Category: 33893-85-5

Electric Literature of 33893-85-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 33893-85-5, name is 4-(Hydroxymethyl)cyclohexanol. This compound has unique chemical properties. The synthetic route is as follows.

Into a stirred mixture of 4-(hydroxymethyl)cyclohexan-1-ol (0.13 g, 1.0 mmol) and Ph3P (0.39 g, 1.5 mmol) in THF (5 mL) at 0 C. was added DIAD (0.22 g, 1.1 mmol). After 10 mins at 0 C., it was added compound from Step 1c (0.32 g, 1.0 mmol) and stirred at rt for 18 h. It was concentrated and the crude was chromatographed (silica, hexanes/EtOAc) to give the desired compounds as a mixture of two diastereomers (0.22 g, 51%). ESI-MS m/z=428.07, 430.07 [M-H]-.

According to the analysis of related databases, 33893-85-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; Qiu, Yao-Ling; Gao, Xuri; Li, Wei; Cao, Hui; Jin, Meizhong; Kass, Jorden; Peng, Xiaowen; Or, Yat Sun; (186 pag.)US2017/253609; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 33893-85-5 , The common heterocyclic compound, 33893-85-5, name is 4-(Hydroxymethyl)cyclohexanol, molecular formula is C7H14O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 42 Synthesis of Compound I-31 To a solution of 4-(hydroxymethyl)cyclohexan-1-ol (0.237 g, 1.82 mmol) in THF (15 mL) was added triphenylphosphine (0.718 g, 2.74 mmol) and 4,6-Dichloropyrimidin-5-ol (0.3 g, 1.82 mmol). To the mixture was added di-tert-butyl azodicarboxylate (0.63 g, 2.74 mmol) at 0 C., the mixture was stirred at room temperature for 18 hr. The reaction mixture was concentrated in vacuo. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=9:1 as eluent) to afford the 4-(((4,6-dichloropyrimidin-5-yl)oxy)methyl)cyclohexan-1-ol (0.15 g, 30% yield). LC/MS APCI: Calculated 276.04; Observed m/z [M+H)]+ 277.0.

The synthetic route of 33893-85-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Arrien Pharmaceuticals LLC; Vankayalapati, Hariprasad; US2020/131154; (2020); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 33893-85-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 33893-85-5 as follows.

EXAMPLE 5 To acetic acid in which Ce (IV)/PFCP (50 mg, 0.027 mmole) and 200 mg of NaBrO3 were dispersed and dissolved, 1.0 mmole of 1,10-undecane diol and 1.0 mmole of 4-hydroxymethyl cyclohexanol were added, respectively. The reaction mixture was heated for three hours at 55 C. and the product was purified with a column chromatography to yield 154 mg (82% yield) of 10-undecane-1-ol and 93 mg (73% yield) of 4-hydroxymethyl cyclohexanone.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,33893-85-5, its application will become more common.

Reference:
Patent; E. I. Du Pont de Nemours and Company; US4617153; (1986); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 33893-85-5, Adding some certain compound to certain chemical reactions, such as: 33893-85-5, name is 4-(Hydroxymethyl)cyclohexanol,molecular formula is C7H14O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33893-85-5.

Operation steps: The four-necked flask is equipped with a stirring paddle, a thermometer, a water separator, and a reflux condenser is connected to the upper part of the water separator. 150.2g of p-methylolcyclohexanol and 92g of acrylic acid were placed in a 500mL four-necked flask, and 4.2g of p-hydroxyanisole, 8.6g of p-toluenesulfonic acid, 1.95g of hypophosphorous acid, and 80g of toluene were added. After stirring, the vacuum pump was started at 30KPa When the temperature is raised to 86 C, the reflux flow rate of the solvent in the reflux condenser is stable, and a water layer appears in the water separator. The water output is recorded once every hour. When the water output is less than 0.1g / h, the reaction is completed and the reaction time is 16 ~ 18h.After the reaction, the temperature was lowered to 45 C., 80 g of toluene was added to the product after the reaction, and 50 g of water was added for washing. After stirring at 40 C. for 5 minutes, it was placed in a separating funnel and allowed to stand for water separation. At 40 C, 50g of 1N sodium bicarbonate and 1N sodium hydroxide aqueous solution were added to neutralize, and the mixture was left standing to separate water. This operation was repeated 3 times. After neutralization is completed, add 0.3g of p-hydroxyanisole, spin-dry the solvent,Obtained colorless transparent viscous monomer A3,

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 33893-85-5, 4-(Hydroxymethyl)cyclohexanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangdong Boxing New Materials Technology Co., Ltd.; Huang Lijiang; Pang Laixing; Li Zhiyun; Wang Hui; Su Hang; Tan Haiding; Li Lin; (11 pag.)CN110452191; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts