Category: 32462-30-9

Salerno, Anna; Fragasso, Gabriele; Montanaro, Claudia; Cera, Michela; Torlasco, Camilla; Maranta, Francesco; Margonato, Alberto published an article in 2010, the title of the article was Role of metabolic modulation in the management of chronic ischemic heart disease.SDS of cas: 32462-30-9 And the article contains the following content:

Abstract: Coronary artery disease (CAD) is a major cause of morbidity and mortality in the world. Therapy for stable CAD is currently based on conventional medical therapy, including nitrates, β-blockers and calcium-channels antagonists and, more recently, metabolic therapy, of which a pivotal therapeutic role is increasingly recognized. Under normoxic condition, the healthy heart derives 2/3 of its energy from the free fatty acid (FFA) pathway, the other source of energy being derived from glucose oxidation However, glycolysis requires less O2 per mol of ATP generated compared with FFA oxidation On this basis, shifting energy substrate utilization from fatty acid metabolism to glucose metabolism can be more efficient in terms of ATP production per mol of oxygen utilized. A number of different approaches have been used to manipulate energy metabolism in the heart. These approaches include direct agents, such as dichloroacetate, -carnitine, ribose or lipoic acid which directly increase glucose oxidation, or indirect methods, through the inhibition of free fatty acids oxidation Among these, the most important are carnitil-palmitoyl-transpherase I (CPT-I) inhibitors, which inhibit FFA mitochondrial uptake (e.g. etomoxir, perhexiline, oxphenicine), or 3-ketoacyl-coenzyme-A thiolase (3-KAT) inhibitors, such as trimetazidine, which inhibits the last enzyme involved in β-oxidation In most patients with ischemic heart disease metabolic abnormalities, if not adequately treated, will heavily contribute to the occurrence of complications, of whom severe left ventricular dysfunction is at present one of the most frequent and insidious. In this paper, all possible metabolic approaches to ischemic heart disease are reviewed and discussed. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).SDS of cas: 32462-30-9

The Article related to metabolic therapy ischemic heart disease cardioprotectant, Pharmacology: Effects Of Cardiovascular, Hematologic, and Renal Drugs and other aspects.SDS of cas: 32462-30-9

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On October 31, 2011, Qu, Yixin; Li, Tian; Wang, Shui published an article.Category: alcohols-buliding-blocks The title of the article was Solubility of D-p-hydroxyphenylglycine p-toluenesulfonate and L-p-hydroxyphenylglycine in different solvents. And the article contained the following:

The solubility of D-p-hydroxyphenylglycine p-toluenesulfonate and L-p-hydroxyphenylglycine in different solvents was measured using a laser monitoring observation technique. The solubility data were accurately correlated by the modified Apelblat equation, the calculated results of which were proved to show fine representation of exptl. data. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Category: alcohols-buliding-blocks

The Article related to hydroxyphenylglycine solubility, toluenesulfonate hydroxyphenylglycine solubility, Phase Equilibriums, Chemical Equilibriums, and Solutions: Phase Equilibriums, Solubility and other aspects.Category: alcohols-buliding-blocks

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On April 30, 2011, Dey, Raja; Chen, Lin published an article.Computed Properties of 32462-30-9 The title of the article was In search of allosteric modulators of α7-nAChR by solvent density guided virtual screening. And the article contained the following:

Nicotinic acetylcholine receptors (nAChR) are pentameric ligand gated ion channels whose activity can be modulated by endogenous neurotransmitters as well as by synthetic ligands that bind the same or distinct sites from the natural ligand. The subtype of α7 nAChR has been considered as a potential therapeutic target for Alzheimer’s disease, schizophrenia, and other neurol. and psychiatric disorders. A homol. model was developed for α7 nAChR based on 2 high resolution crystal structures with Brookhaven Protein Data Bank (PDB) codes 2QC1 and 2WN9 for threading on one monomer and then for building a pentamer, resp. A number of small mol. binding sites are identified using Pocket Finder of Internal Coordinate Mechanics (ICM). Remarkably, these computer-identified sites match perfectly with ordered solvent densities found in the high-resolution crystal structure of α1 nAChR, suggesting that the surface cavities in the α7 nAChR model are likely binding sites of small mols. A high throughput virtual screening by flexible ligand docking of 5008 small mol. compounds was performed at 3 potential allosteric modulator (AM) binding sites of α7 nAChR using Molsoft ICM software. Some exptl. verified allosteric modulators of α7 (CCMI comp-6, LY 7082101, 5-HI, TQS, PNU-120596, genistein, and NS-1738) ranked among top 100 compounds, while the rest of the compounds in the list could guide further search for new allosteric modulators. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Computed Properties of 32462-30-9

The Article related to nicotinic acetylcholine receptor allosteric modulator virtual screening homol modeling, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Computed Properties of 32462-30-9

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On November 30, 2017, Foster, Alan C.; Rangel-Diaz, Natalie; Staubli, Ursula; Yang, Jia-Ying; Penjwini, Mahmud; Viswanath, Veena; Li, Yong-Xin published an article.Name: H-Phg(4-OH)-OH The title of the article was Phenylglycine analogs are inhibitors of the neutral amino acid transporters ASCT1 and ASCT2 and enhance NMDA receptor-mediated LTP in rat visual cortex slices. And the article contained the following:

The N-methyl-D-aspartate receptor (NMDA) co-agonist D-serine is a substrate for the neutral amino acid transporters ASCT1 (SLC1A4) and ASCT2 (SLC1A5). We identified L-phenylglycine (PG) and its analogs as inhibitors of ASCT1 and ASCT2. PG analogs were shown to be non-substrate inhibitors of ASCT1 and ASCT2 with a range of activities relative to other amino acid transport systems, including sodium-dependent glutamate transporters, the sodium-independent D-serine transporter asc-1 and system L. L-4-chloroPG was the most potent and selective ASCT1/2 inhibitor identified. The PG analogs facilitated theta-burst induced long-term potentiation in rat visual cortex slices in a manner that was dependent on extracellular D-serine. For structurally-related PG analogs, there was an excellent correlation between ASCT1/2 transport inhibition and enhancement of LTP which was not the case for inhibition of asc-1 or system L. The ability of PG analogs to enhance LTP is likely due to inhibition of D-serine transport by ASCT1/2, leading to elevated extracellular levels of D-serine and increased NMDA receptor activity. These results suggest that ASCT1/2 may play an important role in regulating extracellular D-serine and NMDA receptor-mediated physiol. effects and that ASCT1/2 inhibitors have the potential for therapeutic benefit. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Name: H-Phg(4-OH)-OH

The Article related to l phenylglycine asct1 asct2 inhibitor long term potentiation, asct1, asct2, d-serine, ltp, nmda, phenylglycine, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Name: H-Phg(4-OH)-OH

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On September 29, 2017, Shen, Peng; Hu, Qingchuan; Dong, Meixue; Bai, Shunjie; Liang, Zihong; Chen, Zhi; Li, Pengfei; Hu, Zicheng; Zhong, Xiaogang; Zhu, Dan; Wang, Haiyang; Xie, Peng published an article.Reference of H-Phg(4-OH)-OH The title of the article was Venlafaxine exerts antidepressant effects possibly by activating MAPK-ERK1/2 and P13K-AKT pathways in the hippocampus. And the article contained the following:

Serotonin noradrenaline reuptake inhibitors are effective antidepressant drugs, which include venlafaxine and duloxetine. Venlafaxine is commonly used in a clin. context, but the mol. biol. mechanisms behind its effects have not been fully determined Here, we explored the potential biol. effects of venlafaxine on mouse hippocampus. Mice were randomly divided into two groups and injected daily with 0.9% NaCl solution or venlafaxine. A GC-MS-based metabolomic approach was used to identify possible metabolic differences between these groups, and the key proteins involved in the relevant pathways were validated by western blotting. In our experiments, 27 hippocampal metabolites that distinguished the venlafaxine group from the control group were identified. These differential metabolites were subjected to Ingenuity Pathway Anal., which revealed that they were strongly related to two metabolic pathways (MAPK-ERK1/2 and P13K-AKT signaling pathways). Six key proteins, BDNF, p-c-Raf, p-MAPK, p-MEK, p-AKT, and CREB, were verified by western blotting and the results were consistent with the differential metabolites identified by GC-MS. This study sheds light on the biol. mechanisms underlying the effects of venlafaxine. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Reference of H-Phg(4-OH)-OH

The Article related to venlafaxine antidepressant hippocampus mapk erk1 erk2 p13k akt, antidepressant, hippocampus, mechanism, metabolomics, venlafaxine, western blotting, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Reference of H-Phg(4-OH)-OH

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Brandhofer, Tobias; Stinglhamer, Martin; Derdau, Volker; Mendez, Maria; Poverlein, Christoph; Garcia Mancheno, Olga published an article in 2021, the title of the article was Easy access to drug building-blocks through benzylic C-H functionalization of phenolic ethers by photoredox catalysis.Category: alcohols-buliding-blocks And the article contains the following content:

A visible light-mediated photocatalyzed C-C-bond forming method for the benzylic C-H functionalization of phenolether containing synthetic building blocks based on a radical-cation/deprotonation strategy is reported. This method allows the mild, selective generation of benzyl radicals in phenolic complex mols. and drug-like compounds, providing new entries in synthetic and medicinal chem. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Category: alcohols-buliding-blocks

The Article related to tyrosine methyl ester functionalization alkylation methyl acrylate photoredox catalysis, peptide synthesis alkylation photoredox catalysis reaction mechanism cyclic voltammetry and other aspects.Category: alcohols-buliding-blocks

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On May 1, 2022, Li, Yan; Xin, Jianpan; Tian, Runan published an article.COA of Formula: C8H9NO3 The title of the article was Physiological defense and metabolic strategy of Pistia stratiotes in response to zinc-cadmium co-pollution. And the article contained the following:

Pistia stratiotes is a cadmium (Cd) hyperaccumulating plant with strong bioaccumulation and translocation capacity for Cd. A hydroponic experiment was used to evaluate the combined effect of Zinc (Zn) and Cd at different concentrations on leaf growth and metabolism of P. stratiotes. This study revealed the physiol. defense and metabolic strategy of responses to Zn-Cd co-pollution. With the Zn50Cd1, Zn50Cd10, Zn100Cd1, and Zn100Cd10 treatments for 9 d, the relative crown diameter, relative leave number, and ramet number of the plant had no significant difference with the control. Under the compound treatments containing Zn50Cd50 and Zn100Cd50, the activity of the glyoxalase system and amino acid metabolism in the leaves were inhibited. The leaf photosynthetic apparatus increased heat dissipation to reduce the damage to the photosystem II (PS II) reaction center caused by excess excitation energy under Zn-Cd stress. This safeguarded the balance between the absorption and utilization of light energy. Compared to the control, the Zn and Cd co-pollution for 9 d had no effect on the reduced glutathione (GSH) and oxidized glutathione (GSSG) contents. There was no effect on the dehydroascorbate reductase (DHAR) and glutathione reductase (GR) activities, but there was increased ascorbate peroxidase (APX) activity and oxidized ascorbic acid (DHA) content. These increased the antioxidant capacity of the ascorbate-glutathione (AsA-GSH) cycle. The treated plants also had increased levels of carnosol and substances related to lipid metabolism including 9, 10-Dihydroxystearate, Prostaglandin G2, Sphingosine, and 13-L-Hydroperoxylinoleic acid, maintaining the cell stability and resistance to the Zn-Cd stress. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).COA of Formula: C8H9NO3

The Article related to pistia physiol defense metabolism zinc cadmium pollution, ascorbate-glutathione cycle, glyoxalase system, metabolomics, photosynthesis, pistia stratiotes, zinc-cadmium co-contamination and other aspects.COA of Formula: C8H9NO3

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On August 8, 2013, Marson, Charles M.; Matthews, Christopher J.; Yiannaki, Elena; Atkinson, Stephen J.; Soden, Peter E.; Shukla, Lena; Lamadema, Nermina; Thomas, N. Shaun B. published an article.Recommanded Product: H-Phg(4-OH)-OH The title of the article was Discovery of Potent, Isoform-Selective Inhibitors of Histone Deacetylase Containing Chiral Heterocyclic Capping Groups and a N-(2-Aminophenyl)benzamide Binding Unit. And the article contained the following:

The synthesis of a novel series of potent chiral inhibitors of histone deacetylase (HDAC) is described that contain a heterocyclic capping group and a N-(2-aminophenyl)benzamide unit that binds in the active site. In vitro assays for the inhibition of HDAC1, HDAC2, HDAC3-NCoR1, and HDAC8 by the N-(2-aminophenyl)benzamide I gave resp. IC50 values of 930, 85, 12, and 4100 nM, exhibiting class I selectivity and potent inhibition of HDAC3-NCoR1. Both imidazolinone and thiazoline rings are shown to be effective replacements for the pyrimidine ring present in many other 2-(aminophenyl)benzamides previously reported, an example of each ring system at 1 μM causing an increase in histone H3K9 acetylation in the human cell lines Jurkat and HeLa and an increase in cell death consistent with induction of apoptosis. Inhibition of the growth of MCF-7, A549, DU145, and HCT116 cell lines by I was observed, with resp. IC50 values of 5.4, 5.8, 6.4, and 2.2 mM. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Recommanded Product: H-Phg(4-OH)-OH

The Article related to aminophenylbenzamide pyrimidine imidazolinone thiazoline capped preparation histone deacetylase inhibition, thiazoline capped hdac3 ncor1 inhibitor preparation antitumor activity apoptosis and other aspects.Recommanded Product: H-Phg(4-OH)-OH

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Becker, Dominic; Kazmaier, Uli published an article in 2015, the title of the article was Synthesis of simplified halogenated chondramide derivatives with strong cytostatic properties.HPLC of Formula: 32462-30-9 And the article contains the following content:

Removing the Me groups and the stereogenic centers from the ω-hydroxy acid of the chondramides results in a significant drop in the cytotoxicity of these interesting depsipeptides. This effect can be almost compensated for by introduction of a second chlorine atom on the β-tyrosine moiety of the natural products. These simplified chondramides are much easier accessible than natural chondramides. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).HPLC of Formula: 32462-30-9

The Article related to cyclic peptide depsipeptide halogenated chondramide enantioselective synthesis antitumor agent, hydroxy acid esterification tryptophan protection amination peptide coupling cyclization and other aspects.HPLC of Formula: 32462-30-9

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On December 3, 2021, Jo, Hwi Yul; Lee, Jeong Min; Pietrasiak, Ewa; Lee, Eunsung; Rhee, Young Ho; Park, Jaiwook published an article.Safety of H-Phg(4-OH)-OH The title of the article was Generation of N-H imines from α-Azidocarboxylic Acids through Ru-catalyzed Decarboxylation. And the article contained the following:

A new method for the synthesis of N-H imines from α-azidocarboxylic acids was developed, which proceeded through decarboxylative C-C bond cleavage catalyzed by a com. diruthenium complex ([CpRu(CO)2]2) under visible light irradiation at room temperature within several minutes. The reactive products undergo condensation forming cyclic trimers (2,4,6-trialkylhexahydro-1,3,5-triazines) or linear N,N’-bis(arylmethylidene)arylmethanediamines in quant. yields. Alternatively, the N-H imines was trapped with benzylamine and 2-(aminomethyl)aniline providing stable N-benzylimines and tetrahydroquinazolines, resp. Subsequent oxidation of tetrahydroquinazolines produced quinazolines. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Safety of H-Phg(4-OH)-OH

The Article related to azidoethanoic acid ruthenium catalyzed decarboxylation condensation, hexahydrotriazine bismethylidenemethanediamine preparation, benzylmethylidene amine preparation, quinazoline preparation and other aspects.Safety of H-Phg(4-OH)-OH

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