Category: 3513-81-3

Related Products of 3513-81-3, Adding some certain compound to certain chemical reactions, such as: 3513-81-3, name is 2-Methylenepropane-1,3-diol,molecular formula is C4H8O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3513-81-3.

To a solution of 2-methylene-1, 3-propane diol (5.28g, 0.06 mmol) and di-tert-butyl dicarbonate (35 g, 0.16 mol) in 150 ml of dichloromethane was added 6N NaOH (70 ml) and tetrabutylammoniahydrogensulfate (3.4 g, 10 mmol). The mixture was stirred at room temperature overnight. The organic layer was separated, washed with NaHC03 (200 mi x 3) and brine (200 ml), dried over anhydrous MgS04, concentrated and dried over vacuum to give the title compound. ‘H NMR (CDC13) : 5 5.20 (s, 2H); 4.44 (s, 4H); 1. 18 (s, 18H). 13c NMR (CDC13) : No. 153.3, 138.5, 117.3, 82.3, 66.9, 27.8.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3513-81-3, 2-Methylenepropane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; WO2005/61526; (2005); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3513-81-3, name is 2-Methylenepropane-1,3-diol. A new synthetic method of this compound is introduced below., Formula: C4H8O2

Preparation 3 3-Octadecylaminocarbonyloxy-2-methylenepropan-1-ol Octadecyl isocyanate (59.1 g) and 2-methylene-propane-1,3-diol (17.7 g) were dissolved and stirred in pyridine (100 ml) for 24 hours at 22°C. Water (200 ml) was added, and the mixture was extracted with chloroform (3 * 200 ml). The chloroform extracts were washed with water, dried over anhydrous magnesium sulfate, filtered and evaporated to dryness in vacuo . The mixture was purified through a column of silica gel 60 (70-230 mesh, 100 g) eluding with chloroform/ether 1: 1. Further purification was achieved by chromatography on a Waters PrepLC.(R)./System 500A using a PrepPAK.(R).-500/SILICA cartridge with chloroform/ether/pentane 1: 1: 3 as eluent. The product was recrystallized from acetone. Mp. 71-73°C. Elemental analysis: calculated C 71.99percent, H 11.82percent, N 3.65percent, found C 71.93percent, H 11.93percent, N 3.64percent.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3513-81-3, 2-Methylenepropane-1,3-diol.

Reference:
Patent; LEO PHARMACEUTICAL PRODUCTS LTD. A/S, (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB); EP247201; (1991); B1;,
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Electric Literature of 3513-81-3, Adding some certain compound to certain chemical reactions, such as: 3513-81-3, name is 2-Methylenepropane-1,3-diol,molecular formula is C4H8O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3513-81-3.

2-Methylene-propane-1,3-diol (2.2 g; 24.96 mmol) and dibutyltin oxide (6.85 g; 27.96 mmol) were refluxed in chloroform/methanol (100 ml 10: 1) for 24 h to obtain a clear solution. The solvent was removed under reduced pressure to give the stannoxane derivative as a white solid. Cesium fluoride (7.25 g; 47.7 mmol) was added and the mixture was dried under high vacuum. To this reaction mixture, DMF (20 ml) and benzyl bromide (3.27 ml ; 27.5 mmol) were added and the reaction mixture was stirred for 24 h at 25 °C. After that, the reaction mixture was heated at 50 °C for 1 h. The mixture is cooled to 25 °C and diluted with ethyl acetate (100 ml) and water (2 ml). The reaction mixture is stirred vigorously for 30 min and then filtered through a pad of celite to remove dibutyltin oxide. The filtrate was washed with water and then with brine, dried over Na2SO4 and the solvent was removed under reduced pressure. The crude product was purified by silica gel column chromatography eluting with 20 percent ethyl acetate/hexane to yield 2.6 g (60percent) compound 71a) as oil. 1H-NMR (CDCl3) : delta 7.36-7.28 (m, 5H), 5.20 (s, 1H), 5.15 (s, 1H), 4.51 (s, 2H), 4.19 (s, 2H), 4.10 (s, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3513-81-3, 2-Methylenepropane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/92881; (2005); A1;,
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Adding a certain compound to certain chemical reactions, such as: 3513-81-3, 2-Methylenepropane-1,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 3513-81-3, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C4H8O2

To a solution of di-tert-butyl dicarbonate (6.6 kg) in methylene chloride (15.0 L, 15 volumes) was added 2-methylene-1,3-propanediol (1.00 kg) and phase transfer catalyst tetrabutylammonium hydrogensulfate (0.641 kg). The resulting reaction mixture was then agitated vigorously at about 15° C. while adding over a 2 hr period, 6M aqueous sodium hydroxide solution (13.2 L) and controlling the temperature between 25 to 30° C. The resulting two-phase reaction mixture was subsequently agitated for a period of 2-3 hrs at 25° C.The aqueous layer was discarded and additional phase transfer catalyst tetrabutylammonium hydrogensulfate (0.064 kg, 10percent of the initial amount), di-tert-butyl dicarbonate (0.66 kg, 10percent of the initial amount), and methylene chloride (2.0 L, 2 volumes) was added to the remaining organic reaction mixture. To the reaction mixture was also added 6M aqueous sodium hydroxide solution (1.32 L, 10percent of the initial amount) over a period of about 0.5 to 1 hr, while controlling the temperature between 25 to 30° C. The resulting two-phase reaction mixture was then agitated at about 25° C. for additional 3 to 4 hr. Allowing more than 3 hrs of agitation time is often required to complete the hydrolysis of the excess di-tert-butyl dicarbonate. The aqueous layer was discarded. The resulting organic phase was washed with water (3.x.8.0 L), diluted with EtOAc (6 L, 6 volumes), and distilled to an oil foam with quantitative yield.1H (500 MHz, CDCl3) delta 5.15, 4.98, 4.79, 4.68, 4.68, 4.33, 4.31, 3.89, 3.77, 3.67, 3.45, 3.35, 3.19, 2.88, 2.78, 2.74, 2.42, 2.17, 2.11, 2.06, 1.95, 1.72, 1.66, 1.51, 1.48, 1.43, 1.34, 1.27, 1.19, 1.19, 1.18, 1.14, 1.13, 1.11, 0.95, 0.85.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3513-81-3, its application will become more common.

Reference:
Patent; Xu, Guoyou; Gai, Yonghua; Wang, Guoqlang; Or, Yat Sun; Wang, Zhe; US2007/207972; (2007); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3513-81-3, name is 2-Methylenepropane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C4H8O2

Example 7; 5-Cvclopropyl-2-(4-fluorophenyl)-6-rr(2-hvdroxy-1 ,2-oxaborolan-4- yl)methyll(methylsulfonyl)aminol-N-methyl-1 -benzofuran-3-carboxamide Step 1 : 3-chloro-2-(chloromethyl)prop-1 -eneA solution of thionyl chloride (290 g, 1 19 mmol) in DCM (200 mL) was added dropwise into a mixture of 2-methylenepropane-1 ,3-diol (88 g, 1 mol), dry pyridine (150 mL), and dry DCM (100 mL). The reaction mixture was heated to reflux with stirring for 3 hours and then allowed to stand overnight. The mixture was cooled to room temperature and poured into ice. The solution was neutralized with solid sodium bicarbonate and then extracted with diethyl ether(3 <0.6 L) followed by washing the ether extracts with dilute sulfuric acid. The combined organic layers were dried with anhydrous sodium sulfate, filtered, and concentrated in vacuo to give a residue which was fractionated to give 3-chloro-2- (chloromethyl)prop-l -ene (40.1 g, 32percent) as a colorless oil. With the rapid development of chemical substances, we look forward to future research findings about 3513-81-3. Reference:
Patent; GLAXO GROUP LIMITED; JOHNS, Brian Alvin; SHOTWELL, John Brad; HAIGH, David; WO2012/67663; (2012); A1;,
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Reference of 3513-81-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3513-81-3 as follows.

2-METHYLENE-1, 3-propanediol (2.20 g, 25.0 MM) was stirred in dichloromethane (20 ML) and cooled to 0 °C. A 1 N solution of diethylzinc in hexanes (3.40 g, 27.5 MM) was added followed by a solution OF 4-BROMO-3-FLUORO-N-HYDROXYBENZENECARBOXIMIDOYL chloride (6.30 g, 25.0 MM) in dichloromethane (40 mL). The reaction was allowed to warm to room temperature and was complete after four hours. The solution was diluted with ammonium chloride and extracted using dichloromethane. The organic layer was dried (magnesium sulfate), filtered and concentrated to give the desired product as a yellow solid (4.72 g). MS (ESP : 305 (MH+) for CLLHLLBREINO3 300 MHz NMR (DMSO-D 6 : 3.29 (s, 2H); 3.55 (s, 2H); 3.57 (s, 2H) ; 5.10 (t, 2H); 7.52 (d, 1H); 7.68 (d, 1H); 7.86 (t, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3513-81-3, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/48392; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 3513-81-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3513-81-3, name is 2-Methylenepropane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows.

Step A Synthesis of Compound Int-19a TBDPSC1 (9.0 mL, 35.0 mmol) was added dropwise to a stirred hazy solution of 2- methylenepropane-l,3-diol (3 g, 34.1 mmol) and imidazole (4.70 g, 69.0 mmol) in DCM (340 mL). The reaction mixture was stirred at room temperature overnight. The following morning, the reaction mixture was concentrated under reduced pressure (~80 mL) before being filtered through a pad of celite, rinsing over with additional DCM / MeOH. The filtrate was evaporated under reduced pressure. The resulting oil was purified by silica gel column (220 g) (0452) chromatography eluting with 0-20% EtOAc / hexanes to afford compound Int-19a. NMR (500 MHz, CDCb): d 7.69 (d, J = 7.4 Hz, 4H); 7.49 – 7.37 (m, 6H); 5.16 (app. s, 1H); 5.13 (app. s, 1H); 4.27 (s, 2H); 4.19 (d, J = 6.2 Hz, 2H); 1.80 (t, J = 6.1 Hz, 1H); 1.08 (s, 9H).

According to the analysis of related databases, 3513-81-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; YU, Tao; APGAR, James, M.; WHITEHEAD, Alan; ZHANG, Yonglian; HU, Zhiyong; SHURTLEFF, Valerie, W.; MCCAULEY, John, A.; RAHEEM, Izzat, T.; (97 pag.)WO2019/209667; (2019); A1;,
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Reference of 3513-81-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3513-81-3, name is 2-Methylenepropane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows.

Step A Synthesis of Compound Int-19a TBDPSC1 (9.0 mL, 35.0 mmol) was added dropwise to a stirred hazy solution of 2- methylenepropane-l,3-diol (3 g, 34.1 mmol) and imidazole (4.70 g, 69.0 mmol) in DCM (340 mL). The reaction mixture was stirred at room temperature overnight. The following morning, the reaction mixture was concentrated under reduced pressure (~80 mL) before being filtered through a pad of celite, rinsing over with additional DCM / MeOH. The filtrate was evaporated under reduced pressure. The resulting oil was purified by silica gel column (220 g) (0452) chromatography eluting with 0-20% EtOAc / hexanes to afford compound Int-19a. NMR (500 MHz, CDCb): d 7.69 (d, J = 7.4 Hz, 4H); 7.49 – 7.37 (m, 6H); 5.16 (app. s, 1H); 5.13 (app. s, 1H); 4.27 (s, 2H); 4.19 (d, J = 6.2 Hz, 2H); 1.80 (t, J = 6.1 Hz, 1H); 1.08 (s, 9H).

According to the analysis of related databases, 3513-81-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; YU, Tao; APGAR, James, M.; WHITEHEAD, Alan; ZHANG, Yonglian; HU, Zhiyong; SHURTLEFF, Valerie, W.; MCCAULEY, John, A.; RAHEEM, Izzat, T.; (97 pag.)WO2019/209667; (2019); A1;,
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Synthetic Route of 3513-81-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3513-81-3, name is 2-Methylenepropane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows.

Step lb : Compound of formula 1-3: R_ = H and Rl = t-Bu :; To a solution of 2-methylene-1, 3-propane diol (5. 28g, 0.06 mmol) and di-tert-butyl dicarbonate (35 g, 0.16 mol) in 150 ml of dichloromethane was added 6N NaOH (70 ml) and tetrabutylammoniahydrogensulfate (3.4 g, 10 mmol). The mixture was stirred at room temperature overnight. The organic layer was separated, washed with NaHC03 (200 ml x 3) and brine (200 ml), dried over anhydrous MgSO4, concentrated and dried over vacuum to give the title compound. ‘H NMR (CDC13) : 5. 20 (s, 2H) ; 4.44 (s, 4H) ; 1.18 (s, 18H). 13C NMR (CDCl3) : 8 153. 3, 138. 5,117. 3,82. 3,66. 9,27. 8.

According to the analysis of related databases, 3513-81-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; WO2003/97659; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts