Category: 346-06-5

Reference of 346-06-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a stirred mixture of Ph2PCl (6.0mmol), NaI (6.0 mmol) and anhydrous CH3CN (5 mL) was added alcohol 2 (1.0 mmol) at room temperature under argon atmosphere. The reaction mixture was stirred at 80 ¡ãC in oil bath for 12 h. When the reaction temperature was cooled to room temperature, aqueous Na2S2O3 (2.0 mL) was added to the reaction mixture, and stirred for another 10 minutes. The organic layer was extracted with dichloromethane, washed with brine, dried over MgSO4, and concentrated under reduced pressure. The residue was purified by chromatography on silica gel to obtain the corresponding phosphine sulfoxide.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 346-06-5, (2-(Trifluoromethyl)phenyl)methanol.

Reference:
Article; Ma, Yutao; Chen, Feng; Bao, Jifeng; Wei, Hao; Shi, Min; Wang, Feijun; Tetrahedron Letters; vol. 57; 23; (2016); p. 2465 – 2467;,
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Adding a certain compound to certain chemical reactions, such as: 346-06-5, (2-(Trifluoromethyl)phenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 346-06-5, blongs to alcohols-buliding-blocks compound. 346-06-5

Example 20 3-Propyl-7-(2-(trifluoromethyl)benzyl)-[1,2,4]triazolo[4,3-a]pyrazin-8(7H)-one: To a solution of 8-chloro-3-propyl-[1 ,2,4]triazolo[4,3-a]pyrazine (88 mg, 0.45 mmol) and (2-(thfluoromethyl)phenyl)methanol (1 1 1 mg, 0.629 mmol) in dimethoxyethane (3.5 ml) was added NaH 60percent in mineral oil (35 mg, 0.88 mmol) at RT and the reaction was stirred for 2 hours. Sodium iodide (1 10 mg, 0.734 mmol) was added and the reaction was heated at 200 ¡ãC for 20 min under microwave irradiation. The reaction mixture was concentrated in vacuo and purified by flash chromatography using a gradient of (petroleum ether: EtOAc: 5percentEt3N/10percentMeOH/85percentEtOAc = 1 :0:0 to 0:1 :0 to 0:0:1 ) to yield 31 mg (17percent) 3-propyl-7-(2-(trifluoromethyl)benzyl)- [1 ,2,4]triazolo[4,3-a]pyrazin-8(7H)-one. 1H NMR (CDCI3 500 MHz): delta 7.76 (m, 1 H), 7.56 (m, 1 H), 7.45 (m ,1 H), 7.40 (m, 1 H), 6.93 (d, J=6.0 Hz, 1 H), 6.60 (d, J=6.0 Hz, 1 H), 5.40 (s, 2 H), 2.98 (t, J=7.6 Hz, 2 H), 1 .92 (m, 2 H), 1 .09 (t, J=7.4 Hz, 3 H). LCMS (MH+): m/z = 337.2, tR (minutes, Method 1 ) = 0.60.

With the rapid development of chemical substances, we look forward to future research findings about 346-06-5.

Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars, Kyhn; JESSING, Mikkel; (126 pag.)WO2016/55618; (2016); A1;,
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In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 346-06-5 as follows., 346-06-5

Step A: Preparation of 2-(2-(trifluoromethyl)phenyl)furo[2,3-c]pyridin-3-amine: To an ice cooled (0¡ã C.) suspension of NaH (61.93 mg, 1.548 mmol) in DMF (5 mL) was added (2-(trifluoromethyl)phenyl)methanol (0.2262 mL 1.703 mmol) and the reaction mixture was stirred 10 minutes. 3-Bromoisonicotinonitrile (283.4 mg, 1.548 mmol) in 5 mL DMF was added, and the reaction mixture was stirred overnight while warming to 60¡ã C., then cooled to room temperature, diluted with water and EtOAc, and the layers were separated. Purification by column chromatography (10percent MeOH/CH2Cl2) provided 67 mg (15percent) of the desired product. MS (APCI-pos) M+1=279.5.

The chemical industry reduces the impact on the environment during synthesis 346-06-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Miknis, Greg; Lyssikatos, Joseph P.; Laird, Ellen; Tarlton, Eugene; Buckmelter, Alexandre J.; Ren, Li; Rast, Bryson; Schlacter, Stephen T.; Wenglowsky, Steven Mark; US2007/49603; (2007); A1;,
Alcohol – Wikipedia,
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Some common heterocyclic compound, 346-06-5, molecular formula is C8H7F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.346-06-5

Example 22 (4Z)-1-ethyl-5-imino-4-[(3-methoxy-4-{[2-(trifluoromethyl)benzyl]oxylphenyl)methylidenelimidazolidin-2-one; [Show Image] To a solution (5 mL) of (4Z)-1-ethyl-4-[(4-hydroxy-3-methoxyphenyl)methylidene]-5-iminoimidazolidin-2-one (200 mg) in tetrahydrofuran were added [2-(trifluoromethyl)phenyl]methanol (278 mg), diethyl azodicarboxylate (700 muL) and triphenylphosphine (414 mg), and the mixture was stirred at room temperature for 16 hr. Water (30 mL) was added and the mixture was extracted with ethyl acetate (50 mL). The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (eluent: hexane/ethyl acetate=10 – 60percent) to give the title compound as a pale-yellow powder (yield: 46.3 mg, 14percent), which was recrystallized from ethyl acetate/n-heptane to give the title compound as colorless crystals (yield: 12.6 mg, 4percent). 1H-NMR (DMSO-d6, 300 MHz):delta1.11 (3H, t, J = 7.6 Hz), 3.56 (2H, d, J = 7.6 Hz), 3.84 (3H, d, J = 1.5 Hz), 5.24 (2H, s), 6.55 (1H, s), 6.96-7.11 (3H, m), 7.55-7.64 (1H, m), 7.69-7.86 (3H, m), 8.73 (1H, brs), 10.19 (1H, brs).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 346-06-5.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2450352; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 346-06-5, (2-(Trifluoromethyl)phenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 346-06-5, blongs to alcohols-buliding-blocks compound. 346-06-5

Polystyrene triphenylphoshine (9.84 g, 1.58 mmol/gram, 15.5 mmol) was stirred in 100 mL of [DICHLOROMETHANE] for ten minutes. The regioisomeric mixture of methyl [5- (6-] { [(1,1-dimethylethyl)(diphenyl)silyl]oxy}-1H-benzimidazol-1-yl)-3-hydroxy-2- [THIOPHENECARBOXYLATE] and methyl [5- (5-] { [(1,1-dimethylethyl)-(diphenyl)silyl]oxy}-1H- [BENZIMIDAZOL-1-YL)-3-HYDROXY-2-THIOPHENECARBOXYLATE] (5.48 g, 10.4 mmol) was added in a single portion. 2-(Trifluromethyl)benzyl alcohol (1.68 mL, 12.6 mmol) was added via syringe, and the solution was cooled to [0] [OC.] [DI-TERT-BUTYL AZODICARBOXYLATE] (3.58 g, 15.5 mmol) was dissolved in 20 [ML OF DICHLOROMETHANE] and added dropwise via addition funnel. The reaction was warmed to room temperature and stirred for 1.5 hours. The mixture was filtered through filter paper, and the solid was washed with dichloromethane and methanol. The filtrate was concentrated and purified by flash chromatography to afford 2.89 g [(41percent)] of methyl 5-(5-{[(1, 1- dimethylethyl)(diphenyl)silyl]oxy}-1H-benzimidazol-1-yl)-3-({[2- [(TRIFLUOROMETHYL) PHENYL] METHYL} OXY)-2-THIOPHENECARBOXYLATE] and 2.69 g [(38percent)] of methyl [5- (6- { [ (1, 1-DIMETHYLETHYL) (DIPHENYL) SILYL] OXY}-1 H-BENZIMIDAZOL-1-YL)-3- ( { [2-] (trifluoromethyl)phenyl]methyl}oxy)-2-thiophenecarboxylate. Data for 5-OTBDPS regioisomer [:APOS;H] NMR (300 MHz, [DMSO-D6)] [8] 8.66 (s, 1 H), 7.98 (d, J = 7.6 Hz, 1 H), 7.86- 7.60 (m, 9H), 7.56-7. 44 (m, 6H), 7.01 (s, 1 H), 6.99 (dd, J = 6.7, 2.4 Hz, 1 H), 5.51 (s, 2H), 3.79 (s, 3H), 1.10 (s, 9H). MS [(ES+,] m/z) 687 [(M+1).] Data for 6-OTBDPS regioisomer: ‘H NMR (300 MHz, [DMSO-D6)] 8 8.60 (s, [1 H),] 7.99 (d, J= 7.6 Hz, [1 H),] 7.87-7. 57 (m, 9H), 7.54-7. 42 (m, 6H), 7.07 (d, J = 2.0 Hz, 1 H), 6.92 [(DD,] J = 8.8, 2.3 Hz, 1 H), 5.46 (s, 2H), 3.84 (s, [3H),] 1.11 (s, 9H). MS [(ES+,] m/z) 687 [(M+1).]

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,346-06-5, its application will become more common.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2004/14899; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts