Category: 3458-28-4

Chen, Guangjing; Li, Changfeng; Wang, Shasha; Mei, Xiaofei; Zhang, Hongxin; Kan, Jianquan published the artcile< Characterization of physicochemical properties and antioxidant activity of polysaccharides from shoot residues of bamboo (Chimonobambusa quadrangularis): Effect of drying procedures>, Electric Literature of 3458-28-4, the main research area is Chimonobambusa bamboo shoot residue antioxidant polysaccharide drying; Antioxidant activity; Bamboo shoots processing by-products; Chimonobambusa quadrangularis polysaccharides; Drying procedures; Physicochemical characterization.

In the present study, the bamboo shoot (Chimonobambusa quadrangularis) residue (BSR)-derived polysaccharides (CPS) were dried using different drying procedures, including hot air-, vacuum-, freeze-, and spray-drying. The influences of different drying procedures on the chem. compositions, physicochem. characteristics, and antioxidant activity of CPS were investigated. The results indicate that freeze-dried CPS possessed the highest polysaccharide yield (8.86%) and uronic acid content (9.42%), and the lowest medium-high mol. weight (117.49 kDa) and glucose content (5.81 mol%). Also, freeze-dried CPS had better water (5.17 g/g) and oil retention capacities (2.32 g/g) than hot air- and vacuum-dried CPS. Moreover, freeze-dried CPS exhibited the most potent antioxidant ability. Based on correlation anal., a higher uronic acid content, lower mol. weight and lower glucose content might be closely associated with the better antioxidant activity of the freeze-dried CPS. Hence, the above results revealed freeze-drying was the optimal method for industrial production of high quality CPS.

Food Chemistry published new progress about Air drying process (hot). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lu, Yan; Xu, Lei; Cong, Yunzhe; Song, Ge; Han, Jun; Wang, Guodong; Zhang, Pengying; Chen, Kaoshan published the artcile< Structural characteristics and anticancer/antioxidant activities of a novel polysaccharide from Trichoderma kanganensis>, Application of C6H12O6, the main research area is Trichoderma kanganensis anticancer antioxidant polysaccharide structure; Anticancer activity; Antioxidant activity; Polysaccharide; Structural characteristics; Trichoderma kanganensis.

A novel water-soluble polysaccharide designated as TPS was isolated from the fermentation mycelia of Trichoderma kanganensis. TPS had a weight-average mol. mass of 3.074 × 105 Da, and the monosaccharide composition was consisted of Man (45.5%), GlcA (5.5%), Glc (10%), and Gal (39%). The major backbone of TPS was →6-α-D-Galp-1→5-β-D-Manf-1→5,6-β-D-Manf-1→5,6-β-D-Manf-1→, and the side chains are α-D-Glcp-1→4-α-D-Glcp-1→, β-D-Galf-1→, and α-D-Glcp-1→. In addition, we demonstrated that TPS was non-toxic in normal cells (LO2 cells) and inhibited the proliferation of mouse colon cells (CT26 cells). TPS also showed free radical scavenging activity against hydrogen peroxide. Overall, these results suggested that TPS from Trichoderma kanganensis may have potential application in biomedical fields.

Carbohydrate Polymers published new progress about Antitumor agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Feng, Simin; Luan, Di; Ning, Ke; Shao, Ping; Sun, Peilong published the artcile< Ultrafiltration isolation, hypoglycemic activity analysis and structural characterization of polysaccharides from Brasenia schreberi>, Application In Synthesis of 3458-28-4, the main research area is Brasenia hypoglycemic structural characterization; Brasenia schreberi; Hypoglycemic; Molecular conformation; Polysaccharides.

Brasenia schreberi (B. schreberi) is a rare and precious vegetable, which coat with a gelatinous mucilage. This study is aiming to investigate the relationship between structural characteristics and hypoglycemic activities of polysaccharides with different mol. weight (Mw) range. Three polysaccharides fractions, namely BSP-U100 (50-100 kDa), BSP-U50 (10-50 kDa) and BSP-U10 (<10 kDa), were isolated from B. schreberi mucilage using ultrafiltration method. Compared to other polysaccharide samples, only BSP-U100 had a triple helix structure and existed as the ordered structure in aqueous solution Furthermore, BSP-U100 exhibited higher α-amylase (IC50 = 0.4414 mg/mL) and α-glucosidase (IC50 = 0.5993 mg/mL) inhibitory activity. A heteropolysaccharide BSP-1a, which average Mw was 83.98 kDa, was purified from BSP-U100 by DEAE Sepharose Fast Flow and Sephadex G-75 column. D-galactose (66.85%), D-glucose (2.05%) and D-mannose (1.65%) were three main monosaccharides of BSP-1a. Structural characterization of BSP-1a showed that BSP-1a might be a kind of L-D-pyranose type galactose and mainly composed of α-1 → 6-linked Galp, α-1 → 3-linked Manp and α-1 → 4-linked Glcp. This study provided a theor. basis for the development and application of B. schreberi polysaccharides as a potential anti-diabetic supplement. International Journal of Biological Macromolecules published new progress about Antidiabetic agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application In Synthesis of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pan, Li-Chao; Zhu, Yong-Ming; Zhu, Zhen-Yuan; Xue, Wei; Liu, Chun-Yu; Sun, Hui-Qing; Yue-Yin published the artcile< Chemical structure and effects of antioxidation and against α-glucosidase of natural polysaccharide from Glycyrrhiza inflata Batalin>, Related Products of 3458-28-4, the main research area is Glycyrrhiza antioxidant alpha glucosidase natural polysaccharide free radical scavenger; Antioxidant activity; Glycyrrhiza inflata Batalin; Polysaccharide; Structural characterization; Surface plasmon resonance; α-Glucosidase inhibition.

GIBP, a homogeneous polysaccharide extracted from Glycyrrhiza inflata Batalin with a mol. weight 1.96 x 103 kDa, had a triple helix structure, smooth and sheet-like structure. Comprehensive anal. showed that the main chain of GIBP was composed of α-D-1,4 linked glucose, branch points were composed of α-D-1,3,6 and α-D-1,2,3,6 linked glucoses, and side chains were composed of α-D-1,3 and β-D-1,6 linked galactose, β-L-1,2 linked arabinose, α-D-1,3 and β-D-1,3 mannose. The scavenging abilities of GIBP (3 mg/mL) against DPPH· radical, ·OH radical, O2-· radical and ABTS were 50.75 ± 0.13% and 52.32 ± 0.13, 25.84 ± 0.35% and 44.57 ± 0.15% and it also demonstrated an obvious dose-effect relationship. The inhibitory activity of α-glucosidase showed that the inhibitory effect of GIBP was enhanced with the increase of concentration When the concentration reached 6 mg/mL, the inhibition rate of α-glucosidase activity reached 64.77%. And the ka, kd and KD were 6.472 x 104 1/Ms., 2.934 x 10-3 1/s and 4.534 x 10-8 M.

International Journal of Biological Macromolecules published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Xin; Che, Chengchuan; Zhang, Junming; Gong, Zhijin; Si, Meiru; Yang, Ge; Cao, Li; Liu, Jinfeng published the artcile< Structural characterization and immunomodulating activities of polysaccharides from a newly collected wild Morchella sextelata>, Computed Properties of 3458-28-4, the main research area is polysaccharide Morchella sextelata immunomodulator macrophage; Immunomodulatory; Morchella sextelata; Polysaccharides; Purification.

A purified polysaccharide was acquired from a newly collected wild Morchella. The strain identification initially showed that the strain was Morchella sextelata. This study aimed to investigate the structural features and immunomodulating activities of the polysaccharide. Polysaccharide extracted from mycelia was purified by DEAE-cellulose chromatog. and Sephadex G-25 size-exclusion chromatog. in sequence. The main fraction of polysaccharide (MSP-II) was obtained during purification process. High Performance Liquid Chromatog. (HPLC) anal. revealed that MSP-II was composed of Glc, Ara, Gal, Man, Rha, Fuc, GalUA and GluUA in ratio of 34.95:8.7:9.55:4.55:5.0:1.45:12.7:7.65. The structure of MSP-II was furtherly analyzed by FT-IR spectrum and 1 H and 13 C NMR spectroscopy, the results showed that MSP contained β glycosidic bonds as well as Α glycosidic linkages. In vitro tests proved that MSP-II could not only promote the proliferation and phagocytosis of RAW264.7 cells, but also induce the section of nitric oxide (NO) of macrophages. Consequently, the polysaccharide has a potent immunomodulatory activity by stimulating macrophages and can be considered as a novel potential immunopotentiator in medical and food industries.

International Journal of Biological Macromolecules published new progress about Cell proliferation. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Computed Properties of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Juan; Ji, Haiyu; Yang, Zhizhi; Liu, Anjun published the artcile< Relationship between structural properties and antitumor activity of Astragalus polysaccharides extracted with different temperatures>, Application In Synthesis of 3458-28-4, the main research area is Astragalus polysaccharide structure antitumor temperature; Antitumor activity; Astragalus membranaceus polysaccharides; Structural characterization.

This study investigated the effects of different temperatures on structural characterization and antitumor activity of polysaccharides from Astragalus membranaceus. APS4 and APS90 were extracted at 4°C and 90°C, resp., and purified by Sephadex G-200 column. APS4-90 were obtained from APS4 after treatment at 90°C for 6 h. MTT results showed that APS4 possessed the highest inhibitory effects on MGC-803, A549 and HepG2 cells. HPGPC anal. showed that the average mol. weights of these polysaccharides were approx. 1.5 × 106 Da, while the asym. peak of APS4-90 suggested heat degradation and configuration changes of APS4. GC, NMR and methylation results showed that these three polysaccharides had similar monosaccharide components (mainly contain glucose), and their backbones were composed of (1→2)-α-D-Glcp. However, APS4 showed higher content of (1→2,6)-α-D-Glcp compared to APS4-90 and APS90, which indicated that higher branched degree would be responsible for the stronger in vitro antitumor activity in APS4. These results were also confirmed by sp. rotation and SEM anal. Our study suggested that APS4 had the potential application for cancer treatment.

International Journal of Biological Macromolecules published new progress about Antitumor agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application In Synthesis of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gan, Longzhan; Li, Xiaoguang; Zhang, Heming; Zhang, Ruoshi; Wang, Hongbin; Xu, Zhe; Peng, Biyu; Tian, Yongqiang published the artcile< Preparation, characterization and functional properties of a novel exopolysaccharide produced by the halophilic strain Halomonas saliphila LCB169T>, Electric Literature of 3458-28-4, the main research area is Halomonas exopolysaccharide mannose glucose food fermentation; Exopolysaccharide; Functional properties; Halomonas saliphila; Halophiles; Structure.

A novel exopolysaccharide, designated hsEPS, was successfully prepared from the high-salt-fermented broth of a novel species Halomonas saliphila LCB169T by ethanol precipitation, anion-exchange and gel-filtration chromatog., and its structure was well-characterized by means of chem. and spectral analyses. Results showed that hsEPS was primarily composed of mannose and glucose with a relative weight-average mol. weight of 5.133 x 104 g/mol. It was deduced that the major backbone contained (1→2)-linked α-D-Manp and (1→6)-linked α-D-Manp with branches substituted at C-2 by T-α-D-Manp and at C-6 by the fragment of T-α-D-Manp-(1→2)-α-D-Manp-(1→. A sheet-like structure was observed under high magnification. The water solubility index, water holding capacity, oil holding capacity and foaming capacity of hsEPS were 98.0, 19.3, 1386.7 and 82.2%, resp. It also exhibited outstanding emulsifying activity against all tested edible oils. Together, the resulted data indicated that hsEPS might serve as an active ingredient in food, cosmetics and detergents.

International Journal of Biological Macromolecules published new progress about Actinobacteria, halophilic. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Liang; Castan, Andreas; Stevenson, Joanne; Chatzissavidou, Nathalie; Vilaplana, Francisco; Chotteau, Veronique published the artcile< Combined effects of glycosylation precursors and lactate on the glycoprofile of IgG produced by CHO cells>, Computed Properties of 3458-28-4, the main research area is CHO cell monoclonal antibodies IgG; Chinese hamster ovary cells (CHO cells); Glycosylation; IgG; Monoclonal antibody; Sugars; mAbs.

The glycosylation profile of therapeutic monoclonal antibodies (mAbs) is a crucial quality parameter for industrial IgG (IgG) production Several alternative carbon sources, which function as glycosylation precursors, have been reported to impact the glycosylation pattern. Since the cells give priority to glucose uptake, the presence of this substrate can lower the effects of alternative sugars on the glycosylation. In order to get a better understanding of the influence of alternative sugars on the glycosylation and to investigate how they impact each other, combinations of mannose, fructose, galactose and fucose were fed to Chinese hamster ovary (CHO) cells in batch culture when the glucose became depleted and the lactate, accumulated in the culture, was used as carbon source. Feeding with a feed containing mannose or glucose decreased by 3-7% the percentage of high mannose glycans compared to a feed without mannose or glucose. Feeding with a feed containing galactose led to 8-20% increase of monogalactoglycans (G1) glycans and 2-6% rise of digalactoglycans (G2) glycans compared to feeding without galactose or glucose. The cells fed with fucose exhibited a significantly higher concentration of intracellular GDP-Fucose. This work indicates that a feeding strategy based on non-glucose sugars and potentially lactate, could be adopted to obtain a targeted glycosylation profile.

Journal of Biotechnology published new progress about Antibodies and Immunoglobulins Role: BMF (Bioindustrial Manufacture), BIOL (Biological Study), PREP (Preparation). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Computed Properties of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jiang, Yuan-yuan; Yu, Jun; Li, Ya-bo; Wang, Long; Hu, Liang; Zhang, Li; Zhou, Yong-hong published the artcile< Extraction and antioxidant activities of polysaccharides from roots of Arctium lappa L.>, COA of Formula: C6H12O6, the main research area is Arctium root polysaccharide ultrasonic assisted extraction antioxidant; Antioxidant activities; Arctium lappa L.; Polysaccharides; Ultrasonic-assisted extraction.

Polysaccharides were extracted from the roots of Arctium lappa L. (ALPs) using response surface methodol. with ultrasonication. A central composition design was used to optimize extraction parameters by maximizing the polysaccharide extraction yield. The modified optimal conditions were as follows: water to raw material ratio of 31 mL/g, ultrasonic power of 158 W, extraction time of 83 min, and extraction temperature of 50°C. Furthermore, fractions of ALP40-1, ALP60-1, and ALP80-1 were obtained for chem. and antioxidant activity analyses after purification Results indicated that the three fractions had a mol. weight of 218, 178, and 60 kDa, resp., and were composed of mannose, glucose, fructose, and galactose. ALP60-1 exhibited strong scavenging activities on 1,1-diphenyl-2-picryhydrazyl, hydroxyl, and superoxide radicals. These results demonstrate that ultrasonic-assisted extraction is a very effective method for extracting ALPs, and ALP60-1 is a potential novel natural antioxidant. However, further structure elucidation and in vivo experiments are required.

International Journal of Biological Macromolecules published new progress about Arctium lappa. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Shuai; Xu, Chang-Yuan; Xia, Jie; Feng, Yan-Ni; Zhang, Xi-Feng; Yan, You-Yu published the artcile< Extraction of polysaccharides from Codonopsis pilosula by fermentation with response surface methodology>, Electric Literature of 3458-28-4, the main research area is Codonopsis polysaccharide antioxidant response surface methodol; antioxidation; codonopsis; polysaccharide; response surface method.

Codonopsis pilosula is a kind of traditional Chinese medicine used to treat weak spleens, stomach problems, anemia, and fatigue. Polysaccharide is one of main components of Codonopsis pilosula. In this study, response surface methodol. (RSM) was used to optimize the extraction parameters of Codonopsis pilosula polysaccharides (CPP) by fermentation The exaction temperature (°C), yeast liquid volume (2 mg/mL, ml), and time (h) were employed effects. Results indicated that the best extraction conditions were the following: extraction temperature 24.75°C, yeast liquid volume 2.96 mL (5.92 mg), and a fermentation time of 21.03 h. After purification with DE52 and Sephadex G-100, the mol. structure was determined by UV-visible (UV) spectroscopy, Fourier transform IR (FTIR) spectroscopy, and NMR (NMR) (1H and 13C). The monosaccharide composition of CPP1 was determined to be mannose (1.76%), glucose (97.38%), and arabinose (0.76%). CPP1 exhibited high antioxidant activities in scavenging ABTS radicals, ferreous ions, and superoxide ion radicals. Thus, CPP1 could be used as an antioxidant or functional food.

Food Science & Nutrition (Hoboken, NJ, United States) published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts