Category: 32462-30-9

Reddy, Ambavaram Vijaya Bhaskar; Yusop, Zulkifli; Jaafar, Jafariah; Bin Aris, Azmi; Abdul Majid, Zaiton published an article in 2017, the title of the article was A simple, selective, and sensitive gas chromatography-mass spectrometry method for the analysis of five process-related impurities in atenolol bulk drug and capsule formulations.Reference of H-Phg(4-OH)-OH And the article contains the following content:

An extremely sensitive and simple gas chromatog. with mass spectrometry method was developed and completely validated for the anal. of five process-related impurities, viz., 4-hydroxy-L-phenylglycine, 4-hydroxyphenylacetonitrile, 4-hydroxyphenylacetic acid, methyl-4-hydroxyphenylacetate, and 2-[4-{(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl]acetonitrile, in atenolol. The separation of impurities was accomplished on a BPX-5 column with dimensions of 50 m × 0.25 mm i.d. and 0.25 μm film thickness. The method validation was performed following International Conference on Harmonisation guidelines in which the method was capable to quantitate 4-hydroxy-L-phenylglycine, 4-hydroxyphenylacetonitrile, and 4-hydroxyphenylacetic acid at 0.3 ppm, and methyl-4-hydroxyphenylacetate and 2-[4-{(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl]acetonitrile at 0.35 ppm with respect to 10 mg/mL of atenolol. The method was linear over the concentration range of 0.3-10 ppm for 4-hydroxy-L-phenylglycine, 4-hydroxyphenylacetonitrile, and 4-hydroxyphenylacetic acid, and 0.35-10 ppm for methyl-4-hydroxyphenylacetate and 2-[4-{(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl]acetonitrile. The correlation coefficient in each case was found ≥0.998. The repeatability and recovery values were acceptable, and found between 89.38% and 105.60% for all five impurities under optimized operating conditions. The method developed here is simple, selective, and sensitive with apparently better resolution than the reported methods. Hence, the method is a straightforward and good quality control tool for the quantitation of selected impurities at trace concentrations in atenolol. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Reference of H-Phg(4-OH)-OH

The Article related to atenolol impurity analysis gc ms, beta-blockers, genotoxicity, mass spectrometry, method validation, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Reference of H-Phg(4-OH)-OH

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Salerno, Anna; Fragasso, Gabriele; Montanaro, Claudia; Cera, Michela; Torlasco, Camilla; Maranta, Francesco; Margonato, Alberto published an article in 2010, the title of the article was Role of metabolic modulation in the management of chronic ischemic heart disease.SDS of cas: 32462-30-9 And the article contains the following content:

Abstract: Coronary artery disease (CAD) is a major cause of morbidity and mortality in the world. Therapy for stable CAD is currently based on conventional medical therapy, including nitrates, β-blockers and calcium-channels antagonists and, more recently, metabolic therapy, of which a pivotal therapeutic role is increasingly recognized. Under normoxic condition, the healthy heart derives 2/3 of its energy from the free fatty acid (FFA) pathway, the other source of energy being derived from glucose oxidation However, glycolysis requires less O2 per mol of ATP generated compared with FFA oxidation On this basis, shifting energy substrate utilization from fatty acid metabolism to glucose metabolism can be more efficient in terms of ATP production per mol of oxygen utilized. A number of different approaches have been used to manipulate energy metabolism in the heart. These approaches include direct agents, such as dichloroacetate, -carnitine, ribose or lipoic acid which directly increase glucose oxidation, or indirect methods, through the inhibition of free fatty acids oxidation Among these, the most important are carnitil-palmitoyl-transpherase I (CPT-I) inhibitors, which inhibit FFA mitochondrial uptake (e.g. etomoxir, perhexiline, oxphenicine), or 3-ketoacyl-coenzyme-A thiolase (3-KAT) inhibitors, such as trimetazidine, which inhibits the last enzyme involved in β-oxidation In most patients with ischemic heart disease metabolic abnormalities, if not adequately treated, will heavily contribute to the occurrence of complications, of whom severe left ventricular dysfunction is at present one of the most frequent and insidious. In this paper, all possible metabolic approaches to ischemic heart disease are reviewed and discussed. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).SDS of cas: 32462-30-9

The Article related to metabolic therapy ischemic heart disease cardioprotectant, Pharmacology: Effects Of Cardiovascular, Hematologic, and Renal Drugs and other aspects.SDS of cas: 32462-30-9

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On February 25, 2021, Le Manach, Claire; Dam, Jean; Woodland, John G.; Kaur, Gurminder; Khonde, Lutete P.; Brunschwig, Christel; Njoroge, Mathew; Wicht, Kathryn J.; Horatscheck, Andre; Paquet, Tanya; Boyle, Grant A.; Gibhard, Liezl; Taylor, Dale; Lawrence, Nina; Yeo, Tomas; Mok, Sachel; Eastman, Richard T.; Dorjsuren, Dorjbal; Talley, Daniel C.; Guo, Hui; Simeonov, Anton; Reader, Janette; van der Watt, Mariette; Erlank, Erica; Venter, Nelius; Zawada, Jacek W.; Aswat, Ayesha; Nardini, Luisa; Coetzer, Theresa L.; Lauterbach, Sonja B.; Bezuidenhout, Belinda C.; Theron, Anjo; Mancama, Dalu; Koekemoer, Lizette L.; Birkholtz, Lyn-Marie; Wittlin, Sergio; Delves, Michael; Ottilie, Sabine; Winzeler, Elizabeth A.; von Geldern, Thomas W.; Smith, Dennis; Fidock, David A.; Street, Leslie J.; Basarab, Gregory S.; Duffy, James; Chibale, Kelly published an article.Electric Literature of 32462-30-9 The title of the article was Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts. And the article contained the following:

A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold provided an attractive starting point for a hit-to-lead medicinal chem. optimization and biol. profiling program. Structure-activity-relationship studies led to the identification of compounds that showed low nanomolar asexual blood-stage activity (<50 nM) together with strong gametocyte sterilizing properties that translated to transmission-blocking activity in the standard membrane feeding assay. Mechanistic studies through resistance selection with one of the analogs followed by whole-genome sequencing implicated the P. falciparum cyclic amine resistance locus in the mode of resistance. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Electric Literature of 32462-30-9

The Article related to malaria antimalarial plasmodium diazaspirooctane pharmacokinetic, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Electric Literature of 32462-30-9

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On August 13, 2020, Kuehl, Nikos; Graf, Dominik; Bock, Josephine; Behnam, Mira A. M.; Leuthold, Mila-Mareen; Klein, Christian D. published an article.Application of 32462-30-9 The title of the article was A New Class of Dengue and West Nile Virus Protease Inhibitors with Submicromolar Activity in Reporter Gene DENV-2 Protease and Viral Replication Assays. And the article contained the following:

Dengue and West Nile virus are rapidly spreading global pathogens for which no specific therapeutic treatments are available. One of the promising targets for drug discovery against dengue and other flaviviruses is the viral serine protease NS2B-NS3. We present the design, synthesis, and in vitro and cellular characterization of a novel chemotype of potent small-mol. non-peptidic dengue protease inhibitors derived from 4-benzyloxyphenylglycine. A newly developed luciferase-based DENV-2 protease reporter system in HeLa cells (DENV2proHeLa) was employed to determine the activity of the compounds in a cellular environment. Specificity and selectivity of the DENV2proHeLa system were confirmed by viral titer reduction assays. The compounds reach low micromolar to upper nanomolar inhibitory potency in cell-based assays, are selective against other serine proteases, and do not show relevant cytotoxicity. An extensive structure-activity relationship study provides a perspective for further drug development against flaviviral infections. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Application of 32462-30-9

The Article related to dengue west nile virus protease inhibitors sar flaviviral infections, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Application of 32462-30-9

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On March 31, 2014, Takenaka, Shinji; Yoshida, Kenji; Tanaka, Kosei; Yoshida, Ken-ichi published an article.Reference of H-Phg(4-OH)-OH The title of the article was Molecular characterization of a novel N-acetyltransferase from Chryseobacterium sp.. And the article contained the following:

N-Acetyltransferase from Chryseobacterium sp. strain 5-3B is an acetyl CoA (acetyl-CoA)-dependent enzyme that catalyzes the enantioselective transfer of an acetyl group from acetyl-CoA to the amino group of L-2-phenylglycine to produce (2S)-2-acetylamino-2-phenylacetic acid. We purified the enzyme from strain 5-3 B and deduced the N-terminal amino acid sequence. The gene, designated natA, was cloned with two other hypothetical protein genes; the three genes probably form a 2.5-kb operon. The deduced amino acid sequence of NatA showed high levels of identity to sequences of putative N-acetyltransferases of Chryseobacterium spp. but not to other known arylamine and arylalkylamine N-acetyltransferases. Phylogenetic anal. indicated that NatA forms a distinct lineage from known N-acetyltransferases. We heterologously expressed recombinant NatA (rNatA) in Escherichia coli and purified it. RNatA showed high activity for L-2-phenylglycine and its chloro- and hydroxyl-derivatives The Km and Vmax values for L-2-phenylglycine were 0.145 ± 0.026 mM and 43.6 ± 2.39 μmol·min-1·mg protein-1, resp. The enzyme showed low activity for 5-aminosalicylic acid and 5-hydroxytryptamine, which are reported as good substrates of a known arylamine N-acetyltransferase and an arylalkylamine N-acetyltransferase. RNatA had a comparatively broad acyl donor specificity, transferring acyl groups to L-2-phenylglycine and producing the corresponding 2-acetylamino-2-phenylacetic acids (relative activity with acetyl donors acetyl-CoA, propanoyl-CoA, butanoyl-CoA, pentanoyl-CoA, and hexanoyl-CoA, 100:108:122:10:<1). The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Reference of H-Phg(4-OH)-OH

The Article related to acetyltransferase chryseobacterium aminosalicylate protein sequence phenylglycine phylogeny, Enzymes: Separation-Purification-General Characterization and other aspects.Reference of H-Phg(4-OH)-OH

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On May 5, 2022, Li, Si-nong; Cao, Meng-ru; Li, Yi-qi; Yang, Jia-xin; Zhao, Mei-hong; Song, Hui-Hua published an article.Product Details of 32462-30-9 The title of the article was Three pairs of Pb(II), Cd(II) and Cu(II) enantiomeric coordination compounds based on D-(-)- and L-(+) -4-Hydroxyphenylglycine: Synthesis, structures and properties. And the article contained the following:

Three pairs of stable chiral coordination compounds [Pb(D-hpg)2(bpe)2]·(NO3)2 (1), [Pb(L-hpg)2(bpe)2]·(NO3)2 (2); {[Cd (D-hpg)(bpe)(H2O)]·(NO3)·(H2O)}n (3), {[Cd(L-hpg)(bpe)(H2O)]·(NO3)·(H2O)}n (4); {[Cu2(D-hpg)2(bpe)(H2O)2]·(NO3)2·H2O}n (5), {[Cu2(L-hpg)2(bpe)(H2O)2]·(NO3)2·H2O}n (6) (D-Hhpg = D-(-)-4-Hydroxyphenylglycine, L-Hhpg = L-(+)-4-Hydroxyphenylglycine, bpe = 1,2-bis(4-pyridyl)ethane) have been successfully synthesized. Their structures were determined by single-crystal X-ray diffraction anal. and characterized by elemental anal., IR spectroscopy, thermogravimetric anal., powder X-ray diffraction and CD. Compounds 1 and 2 feature 0D mol. structures, compounds 3 and 4 are 2D rectangular grid networks and compounds 5 and 6 exhibit 2D hexagonal grid networks with an ABAB stacking sequence. Compounds 1-6 are further extended into 3D supramol. architectures through hydrogen-bonding interactions. Our results highlight that the modulation of coordination polymers with different structures can be accomplish by selecting the center metal of different electronic structures. Luminescent properties of compounds 1 and 2 were investigated at room temperature 1 and 2 show similar selectivity toward Fe3+ions through luminescent quenching in aqueous solution Moreover, the electrochem. behaviors of compounds 5 and 6 were further studied by cyclic voltammetry, indicating a surface-controlled electrochem. process. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Product Details of 32462-30-9

The Article related to lead cadmium copper hydroxyphenylglycine bispyridylethane complex preparation structure luminescence, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Product Details of 32462-30-9

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On June 30, 2012, Maarman, Gerald; Marais, Erna; Lochner, Amanda; du Toit, Eugene F. published an article.Category: alcohols-buliding-blocks The title of the article was Effect of Chronic CPT-1 Inhibition on Myocardial Ischemia-Reperfusion Injury (I/R) in a Model of Diet-Induced Obesity. And the article contained the following:

Purpose By increasing circulating free fatty acids and the rate of fatty acid oxidation, obesity decreases glucose oxidation and myocardial tolerance to ischemia. Partial inhibition of fatty acid oxidation may improve myocardial tolerance to ischemia/reperfusion (I/R) in obesity. We assessed the effects of oxfenicine treatment on post ischemic cardiac function and myocardial infarct size in obese rats. Methods Male Wistar rats were fed a control diet or a high calorie diet which resulted in diet induced obesity (DIO) for 16 wk. Oxfenicine (200 mg/kg/day) was administered to control and DIO rats for the last 8 wk. Isolated hearts were perfused and infarct size and post ischemic cardiac function was assessed after regional or global ischemia and reperfusion. Cardiac mitochondrial function was assessed and myocardial expression and activity of CPT-1 (carnitine palmitoyl transferase-1) and IRS-1 (insulin receptor substrate-1) was assessed using Western blot anal. Results In the DIO rats, chronic oxfenicine treatment improved post ischemic cardiac function and reduced myocardial infarct size after I/R but had no effect on the cardiac mitochondrial respiration. Chronic oxfenicine treatment worsened post ischemic cardiac function, myocardial infarct size and basal mitochondrial respiration in control rat hearts. Basal respiratory control index (RCI) values, state 2 and state 4 respiration rates and ADP phosphorylation rates were compromised by oxfenicine treatment. Conclusion Chronic oxfenicine treatment improved myocardial tolerance to I/R in the obese rat hearts but decreased myocardial tolerance to I/R in control rat hearts. This decreased tolerance to ischemia of oxfenicine treated controls was associated with adverse changes in basal and reoxygenation mitochondrial function. These changes were absent in oxfenicine treated hearts from obese rats. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Category: alcohols-buliding-blocks

The Article related to chronic cpt1 myocardial ischemia reperfusion injury obesity, Mammalian Pathological Biochemistry: Cardiovascular Diseases and other aspects.Category: alcohols-buliding-blocks

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On July 31, 2014, Marina Prendes, M. G.; Hermann, R.; Torresin, M. E.; Souto, P.; Tallis, S.; Savino, E. A.; Varela, A.; Jaitovich, M. M. published an article.Computed Properties of 32462-30-9 The title of the article was Involvement of energetic metabolism in the effects of ischemic postconditioning on the ischemic-reperfused heart of fed and fasted rats [Erratum to document cited in CA155:680168]. And the article contained the following:

On page 303, an author was erroneously omitted from the author list; the corrected author list is given. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Computed Properties of 32462-30-9

The Article related to erratum energy metabolism ischemic postconditioning reperfusion fed fasting heart, Mammalian Pathological Biochemistry: Cardiovascular Diseases and other aspects.Computed Properties of 32462-30-9

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On July 31, 2011, Marina Prendes, M. G.; Hermann, R.; Torresin, M. E.; Souto, P.; Tallis, S.; Savino, E. A.; Varela, A.; Jaitovich, M. M. published an article.Product Details of 32462-30-9 The title of the article was Involvement of energetic metabolism in the effects of ischemic postconditioning on the ischemic-reperfused heart of fed and fasted rats. And the article contained the following:

The effects of ischemic-postconditioning (IPOC) on functional recovery and cell viability of ischemic-reperfused hearts from fed and fasted rats were studied in relation to triacylglycerol and glycogen mobilization, ATP content, glucose-6-phosphate dehydrogenase activity and reduced/oxidized glutathione (GSH/GSSG). Oxidative damage was estimated by measuring thiobarbituric acid reactive substances (TBARS). IPOC improved contractile recovery and cell viability in the fed but attenuated them in the fasted hearts. In both groups ischemia lowered glycogen. IPOC further reduced it. Triacylglycerol remained unchanged during ischemia-reperfusion in both groups, but triacylglycerol mobilization was activated by IPOC in the fasted group. ATP was increased by IPOC in the fed hearts, but lowered in the fasted ones, which appeared to be associated with the rates of ATP synthesis in isolated mitochondria. In the fed hearts IPOC raised glucose-6-phosphate dehydrogenase activity and GSH/GSSG, and lowered TBARS. These results suggest that IPOC effects are associated with changes in the ATP supply, mobilization of energy sources and glutathione antioxidant ratio. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Product Details of 32462-30-9

The Article related to energy metabolism ischemic postconditioning reperfusion fed fasting heart, Mammalian Pathological Biochemistry: Cardiovascular Diseases and other aspects.Product Details of 32462-30-9

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Chen, Jiying; Zhou, Qinger; Zhang, Yonggang; Tan, Wenqing; Gao, Hanchao; Zhou, Liying; Xiao, Shuixiu; Gao, Jinhua; Li, Jing; Zhu, Zhiying published an article in 2021, the title of the article was Discovery of novel serum metabolic biomarkers in patients with polycystic ovarian syndrome and premature ovarian failure.Recommanded Product: H-Phg(4-OH)-OH And the article contains the following content:

Several widely recognized metabolites play a role in regulating the pathophysiol. processes of various disorders. Nonetheless, the lack of effective biomarkers for the early diagnosis of polycystic ovarian syndrome (PCOS) and premature ovarian failure (POF) has led to the discovery of serum-based metabolic biomarkers for these disorders. We aimed to identify various differentially expressed metabolites (DEMs) through serum-based metabolic profiling in patients with PCOS and POF and in healthy individuals by using liquid chromatog.-mass spectrometry anal. Furthermore, heatmap clustering, correlation, and Z-score analyses were performed to identify the top DEMs. Kyoto Encyclopedia of Genes and Genomes enriched pathways of DEMs were determined using metabolite-based databases. Moreover, the clin. significance of these DEMs was evaluated on the basis of area under the receiver operating characteristic curve. Significantly dysregulated expressions of several metabolites were observed in the intergroup comparisons of the PCOS, POF, and healthy control groups. Furthermore, 6 DEMs were most frequently observed among the three groups. The expressions of these DEMs were not only directly correlated but also exhibited potential significance in patients with PCOS and POF. Novel metabolites with up/downregulated expressions can be discovered in patients with PCOS and POF using serum-based metabolomics; these metabolites show good diagnostic performance and can act as effective biomarkers for the early detection of PCOS and POF. Furthermore, these metabolites might be involved in the pathophysiol. mechanisms of PCOS and POF via interplay with corresponding genes. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Recommanded Product: H-Phg(4-OH)-OH

The Article related to polycystic ovarian syndrome premature failure metabolic biomarkers human, metabolic biomarkers, polycystic ovarian syndrome, premature ovarian failure, Mammalian Pathological Biochemistry: Obstetrics – Gynecology and other aspects.Recommanded Product: H-Phg(4-OH)-OH

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