Category: 35106-82-2

Related Products of 35106-82-2 ,Some common heterocyclic compound, 35106-82-2, molecular formula is C9H10O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of the corresponding alkene (0.75 mmol) and (R)-1-phenylpent-4-en-3-ol (363 mg,2.2 mmol, 3.0 equiv) in CH2Cl2 (4 mL) was added Grubbs catalyst 2nd generation (6 mg, 7.5 mumol,0.01 equiv). The mixture was refluxed for 6 hours under an Ar atmosphere. After cooling, the reactionmixture was condensed its volume to 1 mL under the reduced pressure and the mixture wascharged directly on silica gel column chromatography to purify the corresponding cross-metathesisproduct.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,35106-82-2, its application will become more common.

Reference:
Article; Ida, Akiko; Kitao, Kazuyuki; Hoshiya, Naoyuki; Uenishi, Jun’ichi; Tetrahedron Letters; vol. 56; 15; (2015); p. 1956 – 1959;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 35106-82-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.35106-82-2, name is (2-Vinylphenyl)methanol, molecular formula is C9H10O, molecular weight is 134.1751, as common compound, the synthetic route is as follows.

Step 1: 2-vinylbenzyl acetate To a solution of (2-vinylphenyl)methanol (3.0 g, 22.4 mmol) and triethylamine (4.5 g, 44.7 mmol) in DCM (20 mL) was added acetic anhydride (Ac2O) (4.6 g, 44.7 mmol) and catalytic amount of 4-dimethylaminopyridine (DMAP) (50 mg). The resulted mixture was stirred at room temperature for overnight, and then diluted with DCM (30 mL). The organic layer was washed with H2O and brine successively, dried over sodium sulfate, filtered and concentrated. The residue was purified by column chromatography on silica gel to afford 2-vinylbenzyl acetate (3.9 g, yield: 96percent) as light yellow oil.

Statistics shows that 35106-82-2 is playing an increasingly important role. we look forward to future research findings about (2-Vinylphenyl)methanol.

Reference:
Patent; SHANGHAI DE NOVO PHARMATECH CO. LTD.; GAO, Daxin; YANG, Heping; WANG, Pei; (84 pag.)US2017/37038; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 35106-82-2 ,Some common heterocyclic compound, 35106-82-2, molecular formula is C9H10O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 1: 1-(chloromethyl)-2-vinylbenzene A solution of (2-vinylphenyl)methanol (3.10 g, 23.1 mmol) in DCM (30 mL) was cooled down to 0¡ã C., and then added MsCl (2.01 mL, 27.7 mmol) dropwise. The resulted mixture was stirred at room temperature for overnight. After the mixture was diluted with DCM (50 mL), the organic layer was washed with H2O (30 mL*2), saturated NaHCO3 aqueous solution and brine successively, then dried over sodium sulfate, filtered and concentrated to afford 1-(chloromethyl)-2-vinylbenzene (2.92 g, yield: 83percent) as colorless oil, which can directly used for next step.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 35106-82-2, (2-Vinylphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SHANGHAI DE NOVO PHARMATECH CO. LTD.; GAO, Daxin; YANG, Heping; WANG, Pei; (84 pag.)US2017/37038; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 35106-82-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35106-82-2, name is (2-Vinylphenyl)methanol, molecular formula is C9H10O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Synthesis of 4-bromobutoxymethylstyrene An amount of 20 g (0.5 mol) of sodium hydroxide and 20 ml of water were placed into a four-necked flask of 300 ml in capacity and then stirred to prepare a homogeneous solution. The temperature of this solution was reverted to room temperature, and then thereto a solution as prepared by dissolving 13.42 g (0.1 mol) of vinylbenzyl alcohol (mixture of m-isomer and p-isomer), 32.39 g (0.15 mol) of 1,4-dibromobutane, and 3.22 g (0.01 mol) of tetrabutylammonium bromide into 100 ml of toluene was added. While being vigorously stirred, the resultant mixed solution was allowed to react at 40¡ã C. for 6 hours. Thereafter, the solution was separated and then sufficiently washed with water. The resultant organic layer was dried by adding thereto magnesium sulfate, and then toluene was distilled off under reduced pressure. The resultant solution was distilled in the presence of DPPH (diphenylpicryl-2-hydrazyl) under vacuum (boiling point: 125~128¡ã C./16 Pa) to obtain a colorless transparent liquid of 4-bromobutoxymethylstyrene. The yield amount was 15.0 g, and the yield ratio was 56 mol percent.

According to the analysis of related databases, 35106-82-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nippon Shokubai Co., Ltd.; US6414182; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 35106-82-2, (2-Vinylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 35106-82-2, blongs to alcohols-buliding-blocks compound. name: (2-Vinylphenyl)methanol

Step 3: (1,3-dihydroisobenzofuran-1-yl)methanol To a mixture of (2-vinylphenyl)methanol (obtained from step 2) (1.0 g, 7.45 mmol) in DCM (10 mL) was added m-CPBA (1.82 g, 8.94 mmol) in small portions at 0¡ã C. The reaction mixture was stirred at room temperature for overnight, and then the mixture was diluted with DCM (30 mL) and washed with saturated NaHCO3 aqueous solution and brine. The organic layer was dried over sodium sulfate and concentrated under vacuum. The residue was purified by prep-TLC (petroleum ether:ethyl acetate=4:1) to afford (1,3-dihydroisobenzofuran-1-yl) methanol (260 mg, yield: 23percent) as yellow oil. m/z: [M+H]+ 151.1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,35106-82-2, its application will become more common.

Reference:
Patent; SHANGHAI DE NOVO PHARMATECH CO. LTD.; GAO, Daxin; YANG, Heping; WANG, Pei; (84 pag.)US2017/37038; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts