Category: 3376-59-8

Application of 3376-59-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3376-59-8, name is 2,3-Dihydroxypropyl benzoate. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred suspension of sodium hydride (0.273 g, 0.68mol, 60% in oil) in anhydrous THF (100 mL) under a nitrogenatmosphere at 0C, a solution of (¡À)-1 (33.3 g, 0.17 mol)in anhydrous THF (150 mL) was added over a period of 1 hmaintaining the internal temperature below 5C. After stirringat room temperature for 12 h, 1-bromotetradecane(187.7 g, 0.68 mol) was added at 0C over a period of 1 h.After complete addition, the reaction mixture was stirred for2 h at room temperature and this was gradually increasedwhen reaching reflux, and then stirred for 24 h. A LiOH solution(10% wt/v,100 mL) was added, and stirring and thetemperature were maintained for 12 h. The mixture was dilutedwith saturated ammonium chloride (300 mL). Theaqueous layer was extracted with dichloromethane (700 mL),washed with water (3 150 mL), and dried over Na2SO4.The unreacted 1-bromotetradeane was removed by distillationunder reduced pressure (1 mm of Hg and 125 C). Theresidue was purified by column chromatography eluting withhexane to obtain (¡À)-2 (39.5 g, 48%) as a white solid, mp.43-45 C (lit. 42.5-43.5C) [18]. 1H NMR (CDCl3, 200MHz) 0.87 (t, J = 6.7 Hz, 6H, C12-C12H3), 1.25 (br s, 44H,C11-C11H2), 1.58-1.61 (m, 4H, C10-C10H2), 3.37-3.73(m, 9H; C9-C9-C3-C2H2, C1H); 13C NMR (CDCl3,200MHz) 14.1 (C16-16), 22.8 (C15-15), 27.6 (C12-12),29.1-29.5 (C13-13), 29.7 (C11-11), 32.5 (C14-14), 32.8(C10-10), 64.3 (3C), 65.5 (C1), 71.0 (C9), 70.9(C9),72.0(C3), 78.4 (C2). EI-LR-MS, m/z, M+: 484.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3376-59-8, 2,3-Dihydroxypropyl benzoate.

Reference:
Article; Rustoy, Eduardo M; Dana, Alejandro; Letters in Organic Chemistry; vol. 13; 1; (2016); p. 71 – 75;,
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Adding a certain compound to certain chemical reactions, such as: 3376-59-8, 2,3-Dihydroxypropyl benzoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 3376-59-8, blongs to alcohols-buliding-blocks compound. SDS of cas: 3376-59-8

To a solution of 35.5 g (181 mmol) of (-)-1-benzoyl glycerol (G) in 250 ml of dry pyridine at 0 C. is added 83 g (433 mmol) of p-toluenesulfonyl chloride. The mixture is stirred at 0 C. for 15 minutes and then stored in a refrigerator for 144 hours. After cooling the reaction mixture to 0 C., 10 ml of water are added, the mixture is stirred for 10 minutes, and then poured into excess water. The aqueous solution is separated from the gummy product, and extracted with chloroform. The gummy residue is dissolved in chloroform and the combined chloroform solution is washed sequentially with 3 N hydrochloric acid, water, 5% sodium bicarbonate solution, and water. The chloroform solution is dried over Na2 SO4 and concentrated under reduced pressure to obtain a solid which, upon recrystallization from absolute ethanol, gives 65.5 g (130 mmol, 72%) of (-)-1-benzoyl-2,3-di-p-toluenesulfonyl glycerol (see Formula (H) in Scheme 2), m.p. 105-106 C. [alpha]D2 -22.7 (c, 5.92, CHCl3). 1 H NMR (CDCl3) delta8-7 (m, 13H); 4.9 (m, 1H); 4.45 (d, 2H, J=6 Hz); 4.35 (d, 2H, J=5 Hz); 2.42 (s, 3H); 2.38 (s, 3H). 13 C NMR (CDCl3) 165.162, 145.136, 133.108, 132.466, 131.649, 129.430, 128.671, 128.087, 127.678, 75.306, 66.899, 61.994, 21.591 ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3376-59-8, its application will become more common.

Reference:
Patent; Stille; John K.; US4393240; (1983); A;,
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