Category: 3458-28-4

Zhang, Jixian; Wen, Chaoting; Gu, Jinyan; Ji, Chenchen; Duan, Yuqing; Zhang, Haihui published the artcile< Effects of subcritical water extraction microenvironment on the structure and biological activities of polysaccharides from Lentinus edodes>, Quality Control of 3458-28-4, the main research area is Lentinus polysaccharide structure subcritical water extraction microenvironment antioxidant antitumor; Biological activities; Microenvironment; Polysaccharides; Structure; Subcritical water.

In the present study, we investigated the effects of subcritical water microenvironment on the structure and biol. activities of polysaccharides from Lentinus edodes. The results showed that, under different SWE conditions (100-150°C for 15 min, and 150°C for 10-30 min), all the polysaccharides were heteropolysaccharides and consisted of glucose, mannose and galactose with different molar ratios. In addition, FT-IR results showed that all samples were typical β-pyranose and protein-free polysaccharides. Moreover, Congo red staining and at. force microscope (AFM) analyses showed that when the temperature was above 150°C for 15 min, the triple-helix structure no longer existed. Furthermore, various polysaccharides had varying degrees of inhibitory effect on HepG2 cells and MCF-7 cells in vitro. These findings indicated that subcritical water microenvironment has an extremely important effect on the structure and bioactivities of polysaccharides. The polysaccharides may be extracted more effectively by changing the subcritical water microenvironment.

International Journal of Biological Macromolecules published new progress about Acid hydrolysis. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Quality Control of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Uddin Pk, Moyen Md.; Islam, Mohammad Sayful; Pervin, Rumana; Dutta, Subhajit; Talukder, Rabiul Islam; Rahman, Matiar published the artcile< Optimization of extraction of antioxidant polysaccharide from Pleurotus ostreatus (Jacq.) P. Kumm and its cytotoxic activity against murine lymphoid cancer cell line>, SDS of cas: 3458-28-4, the main research area is Pleurotus polysaccharide antioxidant cytotoxicity lymphoid cancer cell.

The purpose of this study was to optimize the extraction method for polysaccharide from the fruiting bodies of Pleurotus ostreatus (Jacq.) P.Kumm and to assess the antioxidant and cytotoxic potentials of polysaccharide. In this investigation, polysaccharides from Pleurotus ostreatus (Jacq.) P.Kumm were extricated by utilizing the hot water. One-single factor and response surface methodol. was established to optimize the extraction conditions for polysaccharide from Pleurotus ostreatus (Jacq.) P.Kumm. Examination of antioxidant activity of Pleurotus ostreatus polysaccharide (POP) was directed by utilizing 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2-azino-bis-3-ethyl-benzothiazoline-6-sulfonic acid (ABTS) techniques. Cytotoxicity of POP was evaluated using an MTT assay. The exptl. data were fitted to a quadratic equation utilizing multiple regression investigations, and the ideal conditions were as per the following: water/crude material proportion, 26.04 mL/g; an extraction time of 62.08 min; and an extraction temperature 70.5°C. Under such conditions, the polysaccharide yield was 5.32 ± 0.12% with the anticipated yield. POP showed good scavenging activity against DPPH radical (p<0.001, EC50 = 1036.38 μg/mL, R2 = 0.8313) and ABTS radicals (p<0.001, EC50 = 824.37 μg/mL, R2 = 0.8223), with a dose (p<0.001)-and-time (p<0.001) dependent cytotoxic potential on Ehrlich ascites carcinoma cell line in vitro. This demonstrated that polysaccharides (POP) had certain cancer prevention agent exercises. In this manner, these examinations give reference to addnl. research and reasonable improvement of Pleurotus ostreatus (Jacq.) P. Kumm polysaccharide and POP may prove a useful therapeutic agent, due to its robust antioxidant and cytotoxic activity. PLoS One published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, SDS of cas: 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Dejian; Li, Peipei; Dong, Zhe; Wang, Teng; Sun, Kunlai; Zhao, Yuqin; Wang, Bin; Chen, Yin published the artcile< Structure and immunoregulatory activity of β-D-galactofuranose-containing polysaccharides from the medicinal fungus Shiraia bambusicola>, SDS of cas: 3458-28-4, the main research area is galactofuranose polysaccharide immunoregulation macrophage Shiraia; Galactofuranose; Macrophages; Medical fungi; Polysaccharide; Structure.

To explore bioactive polysaccharides from medicinal fungi, a homogeneous heteropolysaccharide SB1-1 was extracted from the stroma of Shiraia bambusicola by enzyme assisted extraction, ethanol precipitation, anion-exchange and size-exclusion chromatogs. Chem. and spectroscopic analyses showed that SB1-1 was a neutral polysaccharide composed of mannose, glucose and galactose at a molar ratio of 1.1:1.9:1.0, and had a mol. weight of 18.3 kDa. SB1-1 was composed of a mannan core and glucose and galactose side chains. The mannan core was composed of (1 → 2)-α-Manp substituted by the side chains (1 → 6)-α-D-Manp, (1 → 4)- α-D-Glcp and (1 → 6)-α-D-Glcp with different ds.p. at the C-6. The galactose side chains had the backbone of (1 → 6)-β-D-Galf. There were two branch sites on every five sugars on average at the O-2 of →6)-β–Galf(1→, and the branches consisted of (→2)-β-D-Galf(1→ and terminal β-D-Galf) 1→. The potential immunomodulatory activities of SB1-1 on RAW264.7 macrophages were investigated. The results showed that SB1-1 could activate macrophage and significantly improve its phagocytic ability by neutral red uptake assay. Addnl., SB1-1 enhanced the productions of IL-1, IL-6, IL-12 and TNF-α in the RAW264.7 macrophages by stimulation of SB1-1, while significantly increased the production of inducible nitric oxide synthase (iNOS) production This study demonstrated that the galactofuranose-containing polysaccharide SB1-1 from S. bambusicola which is a novel mannogalactoglucan, could enhance the activation of macrophages.

International Journal of Biological Macromolecules published new progress about Acid hydrolysis. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, SDS of cas: 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shi, Xiao-Dan; Yin, Jun-Yi; Zhang, Liu-Jing; Huang, Xiao-Jun; Nie, Shao-Ping published the artcile< Studies on O-acetyl-glucomannans from Amorphophallus species: Comparison of physicochemical properties and primary structures>, Name: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Amorphophallus O acetylglucomannan physicochem property primary structure.

Plants in Amorphophallus genus are rich in soluble dietary fibers and have long been used as food and traditional medicine in Asian countries. In the present investigation, natural O-acetyl-glucomannans were extracted from tubers of Amorphophallus rivirei (konjac), A. albus and two local types of A. bulbifer (wild type M and wild type B), which were designated as KGM, AGM, MGM, and BGM, successively. Comparative studies were conducted on their physicochem. properties and primary structures. The four AcGMs had about 90% (weight/weight) neutral sugar, 11% (weight/weight) moisture, and 1%-2% (weight/weight) ash. Relatively high contents of acetyl groups (17%-24%, weight/weight) were detected. Mannose and glucose as the main components existed in molar ratios of 1.41, 1.41, 1.21, and 1.58 for KGM, AGM, MGM, and BGM, resp. Relative mol. weights of AcGMs increased in the order of: KGMName: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Hong; Sun, Jian; Liu, Jun; Gou, Yarun; Zhang, Xin; Wu, Xiaonan; Sun, Rui; Tang, Sixue; Kan, Juan; Qian, Chunlu; Zhang, Nianfeng; Jin, Changhai published the artcile< Structural characterization and anti-inflammatory activity of alkali-soluble polysaccharides from purple sweet potato>, Reference of 3458-28-4, the main research area is purple sweet potato polysaccharide structural property antiinflammatory; Alkali-soluble polysaccharide; Anti-inflammation activity; Purple sweet potato; Structural characterization.

In this study, the structural characterization and anti-inflammation effect of dilute alkali-soluble polysaccharides from purple sweet potato were investigated. Three fractions (F-1, F-2 and F-3) were obtained by purifying crude polysaccharides on DEAE-52 cellulose column. The main fraction (F-1) was further purified on Sephadex G-200 column to afford purified alkali-soluble sweet potato polysaccharide (ASPP). The chem. structure of ASPP was analyzed by gas chromatog., Fourier transform IR spectroscopy, methylation anal. and NMR spectroscopy. Monosaccharide compositional anal. showed ASPP was composed of rhamnose, arabinose, xylose, mannose and glucose in the molar ratio of 2.8:1.9:1.0:7.6:53.3. Moreover, the backbone of ASPP was composed of 1,4-linked Glcp with side chains attached to the O-6 position. The anti-inflammation effect of ASPP was further investigated by in vitro and in vivo experiments Results showed ASPP could inhibit the levels of nitric oxide, interleukin (IL)-6, IL-1β and TNF-α but increase the production of IL-10 in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells. In addition ASPP could reduce the secretion of IL-6, IL-1β and TNF-α in LPS-treated mice. Our results suggest ASPP can be developed as a novel anti-inflammation agent.

International Journal of Biological Macromolecules published new progress about Anti-inflammatory agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Rugang; Zhang, Xinyu; Wang, Yu; Zhang, Lijiao; Zhao, Jing; Chen, Gang; Fan, Jungang; Jia, Youfeng; Yan, Fengwen; Ning, Chong published the artcile< Characterization of polysaccharide fractions from fruit of Actinidia arguta and assessment of their antioxidant and antiglycated activities>, COA of Formula: C6H12O6, the main research area is polysaccharide Actinidia antioxidant AGE; Actinidia argute; Antiglycation; Antioxidation; Characterization; Polysaccharide.

A novel cell-wall polysaccharides (AAPs) were extracted from the fruits of Actinidia arguta and separated into four parts which were named water-eluted polysaccharide (WPS), salt-eluted polysaccharide (SPS)-1, SPS-2 and SPS-3. The monosaccharide composition and structural anal. showed that SPS-3 and SPS-2 were homogalacturonan (HG)-rich pectin, SPS-1 was rhamnogalacturonan (RG)-rich pectin and WPS was starch-like polysaccharides. All four kinds of polysaccharides displayed the ability to scavenge free radicals, chelate iron ion, inhibit lipid peroxidation and inhibit protein glycation, but SPS was obviously stronger than WPS. Especially SPS-3 displayed the strongest antioxidant and anti-glycated activities. In addition, the inhibitory effect of AAPs on AGEs formation is attributed to the inhibitory activity on the production of protein carbonyl group and the protective effects on the protein thiol group but not the scavenging capacity of dicarbonyl compounds, suggesting that its mechanisms of antiglycated effects may be of concern to their antioxidant activities.

Carbohydrate Polymers published new progress about Actinidia arguta. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Yaqin; Liu, Ningyue; Fu, Xueting; Wang, Lixuan; Yang, Yu; Ren, Yaoyu; Liu, Jiayin; Wang, Libo published the artcile< Structural characteristics, biological, rheological and thermal properties of the polysaccharide and the degraded polysaccharide from raspberry fruits>, Related Products of 3458-28-4, the main research area is Rubus fruit polysaccharide degradation structural antioxidant rheol thermal property; Activities; Fe(2+)-H(2)O(2) degradation; Polysaccharides; Rheological behavior; Structural characterization; Thermal properties.

A native polysaccharide (RCPI) with sugar content of 79.94 ± 0.57% was isolated from raspberry fruits. A degraded polysaccharide (DRCPI) with sugar content of 83.82 ± 0.71% was obtained from the crude polysaccharides after degradation by Fe2+-H2O2 treatment. The mol. weights of RCPI and DRCPI were determined to be 411,000 and 8010 Da, resp. GC anal. revealed that both RCPI and DRCPI were composed of the same monosaccharides (rhamnose, arabinose, xylose, mannose, glucose, galactose, and galacturonic acid) in different molar ratios. IR and NMR spectroscopy confirmed that RCPI and DRCPI possessed similar structural characteristics, although DRCPI displayed higher antioxidant activities and greater thermal stability. Furthermore, DRCPI exhibited excellent rheol. properties. These data provide evidence to support the application of raspberry-derived polysaccharides in functional foods.

International Journal of Biological Macromolecules published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Jia; Gu, Feifei; Cai, Chao; Hu, Minghua; Fan, Luodi; Hao, Jiejie; Yu, Guangli published the artcile< Purification, structural characterization, and immunomodulatory activity of the polysaccharides from Ganoderma lucidum>, Name: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Ganoderma polysaccharide purification immunomodulatory activity; Chain conformation; Ganoderma lucidum; Immunomodulatory activity; NMR; β-d-glucan.

A preliminary relationship was illustrated between the structural characteristics and corresponding immunomodulatory activities of G. lucidum polysaccharides. Two polysaccharides (GLP-1 and GLP-2) were purified from Ganoderma lucidum extracts by gradient ethanol precipitation and a Q-Sepharose Fast Flow (QFF) strong anion-exchange column. The monosaccharide composition, high-performance gel permeation chromatog.-multi-angle laser light scattering-refractive index (HPGPC-MALLS-RI), Fourier-transform IR spectroscopy (FT-IR), at. force microscopy (AFM), methylation anal., and NMR (NMR) were used to characterize these polysaccharides. The GLP-1 polysaccharide was elucidated as D-galactoglucan with a flexible random linear conformation that mainly composed of →6)-β-D-Glcp-(1→, →6)-α-D-Galp-(1→, and →3)-β-D-Glcp-(1→ residues. GLP-2 was found to be a relatively homogeneous β-D-glucan that possessing →6)-β-D-Glcp-(1→ and →3)-β-D-Glcp-(1→ residues packaged into a spherical conformation. Immunomodulatory activities in vivo demonstrated that GLP-1 produced better protection of the spleen and thymus and was more effective for promoting hematopoiesis and improving IgA levels in serum. Our results suggest that the immunomodulatory activities of G. lucidum polysaccharides are highly corresponded to their structural characteristics such as carbohydrate composition, mol. weight and advanced conformation. This study provides a preliminary basis for studying the relationship between polysaccharide structure characterization and pharmacol. activities.

International Journal of Biological Macromolecules published new progress about Blood serum. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Name: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zeng, Ying-Jie; Yang, Hui-Rong; Wu, Xiao-Ling; Peng, Fei; Huang, Zhi; Pu, Lei; Zong, Min-Hua; Yang, Ji-Guo; Lou, Wen-Yong published the artcile< Structure and immunomodulatory activity of polysaccharides from Fusarium solani DO7 by solid-state fermentation>, Quality Control of 3458-28-4, the main research area is fermentation polysaccharide Fusarium solani; Polysaccharides from Fusarium solani DO7; Solid-state fermentation; Structure-activity relationship.

Two polysaccharides, DGS1 and DGS2, were obtained by solid-state fermentation (SSF) of Fusarium solani DO7, an endophytic fungus isolated from the orchid Dendrobium officinale. Structural characterizations revealed that DGS1 consisted of arabinose, glucose, mannose and galactose with a molar ratio of 2.9:13.4:3.0:1, resp., and contained (1 → 5)-Araf, (1 → 4)-Glcp, (1 → 6)-Glcp, (1 → 3)-Manp, (1 → 2,6)-Manp and (1 → 6)-Galp glycosidic linkages, while DGS2 was composed of arabinose, glucose, mannose and galactose in a molar ratio of 3.5:8.1:2.1:1, resp., and contained (1 → 5)-Araf, (1 → 4)-Glcp, (1 → 6)-Glcp, (1 → 3)-Manp and (1 → 6)-Galp glycosidic linkages. Neither polysaccharide was toxic to human embryonic kidney cells or mouse RAW 264.7 macrophage cells. An immunomodulatory activity assay indicated that both polysaccharides could significantly enhance the levels of TNF-α, IL-6 and NO by activating TNF-α, IL-6 and iNOs gene expression, resp., especially DGS2. Interestingly, DGS2 also possessed relatively high antioxidant activity. These results illustrate that, due to its cost-effectiveness and environmentally friendly features, SSF has significant potential as a com. competitive source of natural products, including fungal polysaccharides, with immunomodulatory activity.

International Journal of Biological Macromolecules published new progress about Fusarium solani. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Quality Control of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yan, Jing-Kun; Wu, Li-Xia; Qiao, Ze-Ru; Cai, Wu-Dan; Ma, Haile published the artcile< Effect of different drying methods on the product quality and bioactive polysaccharides of bitter gourd (Momordica charantia L.) slices>, Category: alcohols-buliding-blocks, the main research area is drying polysaccharide bitter gourd antioxidant antidiabetic; Bioactivity; Bitter gourd (Momordica charantia L.); Drying method; Physicochemical property; Polysaccharide.

In this study, three drying methods, namely, hot-air drying, freeze drying (FD), and IR radiation drying (ID), were applied to dry bitter gourd (Momordica charantia L.) slices. Results showed that the drying methods had significant influences on appearance, color, rehydration ratio, and microstructure of dried bitter gourd. FD provided high-quality dried bitter gourd products due to the uniform honeycomb network and less collapsed structure. Three water-soluble bitter gourd polysaccharides (BPS-H, BPS-F, and BPS-I) were obtained from the bitter gourd dried using the three drying methods. The three polysaccharides exhibited similar preliminary structural characteristics with different monosaccharide compositions and mol. weights BPS-I obtained from ID-dried bitter gourd had higher sugar and uronic acid contents than BPS-H and BPS-F. BPS-I exhibited stronger antioxidant activities and bile acid-binding capacity in vitro than BPS-H and BPS-F. Moreover, BPS-F and BPS-I showed significant α-amylase inhibitory activities in vitro.

Food Chemistry published new progress about Air drying process. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts