Synthetic Route of 34145-05-6 ,Some common heterocyclic compound, 34145-05-6, molecular formula is C7H6Cl2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Compound 96-a (1.00 g, 5.65 mmol, 1.00 eq) and CDI (2.75 g, 16.95 mmol, 3.00 eq) was dissolved in tetrahydrofuran (20 mL), and stirred at 20C for 1 hour. Compound 7-a (1.78 g, 11.30 mmol, 1.74 mL, 2.00 eq) and triethylamine (1.72 g, 16.95 mmol, 2.35 mL, 3.00 eq) were then added to the above solution, and stirred at 80C for another 15 hours. After the reaction was completed, the reaction solution was added with 100 mL of water, and separated. The aqueous phase was further extracted with dichloromethane (200 mL 3 2). The organic phases were combined, and washed with saturated sodium hydrogen carbonate solution (150 mL) and saturated brine (100 mL). The organic phase was dried over anhydrous sodium sulfate, filtered, concentrated, and separated by column chromatography (petroleum ether : ethyl acetate = 10:1?6:1) to give the product of compound 96-b (1.9 g, yield: 93%). 1HNMR (400MHz, CHLOROFORMd) delta= 7.38 (d, J=2.4Hz, 1H), 7.34-7.28 (m, 1H), 7.26-7.22 (m, 1H), 5.21 (br. s., 2H), 4.17 (q, J=7.2 Hz, 4H), 3.09-2.89 (m, 2H), 2.50 (s, 1H), 1.99-1.89 (m, 2H), 1.76-1.64 (m, 2H), 1.28 (t, J=7.1 Hz, 3H). LCMS m/z = 360.0 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 34145-05-6, (2,5-Dichlorophenyl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Medshine Discovery Inc.; HE, Haiying; WU, Songliang; LUO, Zhi; MOU, Jianfeng; GUO, Fengying; WANG, Chuan; LI, Guoqing; ZENG, Minggao; CHEN, Shuhui; (199 pag.)EP3456711; (2019); A1;,
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