Category: 3458-28-4

Cvetko, Ana; Kifer, Domagoj; Gornik, Olga; Klaric, Lucija; Visser, Elizabeth; Lauc, Gordan; Wilson, James F.; Stambuk, Tamara published the artcile< Glycosylation alterations in multiple sclerosis show increased proinflammatory potential>, Category: alcohols-buliding-blocks, the main research area is glycosylation multiple sclerosis proinflammatory potential; N-glycosylation; biomarkers; immunoglobulin G in inflammation; multiple sclerosis; plasma glycoproteins.

Multiple sclerosis (MS) is an inflammatory autoimmune disorder affecting the central nervous system (CNS), with unresolved etiol. Previous studies have implicated N-glycosylation, a highly regulated enzymic attachment of complex sugars to targeted proteins, in MS pathogenesis. We investigated individual variation in N-glycosylation of the total plasma proteome and of IgG in MS. Both plasma protein and IgG N-glycans were chromatog. profiled and quantified in 83 MS cases and 88 age- and sex-matched controls. Comparing levels of glycosylation features between MS cases and controls revealed that core fucosylation (p = 6.96 x 10-3) and abundance of high-mannose structures (p = 1.48 x 10-2) were the most prominently altered IgG glycosylation traits. Significant changes in plasma protein N-glycome composition were observed for antennary fucosylated, tri- and tetrasialylated, tri- and tetragalactosylated, high-branched N-glycans (p-value range 1.66 x 10-2-4.28 x 10-2). Classification performance of N-glycans was examined by ROC curve anal., resulting in an AUC of 0.852 for the total plasma N-glycome and 0.798 for IgG N-glycome prediction models. Our results indicate that multiple aspects of protein glycosylation are altered in MS, showing increased proinflammatory potential. N-glycan alterations showed substantial value in classification of the disease status, nonetheless, addnl. studies are warranted to explore their exact role in MS development and utility as biomarkers.

Biomedicines published new progress about Autoimmune disease (inflammatory). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lu, Jike; Li, Jingjing; Jin, Ruichong; Li, Shufang; Yi, Juanjuan; Huang, Jinyong published the artcile< Extraction and characterization of pectin from Premna microphylla Turcz leaves>, Category: alcohols-buliding-blocks, the main research area is Premna leaf pectin response surface methodol microwave pretreatment; Characterization; Pectin; Premna microphylla Turcz leaves.

N this work, response surface methodol. (RSM) and microwave pretreatment were used to extract pectin from Premna microphylla Turcz leaves (PMTL). The process variables were optimized by the isovariant central composite design to improve the pectin extraction yield. The optimum conditions obtained were as follows, extraction time 2 h, temperature 90 °C, pH 2 and liquid-solid (LS) ratio 50 mL/g. The extraction yield was 18.25% under these conditions, which was close to the predicted value (17.60%). Then the pectin was characterized by gas chromatog. (GC), spectrophotometric (UV-visible Spectroscopy) and spectroscopic (Fourier transform IR) methods. The galacturonic acid content was 82.75%, and on this basis, the other monosaccharide composition anal. illustrated that pectin from PMTL was also composed of rhamnose, arabinose, mannose, glucose and galactose in a ratio of 2.96:1.17:1.04:8.07:2.05. The pectin of PMTL had an esterification degree of 62.50% and it showed good antioxidant activity. Taken together, the pectin of PMTL could be used as potential additive in food industry.

International Journal of Biological Macromolecules published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Hongyan; Xie, Wancui; Sun, Haihong; Cao, Kewei; Yang, Xihong published the artcile< Effect of the structural characterization of the fungal polysaccharides on their immunomodulatory activity>, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is immunomodulatory agent extracellular polysaccharide Aspergillus Sanguisorba Rumia Zizania; Extracellular polysaccharide; Fungus; Immunomodulatory activity; Structural characterization.

The immunomodulatory effects of the four extracellular polysaccharides, namely WPA, WPB, AP2A, and TP1A, which were isolated from the fermented broth of Aspergillus aculeatus, A. terreus and Trichoderma sp. KK19L1, were investigated in vitro. WPA, WPB, AP2A, and TP1A were not toxic to RAW264.7 cells. These polysaccharides enhanced cell viability. WPA, WPB, AP2A, and TP1A showed increased immunomodulatory effect by strengthening the phagocytic activity and enhancing the release of NO, TNF-α and IL-6 from RAW264.7 cells. WPA, WPB, AP2A, and TP1A exhibited different immunomodulatory activity in vitro due to their different structural characterizations, and their immunoregulatory effects decreased successively in the following order: WPA, WPB, AP2A, and TP1A. The extracellular polysaccharides WPA, WPB, AP2A, and TP1A had potent immunomodulatory effects and could be used as potential immunomodulatory agents in the fields of functional food and medicine.

International Journal of Biological Macromolecules published new progress about Animal gene, TNFA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Han, Qiao-Hong; Liu, Wen; Li, Hong-Yi; He, Jing-Liu; Guo, Huan; Lin, Shang; Zhao, Li; Chen, Hong; Liu, Yao-Wen; Wu, Ding-Tao; Li, Shu-Qing; Qin, Wen published the artcile< Extraction optimization, physicochemical characteristics, and antioxidant activities of polysaccharides from kiwifruit (Actinidia chinensis Planch.)>, Category: alcohols-buliding-blocks, the main research area is Actinidia polysaccharide antioxidant physicochem property; Actinidia chinensis Planch.; antioxidant activity; chemical structure; microwave-assisted extraction; polysaccharide; ultrasonic-assisted extraction.

In order to evaluate effects of extraction techniques on the physicochem. characteristics and antioxidant activities of kiwifruit polysaccharides (KPS), and further explore KPS as functional food ingredients, both microwave-assisted extraction (MAE) and ultrasonic-assisted extraction (UAE) were optimized for the extraction of KPS. Furthermore, the physicochem. structures and antioxidant activities of KPS extracted by different techniques were investigated. The optimal extraction conditions of UAE and MAE for the extraction of KPS were obtained by response surface methodol. Different extraction techniques significantly affected the contents of uronic acids, mol. weights, molar ratios of constituent monosaccharides, and the degree of esterification of KPS. Results showed that KPS exhibited remarkable DPPH and ABTS radical scavenging activities, and reducing power. The high antioxidant activities observed in KPS extracted by the MAE method (KPS-M) might be partially attributed to its low mol. weight and high content of unmethylated galacturonic acid. Results suggested that the MAE method could be a good potential technique for the extraction of KPS with high antioxidant activity, and KPS could be further explored as functional food ingredients.

Molecules published new progress about Actinidia chinensis. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Han, Qiao-Hong; Liu, Wen; Li, Hong-Yi; He, Jing-Liu; Guo, Huan; Lin, Shang; Zhao, Li; Chen, Hong; Liu, Yao-Wen; Wu, Ding-Tao; Li, Shu-Qing; Qin, Wen published the artcile< Extraction optimization, physicochemical characteristics, and antioxidant activities of polysaccharides from kiwifruit (Actinidia chinensis Planch.)>, Category: alcohols-buliding-blocks, the main research area is Actinidia polysaccharide antioxidant physicochem property; Actinidia chinensis Planch.; antioxidant activity; chemical structure; microwave-assisted extraction; polysaccharide; ultrasonic-assisted extraction.

In order to evaluate effects of extraction techniques on the physicochem. characteristics and antioxidant activities of kiwifruit polysaccharides (KPS), and further explore KPS as functional food ingredients, both microwave-assisted extraction (MAE) and ultrasonic-assisted extraction (UAE) were optimized for the extraction of KPS. Furthermore, the physicochem. structures and antioxidant activities of KPS extracted by different techniques were investigated. The optimal extraction conditions of UAE and MAE for the extraction of KPS were obtained by response surface methodol. Different extraction techniques significantly affected the contents of uronic acids, mol. weights, molar ratios of constituent monosaccharides, and the degree of esterification of KPS. Results showed that KPS exhibited remarkable DPPH and ABTS radical scavenging activities, and reducing power. The high antioxidant activities observed in KPS extracted by the MAE method (KPS-M) might be partially attributed to its low mol. weight and high content of unmethylated galacturonic acid. Results suggested that the MAE method could be a good potential technique for the extraction of KPS with high antioxidant activity, and KPS could be further explored as functional food ingredients.

Molecules published new progress about Actinidia chinensis. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yan, Jingmin; Zhu, Lei; Qu, Yunhe; Qu, Xian; Mu, Meixia; Zhang, Mengshan; Muneer, Gul; Zhou, Yifa; Sun, Lin published the artcile< Analyses of active antioxidant polysaccharides from four edible mushrooms>, Application In Synthesis of 3458-28-4, the main research area is edible mushroom antioxidant polysaccharide analyzes; Antioxidant activities; Mushroom polysaccharides; Structural characterization.

Four water-soluble polysaccharides were extracted from Pleurotus eryngii, Flammulina velutipes, Pleurotus ostreatus and white Hypsizygus marmoreus. Using anion exchange and gel permeation chromatog., a neutral and an acidic fraction were purified from each water-soluble polysaccharide. Their mol. weights were all around 20 kDa except that the acidic polysaccharide from Pleurotus ostreatus (named WPOPA) had a lower mol. weight of 5 kDa. Four neutral polysaccharides were mainly composed of galactose (42.7%-69.1%), followed by Man (19.4%-39.3%) and Glc (1.1%-15.9%). Four acidic polysaccharides contained glucose (59.0%-81.8%) as major sugar and minor glucuronic acid (4.5%-9.5%). Acidic polysaccharides exhibited stronger antioxidant activities than neutral fractions, and WPOPA showed the best antioxidant effects. Structural anal. indicated WPOPA had β-(1 → 6)-glucan backbone branched at O-3 by β-1,3-D-Glcp, t-β-D-Glcp and t-β-D-GlcpA. This investigation would be useful for screening natural antioxidants and significant in developing mushroom polysaccharides as functional foods.

International Journal of Biological Macromolecules published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application In Synthesis of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Yuqing; Liu, Dan; Wang, Dingyi; Lai, Shanshan; Zhong, Ruting; Liu, Yuanyuan; Yang, Chengfeng; Liu, Bin; Sarker, Moklesur Rahman; Zhao, Chao published the artcile< Hypoglycemic activity and gut microbiota regulation of a novel polysaccharide from Grifola frondosa in type 2 diabetic mice>, Related Products of 3458-28-4, the main research area is Grifola polysaccharide type 2 diabetes gut microbiota regulation hypoglycemia; Grifola frondosa polysaccharide; Hypoglycemic; Intestinal microflora; Purification; Single-molecule real-time sequencing.

GFP-N, a novel heteropolysaccharide with a mol. weight of 1.26 × 107 Da, was isolated from maitake mushroom and purified by anion-exchange chromatog. on a DEAE cellulose-52 column and gel-filtration chromatog. on a Sephadex G-100 column. Its structure was characterized by Fourier transform IR spectroscopy and one-dimensional (1H- and 13C-) NMR spectra, 1H-1H correlation spectroscopy, and 1H-13C heteronuclear single-quantum coherence spectroscopy. The structure of GFP-N consisted of L-arabinose, D-mannose and D-glucose and mainly contained three kinds of linkage type units as( →2,6)-a-D-Manp-(1 → 4, a-L-Araf-C1→, and →3,6)-β-D-Glcp-(1 →). GFP-N could activate insulin receptor substrate 1, phosphatidylinositol-3-kinase, and glucose transporter 4 and inhibit c-Jun N-terminal kinase 1/2 for hypoglycemic effects in diabetic mouse livers. This is also the first report of the regulatory efficacy of Grifola frondosa polysaccharide on intestinal microflora in vivo using single-mol. real-time sequencing. These results indicated that polysaccharide from maitake mushroom could be as an enhancer to improve type 2 diabetes and a healthy food option to help regulate gut microbiota in diabetic individuals.

Food and Chemical Toxicology published new progress about Actinobacteria. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lin, Ximeng; Ji, Xiaolong; Wang, Min; Yin, Sheng; Peng, Qiang published the artcile< An alkali-extracted polysaccharide from Zizyphus jujuba cv. Muzao: Structural characterizations and antioxidant activities>, Product Details of C6H12O6, the main research area is Zizyphus fruit acidic polysaccharide antioxidant; Acidic polysaccharide; Alkaline extraction; Antioxidant activities; Structural characterization; Ziziphus jujuba cv, Muzao.

An acidic polysaccharide (SAZMP3) was isolated from jujube fruit residues by alk. extraction and purified with DEAE-Sepharose Fast Flow and Sephacryl S-300 column chromatog. The structural characterizations of SAZMP3 were determined by high-performance gelpermeation chromatog., gas chromatog., Fourier transform IR spectroscopy, methylation anal., NMR spectroscopy, SEM, and at. force microscopy. The results determined SAZMP3 was an acidic polysaccharide mainly contained rhamnose, galactose, and galacturonic acid with a mol. weight of 9.37 kDa and its backbone might mainly be composed of 1,4-α-D-GalAp with side chains of 1,3-β-D-Galp, 1,3,5-linked Araf, 1,2,4-α-L-Rhap and terminals of 1-linked Araf, 1-linked Rhap, 1-linked Galp by methylation and NMR anal. Besides, SAZMP3 has shown potential antioxidant activity in scavenging free radicals suggesting that it is an antioxidant agent, which might contribute to the functional food qualities of jujube fruit.

International Journal of Biological Macromolecules published new progress about Acidic polysaccharides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Xuegui; Bian, Jun; Li, Danqi; Liu, Changfeng; Xu, Shuangshuang; Zhang, Gongling; Zhang, Lixin; Gao, Pinyi published the artcile< Structural features, antioxidant and acetylcholinesterase inhibitory activities of polysaccharides from stem of Physalis alkekengi L.>, Formula: C6H12O6, the main research area is Physalis stem polysaccharide antioxidant acetylcholinesterase structural property.

Physalis alkekengi L.(P. alkekengi) is an important medicinal plant in China. In this study, two polysaccharides (SPAP-1 and SPAP-2) were isolated from the stem of P. alkekengi using hot water extraction method. The extract was further purified by DEAE-cellulose and Sephadex G-200 chromatog. The chem. characteristics, surface features and thermal stability of SPAP-1 and SPAP-2 were evaluated. For the first time, high-performance liquid chromatog. with refractive index detection and amino column (without sample derivatization) was performed to analyze the monosaccharide composition of polysaccharides obtained from the stem of P. alkekengi. As a result, SPAP-1 (Mw = 9.1 kDa) consisted of rhamnose, arabinose, galacturonic acid, mannose, and glucose in the ratio of 1.0:1.5:1.9:29.1:1.03, while SPAP-2 (Mw = 13.5 kDa) comprised of rhamnose, xylose, arabinose, mannose and glucose in the ratio of 31.8:14.8:1.0:6.5:22.6. Addnl., the antioxidant effects of SPAP-1 and SPAP-2 were evaluated by ferric reducing power, 2,2′-Azinobis-(3-ethylbenzthiazoline-6-sulfonate acid) (ABTS) and 2.2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays. The results showed that the purified polysaccharides exerted significant scavenging activities. Subsequently, acetylcholinesterase inhibitory effects in vitro of the polysaccharides were investigated, which showed that, SPAP-1 and SPAP-2 showed moderate acetylcholinesterase inhibitory activities. Thus, the polysaccharide content in P. alkekengi stem as promising source of natural products possess good antioxidant activities and may exert beneficial effects on cognitive function.

Industrial Crops and Products published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wei, Zewei; Huang, Lianfang; Cui, Liao; Zhu, Xiao published the artcile< Mannose: Good player and assister in pharmacotherapy>, Synthetic Route of 3458-28-4, the main research area is review mannose anticancer agent cancer; Cancer; Mannose; Medicinal function; Nanovaccine; Photodynamic therapy.

A review. Mannose is a monosaccharide widely distributed in body fluids and tissues, especially in the nerve, skin, testicles, retina, liver and intestines. It is used to synthesize glycoproteins and participate in immune regulation. In recent years, mannose has been applied more and more widely in the biomedical context as people have a deeper understanding of its biol. effects. This review introduces the use of mannose in treating various diseases (including cancer, urinary tract infections, type 1 diabetes, and diabetic wounds), preventing pancreatic fistula, and improving magnetic resonance imaging for acute pancreatitis. We also demonstrate that mannose has the potential for clin. applications.

Biomedicine & Pharmacotherapy published new progress about Acute pancreatitis. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts