Category: 34231-22-6

Application of 34231-22-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 34231-22-6, name is 3-(Aminomethyl)benzyl Alcohol, molecular formula is C8H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3-Aminomethylbenzyl alcohol (1.12 g, 8.2 mmol) was weighed into a 100 mL round bottom flask,Tetrahydrofuran (10 mL) was added and triethylamine (0.873 mL, 6.2 mmol) was added to the reaction mixture.Trifluoroacetic anhydride (0.897 mL, 6.2 mmol) was added dropwise under ice-cooling,Dropping process continued for about 30min, dropping to room temperature after stirring the reaction 3.5h,The progress of the reaction was monitored by TLC. After the reaction was completed,Adding ethyl acetate and water according to a volume of 1: 1 composition of the mixture was extracted,After the organic phase was washed with saturated ammonium chloride solution,After drying over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure at 37 C,Purification by silica gel column chromatography, eluent ethyl acetate and petroleum ether,With gradient elution,The volume ratio of ethyl acetate / petroleum ether gradually increased from 1: 1 to 1: 2,Drying in vacuo at 37 C gave 2,2,2-trifluoro-N- (3- (hydroxymethyl) benzyl) acetamide (1.54 g,6.56 mmol) in 80% yield.

According to the analysis of related databases, 34231-22-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beijing University of Technology; Zhao Lijiao; Liu Junjun; Lai Xinxin; Song Xiuqing; Ren Ting; Zhong Rugang; (29 pag.)CN107235981; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 34231-22-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.34231-22-6, name is 3-(Aminomethyl)benzyl Alcohol, molecular formula is C8H11NO, molecular weight is 137.18, as common compound, the synthetic route is as follows.

Fmoc-OSu (38.6 g, 115 mmol) was added to a solution of [3-(amino-methyl)phenyl]methanol (S14, 16.5 g, 121 mmol) in THF (150 mL), water (75 mL) and sodium bicarbonate (20.3 g, 241 mmol) at room temperature (rt) and the reaction stirred overnight (o/n). At that point, a small sample was diluted with MeOH, acidified with a drop of HOAc, and analyzed by LC-MS, which showed the desired product with no Fmoc-OSu reagent. The reaction was acidified with 1M HCl, diluted with ethyl acetate (EtOAc), and stirred for 2 h. The white solid was filtered off, washed well with water, then EtOAc, and air dried for 3 h until a constant weight was attained. The product thus obtained, Fmoc-S14 (15.3 g), was found by LC-MS to be free of identifiable organic impurities. The aqueous layer was extracted with EtOAc (2×). The combined organic layers were washed with H2O (2×) and brine, then dried over anhydrous MgSO4. The desiccant was removed by filtration and the filtrate concentrated under reduced pressure to give additional amounts of the desired product as a white solid (34.1 g). The combined solids were triturated with ethyl acetate at reflux for a few minutes, then o/n at rt to give Fmoc-S14 in 88% yield (38.1 g).

Statistics shows that 34231-22-6 is playing an increasingly important role. we look forward to future research findings about 3-(Aminomethyl)benzyl Alcohol.

Reference:
Patent; CYCLENIUM PHARMA INC.; MACDONALD, Dwight; DUBE, Daniel; WAHHAB, Amal; THOMAS, Helmut; RICHARD, Luc; PETERSON, Mark L.; US2019/153620; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 34231-22-6 ,Some common heterocyclic compound, 34231-22-6, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To 3-(difluoromethyl)-i -methyl- 1H-pyrazole-4- carboxylic acid (1.5 g, 8.52 mmol) was added dropwise 20 mE sulthryl dichloride, and then heated to reflux for 3 h, the excessive sulfuryl dichloride was evaporated under reduced pressure to get 3-(difluoromethyl)-i -methyl- 1H-pyrazole-4- carbonyl chloride, and then the carbonyl chloride was dissolved in 30 mE dichloromethane for the following reaction. To a cooled solution of (3-(aminomethyl)phenyl)methanol (1.17 g, 8.52 mmol) dissolved in 20 mE dichloromethane and 5 mE triethylamine was added dropwise the solution of the carbonyl chloride at 0-5 C. After the reaction was stirred for 6 h at room temperature, analysis by Thin-Layer Chromatography showed complete conversion to product, the excessive solvent was evaporated under reduced pressure. the residual was purified by column chromatography on silica gel (eluent: ethyl acetate:petroleum ether=i :3; silica gel: 100-140 mesh, Qingdao Marine Chemical Co., Ltd.) to obtain 3-(difluoromethyl)-N-(3-(hydroxymethyl)benzyl)-i – methyl-1H-pyrazole-4-carboxamide (1.8 g) as white solid with yield of 72%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 34231-22-6, 3-(Aminomethyl)benzyl Alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shenyang Sinochem Agrochemicals R&D Co., Ltd.; CHENG, Xueming; ZHANG, Lixin; CHEN, Liang; SUN, Qin; LIU, Junli; LI, Zhinian; ZHAO, Jie; XU, Jingbo; WU, Hongfei; (60 pag.)US2018/362450; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 34231-22-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 34231-22-6, name is 3-(Aminomethyl)benzyl Alcohol, molecular formula is C8H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Fmoc-OSu (38.6 g, 1 15 mmol) was added to a solution of [3-(amino- methyl)phenyl]methanol (S14, 16.5 g, 121 mmol) in THF (150 ml_), water (75 ml_) and sodium bicarbonate (20.3 g, 241 mmol) at room temperature (rt) and the reaction stirred overnight (o/n). At that point, a small sample was diluted with MeOH, acidified with a drop of HOAc, and analyzed by LC-MS, which showed the desired product with no Fmoc-OSu reagent. The reaction was acidified with 1 M HCI, diluted with ethyl acetate (EtOAc), and stirred for 2 h. The white solid was filtered off, washed well with water, then EtOAc, and air dried for 3 h until a constant weight was attained. The product thus obtained, Fmoc-S14 (15.3 g), was found by LC-MS to be free of identifiable organic impurities. The aqueous layer was extracted with EtOAc (2x). The combined organic layers were washed with H2O (2x) and brine, then dried over anhydrous MgSO4. The dessicant was removed by filtration and the filtrate concentrated under reduced pressure to give additional amounts of the desired product as a white solid (34.1 g). The combined solids were triturated with ethyl acetate at reflux for a few minutes, then o/n at rt to give Fmoc-S14 in 88% yield (38.1 g).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 34231-22-6, 3-(Aminomethyl)benzyl Alcohol.

Reference:
Patent; CYCLENIUM PHARMA INC.; WAHHAB, Amal; DUBE, Daniel; MACDONALD, Dwight; PETERSON, Mark L.; RICHARD, Luc; THOMAS, Helmut; (313 pag.)WO2018/232506; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 34231-22-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 34231-22-6, name is 3-(Aminomethyl)benzyl Alcohol, molecular formula is C8H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 205W-(3-(Hydroxymethyl)benzyl)-4-(2-(((frans)-4-acetamidocyclohexyl)methyl)-2W-tetrazol-5-yl)-6- methylpicolinamidelambda/,lambda/,lambda/’,lambda/’-Tetramethyl-O-(1/-/-benzotriotaazol-1-yl)uroniotaum hexafluorophosphate (159 mg, 0 42 mmol) was added to a mixture of 4-(2-((4-acetamiotadocyclohexyl)methyl)-2H-tetrazol-5-yl)-6- methylpicolinic acid (prepared as described in step 1 of the synthesis of 4-(2-(((frans)-4- acetamiotadocyclohexyl)methyl)-2/-/-tetrazol-5-yl)-lambda/-((6-hydroxypyriotadiotan-2-yl)methyl)-6-methylpiotacoliotanamiotade, Example 204) (50 mg, 0 14 mmol), (3-(amiotanomethyl)pheny.)methanol (prepared as described in step 1 of the synthesis of lambda/-(3-(hydroxymethyl)benzyl)-6-methyl-4-(2-(((/rans)-4-(methylsulfonamiotado)cydohexyl)methyl)-2H-tetrazol-5-yl)piotacoliotanamiotade, Example 183) (29 mg, 0 21 mmol), and triethylamine (0 03 mL, 0 21 mmol) in lambda/,lambda/-diotamethylformamiotade (2 mL) The mixture was stirred at room temperature for 18 hours The reaction mixture was purified by reverse phase preparative HPLC Fractions containing desired product were combined and concentrated The resulting residue was taken up in methanol and passed through a carbonate cartridge The filtrate was concentrated to afford the title compound as a solid (22 mg, 33%) MS (ES+) m/z 478 (M+H) 1H NMR (400 MHz, DMSO-d6) delta ppm 1 04 – 1 26 (m, 6 H), 1 56 – 1 67 (m, 2 H), 1 71 – 1 85 (m, 5 H), 1 91 – 2 03 (m, 1 H), 2 67 (s, 3 H), 3 25 – 3 35 (m, 1 H), 4 48 (s, 2 H), 4 54 (d, J=6 59 Hz, 2 H), 4 67 (d, J=I 32 Hz, 2 H), 7 14 – 7 34 (m, 3 H), 7 66 (d, J=I 32 Hz, 1 H), 8 08 (s, 1 H), 8 44 (s, 1 H), 9 22 (t, J=5 86 Hz, 1 H)

According to the analysis of related databases, 34231-22-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PFIZER INC.; WO2009/16498; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 34231-22-6, name is 3-(Aminomethyl)benzyl Alcohol. A new synthetic method of this compound is introduced below., Quality Control of 3-(Aminomethyl)benzyl Alcohol

Step 3 Preparation of (frans)-methyl 4-((5-(2-((3-(hvdroxymethyl)benzyl)carbamoyl)-6-methylpyriotadiotan-4- vO-2H-tetrazol-2-yl)methyl)cvclohexanecarboxvlate(3-(Amiotanomethyl)phenyl)methanol (prepared as described in step 1 of the synthesis of lambda/-(3- (hydroxymethyl)benzyl)-6-methyl-4-(2-(((frans)-4-(methylsulfonamido)cyclohexyl)methyl)-2H-tetrazol- 5-yl)piotacoliotanamiotade, Example 183) (1 15 mg, 0 838 mmol) was added to a solution of methyl 4-(2- (((trans )-4-(methoxycarbonyl)cyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methylpiotacoliotanate (75 mg, 0 201 mmol) in lambda/,lambda/-diotamethylformamiotade (6 mL) and the mixture was heated at 60 0C for 3 days The reaction mixture was purified by reverse-phase preparative HPLC to afford the title compound as a solid (50 mg, 65%) LC/MS (0%-25% CH3CN/H2O, 5 mm ) 3 010 mm , m/z 479 (M+H) 1H NMR (400 MHz, methanol-^) delta ppm 1 10 – 1 24 (m, 2 H), 1 34 – 1 49 (m, 2 H), 1 74 (dd, ,7=13 7, 3 0 Hz, 2 H), 1 99 (dd, .7=13 8, 3 1 Hz, 2 H), 2 03 – 2 16 (m, 1 H), 2 23 – 2 35 (m, 1 H), 2 65 – 2 71 (m, 3 H), 3 62 (s, 3 H), 3 96 (s, 1 H), 4 62 (d, J=7 0 Hz, 2 H), 4 74 (s, 2 H), 7 77 (d, J=8 1 Hz, 1 H), 8 03 (dd, .7=8 2, 1 5 Hz, 1 H), 8 09 (d, J= 1 1 Hz, 1 H), 8 54 (s, 1 H), 8 72 (d, J= 1 6 Hz, 1 H)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 34231-22-6, 3-(Aminomethyl)benzyl Alcohol.

Reference:
Patent; PFIZER INC.; WO2009/16498; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts