Category: 3360-41-6

Related Products of 3360-41-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3360-41-6, name is 4-Phenylbutan-1-ol. A new synthetic method of this compound is introduced below.

Step 2 1-(4-(6-Bromohexyloxy)butyl)benzene: At 0~10 C., a solution of 4-phenylbutan-1-ol (8.4 g; 53.2 mmol; 1.00 equiv) in tetrahydrofuran (150 mL) was added to a suspension of sodium hydride (2.5 g; 62.5 mmol; 1.17 equiv) in tetrahydrofuran (50 mL). The resulting mixture was stirred at ambient temperature for about 1 hour and then 1,6-dibromohexane (41.0 g; 166 mmol; 3.13 equiv) and tetra-N-butylammonium bromide (100 mg; 0.27 mmol; 0.01 equiv) were added. The mixture was maintained at ambient temperature for about 16 hours, and then water was added. Following standard extractive workup with ethyl acetate, the crude residue was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1/8) to afford the title product as a yellow liquid (14.2 g; 84% yield). 1H NMR (300 MHz, CDCl3) delta: 7.30 (m, 2H), 7.15 (m, 3H), 3.43 (m, 6H), 2.66 (t, J=7.2, 7.5 Hz, 2H), 1.89 (m, 2H), 1.75~1.58 (m, 6H), 1.56~1.37 (m, 4H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3360-41-6, its application will become more common.

Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; US2010/9950; (2010); A1;,
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Reference of 3360-41-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3360-41-6, name is 4-Phenylbutan-1-ol. A new synthetic method of this compound is introduced below.

A CH2Cl2 solution (25 mL) of PPh3 (1.97 g,7.50 mmol) and I2 (1.90 g, 7.50 mmol) was stirred for 10 min at room temperature.Imidazole (851 mg, 12.5 mmol) was added to the resulting mixture. After a 10 min,4-phenylbutan-1-ol (751 mg, 5.00 mmol) was added to the mixture, and the resultingmixture was further stirred for 2 h. The mixture was quenched by the addition of satd.Na2S2O5 (25 mL). The aqueous and organic layers were separated, followed byextraction of the aqueous phase with CH2Cl2 (25 mL x 3). The combined organic phases were dried over anhydrous MgSO4, and the solvent was evaporated under reducedpressure. The crude product was purified by silica gel chromatography (eluent:hexane/AcOEt = 95/5) to give 4-iodobutylbenzene (1.14 g, 88%) as colorless oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3360-41-6, 4-Phenylbutan-1-ol, and friends who are interested can also refer to it.

Reference:
Article; Sakai, Norio; Kobayashi, Taichi; Ogiwara, Yohei; Chemistry Letters; vol. 44; 11; (2015); p. 1503 – 1505;,
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Related Products of 3360-41-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3360-41-6, name is 4-Phenylbutan-1-ol, molecular formula is C10H14O, molecular weight is 150.22, as common compound, the synthetic route is as follows.

The title compound can be prepared in a three-step process based on publication by Rong and Ruoho (1999). First, the alkoxide generated with NaH from 4-phenylbutanol can be alkylated with 1, 6-dibromohexane in presence of catalytic tetrabutylammonium bromide. The thus obtained bromide can be substituted by heating with sodium azide and catalytic sodium iodide in DMSO at 80C. The azide can then be reduced by hydrogenation in presence of palladium catalyst and di-t-butyl dicarbonate, obtaining the desired Boc-protected amine 23.

The chemical industry reduces the impact on the environment during synthesis 3360-41-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; CORUS PHARMA; WO2005/63777; (2005); A1;,
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3360-41-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3360-41-6, name is 4-Phenylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Triphenylphosphine (2.72 g, 10.4 mmol) was added to the 4-phenyl-1-butanol (1.2 g, 8.0 mmol) in CCl4 (10 mL) at room temperature under atmosphere of argon, and the mixture was refluxed for 1 h. The reaction quenched with water and extracted with hexane. The extracts were washed with brine, dried over MgSO4, and concentrated under reduced pressure. The residue was purified by column chromatography with hexane/AcOEt (100:1) to give (4-chlorobutyl)benzene (5d) as a colorless oil in 85% yield. The analytical data were identical with those of a literature compound.10 IR (neat): nu = 2940 (CH2), 699 (Alkyl-Cl); 1H NMR (500 MHz, CDCl3): delta = 1.72-1.86 (4H, m), 2.64 (2H, t, J = 7.2 Hz), 3.54 (2H, t, J = 6.3 Hz), 7.15-7.21 (3H, m), 7.25-7.31 (2H, m); 13C NMR (125 MHz, CDCl3): delta = 28.5, 32.1, 35.1, 44.9, 125.9, 128.4, 141.8; MS (EI) m/z 168 ([M]+).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3360-41-6, 4-Phenylbutan-1-ol.

Reference:
Article; Hatae, Noriyuki; Kujime, Eiko; Yano, Keigo; Kizuka, Mami; Ashida, Rina; Choshi, Tominari; Nishiyama, Takashi; Okada, Chiaki; Iwamura, Tatsunori; Yoshimura, Teruki; Heterocycles; vol. 97; 1; (2018); p. 560 – 568;,
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3360-41-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3360-41-6, name is 4-Phenylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

To a mixture of 5 ml (32.75 mmol) 4-phenylbutanol with 10.1 ml (65.66 mmol) 1,6-dibromohexane is added 8 g (121.2 mmol) powdered KOH and 1.112 g (3.28 mmol) tetrabutylammonium hydrogen sulfate. After allowing the suspension to stir for 20 hr at room temperature, it is filtered and the filtrate dissolved in 50 ml Et2O. The resulting solution is washed with water, dried on anhydrous Na2SO4, the Et2O evaporated and the residue distilled in vacuum (0.1 mmHg), a first fraction up to 100 C. of a mixture of starting products and a second fraction at 150 C. of 4-(6-bromohexyloxy)butylbenzene weighing 7.60 g (74.4 %) being collected. RMN 1H (CDCl3), delta (ppm): 1.3-2.0 (m, 12H), 2.6 (t, 2H, -CH2-C6H5), 3.4 (m, 6H, -CH2-O-CH2-+-CH2Br), 7.1-7.4 (m, 5H, -C6H5).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3360-41-6, 4-Phenylbutan-1-ol.

Reference:
Patent; Bessa Bellmunt, Jordi; Dalmases Barjoan, Pere; Marquillas Olondriz, Francisco; US6388134; (2002); B1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3360-41-6, name is 4-Phenylbutan-1-ol. A new synthetic method of this compound is introduced below., 3360-41-6

REFERENCE EXAMPLE 23 N,N-dimethyl-4-phenylbutylamine To 1.50 g of 4-phenylbutanol was added 385 mul of phosphorus tribromide with ice cooling, and the mixture was stirred at a room temperature for 5 minutes and then at 80 C. for one hour. To the reaction mixture were added 20 ml of ice water and 30 ml of ethyl acetate. The separated organic layer was, successively washed with water, 5% sodium bicarbonate aqueous solution and a saturated sodium chloride aqueous solution, dried over magnesium sulfate, and evaporated under a reduced pressure to obtain an oily residue. The residue was applied to a silica gel column and eluted with hexane/benzene (6:1) to obtain 1.94 g of (4-bromobutyl)benzene as a colorless liquid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3360-41-6, 4-Phenylbutan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Tobishi Yakuhin Kogyo Kabushiki Kaisha; US5093370; (1992); A;,
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3360-41-6, Adding a certain compound to certain chemical reactions, such as: 3360-41-6, 4-Phenylbutan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 3360-41-6, blongs to alcohols-buliding-blocks compound.

General procedure: To 16 (0.6 g, 0.6 mmol) was added dichloromethane (5 mL) in a round-bottom flask. After 10 min, oxalyl chlorideor oxalyl bromide was added (0.6 mmol). The reaction mixture was magnetically stirred at room temperature. Uponcessation of gas evolution, 4 was added (0.5 mmol), and the reaction mixture was heated to reflux. After thereaction was complete according to TLC analysis, the mixture was cooled to room temperature and filtered. Thesolid on the funnel was washed with dichloromethane (3 ¡Á 10 mL), and the filtrate was concentrated under reducedpressure to afford the desired product 5 in an essentially pure state based on 1H and 13C NMR spectroscopicanalyses.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3360-41-6, its application will become more common.

Reference:
Article; Xia, Xuanshu; Toy, Patrick H.; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 1397 – 1405;,
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