Category: 3458-28-4

Jia, Rui-Bo; Wu, Juan; Li, Zhao-Rong; Ou, Zhi-Rong; Zhu, Qiyuan; Sun, Baoguo; Lin, Lianzhu; Zhao, Mouming published the artcile< Comparison of physicochemical properties and antidiabetic effects of polysaccharides extracted from three seaweed species>, Electric Literature of 3458-28-4, the main research area is Ascophyllum Fucus Undaria diabetes polysaccharide physicochem property antidiabetic; Algal polysaccharides; Antidiabetic effects; Structural characterization.

Three algae polysaccharides (APs) extracted from Ascophyllum nodosum (ANP), Fucus vesiculosus (FVP) and Undaria Pinnatifida (USP) significantly differed in the zeta potential, water and oil holding capacity, monosaccharide composition, organic element composition, mol. weight distribution, microstructure and rheol. properties. Antidiabetic effects of APs were compared by oral intervention at the dose of 400 mg/kg·body weight/day in high sugar and fat diets and streptozotocin injection induced type 2 diabetic rats. The anal. of body weight, water intake, fasting blood glucose, insulin, oral glucose tolerance, blood lipid indicators (including total cholesterol (TC), triglyceride (TG), low d. lipoprotein cholesterol (LDL-C) and free fatty acid (FFA)), liver function indexes (involving alanine aminotransferase (ALT) and aspartate aminotransferase (AST)) and renal function profiles (comprising uric acid (UA) and urea nitrogen (BUN)) showed that APs possessed obvious antidiabetic activities, and FVP showed better effects in controlling the levels of FFA, AST, ALT, UA and BUN. Intervention of FVP reduced the total bile acid (TBA) level and elevated high d. lipoprotein cholesterol (HDL-C) level of diabetic rats. Histomorphol. observation further demonstrated that APs, especially FVP, could attenuate liver and kidney damage caused by diabetes. This study concluded that the antidiabetic effects of ANP, FVP and USP were distinctly different, which might be attributed to their different chem. structures. Therefore, the structure-activity relationship and antidiabetic mechanism of APs will be our future research direction.

International Journal of Biological Macromolecules published new progress about Antidiabetic agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xiao, Heng; Chen, Chun; Li, Chao; Huang, Qiang; Fu, Xiong published the artcile< Physicochemical characterization, antioxidant and hypoglycemic activities of selenized polysaccharides from Sargassum pallidum>, Electric Literature of 3458-28-4, the main research area is Sargassum selenium polysaccharide physicochem antioxidant hypoglycemic; Antioxidant; Hypoglycemic; Polysaccharide; Selenylation; Structure.

This study was carried out to study the effects of selenylation on physicochem. and biol. properties of polysaccharide (SPP) extracted from Sargassum pallidum. The selenized derivative of SPP (Se-SPP) with the selenium content of 2419 μg/g was synthesized by sodium selenite/dilute nitric acid method. Physicochem. characterization indicated that selenylation modification resulted in some changes in chem. composition, monosaccharide composition, mol. weight and surface morphol. of polysaccharides. FT-IR spectroscopy showed that a new absorption peak appeared at 675 cm-1 in Se-SPP probably due to the substitution of selenyl groups. Bioactivity assay showed that Se-SPP exhibited higher scavenging radical activities and ferrous ion chelating activities than native SPP. Compared with SPP and acarbose, Se-SPP showed more significantly inhibitory effect on α-glucosidase activity in a noncompetitive inhibition type. The IC50 values of SPP, Se-SPP and acarbose were determined as 1.579, 0.896 and 2.742 mg/mL, resp. These results suggest that Se-SPP can be used to develop a new selenium-complementary ingredient in functional foods.

International Journal of Biological Macromolecules published new progress about Antidiabetic agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Torretta, Simone; Scagliola, Alessandra; Ricci, Luisa; Mainini, Francesco; Di Marco, Sabrina; Cuccovillo, Ivan; Kajaste-Rudnitski, Anna; Sumpton, David; Ryan, Kevin M.; Cardaci, Simone published the artcile< D-mannose suppresses macrophage IL-1β production>, Formula: C6H12O6, the main research area is mannose macrophage IL1beta production.

D-mannose is a monosaccharide approx. a hundred times less abundant than glucose in human blood. Previous studies demonstrated that supraphysiol. levels of D-mannose inhibit tumor growth and stimulate regulatory T cell differentiation. It is not known whether D-mannose metabolism affects the function of non-proliferative cells, such as inflammatory macrophages. Here, we show that D-mannose suppresses LPS-induced macrophage activation by impairing IL-1β production In vivo, mannose administration improves survival in a mouse model of LPS-induced endotoxemia as well as decreases progression in a mouse model of DSS-induced colitis. Phosphomannose isomerase controls response of LPS-activated macrophages to D-mannose, which impairs glucose metabolism by raising intracellular mannose-6-phosphate levels. Such alterations result in the suppression of succinate-mediated HIF-1α activation, imposing a consequent reduction of LPS-induced Il1b expression. Disclosing an unrecognized metabolic hijack of macrophage activation, our study points towards safe D-mannose utilization as an effective intervention against inflammatory conditions.

Nature Communications published new progress about Animal gene, IL1B Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Shengnan; Zhao, Lingling; Li, Qinghua; Liu, Chang; Han, Jinlian; Zhu, Lijie; Zhu, Danshi; He, Yutang; Liu, He published the artcile< Rheological properties and chain conformation of soy hull water-soluble polysaccharide fractions obtained by gradient alcohol precipitation>, Synthetic Route of 3458-28-4, the main research area is soy hull water soluble polysaccharide rheol gradient alc precipitation.

In this study, we aim to reveal the properties of different fractions of soy hull soluble polysaccharide (SHSP) derived by alc. precipitation and the related mechanism. Three fractions were obtained, designated as SHSP20, SHSP40 and SHSP60; every fraction has its advantage(s). The mol. weight, monosaccharide composition, functional groups, morphol., and other rheol. properties of all SHSP fractions were investigated. The results showed that SHSP20 and SHSP40 accounted for 74.3% of soy hull soluble polysaccharide. FTIR spectrum confirmed the presence of uronic acid and protein in SHSP fractions. Also, the mol. weight of the polysaccharide fractions varied from 124.21 to 381.83 kDa. GC anal. indicated that mannose, galacturonic acid, and galactose were the main monosaccharide components of all the SHSP fractions. However, the monosaccharide types and ratios of the three SHSP fractions are significantly different. Furthermore, shear thinning behavior of SHSPs solution was observed SHSP40 exhibited the highest viscosity among samples tested. Atomic force microscopy further confirmed the various morphologies of SHSP fractions. The results suggest that SHSPs obtained by gradient alc. precipitation have different molar masses and chain conformations.

Food Hydrocolloids published new progress about Cell morphology. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Qin; He, Yuan; Xiang, Pan-Yin; Huang, Yue-Jia; Cao, Zheng-Wen; Shen, Si-Wei; Zhao, Li; Zhang, Qing; Qin, Wen; Wu, Ding-Tao published the artcile< Influences of different drying methods on the structural characteristics and multiple bioactivities of polysaccharides from okra (Abelmoschus esculentus)>, Reference of 3458-28-4, the main research area is Abelmoschus polysaccharide bioactivity drying; Antioxidant activity; Binding capacity; Drying method; Enzyme inhibition; Okra polysaccharide; Structural characteristic.

In this study, in order to evaluate the influences of drying methods on the chem. structures and bioactivities of polysaccharides from okra (OPPs), four drying methods, including microwave drying at 400 W, 600 W, and 800 W, freezing drying, hot air drying, and vacuum drying, were applied to dry okra fruits. Six different OPPs were extracted from okra dried by different drying methods. Results showed that physicochem. characteristics and bioactivities of OPPs varied by different drying methods. Noticeable variations in extraction yields, mol. weights, rheol. properties, molar ratios of constituent monosaccharides, contents of uronic acids, degrees of esterification, and contents of total phenolics were observed in OPPs obtained by different drying methods. In addition, results showed that OPPs, especially OPP-H and OPP-V obtained by hot air drying and vacuum drying, resp., exhibited remarkable antioxidant activities (ABTS, DPPH, and nitric oxide radical scavenging activities, and ferric reducing antioxidant powers), strong in vitro binding capacities (fat, cholesterol, and bile acids binding capacities), and obvious inhibitory activities on α-amylase and α-glucosidase. Results suggested that the hot air and vacuum drying techniques could be appropriate drying methods before extraction of OPPs with high bioactivities for applications in the functional food and medicine industries.

International Journal of Biological Macromolecules published new progress about Abelmoschus esculentus. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rozi, Parhat; Abuduwaili, Aytursun; Mutailifu, Paiheerding; Gao, Yanhua; Rakhmanberdieva, Rano; Aisa, Haji Akber; Yili, Abulimiti published the artcile< Sequential extraction, characterization and antioxidant activity of polysaccharides from Fritillaria pallidiflora Schrenk>, Safety of (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Fritillaria polysaccharide extraction antioxidant activity property; Antioxidant activity; Characterization; Fritillaria pallidiflora schrenk; Polysaccharide.

In this paper, Fritillaria pallidiflora schrenk polysaccharides were extracted with different methods and isolated by anion-exchange and gel-permeation chromatog. Physicochem. properties, structural characteristics and antioxidant activities were investigated for the first time. The polysaccharides composed of glucose, galactose, arabinose, xylose, mannose and rhamnose with different molar ratio and mol. weight Fourier transform IR spectroscopy and NMR anal. exhibited the presence of key functional groups of polysaccharides whereas SEM anal. revealed the characteristic morphol. of different fractions. The thermogravimetric anal. manifested the thermal stability of polysaccharides. The reducing power and antioxidant activities of polysaccharides were evaluated in vitro. Among them, the acidic fraction FPSP-H2-1 has a strong antioxidant effect against DPPH, hydroxyl and ABTS free radicals. The results revealed the polysaccharide’s important role as potential natural antioxidant agents during the investigation and application of bioactive polysaccharide.

International Journal of Biological Macromolecules published new progress about Anion exchange. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Safety of (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Biao; Han, Jiannan; Cheng, Yaolan; Cheng, Shujie; Huang, Dechun; McClements, David Julian; Cao, Chongjiang published the artcile< Identification and characterization of antioxidant and immune-stimulatory polysaccharides in flaxseed hull>, Related Products of 3458-28-4, the main research area is antioxidant polysaccharide flaxseed; Flaxseed; Immune-enhancing; MAPK; Polysaccharide.

Flaxseeds are widely consumed for their desirable sensory attributes and health benefits. We focused on enhancing the sustainability and economic potential of flaxseeds by characterizing functional attributes of polysaccharides isolated from flaxseed hull residues. In particular, antioxidant and immune-stimulatory polysaccharides were isolated and purified from flaxseed hull. IR spectroscopy was used to identify the key functional groups. The polysaccharides were composed of mannose, rhamnose, galactose, glucose, galactose, xylose, arabinose, and fucose. In vitro studies showed certain flaxseed hull polysaccharide fractions exhibited strong antioxidant activities, increased nitric oxide levels, and enhanced the production of cytokines (TNF-α and IL-6). In the presence of 200μg/mL of one of these fractions, the levels of p-ERK, p-JNK, and p-p38 increased significantly by 1.8-, 9.0-, and 6.7-fold. These polysaccharide fractions may exhibit their immune-regulatory properties partly by modulating the MAPK pathway. The flaxseed hull polysaccharides identified have potential application as natural antioxidants and immune-enhancing nutraceuticals.

Food Chemistry published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guo, M.-Z.; Meng, M.; Duan, S.-Q.; Feng, C.-C.; Wang, C.-L. published the artcile< Structure characterization, physicochemical property and immunomodulatory activity on RAW264.7 cells of a novel triple-helix polysaccharide from Craterellus cornucopioides>, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Craterellus macrophage immunomodulation polysaccharide; Chemical structure; Craterellus cornucopioides; Polysaccharide; Stability immunomodulatory activity.

In the study, a new triple-helix polysaccharide with favorable stability was purified from C. cornucopioides. Its structural characterization, stability and solution behavior were investigated by the GC-MS, periodate oxidation-smith degradation, FT-IR, 1D and 2D NMR spectroscopy, methylation anal., Scanning electron microscope, Congo-red, CD, TGA and DSC anal. The results showed that Craterellus cornucopioide polysaccharide (CCP) possessed the mol. weight of 1.97 × 103 kDa, is mainly composed of mannose (48.73%), galactose (17.37%), glucose (15.97%) and xylose (17.93%), resp. It was a heteroglycan with (1 → 3)-linked-β-D-Manp-(1 → 6)-linked a-D-Galp backbone distributed by (1 → 4)-linked-a-D-Xylp-t-a-D-Manp and t-β-D-Glup units at O-6. The result of TGA and DSC assay indicated that CCP has a favorable thermal stability. MTT and Scanning electro microscopy (SEM) assay showed that CCP could significantly improve the proliferation activity and induce cells activation of RAW264.7 in a certain range of concentrations and period.

International Journal of Biological Macromolecules published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Salarbashi, Davoud; Bazeli, Javad; Fahmideh-Rad, Elham published the artcile< Fenugreek seed gum: Biological properties, chemical modifications, and structural analysis- A review>, Application In Synthesis of 3458-28-4, the main research area is review Fenugreek seed gum physicochem functional property; Fenugreek seed gum; Functional properties; Physico-chemical properties.

A review. Fenugreek is a leguminous plant belongs to the family Fabaceae, which is extensively cultivated as a semiarid crop in Northern Africa, the Mediterranean, India, and Canada. In the present review paper, first we summarized the extraction, purification, chem. composition, mol. structure, and rheol. behavior of the mucilages isolated from Fenugreek seeds (FSG), and then their functional properties presented to elucidate the potential application of this traditional source of hydrocolloids in food, pharmaceutical, and other industries. To date, there is no technique that can successfully remove the attached protein from FSG. From a structural point of view, galactose and mannose are the most abundant polysaccharide in FSG composition, suggesting a galactomannan-like structure. FSG is the most soluble of the seed gums. FSG solutions at various temperatures and concentrations showed a time-dependent shear thinning behavior. Furthermore, these hydrocolloids can be employed for the fabrication of eco-friendly packaging systems. Antioxidant capacity and anti-fungi activity of FSG has been proved in different studies. In conclusion, industrial applications of FSG are possible due to its strong thickening properties. Addnl., FSG has an excellent emulsification capacity, which enables its application in the food, cosmetic and/or pharmaceutical industries.

International Journal of Biological Macromolecules published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application In Synthesis of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zeng, Fanke; Chen, Wenbo; He, Ping; Zhan, Qiping; Wang, Qian; Wu, Hui; Zhang, Mengmeng published the artcile< Structural characterization of polysaccharides with potential antioxidant and immunomodulatory activities from chinese water chestnut peels>, Product Details of C6H12O6, the main research area is Eleocharis polysaccharide antioxidant immunomodulation; Antioxidant activity; Chinese water chestnut peels; Immunomodulatory activity; Polysaccharides; Structural features.

Chinese water chestnut peels are a kind of vegetable processing waste containing many active components such as polysaccharides, the structure of which remains unknown. To elucidate the structure of polysaccharides from Chinese water chestnut peels, two polysaccharides named WVP-1 and WVP-2 were isolated. WVP-1 (3.16 kDa) consisted of mannose (1.75%), glucose (84.69%), galactose (6.32%), and arabinose (7.24%), while WVP-2 (56.97 kDa) was composed of mannose (3.18%), rhamnose (1.52%), glucuronic acid (1.42%), galacturonic acid (4.83%), glucose (11.51%), galactose (36.02%), and arabinose (41.53%). Linkage and NMR data indicated that WVP-1 was composed mainly of →4)-α-D-Glcp(1→ and a certain proportion of →3)-β-D-Glcp-(1→, including linear and branched polysaccharides simultaneously. WVP-2 was a pectin-like polysaccharide with →4)-α-D-GalpA6Me-(1→ units and the branch points of →3,4)-α-L-Arap-(1→, →3,6)-β-D-Galp-(1→. WVP-2 exhibited stronger potential antioxidant and immunomodulatory activities than WVP-1 in vitro. These results provide a foundation for the further study of polysaccharides from Chinese water chestnut peels.

Carbohydrate Polymers published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts