Category: 349-75-7

Application of 349-75-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation No.23: Synthesis of 2-Fluoro-4-(3-(trifluoromethyl)benzyloxy)benzonitrile; In a 1 L round-bottomed flask, DIAD (14.31 mL, 72.7 mmol) and tnphenylphosphme (19.07 g, 72 7 mmol) m THF (200 mL) were stirred for about 5 mm under nitrogen and cooled to about 0 C. 2-Fluoro-4-hydroxybenzonitrile (6.65 g, 48.5 mmol) was added to give a dark orange solution. The mixture was stirred about an additional 5 mm and then 3-(t?fluoromethyl)benzyl alcohol (7.26 mL, 53 3 mmol) m THF (50 mL) was added. The mixture was stirred overnight at ambient temperature then evapoiated to dryness. The solid was purified on a Combiflash Companion XL system using a 330 g Redi-Sep silica gel column using the following gradient: A: Heptane; B: Ethyl acetate, 10 to 100 %B over 7 column volumes. NMR indicated the presence of t?phenyl phosphme oxide and reduced DIAD. The iesidue was triturated with light petroleum ether (250 mL) for 1 hour, filtered and the solid dried under vacuum overnight. This gave 2-fluoro-4-(3- (t?fluoromethyl)benzyloxy)benzomt?le (9.31 g, 31.2 mmol, 99%). 1H NMR (400 MHz, DMSO- Cl6): delta 7.91 – 7.83 (m, 2H), 7 78 (d, J = 7.7, IH), 7.74 (d, J = 7.8, IH), 7.66 (t, J = 7.7, IH), 7.30 (dd, J = 2.4, 11.9, IH), 7.09 (dd, J = 2.4, 8.8, IH), 5.34 (s, 2H). (Table 2, Method b) Rt = 1.60 mm; MS m/z: 294.04 (M-H) .

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 349-75-7, (3-(Trifluoromethyl)phenyl)methanol.

Reference:
Patent; ABBOTT LABORATORIES; HARRIS, Christopher, M.; HOBSON, Adrian, D.; WILSON, Noel, S.; WO2010/93704; (2010); A1;,
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Electric Literature of 349-75-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 349-75-7 as follows.

General procedure: An alcohol(2.25±6.1 equiv) was added dropwise to a cooled suspension of NaH (60% dispersion in mineraloil; 2.2±6 equiv) in dry THF (0.5±1.5 mL) at 0 C and the mixture was stirred for 1 hunder argon atmosphere. A solution of 10 in dry THF (0.5±1.5 mL) was added dropwise andmixture was stirred overnight letting to warm up to rt. The reaction was quenched with icewater and acidified with a solution of KHSO4 until pH3. The aqueous phase was extractedwith EtOAc. The combined organic layers were washed with brine and the solvent was evaporatedunder reduced pressure at 40 C. The crude residue was purified by flash column chromatographywith appropriate eluents and a gradient.Heptyl 6-(heptyloxy)-2-[(4-methoxyphenoxy)methyl]-5-methylpyrimidine-4-carboxylate(11). General procedure III was followed except that the mixture containing the alkoxidewas added dropwise to the solution of 10. NaH (60% in mineral oil; 69.2 mg, 1.73 mmol, 2.2equiv), dry THF (1.25 mL), 1-heptanol (0.250 mL, 1.77 mmol, 2.25 equiv); compound 10(0.300 g, 0.787 mmol), dry THF (1.25 mL). Flash chromatography eluents: cyclohexane (A),EtOAc (B); gradient: 10%30% B×15 CV. Compound 11 was isolated as an orange oil (46.6mg, 0.0958 mmol, 12.2% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,349-75-7, its application will become more common.

Reference:
Article; Provenzani, Riccardo; Tarvainen, Ilari; Brandoli, Giulia; Lempinen, Antti; Artes, Sanna; Turku, Ainoleena; Jaentti, Maria Helena; Talman, Virpi; Yli-Kauhaluoma, Jari; Tuominen, Raimo K.; Boije af Gennaes, Gustav; PLoS ONE; vol. 13; 4; (2018);,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C8H7F3O

The title compound was prepared from intermediate 6 using the method of example 45 with the reaction being facilitated with microwave irradiation at 120 C. for 20 min: white solid, 20 mg, 16.5% yield: 1H-NMR (DMSO-d6) delta 7.74-7.80 (m, 3H), 7.62-7.66 (m, 1H), 7.37-7.39 (m, 2H), 7.28 (d, 2H), 5.63 (s, 2H), 5.27 (d, 2H), 3.48 (s, 3H), 3.18 (s, 3H). LCMS retention time 2.992 min; LCMS MH+ 479.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 349-75-7, (3-(Trifluoromethyl)phenyl)methanol.

Reference:
Patent; HYDRA BIOSCIENCES, INC.; Chenard, Bertrand L.; Gallaschun, Randall J.; Kimball, Spencer David; US2014/275528; (2014); A1;,
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Synthetic Route of 349-75-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4,6-dimethyl-5-nitro-2-hydroxypyridine (350 mg, 2.08 mmol)Dissolved in 15 mL of dry tetrahydrofuran3-trifluoromethylbenzyl alcohol (0.44 g, 2.50 mmol) was added in the presence of nitrogen,Triphenylphosphine(1.09 g, 4.16 mmol), cooled to 0 C, and azodicarbonyl diisopropyl ester (0.84 mg, 4.16 mmol) was slowly added dropwise. After the drop is finished, the roomStir for three hours. Spin-dried tetrahydrofuran, crude using petroleum ether / ethyl acetate = 30: 1 column to obtain compound 6A, whiteColor solid (589 mg, 86% yield).

According to the analysis of related databases, 349-75-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Jiangsu Xiansheng Pharmaceutical Co., Ltd.; Chen Huanming; Liang Bo; Zhao Zhongqiang; Cao Wenjie; Li Amin; Chen Dexin; Gao Chunhua; Zhang Peng; Xu Wanmei; Chen Xuelian; Zhang Lili; (29 pag.)CN103508943; (2017); B;,
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Application of 349-75-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 349-75-7 as follows.

Aniline (46.5 mg, 0.5 mmol),Cat.[Ir] (5.4 mg, 0.005 mmol, 1 mol%), cesium carbonate (49 mg, 0.15 mmol, 0.3 equiv.),3-trifluoromethylbenzyl alcohol (105.6 mg, 0.6 mmol) and t-amyl alcohol (1 ml) were sequentially added to 5 mLIn a round bottom flask.The reaction mixture was refluxed in air for 12 hours and then cooled to room temperature.The solvent was removed by rotary evaporation, followed by column chromatography (developer: petroleum ether/ethyl acetate) to give the pure target compound. Yield: 86%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,349-75-7, its application will become more common.

Reference:
Patent; Nanjing University of Science and Technology; Fan Hongjun; Li Shun; Liu Pengcheng; Li Feng; (9 pag.)CN107778182; (2018); A;,
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Reference of 349-75-7 , The common heterocyclic compound, 349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a mixture of the alcohol (3.839 mmol), K2CO3 (2.0 equiv, 7.678 mmol) and cyanuric acid (0.1 equiv, 0.384 mmol) in 20 mL of ethyl acetate were added TEMPO or AZADO (3 mol%, 0.115 mmol) and 12% NaOCl (1.2 equiv, 4.607 mmol, Wako Pure Chemical Industries, Ltd.) at 0-10C. The mixture was then stirred to complete. The reaction mixture was extracted with ethyl acetate. The organic layer was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to afford the corresponding product.

The synthetic route of 349-75-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Fukuda, Naohiro; Izumi, Minoru; Ikemoto, Tomomi; Tetrahedron Letters; vol. 56; 25; (2015); p. 3905 – 3908;,
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Synthetic Route of 349-75-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, molecular weight is 176.14, as common compound, the synthetic route is as follows.

3-Trifluoromethylbenzyl alcohol (10 g, 56.8 mmol)And pyridine (6.74 g, 85.2 mmol)Was dissolved in 50 ml of DCM at -10 C,The triphosgene was dissolved in 50 ml of DCM,A solution of 3-trifluoromethylbenzyl alcohol and pyridine in DCM was added dropwise to a solution of triphosgene in DCM,The reaction was carried out at -10 C for 2 hours,Room temperature reaction for 42 hours,TLC monitoring,The reaction was terminated, the solvent was decompressed, extracted with EA,Washed three times with water,Combined organic layer,Concentrated in vacuo to give 12.7 g of a colorless oil,Yield 93.7%.

The chemical industry reduces the impact on the environment during synthesis 349-75-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; North Nationalities University; Hong Wei; Wang Hao; Yang Hao; Ouyang Yifan; Tan Xiaoli; Sun Yutong; Zhu Xuanli; Wang Zhe; (18 pag.)CN106749070; (2017); A;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, molecular weight is 176.14, as common compound, the synthetic route is as follows.COA of Formula: C8H7F3O

Complex 2 (8.3 mg, 10 mmol), CsOHH2O (0.84 g, 5 mmol),alcohol (5 mmol) was added to a 25 mL schlenk tube and the solutionwas heated at 150 C (oil bath) for 24 h in an open systemunder argon. After cooling to room temperature, the degassedwater (5 mL)was added and the mixturewas extracted with diethylether (3 10 mL). A sample of ether phasewas subjected to the GCMSanalysis and the residual solution was evaporated, then subjected to the NMR analysis. The aqueous phase was acidifiedwith 6 M HCl and extracted with ethyl acetate (5 20 mL). Thecombined organic phasewaswashed with brine (25 mL), dried overanhydrous Na2SO4, and evaporated under reduced pressure, thepure carboxylic acid was collected and weighed for calculating theyield, which was further characterized by its 1H NMR which isconsist with the standard sample.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,349-75-7, (3-(Trifluoromethyl)phenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Dai, Zengjin; Luo, Qi; Meng, Xianggao; Li, Renjie; Zhang, Jing; Peng, Tianyou; Journal of Organometallic Chemistry; vol. 830; (2017); p. 11 – 18;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, molecular weight is 176.14, as common compound, the synthetic route is as follows.SDS of cas: 349-75-7

General procedure: 1-methyl-3-[(3-cyanophenylmethoxy)methyl]-2(1H)-pyridinone, 12a. To a 0 C suspension of sodium hydride (41 mg, 60% suspension in mineral oil, 1.01 mmol), in THF (3 mL) was added 3-cyanobenzyl alcohol (100 mg, 0.75 mmol). After the mixture was stirred for 1 h at 0 C, 3-(bromomethyl)-1-methylpyridin-2(1H)-one3 (152 mg, 0.75 mmol) in THF (3mL) was added dropwise. The reaction mixture was slowly allowed to warm to room temperature and stirred for additional 3 h before diluting with saturated aqueous ammonium chloride. After extraction with ethyl acetate, the combined organics were washed with brine, concentrated invacuo and purified by column chromatography using 5:95 MeOH/DCM to get title compound as a colorless soild (136 mg, 71 %).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,349-75-7, (3-(Trifluoromethyl)phenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Khatri, Buddha B.; Vrubliauskas, Darius; Sieburth, Scott McN.; Tetrahedron Letters; vol. 56; 30; (2015); p. 4520 – 4522;,
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Synthetic Route of 349-75-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, molecular weight is 176.14, as common compound, the synthetic route is as follows.

Sequentially capturing meso-Co-N / C (800) (35mg, 0.25mol% Co), 3- trifluoromethyl-benzyl alcohol (176mg, 1mmol), a concentration of 28 mass% aqueous ammonia (280 L) was added to the reaction flask 10ml and tert-amyl alcohol was added 1ml of solvent placed in the reaction vessel, the oxygen charged to 1Mpa, placed in an oil bath of 130 and then detecting the extent of reaction by GC-MS.After completion of the reaction, the biphenyl internal standard was added, the product was analyzed 3-trifluoromethyl-benzonitrile quantitative yield by GC.The reaction 24h, 3- trifluoromethyl-benzonitrile in 83% yield, selectivity of 99%.

The chemical industry reduces the impact on the environment during synthesis 349-75-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Dalian Institute of Chemical Physics; Gao Shuang; Shang Sensen; Wang Lianyue; Lv Ying; (7 pag.)CN106883143; (2017); A;,
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