Category: 349-95-1

Adding a certain compound to certain chemical reactions, such as: 349-95-1, (4-(Trifluoromethyl)phenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: (4-(Trifluoromethyl)phenyl)methanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: (4-(Trifluoromethyl)phenyl)methanol

General procedure: Aq ammonia (28%, 0.5 mmol), the appropriate alcohol 10 (3.4mmol), the catalyst 3 (1 mol% Ir), and the phthalate pH standard solution(0.5 mL, pH 4.01) were mixed in a microwave vial tube at 23 C under air. The vial was sealed with a cap, and the reactionmixture was stirred at 150 C for 24 h in a microwave reactor (25-32 W). After cooling to 23 C, aq NaOH (0.1 M, 1 mL) was addedto the mixture and extracted with EtOAc (3 × 2 mL). The combinedorganic layers were concentrated. The crude product was purifiedby column chromatography over silica gel eluting with hexane-EtOAc (98:2 to 9:1) or CHCl3 to afford the corresponding N-alkylatedamine 11l,o-s

At the same time, in my other blogs, there are other synthetic methods of this type of compound,349-95-1, (4-(Trifluoromethyl)phenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Yamada, Yoichim. A.; Ohta, Hidetoshi; Yuyama, Yoshinari; Uozumi, Yasuhiro; Synthesis; vol. 45; 15; (2013); p. 2093 – 2100;,
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Adding a certain compound to certain chemical reactions, such as: 349-95-1, (4-(Trifluoromethyl)phenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C8H7F3O, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C8H7F3O

General procedure: Under an N2 atmosphere, a mixture of secondary alcohol (0.5 mmol), primary alcohol (0.6 mmol), 1a (5 mol %), NaOH (0.1 mmol), 4 A molecular sieve (0.6 g), and toluene (1.5 mL) was added into a 25 mL Schlenk tube equipped with a stirring bar. The mixture was heated to 120 C under a slow and steady N2 flow for 24 h. After cooling to ambient temperature, 6 mL water was added and the aqueous solution extracted with ethyl acetate (3 x 5 mL). The combined extracts were dried over anhydrous Na2SO4, and concentrated under reduced pressure. The crude product purified on a short flash chromatography column.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,349-95-1, (4-(Trifluoromethyl)phenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Zhang, Shi-Qi; Guo, Bin; Xu, Ze; Li, Hong-Xi; Li, Hai-Yan; Lang, Jian-Ping; Tetrahedron; vol. 75; 47; (2019);,
Alcohol – Wikipedia,
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Application of 349-95-1, Adding some certain compound to certain chemical reactions, such as: 349-95-1, name is (4-(Trifluoromethyl)phenyl)methanol,molecular formula is C8H7F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 349-95-1.

General procedure: N-Alkylation of Amides with Alcohols; General ProcedureThe amide (100 mg, 1 equiv), alcohol (3 equiv) and (Cp*IrCl2)2 (2.5mol%) were added to a microwave reactor tube. The reaction mixturewas subjected to microwave irradiation at 160 C for 3 h. The mixture was allowed to cool to r.t. and H2O (10 mL) was added. Themixture was extracted with EtOAc (3 × 10 mL). The combined organiclayers were dried (Na2SO4) and filtered. The solvent was removedunder reduced pressure and the residue was purified usingflash silica gel chromatography with CH2Cl2-MeOH (95:5) to furnishthe N-alkylamide (Tables 2 and 3).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 349-95-1, (4-(Trifluoromethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Apsunde, Tushar D.; Trudell, Mark L.; Synthesis; vol. 46; 2; (2014); p. 230 – 234;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.349-95-1, name is (4-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, molecular weight is 176.14, as common compound, the synthetic route is as follows.Safety of (4-(Trifluoromethyl)phenyl)methanol

General procedure: 3 1 According to general procedure II (chapter 2.1.2) 4-(trifluoromethyl)benzylCl alcohol 19 (353 mg, 2.00 mmol, 1.0 equiv), FPyr (19.7 ilL, 20.4 mg, 0.20 mmol,F3C 10 mol%), dioxane (1 mL, 2 M) and benzoyl chloride (282 ilL, 341 mg,62.40 mmol, 1.2 equiv) were combined and stirred for 24 h at ambient2910 temperature. After quenching with ethanolamine the reaction mixture wasdiluted with DCM (4 mL), saturated, aqueous NaHCO3-soution (2 mL) and water (2 mL). The aqueous phase was extracted with further DCM (2 x 2 mL) and the collected organic phases were dried over MgSO4 and concentrated under reduced pressure to give the crude chloride 29 (490 mg, conversion 98%, 29/39 97:3). Chromatographic purification (mass of crude material/Si02 1:12) provided theproduct 29 as a colorless oil in 85% yield (331 mg, 1.71 mmol). ?H- and ?3C-N MR-data was identicalwith the literature (Klimesova, V.; Koci, J.; Waisser, K.; Kaustova, J.; Moellmann, U. Eur. i. Med. Chem.2009, 44, 2286-2293).(C8H6CIF3) = 194.58 g/mol; rf (Si02, Et20/nPen 5:95) = 0.53; 1H-NMR (400 MHz, CDCI3): 6 [ppm] =7.63 (d, 2 H, H-4, i = 8.4 Hz), 7.51 (dd, 2 H, H-3, i = 8.4 Hz), 4.62 (s, 2 H, H-i); 13C-NMR (100 MHz,CDCI3): 6 [ppm] = 141.3 (C-2), 130.6 (q, C-5, i = 31 Hz), 128.8 (C-3), 125.7 (q, C-4, i = 3.7 Hz), 124.0 (q, C-6, i = 273 Hz) 45.1 (C-i); GC-MS (El, 70 eV) m/z [u] = 194 (35, [M]j, 175 (13, [M-F]j, 159 (100, [MCl]j, 139 (8), 125 (22, [M-CF3]j, 109 (51), 89 (16), 69 (5, [CF3]j, 63 (13), 51 (7).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,349-95-1, (4-(Trifluoromethyl)phenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; UNIVERSITAET DES SAARLANDES; HUY, Peter Helmut; (208 pag.)WO2016/202894; (2016); A1;,
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Electric Literature of 349-95-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 349-95-1, name is (4-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

DL-1-phenylethanol (122 mg, 1.0 mmol), cat. [Ir] (5.3 mg, 0.01 mmol, 1 mol%) and tert-amyl alcohol (1 mL) were successively added to a 5 mL round bottom flask. The reaction mixture was refluxed in air for 6 hours and then cooled to room temperature. Then, cesium carbonate (33 mg, 0.1 mmol, 0.1 equiv.) And 4-trifluoromethylbenzyl alcohol (194 mg, 1.1 mmol) were added, refluxed in air for 6 hours and then cooled to room temperature. The solvent was removed by rotary evaporation and then the title compound was obtained by column chromatography (developing solvent: petroleum ether / ethyl acetate) in 83%

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 349-95-1, (4-(Trifluoromethyl)phenyl)methanol.

Reference:
Patent; Nanjing University of Science and Technology; Wang, Rongzhou; Fan, Hongjun; Li, Feng; (18 pag.)CN106478325; (2017); A;,
Alcohol – Wikipedia,
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Related Products of 349-95-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.349-95-1, name is (4-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, molecular weight is 176.14, as common compound, the synthetic route is as follows.

4-methyl-benzenesulfonamide (171mg, 1mmol), catalyst A (8.3mg, 0.01mmol, 1.0mol%), cesium carbonate (33mg, 0.1mmol, 0.1equiv.), 4- trifluoromethylbenzyl alcohol ( 211mg, 1.2mmol) and water (1ml) were successively added to the reaction flask 25mlSchlenk.After the reaction mixture was reacted at 120 15 hours, cooled to room temperature.Heavy precipitate precipitated, water was removed by filtration, the filter cake was washed with water three times to give the title compound, yield: 84%

Statistics shows that 349-95-1 is playing an increasingly important role. we look forward to future research findings about (4-(Trifluoromethyl)phenyl)methanol.

Reference:
Patent; Nanjing University of Science & Technology; Li, Feng; Qu, panpan; Sun, chunlou; Ma, Juan; (17 pag.)CN104418678; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 349-95-1, (4-(Trifluoromethyl)phenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 349-95-1, blongs to alcohols-buliding-blocks compound. Computed Properties of C8H7F3O

General procedure: [Cp*IrCl2]2 (1 mol %, 0.01 mmol, 8.0 mg), 4a (2 mol %, 0.02 mmol,7.6 mg), KOH (10 mol %, 0.1 mmol, 5.6 mg), and toluene (5 mL) wereadded to a 25mL Schlenk tube with stirring under N2 at roomtemperature. Then ketones/secondary alcohols/amines (1 mmol),primary alcohols (1.1 mmol) were added by syringe. The reactionmixture was heated to 110 C under reflux in an oil bath for 24 h. Itwas cooled to ambient temperature. Then it was concentrated invacuo, and purified by flash column chromatography with petroleumether/ethyl acetate to afford the corresponding alkylatedproduct.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,349-95-1, its application will become more common.

Reference:
Article; Huang, Shuang; Wu, Si-Peng; Zhou, Quan; Cui, He-Zhen; Hong, Xi; Lin, Yue-Jian; Hou, Xiu-Feng; Journal of Organometallic Chemistry; vol. 868; (2018); p. 14 – 23;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

349-95-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 349-95-1, name is (4-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Acetophenone (120mg, 1mmol), cat.1 (5.4mg, 0.01mmol, 1.0mol%), cesium carbonate (33mg, 0.1mmol,0.1equiv.), 4- trifluoromethylbenzyl alcohol (194mg, 1.1mmol) and tert-amyl alcohol (ImL) were sequentially added to a round bottom flask 5mLin. After the reaction mixture was refluxed in air for six hours, cooled to room temperature. The solvent is removed by rotary evaporation, then purified by column chromatography(Eluent: petroleum ether / ethyl acetate) to give pure target compound, yield: 84%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 349-95-1, (4-(Trifluoromethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nanjing University of Science and Technology; Ma, Juan; Li, Lei; Li, Feng; (17 pag.)CN105439787; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

349-95-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 349-95-1, name is (4-(Trifluoromethyl)phenyl)methanol. A new synthetic method of this compound is introduced below.

B. Into another reactor, the concentration is 35%Aqueous hydrochloric acid 150kg and p-trifluoromethyl benzyl alcohol 50kg,Stir and heat to reflux, keep reaction for 24h,Cool to room temperature, layer, take organic layer,Dehydrated with anhydrous sodium sulfate,Distillation under vacuum gives a pairTrifluoromethyl benzyl chlorideThe content is 98.8%. Step B of equation (2) is as follows:

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 349-95-1, (4-(Trifluoromethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jiangsu Bandung Technology Co., Ltd.; Wu Yongcai; (5 pag.)CN107793292; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts