Category: 32462-30-9

On February 24, 2018, Shi, Ya-Jing; Song, Hui-Hua published an article.Safety of H-Phg(4-OH)-OH The title of the article was Three enantiomeric pairs of zinc(II) homochiral coordination compounds based on D-(-)- and L-(+)-4-Hydroxyphenylglycine: Synthesis, structures and luminescent properties. And the article contained the following:

Three enantiomeric pairs of novel homochiral coordination compounds (HCCs) with the formula {[Zn(D-hpg)(4,4′-bipy)(H2O)]·(NO3)}n 1-D, {[Zn(L-hpg)(4,4′-bipy)(H2O)]·(NO3)}n 1-L, {[Zn(D-hpg)(4,4′-bipy)(H2O)]·(ClO4)}n 2-D, {[Zn(L-hpg)(4,4′-bipy)(H2O)]·(ClO4)}n 2-L, [Zn(D-hpg)2(4,4′-bipy)]·(4,4′-bipy)·2H2O 3-D, [Zn(L-hpg)2(4,4′-bipy)]·(4,4′-bipy)·2H2O 3-L (D-Hhpg = D-(-)-4-Hydroxyphenylglycine, L-Hhpg = L-(+)-4-Hydroxyphenylglycine, 4,4′-bipy = 4,4′-bipyridine) have been synthesized and characterized by single-crystal X-ray diffraction, elemental anal., IR spectroscopy, thermal anal. and powder X-ray diffraction. Compounds 1 and 2 are isostructural 2D layer structures with NO-3 or ClO-4 anions between the layers. While compound 3 features a 0D structure without counter anions. Compounds 1-D and 2-D both contain 1D right-hand helical chains via D-Hhpg ligand, while 1-L and 2-L both contain 1D left-hand helical chains via L-Hhpg ligand. It’s worth noting that 3-D forms left-hand supramol. double helical chains, while 3-L forms right-hand supramol. double helical chains. Compounds 1-3 are further extended into 3D supramol. architectures through hydrogen-bonding interactions. CD and luminescent properties of compounds 1-3 were investigated at room temperature Our results highlight that chiral ligands have an important effect on regulating the chirality/helicity of complexes and the frameworks can be controlled via applying different zinc salts and adjusting the pH values. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Safety of H-Phg(4-OH)-OH

The Article related to zinc hydroxyphenylglycine bipyridine polymer preparation homochiral luminescence cd spectra, thermal stability zinc hydroxyphenylglycine bipyridine polymer, crystal structure zinc hydroxyphenylglycine bipyridine polymer and other aspects.Safety of H-Phg(4-OH)-OH

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On July 18, 2014, Bentley, Keith W.; Wolf, Christian published an article.Recommanded Product: H-Phg(4-OH)-OH The title of the article was Comprehensive Chirality Sensing: Development of Stereodynamic Probes with a Dual (Chir)optical Response. And the article contained the following:

The attachment of a salicylaldehyde ring and a cofacial aryl or heteroaryl N-oxide chromophore onto a naphthalene scaffold affords stereodynamic probes designed to rapidly bind amines, amino alcs., or amino acids and to translate this binding event via substrate-to-receptor chirality amplification into a dual (chir)optical response. 1-(3′-Formyl-4′-hydroxyphenyl)-8-(9′-anthryl)naphthalene (1) was prepared via two consecutive Suzuki cross-coupling reactions, and the three-dimensional structure and racemization kinetics were studied by crystallog. and dynamic HPLC. This probe proved successful for chirality sensing of several compounds, but in situ IR monitoring of the condensation reaction between the salicylaldehyde moiety in 1 and phenylglycinol showed that the imine formation takes 2 h. Optimization of the substrate binding rate and the CD and fluorescence readouts led to the replacement of anthracene with smaller fluorophores capable of intramol. hydrogen bonding. 1-(3′-Formyl-4′-methoxyphenyl)-8-(4′-isoquinolyl)naphthalene N-oxide (2) and its pyridyl analog 3 combine fast substrate binding with distinctive chiral amplification. This asym. transformation of the 1st kind prompts CD and fluorescence responses that can be used for in situ determination of the absolute configuration, ee, and total concentration of many compounds The general utility of the three chemosensors was successfully tested on 18 substrates. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Recommanded Product: H-Phg(4-OH)-OH

The Article related to amine chirality sensing stereodynamic probe dual chiroptical response, amino alc chirality sensing stereodynamic probe dual chiroptical response, acid amino chirality sensing stereodynamic probe dual chiroptical response and other aspects.Recommanded Product: H-Phg(4-OH)-OH

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Zhang, Jun-Hui; Xie, Sheng-Ming; Wang, Bang-Jin; He, Pin-Gang; Yuan, Li-Ming published an article in 2018, the title of the article was A homochiral porous organic cage with large cavity and pore windows for the efficient gas chromatography separation of enantiomers and positional isomers.COA of Formula: C8H9NO3 And the article contains the following content:

Porous organic cages composed of discrete cage mols. have attracted considerable recent attention as gas adsorption materials and separation media. The authors report a homochiral porous organic cage CC5 with a large cavity and pore windows as a novel stationary phase for high-resolution gas chromatog. separations The capillary column was prepared by a static coating method. A large number of racemic compounds were resolved on the coated capillary column, including derivatized amino acids, alcs., alc. amines, esters, ethers, ketones, and epoxides. It is interesting that the CC5-coated capillary column exhibits significant chiral recognition complementarity to a com. β-DEX 120 column and a previously reported homochiral porous organic cage CC3-R-coated column, which could expand the range of the analytes amenable to separation on porous organic cage-based capillary columns. Also, the fabricated column also shows excellent selectivity for the separation of positional isomers, including the challenging ethylbenzene and xylene isomers. Exptl. results demonstrate an excellent separation performance and stability of the CC5-coated column, making it promising for gas chromatog. applications. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).COA of Formula: C8H9NO3

The Article related to homochiral porous organic cage large cavity efficient gas chromatog, gas chromatog enantiomer positional isomer separation, chiral separation, gas chromatography, homochiral porous organic cages, positional isomers, stationary phases and other aspects.COA of Formula: C8H9NO3

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Yuan, Li-Ming; Ma, Wei; Xu, Mei; Zhao, Hui-Lin; Li, Yuan-Yuan; Wang, Rui-Lin; Duan, Ai-Hong; Ai, Ping; Chen, Xue-Xian published an article in 2017, the title of the article was Optical resolution and mechanism using enantioselective cellulose, sodium alginate and hydroxypropyl-β-cyclodextrin membranes.Computed Properties of 32462-30-9 And the article contains the following content:

Chiral solid membranes of cellulose, sodium alginate, and hydroxypropyl-β-cyclodextrin were prepared for chiral dialysis separations After optimizing the membrane material concentrations, the membrane preparation conditions and the feed concentrations, enantiomeric excesses of 89.1%, 42.6%, and 59.1% were obtained for mandelic acid on the cellulose membrane, p-hydroxy phenylglycine on the sodium alginate membrane, and p-hydroxy phenylglycine on the hydroxypropyl-β-cyclodextrin membrane, resp. To study the optical resolution mechanism, chiral discrimination by membrane adsorption, solid phase extraction, membrane chromatog., high-pressure liquid chromatog. ultrafiltration were performed. All of the exptl. results showed that the first adsorbed enantiomer was not the enantiomer that first permeated the membrane. The crystal structures of mandelic acid and p-hydroxy phenylglycine are the racematic compounds We suggest that the chiral separation mechanism of the solid membrane is “adsorption – association – diffusion,” which is able to explain the optical resolution of the enantioselective membrane. This is also the first report in which solid membranes of sodium alginate and hydroxypropyl-β-cyclodextrin were used in the chiral separation of p-hydroxy phenylglycine. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Computed Properties of 32462-30-9

The Article related to chiral separation enantioselectivity cellulose sodium alginate hydroxypropyl beta cyclodextrin, cellulose, chiral separation, enantioselective membrane, hydroxypropyl-β-cyclodextrin, optical resolution mechanism of membrane, sodium alginate and other aspects.Computed Properties of 32462-30-9

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On April 15, 2010, Etoga, Jean-Louis G.; Ahmed, S. Kaleem; Patel, Sarjubhai; Bridges, Richard J.; Thompson, Charles M. published an article.Recommanded Product: 32462-30-9 The title of the article was Conformationally-restricted amino acid analogues bearing a distal sulfonic acid show selective inhibition of system Xc- over the vesicular glutamate transporter. And the article contained the following:

A panel of amino acid analogs and conformationally-restricted amino acids bearing a sulfonic acid were synthesized and tested for their ability to preferentially inhibit the obligate cysteine-glutamate transporter system X-c vs. the vesicular glutamate transporter (VGLUT). Several promising candidate mols. were identified: R/S-4-[4′-carboxyphenyl]-phenylglycine, a biphenyl substituted analog of 4-carboxyphenylglycine and 2-thiopheneglycine-5-sulfonic acid both of which reduced glutamate uptake at system X-c – by 70-75% while having modest to no effect on glutamate uptake at VGLUT. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Recommanded Product: 32462-30-9

The Article related to glutamate uptake vglut inhibitor amino acid preparation, vesicular glutamate transporter inhibiting structure activity amino acid, phenylglycine aminothiophene sulfonic acid analog preparation, amino acid hydrolysis sulfonation sulfuric acid and other aspects.Recommanded Product: 32462-30-9

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On November 30, 2012, Sinha, Debarshi; Mandal, Tanmay; Gogoi, Sanjib; Goldman, Joshua J.; Zhao, John Cong-gui published an article.Recommanded Product: H-Phg(4-OH)-OH The title of the article was Asymmetric Aldol Reaction Catalyzed by Modularly Designed Organocatalysts. And the article contained the following:

The self-assembly of pre-catalyst modules, which are amino acids and cinchona alkaloid derivatives, leads to a direct formation of the desired organocatalysts without any synthesis. These modularly designed organocatalysts (MDOs) may be used for catalyzed asym. aldol reaction. Depending on structure of the aldehyde substrates, the corresponding aldol products may be obtained in mediocre to excellent enantiomeric excess (ee) values (up to 92% ee) with moderate diastereoselectivities (up to 79:21 diastereomeric ratio, dr). The synthesis of the target compounds was achieved by a combination of amino acids and analogs, such as (αS)-α-amino-2-chlorobenzeneacetic acid, L-alanine, L-leucine, L-isoleucine. 3-methyl-L-valine, β-alanine. Cinchona alkaloids included N-[3,5-bis(trifluoromethyl)phenyl]-N’-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, (8α,9R)-cinchonan-6′,9-diol (cupreine), (9S)-cinchonan-6′,9-diol (cupreidine), O-benzoylquinine, (8α,9R)-6′-methoxy-9-(phenylmethoxy)cinchonan (O-benzylquinine), etc. The title compounds thus formed included (4S)-4-hydroxy-4-(4-nitrophenyl)-2-butanone (4R)-4-hydroxy-4-(4-nitrophenyl)-2-butanone and (2R)-2-[(R)-hydroxy(4-nitrophenyl)methyl]cyclohexanone (I) and related substances, such as (3R)-tetrahydro-3-[(R)-hydroxy(4-nitrophenyl)methyl]-4H-pyran-4-one, (3R)-tetrahydro-3-[(R)-hydroxy(4-nitrophenyl)methyl]-4H-thiopyran-4-one. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Recommanded Product: H-Phg(4-OH)-OH

The Article related to cinchona alkaloid amino acid chiral catalyst aldol reaction, cyclohexanone hydroxyalkyl preparation aldol addition cinchona alkaloid catalyst, pyranone hydroxyalkyl preparation aldol addition cinchona alkaloid catalyst, thiopyranone hydroxyalkyl preparation aldol addition cinchona alkaloid catalyst and other aspects.Recommanded Product: H-Phg(4-OH)-OH

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On December 19, 2014, Khoury, George A.; Smadbeck, James; Tamamis, Phanourios; Vandris, Andrew C.; Kieslich, Chris A.; Floudas, Christodoulos A. published an article.Synthetic Route of 32462-30-9 The title of the article was Forcefield_NCAA: Ab Initio Charge Parameters to Aid in the Discovery and Design of Therapeutic Proteins and Peptides with Unnatural Amino Acids and Their Application to Complement Inhibitors of the Compstatin Family. And the article contained the following:

We describe the development and testing of ab initio derived, AMBER ff03 compatible charge parameters for a large library of 147 noncanonical amino acids including β- and N-methylated amino acids for use in applications such as protein structure prediction and de novo protein design. The charge parameter derivation was performed using the RESP fitting approach. Studies were performed assessing the suitability of the derived charge parameters in discriminating the activity/inactivity between 63 analogs of the complement inhibitor Compstatin on the basis of previously published exptl. IC50 data and a screening procedure involving short simulations and binding free energy calculations We found that both the approx. binding affinity (K*) and the binding free energy calculated through MM-GBSA are capable of discriminating between active and inactive Compstatin analogs, with MM-GBSA performing significantly better. Key interactions between the most potent Compstatin analog that contains a noncanonical amino acid are presented and compared to the most potent analog containing only natural amino acids and native Compstatin. We make the derived parameters and an associated web interface that is capable of performing modifications on proteins using Forcefield_NCAA and outputting AMBER-ready topol. and parameter files freely available for academic use at http://selene.princeton.edu/FFNCAA. The forcefield allows one to incorporate these customized amino acids into design applications with control over size, van der Waals, and electrostatic interactions. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Synthetic Route of 32462-30-9

The Article related to compstatin analog noncanonical amino acid complement inhibitor drug design, mol dynamics simulation unnatural amino acid therapeutic protein peptide, amber topol noncanonical amino acid pharmacophore compstatin analog design, amber partial charges, compstatin, complement, inhibitors, molecular dynamics, noncanonical amino acids, unnatural amino acids and other aspects.Synthetic Route of 32462-30-9

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On July 19, 2013, Foschi, Francesca; Tagliabue, Aaron; Mihali, Voichita; Pilati, Tullio; Pecnikaj, Ilir; Penso, Michele published an article.Formula: C8H9NO3 The title of the article was Memory of Chirality Approach to the Enantiodivergent Synthesis of Chiral Benzo[d]sultams. And the article contained the following:

Nonracemic polyfluorobenzo[d]sultams (polyfluorodioxobenzoisothiazolecarboxylates) such as I (R = MeO2C, Ph; R1 = Ph, MeO2C; R2 = H, EtCH2, H2C:CHCH2) were prepared using either stereoselective cyclization of nonracemic (polyfluoroarylsulfonyl)phenylglycines such as II or by phase-transfer alkylation of polyfluorobenzosultams I (R = MeO2C, Ph; R1 = Ph, t-BuO2C; R2 = H) followed by preferential crystallization of one enantiomer of the product. Starting from (polyfluoroarylsulfonyl)phenylglycines, both enantiomers of the corresponding polyfluorobenzo[d]sultams were prepared in most cases; when DBU and N,N,N’,N’-tetramethyl-N”-tert-butylguanidine (BTMG) were used as bases in 1,2-dimethoxyethane, sultams were obtained mainly with retention of the phenylglycine stereochem. (6-94% ee), while when BTMG alone in DME was used, the sultams were obtained mainly with inversion of the phenylglycine stereochem. (8-96% ee). The structures of I (R = MeO2C; R1 = Ph; R2 = EtCH2, H2C:CHCH2) and of I (R = Ph; R1 = t-BuO2C; R2 = Me) were determined by X-ray crystallog. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Formula: C8H9NO3

The Article related to fluorobenzosultam enantioselective preparation, fluorodioxobenzoisothiazolecarboxylate enantioselective preparation, base dependent stereoselective cyclization fluoroarylsulfonyl arylglycine, selective crystallization phase transfer alkylation product fluorobenzosultam, allyl propyl methyl fluorodioxobenzoisothiazolecarboxylate mol crystal structure and other aspects.Formula: C8H9NO3

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On March 15, 2020, Deng, Qian-ying; Liu, Man-yu; Shi, Ya-Jing; Wang, Lan-zhi; Feng, Qi; Song, Hui-Hua published an article.Application In Synthesis of H-Phg(4-OH)-OH The title of the article was A pair of stable Zn(II) enantiomeric coordination compounds: synthesis, crystal structures and luminescent recognition properties. And the article contained the following:

A pair of stable chiral coordination compounds {[Zn(D-hpg)(bpe)]·(NO3)·(C2H6O)}n 1-D, {[Zn(L-hpg)(bpe)]·(NO3)·(C2H6O)}n 1-L (D-Hhpg = D-(-)-4-Hydroxyphenylglycine, L-Hhpg = L-(+)-4-Hydroxyphenylglycine, bpe = 1,2-bis(4-pyridyl)ethane) were successfully synthesized. Their structures were determined by single-crystal x-ray diffraction anal. and characterized by elemental anal., IR spectroscopy, TGA and powder X-ray diffraction. They are 2D layer structures that consist of left- or right-handed helical chains, resp. CD and luminescent properties of compounds 1-D and 1-L were studied at room temperature Moreover, 1-D and 1-L show similar selectivity toward Cu2+ ions through luminescent quenching in aqueous solution In addition, 1-D also displays an excellent recognition ability on detecting CH3OH. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Application In Synthesis of H-Phg(4-OH)-OH

The Article related to chemical chains, helical, circular dichroism, crystal structure, luminescence, luminescence quenching, molecular structure, optical sensors, thermal stability and other aspects.Application In Synthesis of H-Phg(4-OH)-OH

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