Category: 346-06-5

Synthetic Route of 346-06-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 99; 5-(2-Trifluoromethylbenzyloxy)-quinazoline-2,4-diamine; [00297] Step 1; 2- (Trifluoromethyl)benzyl alcohol(1.15 g; 6.3 mmol) was added to a cooled (0 °C) slurry of sodium hydride (243.7 mg; 6 mmol) in dimethylformamide under nitrogen atmosphere. The reaction mixture was slowly warmed to room temperature, stirred for 45 min.. The reaction mixture was then added to a cooled (0 °C) solution of 2,6-difluorobenzonitrile in dimethylformamide , stirred for 3 hours at room temperature. The reaction mixture was poured on crushed ice-water, stirred, filtered, washed with water and dried to afford 1.39 grams of 2-fluoro-6-(2-trifluoro- methylphenyl-methoxy) benzonitrile as a white solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 346-06-5, (2-(Trifluoromethyl)phenyl)methanol.

Reference:
Patent; DECODE CHEMISTRY, INC.; SINGH, Jasbir; GURNEY, Mark E.; WO2005/123724; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol, the common compound, a new synthetic route is introduced below. Safety of (2-(Trifluoromethyl)phenyl)methanol

(2) To a 250 mL four-neck round bottom flask (mechanically stirred,Thermometer, reflux condenser) was added 2-trifluoromethylbenzyl alcohol (88.1 g, 0.5 mol), Then heated to 10 ° C,A solution of thionyl chloride (71.4 g, 0.6 mol)After the dropwise addition, the temperature was raised to 60 ° C, and the reaction was allowed to proceed.Keep T ? 55 ~ 65 /P ? 0.09 MPa The remaining SOCl2 was distilled off under reduced pressure,And then distillation at 75-80 ° C / -0.09 MPa under reduced pressure to give colorless transparent liquid 2-trifluoromethylbenzyl chloride purity> 99percent yield 95percent.

The synthetic route of 346-06-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jin Kai (Liaoning) Chemical Co., Ltd.; Fu, Limin; Wang, Yongcan; Jia, Tiecheng; Yang, Xiaoge; Wang, Xiuying; Wu, Jingrui; (8 pag.)CN106588673; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 346-06-5 ,Some common heterocyclic compound, 346-06-5, molecular formula is C8H7F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Adding a metal catalyst (1 mol%) to 10 mL of dried cuvettes,CPA (5 mol%) and activated 4A molecular sieve (100 mg) were sealed with a rubber stopper. Ventilation, replacing the air in the system with nitrogen. Through a syringe into a test tube Dichloromethane (1 mL) was added and stirred at -10 C. After that, the alcohol (1equiv), the diazonium compound (1equiv),1,3,5-triaryl-1,3,5-triazine (0.33 equiv) was dissolved in 1 mL of dichloromethane and slowly added to the reaction solvent with a peristaltic pump at a dropping rate of 1 mL/h.After the end of the dropwise addition, the stirring reaction was continued until the consumption of the diazo compound was completed.Stop the reaction,A small amount of the reaction solution was taken up by a capillary and purified by TLC for chiral HPLC analysis.Final purification by column chromatography (silica gel H, eluent:EA: PE = 1:200 to 1:50) gave the white solid product 5b. The yield was 81% and ee% = 94%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 346-06-5, (2-(Trifluoromethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; East China Normal University; Xing Dong; Che Jiuwei; Niu Li; Jia Shikun; Hu Wenhao; (107 pag.)CN109896969; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 346-06-5, Adding some certain compound to certain chemical reactions, such as: 346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol,molecular formula is C8H7F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 346-06-5.

EXAMPLE 1052-(trifluoromethyl)benzyl 7-bromo-3-oxo-2,3-dihydrospiro[indene-l ,4′-piperidine]-r- carboxylate To o-(trifluoromethyl)benzyl alcohol (35 mg, 0.20 mmol) in CH2Cl2 (4 mL) was added was a solution of carbonyl diimidazole (29 mg, 0.18 mmol) in CH2Cl2 (4 mL). The mixture was stirred at rt for 2 h. A 1-mL aliquot of the resulting solution (0.05 mmol) was added to a solution 7-bromospiro[indene-l,4′-piperidin]-3(2H)-one (14.5 mg, 0.05 mmol) in CH2Cl2 ( ImL). The mixture was stirred at rt for 16 h, concentrated, redissolved in MeCN (1 mL) and heated at 60 °C for 2 h. Prep HPLC afforded the title compound. LC-MS Method 1 tR = 2.06, min, m/z = 484, 482.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 346-06-5, (2-(Trifluoromethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; VITAE PHARMACEUTICALS, INC.; WO2009/108332; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 346-06-5, (2-(Trifluoromethyl)phenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of (2-(Trifluoromethyl)phenyl)methanol, blongs to alcohols-buliding-blocks compound. Safety of (2-(Trifluoromethyl)phenyl)methanol

General procedure: To a soln. or suspension of intermediate A-3 or E-3 (1 eq) and alcohol BB-9 (1.1 to 6 eq) in toluene (3.4 to 24 mL/mmol) was added a 1 M soln. of (tributylphosphoranylidene)acetonitrile in toluene (1.1 to 2 eq) under argon. The rxn mixture was heated to a given temperature and stirred for a given time (see (1477) Table ). When necessary to reach completion of the rxn, extra amounts of a 1M soln. of (tributylphosphoranylidene)acetonitrile in toluene (0.2 eq) were sequentially added under argon. It was quenched with water or a sat. aq. soln. of NaHC( and extracted with EtOAc or DCM. The combined org. phases were washed with brine, dried over MgS04 and concentrated in vacuo. The crude was purified by CC using Hept/EtOAc or DCM/MeOH. When necessary, an additional purification by prep. LC-MS using methods 2, 3, 4 or 5 was performed.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,346-06-5, (2-(Trifluoromethyl)phenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; IDORSIA PHARMACEUTICALS LTD; FROIDEVAUX, Sylvie; HUBLER, Francis; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon; (266 pag.)WO2019/137927; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 346-06-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, molecular weight is 176.14, as common compound, the synthetic route is as follows.

General procedure: To a 100 mL two-necked flask was added substituted benzylalcohol or 4,6-dimethylpyrimidine-2-thiol (2.60 mmol), NaOH (6.40 g, 1.60 mmol) and dimethylsulfoxide (30 mL). The flask was vacuumed and flushed three times with nitrogen. Then the solutionof 8 (0.20 g, 0.87 mmol) in dimethylsulfoxide (510 mL) was added, and the resulting mixture was heated to 80 C and kept at that temperature for approximately 12 h until the completion of the reaction (monitored by TLC). Subsequently, the mixture was cooled to room temperature and diluted with ethyl acetate (100 mL). The mixture was washed with brine to pH 7, and the organic phase was dried with anhydrous sodium sulfate. The organic phase was concentrated to get crude product, which was purified by column chromatography (ethyl acetate/ petroleumether 1:30 as eluent) to get 4a?ac in yields of 27.3?75.1percent.#10;#10;

Statistics shows that 346-06-5 is playing an increasingly important role. we look forward to future research findings about (2-(Trifluoromethyl)phenyl)methanol.

Reference:
Article; Lu, Huan-Huan; Xue, Ping; Zhu, Yuan-Yuan; Ju, Xiu-Lian; Zheng, Xiao-Jiao; Zhang, Xun; Xiao, Ting; Pannecouque, Christophe; Li, Ting-Ting; Gu, Shuang-Xi; Bioorganic and Medicinal Chemistry; vol. 25; 8; (2017); p. 2491 – 2497;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 346-06-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol. A new synthetic method of this compound is introduced below.

a) A solution of 30 ml of phosphorus tribromide in 60 ml of absolute toluene was added dropwise at 20°-30° C. to a solution of 14 g of o-trifluoromethylbenzyl alcohol in 80 ml of absolute toluene. Subsequently, the reaction mixture was stirred at room temperature for 2 hours, the toluene was distilled under reduced pressure, the residue was dissolved in methylene chloride, treated with water and the mixture was adjusted to pH 8.0 with potassium hydrogen carbonate. The aqueous phase was extracted three times with CH2 Cl2 and the organic phases were washed twice with water and once with saturated NaCl solution, dried over Na2 SO4 and evaporated under reduced pressure. o-Trifluoromethylbenzyl bromide was obtained as the residue.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,346-06-5, (2-(Trifluoromethyl)phenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Hoffmann-La Roche Inc.; US5270313; (1993); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 346-06-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol. A new synthetic method of this compound is introduced below.

General procedure: Reactions were performed in a magnetically stirred round bottomed flask fitted with acondenser and placed in a temperature controlled oil bath. 1,2-Diamine (2 mmol)was added to alcohol (3 mmol) and the reaction mixture was allowed to stir at 135°C in an open (air) atmosphere. After disappearance of the diamine (reaction was monitored by TLC)or after the appropriate time, the reaction mixture was cooled to roomtemperature. The crude residue was further purified by column chromatography using silica gel (100-200 mesh) to afford pure products. All the products wereidentified on the basis of NMR and mass spectral data

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,346-06-5, its application will become more common.

Reference:
Article; Marri, Mahender Reddy; Peraka, Swamy; Macharla, Arun Kumar; Mameda, Naresh; Kodumuri, Srujana; Nama, Narender; Tetrahedron Letters; vol. 55; 48; (2014); p. 6520 – 6525;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 346-06-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, molecular weight is 176.14, as common compound, the synthetic route is as follows.

Reference Production Example 3; Into 6 ml of N,N-dimethylformamide was suspended 0.16 g of sodium hydride (60percent oily), and 0.61 g of 2-trifluoromethylbenzyl alcohol was added under water cooling, and the resultant mixture was stirred for 15 minutes. Thereafter, to the mixture was added 0.4 g of 2-cyano-4-chloropyridine, and the mixture was stirred for 2 hours. The resultant reaction mixture was poured into a saturated ammonium chloride aqueous solution, and the mixture was extracted with t-butyl methyl ether three times. The organic layers obtained by extraction were combined and washed with saturated saline, dried over anhydrous magnesium sulfate, then, concentrated. The resultant residue was subjected to silica gel column chromatography to obtain 0.55 g of 4-(2-trifluoromethylbenzyloxy)pyridine-2-carbonitrile. [Show Image] 1H-NMR:5.34(s,2H),7.05(d, 1H),7.28(s, 1H), 7.50(brs, 1H), 7.62(br s,2H), 7.75(d, 1H), 8.53(d, 1H)

Statistics shows that 346-06-5 is playing an increasingly important role. we look forward to future research findings about (2-(Trifluoromethyl)phenyl)methanol.

Reference:
Patent; Sumitomo Chemical Company, Limited; EP2332936; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 346-06-5 ,Some common heterocyclic compound, 346-06-5, molecular formula is C8H7F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

the [(IPr)AuCl](6mg,0.01mmol,1mol%)AgOTf2.6mg,0.01mmol,1mol%Phenylacetylene (102mg, 1mmol), 1,4- dioxane (1ml) and water (36ul, 2equiv.) Were successively added to 5ml microwave tube.After the reaction mixture was microwaved at 120 reactor for one hour, cooled to room temperature.Thereto was added [Cp * IrCl2]2(8mg, 0.01mmol, 1mol%), potassium t-butoxide (112mg, 1mmol),2-trifluoromethylbenzyl alcohol (211mg, 1.2mmol).After the reaction mixture was microwaved at 130 reactor and then reacted for 2 hours, cooled to room temperature.Filtered, and solvent was removed by rotary evaporation, then purified by column chromatography (developing solvent: petroleum ether / ethyl acetate) to give the pure title compound Yield: 84%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,346-06-5, its application will become more common.

Reference:
Patent; Nanjing University of Science and Technology; Li, Feng; Ma, Juan; Qu, panpan; (15 pag.)CN104557500; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts