Category: 32462-30-9

On August 21, 2020, Forneris, Clarissa C.; Nguy, Andy K. L.; Seyedsayamdost, Mohammad R. published an article.Quality Control of H-Phg(4-OH)-OH The title of the article was Mapping and Exploiting the Promiscuity of OxyB toward the Biocatalytic Production of Vancomycin Aglycone Variants. And the article contained the following:

Vancomycin is one of the most important clin. antibiotics in the fight against infectious disease. Its biol. activity relies on three aromatic cross-links, which create a cup-shaped topol. and allow tight binding to nascent peptidoglycan chains. The cytochrome P 450 enzymes OxyB, OxyA, and OxyC have been shown to introduce these synthetically challenging aromatic linkages. The ability to utilize the P 450 enzymes in a chemo-enzymic scheme to generate vancomycin derivatives is appealing but requires a thorough understanding of their reactivities and mechanisms. Herein, we systematically explore the scope of OxyB biocatalysis and report installation of diverse diaryl ether and biaryl cross-links with varying macrocycle sizes and compositions, when the enzyme is presented with modified vancomycin precursor peptides. The structures of the resulting products were determined using one-dimensional/two-dimensional NMR spectroscopy, high-resolution mass spectrometry (HR-MS), tandem HR-MS, and isotopic labeling, as well as UV-visible light absorption and fluorescence emission spectroscopies. An exploration of the biol. activities of these alternative OxyB products surprisingly revealed antifungal properties. Taking advantage of the promiscuity of OxyB, we chemo-enzymically generated a vancomycin aglycon variant containing an expanded macrocycle. Mechanistic implications for OxyB and future directions for creating vancomycin analog libraries are discussed. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Quality Control of H-Phg(4-OH)-OH

The Article related to oxyb monooxygenase vancomycin aglycon variant, biosynthesis, chemo-enzymatic synthesis, macrocycles, vancomycin, Placeholder for records without volume info and other aspects.Quality Control of H-Phg(4-OH)-OH

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On April 13, 2021, Pandey, Renu; Collins, Meghan; Lu, Xiyuan; Sweeney, Shannon R.; Chiou, Jennifer; Lodi, Alessia; Tiziani, Stefano published an article.Electric Literature of 32462-30-9 The title of the article was Novel Strategy for Untargeted Chiral Metabolomics using Liquid Chromatography-High Resolution Tandem Mass Spectrometry. And the article contained the following:

Stereospecific recognition of metabolites plays a significant role in the detection of potential disease biomarkers thereby providing new insights in diagnosis and prognosis. D-Hdroxy/amino acids are recognized as potential biomarkers in several metabolic disorders. Despite continuous advances in metabolomics technologies, the simultaneous measurement of different classes of enantiomeric metabolites in a single anal. run remains challenging. Here, we develop a novel strategy for untargeted chiral metabolomics of hydroxy/amine groups (-OH/-NH2) containing metabolites, including all hydroxy acids (HAs) and amino acids (AAs), by chiral derivatization coupled with liquid chromatog.-high resolution tandem mass spectrometry (LC-HR-MS/MS). Diacetyl-tartaric anhydride (DATAN) was used for the simultaneous derivatization of-OH/-NH2 containing metabolites as well as the resulting diastereomers, and all the derivatized metabolites were resolved in a single anal. run. Data independent MS/MS acquisition (DIA) was applied to pos. identify DATAN-labeled metabolites based on reagent specific diagnostic fragment ions. We discriminated chiral from achiral metabolites based on the reversal of elution order of D and L isomers derivatized with the enantiomeric pair (±) of DATAN in an untargeted manner. Using the developed strategy, a library of 301 standards that consisted of 214 chiral and 87 achiral metabolites were separated and detected in a single anal. run. This approach was then applied to investigate the enantioselective metabolic profile of the bone marrow (BM) and peripheral blood (PB) plasma samples from patients with acute myeloid leukemia (AML) at diagnosis and following completion of the induction phase of chemotherapeutic treatment. The sensitivity and selectivity of the developed method enabled the detection of trace levels of the D-enantiomer of HAs and AAs in primary plasma patient samples. Several of these metabolites were significantly altered in response to chemotherapy. The developed LC-HR-MS method entails a valuable step forward in chiral metabolomics. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Electric Literature of 32462-30-9

The Article related to untargeted chiral metabolomics liquid chromatog high resolution mass spectrometry, tandem, Placeholder for records without volume info and other aspects.Electric Literature of 32462-30-9

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Qian, Heying; Li, Gang; Zhao, Guodong; Liu, Mingzhu; Xu, Anying published an article in 2020, the title of the article was Metabolic characterisation of the Midgut of Bombyx mori varieties after BmNPV infection using GC-MS-based metabolite profiling.Synthetic Route of 32462-30-9 And the article contains the following content:

Bombyx mori nucleopolyhedrovirus (BmNPV) is a silkworm disease that is especially harmful to cocoon production and seriously restricts sericultural development. Our laboratory successfully cultivated a new highly BmNPV-resistant silkworm variety, Huakang 2; however, its mechanism of BmNPV resistance remains unclear. To understand its resistance mechanism, we conducted a metabolomic and transcriptomic study of the midgut of silkworm varieties, Baiyu N and Baiyu after BmNPV infection. We identified 451 differential metabolites, which were mostly comprised of small mols., such as saccharides, acids, amines, alcs., and glycosides. We found that the primary differences in disease resistance between the silkworm varieties are metabolic-pathways, tryptophan metabolism, oxidative phosphorylation, ABC-transporters, beta-alanine metabolism, and phenylalanine metabolism Combined anal. with transcriptomic data suggested that tryptophan metabolism and oxidative phosphorylation are closely related to the silkworms BmNPV resistance. We hypothesize that the roles of the two metabolic pathways in the BmNPV resistance mechanism might be the following: Oxidative phosphorylation generates a large amount of ATP (ATP) in response to BmNPV infection to provide silkworms the energy required for establishing BmNPV resistance. Tryptophan metabolism then activates the aryl hydrocarbon receptor (AhR) through the exogenous virus BmNPV, which activates the silkworm′s immune system to defeat BmNPV infections. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Synthetic Route of 32462-30-9

The Article related to transcriptome metabolome oxidative phosphorylation nucleopolyhedrovirus bombyx, bmnpv, gc-ms, rna-seq, metabolic pathway, silkworm, Placeholder for records without volume info and other aspects.Synthetic Route of 32462-30-9

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On June 30, 2021, Wu, Yue; Yu, Jiaxiao; Liu, Xiyao; Wang, Wenling; Chen, Zhi; Qiao, Juan; Liu, Xiaohui; Jin, Huili; Li, Xin; Wen, Li; Tian, Jing; Saffery, Richard; Kilby, Mark D.; Qi, Hongbo; Tong, Chao; Baker, Philip N. published an article.Formula: C8H9NO3 The title of the article was Gestational diabetes mellitus-associated changes in the breast milk metabolome alters the neonatal growth trajectory. And the article contained the following:

Gestational diabetes mellitus (GDM) is the most common metabolic disturbance during pregnancy and leads to an altered metabolic profile of human breast milk (HBM). The association between HBM metabolites and neonatal growth in GDM pregnancies has not been thoroughly investigated.The primary aim was to quantify differences in the HBM metabolome between normal and GDM pregnancies. The secondary aim was to identify metabolites associated with neonatal growth during the first year postpartum.In the present study, mothers intending to exclusively breastfeed (BF) and their newborns (mother-infant pairs) were recruited at delivery (n = 129 normal pregnancies and n = 98 GDM pregnancies). HBM samples (colostrum, transition milk, and mature milk) from mothers with normal pregnancies (n = 50) and GDM pregnancies (n = 50) were subjected to metabolomic profiling via liquid chromatog. tandem mass spectrometry (LC-MS/MS). Receiver operating characteristic (ROC) anal. revealed the metabolomic fingerprints of GDM-associated mature HBM. Correlations between metabolites and neonatal body weight gain (BWG) were evaluated by Spearman correlation anal.In total, 620 metabolites were identified in each HBM sample; 253 compounds had the same variation patterns, whereas 38 compounds had significantly different pattern transitions between the GDM and normal groups. Moreover, 12, 49 and 28 metabolites exhibited significant differences in the 3 milk types between the 2 groups. Twenty-two metabolites were confirmed by ROC anal. as metabolomic fingerprints in the mature BM of GDM patients. Ten compounds were significantly neg. correlated with neonatal growth, and only 2 unsaturated lipids (eicosatrienoic acid (FA 20:3) and lysophosphatidylcholine (LysoPC) (22:6)) were pos. correlated with neonatal BWG.GDM is associated with alterations in the HBM metabolome. Only a small subset of compounds are associated with neonatal body weight (BW). The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Formula: C8H9NO3

The Article related to metabolome breast milk gestational diabetes mellitus neonate, gestational diabetes mellitus, human breast milk, metabolome, neonatal growth, Placeholder for records without volume info and other aspects.Formula: C8H9NO3

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Yang, Hao; Wang, Zhenfei; Shi, Shujun; Yu, Qin; Liu, Meiling; Zhang, Zhelin published an article in 2022, the title of the article was Identification of cerebrospinal fluid metabolites as biomarkers for neurobrucellosis by liquid chromatography-mass spectrometry approach.Application of 32462-30-9 And the article contains the following content:

Neurobrucellosis is the most morbid form in brucellosis disease. Metabolomics is an emerging method which intends to explore the global alterations of various metabolites in samples. We aimed to identify metabolites in cerebrospinal fluid (CSF) as biomarkers that were potentially unique for neurobrucellosis. CSF samples from 25 neurobrucellosis patients and 25 normal controls (uninfected patients with hydrocephalus) were collected for metabolite detection using liquid chromatog.-mass spectrometry (LC-MS) approach. Inflammatory cytokines in CSF were measured with ELISA (ELISA). The base peak chromatogram in CSF samples showed that small-mol. metabolites were well separated Principal Component Anal. (PCA) anal. exhibited the examined samples were arranged in two main clusters in accordance with their group. Projection to Latent Structures Discriminant Anal. (PLS-DA) revealed there was a noticeable separation between neurobrucellosis and normal groups. Orthogonal Partial Least-Squares-Discriminant Anal. (OPLS-DA) could responsibly illuminate the differences between neurobrucellosis and normal controls. Neurobrucellosis showed a total of 155 differentiated metabolites. Prominent potential biomarkers including 30 metabolites were then selected out, regarded as more capable of distinguishing neurobrucellosis. TNF-α and IL-6 in CSF were remarkably increased in neurobrucellosis. We presented the heatmaps and correlation analyses among the identified 30 potential biomarkers. In conclusion, this study showed that CSF metabolomics based on LC-MS could distinguish neurobrucellosis patients from normal controls. Our data offered perspectives for diagnosis and treatment for neurobrucellosis. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Application of 32462-30-9

The Article related to neurobrucellosis cerebrospinal fluid metabolite biomarker lcms, neurobrucellosis, cerebrospinal fluid, liquid chromatography-mass spectrometry, metabolomics, Placeholder for records without volume info and other aspects.Application of 32462-30-9

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On April 22, 2021, Kuehl, Nikos; Leuthold, Mila M.; Behnam, Mira A. M.; Klein, Christian D. published an article.Category: alcohols-buliding-blocks The title of the article was Beyond Basicity: Discovery of Nonbasic DENV-2 Protease Inhibitors with Potent Activity in Cell Culture. And the article contained the following:

The viral serine protease NS2B-NS3 is one of the promising targets for drug discovery against dengue virus and other flaviviruses. The mol. recognition preferences of the protease favor basic, pos. charged moieties as substrates and inhibitors, which leads to pharmacokinetic liabilities and off-target interactions with host proteases such as thrombin. We here present the results of efforts that were aimed specifically at the discovery and development of noncharged, small-mol. inhibitors of the flaviviral proteases. A key factor in the discovery of these compounds was a cellular reporter gene assay for the dengue protease, the DENV2proHeLa system. Extensive structure-activity relationship explorations resulted in novel benzamide derivatives with submicromolar activities in viral replication assays (EC50 0.24μM), selectivity against off-target proteases, and negligible cytotoxicity. This structural class has increased drug-likeness compared to most of the previously published active-site-directed flaviviral protease inhibitors and includes promising candidates for further preclin. development. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Category: alcohols-buliding-blocks

The Article related to nonbasic small mol denv2 protease inhibitor, denv2 inhibitor structure activity relationship antiviral agent, General Organic Chemistry: Synthetic Methods and other aspects.Category: alcohols-buliding-blocks

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On October 25, 2020, Li, Xiao’Ou; Cheng, Jiahan; Shen, Yongchun; Chen, Jun; Wang, Tao; Wen, Fuqiang; Chen, Lei published an article.Application of 32462-30-9 The title of the article was Metabolomic analysis of lung cancer patients with chronic obstructive pulmonary disease using gas chromatography-mass spectrometry. And the article contained the following:

Chronic obstructive pulmonary disease (COPD), characterized by intermittent exacerbations and clin. subphenotypes like emphysema and chronic bronchitis, poses a significant risk of lung cancer (LC) development. Metabolomic studies of COPD are scarce, and those of LC patients with COPD subphenotypes have not been investigated. To study metabolite profile alteration in LC patients with different COPD subphenotypes, lung paracancer tissue from 10 LC (CON) patients, 10 LC patients with emphysema (E), and 9 LC patients with chronic bronchitis (CB) were analyzed using gas chromatog.-mass spectrometry. Multivariate anal. indicated a distinct separation between LC patients with COPD subphenotypes and LC patients. Overall, 60, 55, 33 and 63 differential metabolites (DM) were identified in comparisons between CB vs. CON, E vs. CON, CB vs. E, and CB + E vs. CON, resp., and of these, 8 DM were shared in all comparisons. Among the high altered metabolites, E samples showed higher ‘acetol’ than CON samples, and lower ‘azelaic acid’, ‘3-methylglutaric acid’ and ‘allose’. CB samples showed higher ‘turanose’ and ‘o-phosphoserine’ and lower ‘anandamide’ than CON and E samples. In CB and E samples, ‘galactonic acid’, ‘2-mercaptoethanesulfonic acid’, ‘D-alanyl-D-alanine’ ‘3-methylglutaric acid’, ‘glycine’, ‘L-4-Hydroxyphenylglycine’ and ‘O-phosphonothreonine’ had common alteration trends compared with those of CON samples. ‘Glycine’, ‘L-4-Hydroxyphenylglycine’ and ‘O-phosphonothreonine’ were significantly enriched in glycine, serine and threonine metabolism pathways. The total differential metabolites detected were remarkably altered in pyrimidine, beta-alanine and purine metabolism Our study provided altered DM patterns of lung paracancer tissue, the key metabolites and their enriched metabolic pathways in LC patients with different COPD subphenotypes. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Application of 32462-30-9

The Article related to metabolomic lung cancer obstructive disease, chronic obstructive pulmonary disease, gas chromatography-mass spectrometry, lung cancer, metabolite, Mammalian Pathological Biochemistry: Oncology and other aspects.Application of 32462-30-9

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On November 30, 2010, Berkecz, Robert; Hyyrylaeinen, Anna R. M.; Fueloep, Ferenc; Peter, Antal; Janaky, Tamas; Vainiotalo, Pirjo; Pakarinen, Jaana M. H. published an article.Recommanded Product: 32462-30-9 The title of the article was Chiral discrimination of β-3-homo-amino acids using the kinetic method. And the article contained the following:

Chiral discrimination of seven enantiomeric pairs of β-3-homo-amino acids was studied by using the kinetic method and trimeric metal-bound complexes, with natural and unnatural α-amino acids as chiral reference compounds and divalent metal ions (Cu2+ and Ni2+) as the center ions. The β-3-homo-amino acids were selected for this study because, first of all, chiral discrimination of β-amino acids has not been extensively studied by mass spectrometry. Moreover, these β-3-homo-amino acids studied have different aromatic side chains. Thus, the emphasis was to study the effect of the side chain (electron d. of the Ph ring, as well as the difference between Ph and benzyl side chains) for the chiral discrimination. The results showed that by the proper choice of a metal ion and a chiral reference compound, all seven enantiomeric pairs of β-3-homo-amino acids could be differentiated. Moreover, it was noted that the β-3-homo-amino acids with benzyl side chains provided higher enantioselectivity than the corresponding Ph ones. However, increasing or decreasing the electron d. of the aromatic ring by different substituents in both the Ph and benzyl side chains had practically no role for chiral discrimination of β-3-homo-amino acids studied. When copper was used as the central metal, the Ph side chain containing reference mols. (S)-2-amino-2-phenylacetic acid (L-Phg) and (S)-2-amino-2-(4-hydroxyphenyl)-acetic acid (L-4′-OHPhg) gave rise to an addnl. copper-reduced dimeric fragment ion, [CuI(ref)(A)]+. The inclusion of this ion improved noticeably the enantioselectivity values obtained. Copyright © 2010 John Wiley & Sons, Ltd. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Recommanded Product: 32462-30-9

The Article related to chiral discrimination homo amino acid kinetic method copper nickel, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Recommanded Product: 32462-30-9

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On August 7, 2010, Lan, Hong-Qiao; Ruan, Yuan-Ping; Huang, Pei-Qiang published an article.Safety of H-Phg(4-OH)-OH The title of the article was The first enantioselective synthesis of cytotoxic marine natural product palau’imide and assignment of its C-20 stereochemistry. And the article contained the following:

Me tetramate derivative I has been developed as a new building block for the flexible and racemization-free synthesis of Me 5-benzyl-3-methyltetramate via alkylation, and used in the first asym. synthesis of palau’imide (II). This allowed the establishment of the hitherto unknown stereochem. at the C-20 of palau’imide as S. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Safety of H-Phg(4-OH)-OH

The Article related to enantioselective synthesis palau’imide alkylation chiral auxiliary, mol structure absolute configuration palau’imide, Alkaloids: Alkaloids Containing Two Nitrogen Atoms and other aspects.Safety of H-Phg(4-OH)-OH

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On December 31, 2021, Ghorbani, Fatemah; Tirgir, Farhang; Jafari, Abbas published an article.SDS of cas: 32462-30-9 The title of the article was Construction and characterization of the novel polymer/Ag nanocomposite coated on glass bead as filter for inactivation of E. coli in water. And the article contained the following:

Abstract: In this project, pseudo-poly(amino acid)s (PAAs) containing different amino acids in main chain were synthesized by direct polyesterification of N,N-(pyromellitoyl)-bis-D-4-hydroxyphenylglycine di-Me ester as biol. active diol with diacid monomer derived from different amino acids was carried by tosyl chloride/pyridine/DMF as condensing agent. All biol. properties of the polymers were determined by biol. evaluation in bacterial media. PAAs containing silver nanoparticles were fabricated by in- situ method using dimethylformaide (DMF) as a solvent which leads to a spontaneous reduce in room temperature Furthermore, these biopolymer nanocomposite/Ag thin films were immobilized on glass microbeads. The chem. structures of synthesized PAAs and PAA/Ag nanocomposite (NC) were considered by FTIR, 1H-NMR spectroscopy, transmission electron microscopy (TEM), elemental anal., differential scanning calorimetry (DSC), thermogravimetric anal. (TGA), SEM, and energy dispersive X-ray (EDAX). The results of EDAX and TEM anal. of PAAs/Ag NC showed that silver particles have homogeneous dispersion and uniformity in nano-dimensions about 50 nm in PAAs matrix. The micro glass beads were coated with PAA/Ag nanocomposite thin film and placed in a column through for the disinfecting effect of Escherichia coli in water was evaluated very well. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).SDS of cas: 32462-30-9

The Article related to filter silver polyester polyimide nanocomposite preparation thermal, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.SDS of cas: 32462-30-9

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