Category: 33524-31-1

Application of 33524-31-1 ,Some common heterocyclic compound, 33524-31-1, molecular formula is C9H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of the benzylic alcohol 1 (1 mmol) and 98% H2SO4 (1 mmol) in DMSO (3 mL) was stirred for the appropriate time under reflux conditions. The mixture was then cooled to r.t., and brine (4 mL) was added. The organic phase was extracted with CH2Cl2 (6 mL), and the organic layer was dried (Na2SO4), filtered, and concentrated under reduced pressure. In all cases, the reaction products were obtained with high purity, and did not require further purification by distillation or column chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,33524-31-1, its application will become more common.

Reference:
Article; Sheikhi, Ehsan; Adib, Mehdi; Karajabad, Morteza Akherati; Gohari, Seyed Jamal Addin; Synlett; vol. 29; 7; (2018); p. 974 – 978;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33524-31-1, name is (2,5-Dimethoxyphenyl)methanol. A new synthetic method of this compound is introduced below., Product Details of 33524-31-1

Example 10; 5-Chloro-1-(2,5-dimethoxybenzyl)-1H-indole-2-carboxylic acid (3-hydroxy-2,2- dimethylpropyDamide EPO A solution of phosphorous tribromide (5.74ml, 60.4mmol) in anhydrous DCM (90ml) was added over 20min to a cooled, stirred solution of 2,5-dimethoxybenzyl alcohol (25.Og, 148.8mmol) in DCM (180ml), maintaining the temperature between -5C and 00C. Following the addition, the reaction was stirred at this temperature for a further 20 min. when water (200ml) was added. After separation of the layers, the organic was washed with water (3x200ml), dried with magnesium sulfate and evaporated to dryness under reduced pressure. The resulting crude product was crystallised from diethyl ether/heptane to afford 2-bromomethyl-1,4-dimethoxy-benzene (24.2g, 72%).The title compound was then prepared in a manner similar to that described in Example 1. 1H NMR (400MHz, CDCI3) deltaH : 0.88(s, 6H), 3.08(d, 2H, J=7.0), 3.25(d, 2H, J=6.8), 3.52(t, 1 H, J=7.0), 3.57(s, 3H), 3.84(s, 3H), 5.75(s, 2H), 6.03(d, 1H, J=2.9), 6.59(br t, 1H, J=6.8), 6.68(dd, 1 H, J=8.8, 2.9), 6.80(d, 1 H, J=8.8), 6.85 (s, 1H), 7.19(dd, J=8.8, 1.9), 7.27(m, 1H), 7.60(d, 1 H, J=1.9); EIMS: m/z = 431.3 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 33524-31-1, (2,5-Dimethoxyphenyl)methanol.

Reference:
Patent; N.V. ORGANON; WO2006/100208; (2006); A1;,
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Synthetic Route of 33524-31-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33524-31-1, name is (2,5-Dimethoxyphenyl)methanol. A new synthetic method of this compound is introduced below.

Benzyl bromides such as 2,5-Dimethoxybenzyl bromide and 2,3- dimethoxybenzyl bromide used in JV-alkylation reactions were optionally prepared from the corresponding benzyl alcohols by treating with carbon tetrabromide and triphenyl phosphine in dry dichloromethane (Scheme 4). The reaction was performed at ambient temperature for 30 minutes and the yield was 85 to 90%. EPO

At the same time, in my other blogs, there are other synthetic methods of this type of compound,33524-31-1, (2,5-Dimethoxyphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; GE HEALTHCARE LIMITED; WO2007/36785; (2007); A2;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33524-31-1, name is (2,5-Dimethoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 33524-31-1

2,5-dimethoxybenzyl alcohol (1.68 g, 10 mmol) was dissolved in 50 mLAnhydrous methylene chloride, stirred for 10 minutes in an ice bath,Phosphorus tribromide (1.0 g, 3.7 mmol) was slowly added dropwise,After the addition was complete, continue to react for 1 hour under ice bath.The reaction mixture was diluted with 200 mL of methylene chloride and washed with water (50 mL × 3)Saturated brine (100 mL × 1), dried over anhydrous sodium sulfate, filtered,After the solvent was evaporated to dryness under reduced pressure, the crude product was purified by column chromatography2,5-dimethoxybenzyl bromide (2.2 g, 96% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 33524-31-1, (2,5-Dimethoxyphenyl)methanol.

Reference:
Patent; Beijing Zhuokai Biological Co., Ltd.; Xie Zuolei; (46 pag.)CN107353239; (2017); A;,
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Adding a certain compound to certain chemical reactions, such as: 33524-31-1, (2,5-Dimethoxyphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C9H12O3, blongs to alcohols-buliding-blocks compound. Computed Properties of C9H12O3

General procedure: The benzyl alcohol derivatives (1 mmol), catalyst 1 or 3 (2 mol%),base (5 mol%) and toluene or p-xylene (20 mmol) were added to aSchlenk tube under argon or nitrogen atmosphere. The mixture wasstirred magnetically at reflux temperature. The yields of the prod-ucts were analyzed by GC chromatography using chlorobenzene asan internal standard.

The synthetic route of 33524-31-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Thangavel, Saravanan; Boopathi, Subramaniam; Mahadevaiah; Kolandaivel, Ponmalai; Pansuriya, Pramod B.; Friedrich, Holger B.; Journal of Molecular Catalysis A: Chemical; vol. 423; (2016); p. 160 – 171;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33524-31-1, name is (2,5-Dimethoxyphenyl)methanol, the common compound, a new synthetic route is introduced below. Computed Properties of C9H12O3

EXAMPLE 1 Preparation of 2,5-dimethoxybenzyl bromide: 2,5-Dimethoxybenzyl bromide was prepared by a modified method described by A. L. Shulgin and E. M. Gal in J. Chem. Soc. (London), 1316 (1953). A solution of 4.35 ml (46.3 mmol) PBr3 in 60 ml CCl4 was added dropwise over a period of 1 hour while cooling with ice to a solution of 20 ml (138.9 mmol) 2,5-dimethoxybenzyl alcohol in 200 ml dry CCl4 and the resulting mixture stirred for 15 h at 20 C. in the absence of moisture. After decantation of the CCl4 phase and washing of the inorganic phase (phosphorous acid) with CCl4, the combined organic phases were chromatographed on neutral aluminium oxide (Alumina Woelm N-Super I) and concentrated. The crude product was purified by sublimation in a high vacuum (T=80-100 C.; 0.1 mbar); white needles (melting point 74.5 C., as measured with a Perkin Elmer DSC 7) (lit. 75-76 C.). Yield 20.2 g=45% of the theoretical.

The synthetic route of 33524-31-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bayer Aktiengesellschaft; US4859731; (1989); A;,
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