name is 2-(3,4-Dichlorophenyl)ethanol, molecular formula is C8H8Cl2O, molecular weight is 191.06, as common compound, the synthetic route is as follows.

General procedure: General procedure: NaBH4 (15 mmol, 3 equiv) was added in portion to a solution of Intermediate 3 (5 mmol) in methanol (200 mL) in an ice bath. The resulting mixture was then warmed to room temperature and stirred for 1 hour. Most of the solvent was evaporated under reduced pressure. Saturated aqueous Na2CCb (50 mL) was added and then the mixture was extracted with EtOAc (3 x 50 mL). Purified from chromatographic column to give alcohol 6 (Scheme 4). The alcohol 6 (0.5 mmol) in DCM (10 mol) was put in ice bath. TEA (0.55 mmol, 1.1 equiv) was added, then methanesulfonyl chloride (0.55 mmol, 1.1 equiv) was added again. The mixture was stirred at 0 C for 2 hours. Removed the DCM and provided crude compound 7 without purification. To a solution of alcohol 4′ (0.5 mmol) and K2CO3 (1 mmol, 2 equiv) in DMF was added mesylate 7 (0.5 mmol). The mixture was stirred overnight at 60 C. Cooled to room temperature and added 50 mL of water. Extracted with EtOAc (2 x 50 mL), Combined the EtOAc layers and washed with brine. Dried (Na2S04), filtered, and concentrated in vacuo. Purified by silica gel chromatography and got the final product II.

Statistics shows that 35364-79-5 is playing an increasingly important role. we look forward to future research findings about 2-(3,4-Dichlorophenyl)ethanol.

Reference:
Patent; UNIVERSITY OF MARYLAND, BALTIMORE; WANG, Hongbing; XUE, Fengtian; LIANG, Dongdong; (178 pag.)WO2018/236856; (2018); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35364-79-5, name is 2-(3,4-Dichlorophenyl)ethanol, the common compound, a new synthetic route is introduced below. Computed Properties of C8H8Cl2O

General procedure: The starting material, 2-(3,4-dimethoxyphenyl)-ethan-1-ol (521 mg, 2.86 mmol, 1.0 equiv) was dissolved in dichloromethane (20 mL) and imidazole (583 mg, 8.58 mmol, 3.0 equiv) was added. The mixture was stirred for 5 minutes. tert-Butyldimethylsilyl chloride (518 mg, 3.43 mmol, 1.2 equiv) was added and the reaction mixture was stirred at room temperature for 1 hr. Water (20 mL) and dichloromethane (20 mL) were added and the mixture was shaken in a separating funnel. The aqueous layer was separated and washed with dichloromethane (2 x 5 mL). The combined organic layers were washed with water (20 mL), brine (20 mL) and dried over MgSO4. Following filtration, the solvent was removed under reduced pressure. The crude material was purified by column chromatography on silica gel (eluting with a gradient from petroleum ether to 1:1 petroleum ether : ether) to afford 820mg of 1a (97%).

The synthetic route of 35364-79-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; O’Brien, Matthew; Konings, Lisette; Martin, Matthew; Heap, Jordan; Tetrahedron Letters; vol. 58; 25; (2017); p. 2409 – 2413;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.35364-79-5, name is 2-(3,4-Dichlorophenyl)ethanol, molecular formula is C8H8Cl2O, molecular weight is 191.06, as common compound, the synthetic route is as follows.Safety of 2-(3,4-Dichlorophenyl)ethanol

[00318] MsCl (2.40 g, 20.92 mmol) was added to a solution of 2-(3,4-dichlorophenyl)ethanol (1.00 g, 5.23 mmol) and TEA (1.59 g, 15.69 mmol, 2.17 mL) in dry DCM (10.00 mL) dropwise under N2 atmosphere for 5 minutes. It was stirred at 0 to 20 C for 0.6 h. The solution was diluted with water and extracted with ethyl acetate. The organic phase was washed with water (100 mL x 2) and brine (100 mL), dried (Na2S04), filtered and concentrated in vacuo to yield the crude product. It was used for the next step directly.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,35364-79-5, 2-(3,4-Dichlorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; NAVITOR PHARMACEUTICALS, INC.; MAHONEY, Sarah; MOLZ, Lisa; NARAYAN, Sridhar; SAIAH, Eddine; (516 pag.)WO2018/191146; (2018); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35364-79-5, name is 2-(3,4-Dichlorophenyl)ethanol, molecular formula is C8H8Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C8H8Cl2O

General procedure: To a solution of 18 (100 mg,0.420 mmol) and [4-(trifluoromethyl)phenyl]methanol (111 mg,0.630 mmol) in THF (10.0 mL), PPh3 (178 mg, 0.68 mmol), a 40%diethyl azodicarbonate toluene solution (309 lL, 0.680 mmol)were added at room temperature, and stirred under N2 atmosphereat 60 C for 4 h. After cooling to room temperature, the solvent wasdistilled off under reduced pressure. The residue was purified bysilica gel column chromatography (hexane/AcOEt = 100:0 to 95:5(v/v)) to obtain 19k as colorless oil (125 mg, 75%).

With the rapid development of chemical substances, we look forward to future research findings about 35364-79-5.

Reference:
Article; Takano, Rieko; Yoshida, Masao; Inoue, Masahiro; Honda, Takeshi; Nakashima, Ryutaro; Matsumoto, Koji; Yano, Tatsuya; Ogata, Tsuneaki; Watanabe, Nobuaki; Hirouchi, Masakazu; Kimura, Takako; Toda, Narihiro; Bioorganic and Medicinal Chemistry; vol. 23; 17; (2015); p. 5546 – 5565;,
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Adding a certain compound to certain chemical reactions, such as: 35364-79-5, 2-(3,4-Dichlorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 35364-79-5, blongs to alcohols-buliding-blocks compound. Quality Control of 2-(3,4-Dichlorophenyl)ethanol

To a solution of alcohol 35 (0.5 mmol) in CH2Cl2 (10 mL) at 0 Cwas added TEA (0.55 mmol, 1.1 equiv) and methanesulfonyl chloride(0.55 mmol, 1.1 equiv). The mixture was stirred at 0 C for anadditional 2 h, and concentrated to provide crude compound 36. To a solution of 2-(3,4-dichlorophenyl)ethan-1-ol (0.5 mmol) andK2CO3 (1 mmol, 2 equiv) in DMF was added compound 36(0.5 mmol). The reaction mixture was stirred at 60 C overnight,cooled, and partitioned between H2O (50 mL) and EtOAc (30 mL).The aqueous layer was extracted twice using EtOAc (30 mL 2).The combined organic layers were washed using brine, dried overNa2SO4, and concentrated. The crude material was purified by flashchromatography to give compound 5 (28%): 1H NMR (400 MHz,CDCl3): d 7.78 (d, J 8.0 Hz, 2H), 7.60 (d, J 8.0 Hz, 2H), 7.53 (d,J 8.0 Hz, 1H), 7.48 (d, J 3.6 Hz, 2H), 7.38 (d, J 3.6 Hz, 1H), 7.20(d, J 8.4 Hz, 1H), 7.01 (d, J 3.6 Hz, 1H), 4.97 (s, 2H), 3.88 (t,J 5.6 Hz, 2H), 3.04 (t, J 5.6 Hz, 2H); 13C NMR (100 MHz, CDCl3):d 149.6, 145.0, 139.3, 133.6, 132.5, 132.2, 130.8, 130.3, 130.2, 129.0,128.8, 128.3, 118.7, 117.8, 112.7, 70.0, 62.7, 35.3; HRMS (ESI): Exactmass calcd for C20H16Cl3N2OS [MH] 437.0049, found 437.0051;HPLC analysis: retention time 5.7 min, peak area 97.6%, 80:20CH3CN/H2O.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,35364-79-5, its application will become more common.

Reference:
Article; Liang, Dongdong; Li, Linhao; Lynch, Caitlin; Mackowiak, Bryan; Hedrich, William D.; Ai, Yong; Yin, Yue; Heyward, Scott; Xia, Menghang; Wang, Hongbing; Xue, Fengtian; European Journal of Medicinal Chemistry; vol. 179; (2019); p. 84 – 99;,
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Application of 35364-79-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 35364-79-5, name is 2-(3,4-Dichlorophenyl)ethanol. A new synthetic method of this compound is introduced below.

a. 2-(3,4-Dichlorophenyl)ethyl methansulfonate Using the method of Example 1a, but substituting 3,4-dichlorophenethyl alcohol for 3-methoxyphenethyl alcohol, the title product was obtained as a yellow oil in 88% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,35364-79-5, 2-(3,4-Dichlorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; McNeilab, Inc.; US4729994; (1988); A;; ; Patent; McNeilab, Inc.; EP256888; (1991); B1;,
Alcohol – Wikipedia,
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35364-79-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35364-79-5, name is 2-(3,4-Dichlorophenyl)ethanol, molecular formula is C8H8Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

PREPARATION 14 Preparation of 3,4-dichlorophenethyl bromide STR37 Phosphorus tribromide (2.17 g) was added, dropwise, to a solution of 3,4-dichlorophenethyl alcohol (4.26 g) in carbon tetrachloride (30 ml). The mixture was stirred at room temperature for 10 minutes then heated under reflux for 2 hours. 5% Aqueous sodium carbonate (10 ml) was added dropwise and the mixture was extracted with dichloromethane (3*70 ml). The combined dichloromethane extracts were dried (MgSO4) and concentrated in vacuo to give a yellow oil which was purified by column chromatography on silica eluding with dichloromethane containing hexane (30% down to 0%). The product-containing fractions were combined and concentrated in vacuo to give the title compound as a colourless oil, yield, 1.8 g. 1 H-N.M.R. (CDCl3) delta=7.50-7.30 (m, 2H); 7.15-7.05 (m, 1H); 3.65-3.50 (t, 2H); 3.20-3.10 (t, 2H) ppm.

The chemical industry reduces the impact on the environment during synthesis 35364-79-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Pfizer Inc.; US5340831; (1994); A;,
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